• 농촌의학ㆍ지역보건
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• 제48권1호
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• pp.1-12
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• 2023

Objective: The purpose of this study was to identify factors associated with subjective memory impairment in patients with diabetes mellitus in a metropolitan city. Methods: The subjects of this study were 351 patients with diabetes mellitus aged 50 and over from five districts of Gwangju who participated in the 2018 Community Health Survey. We analyzed general characteristics, health-related behaviors and health related conditions and subjective experience of memory impairment. To find factors associated with subjective memory impairment, the chi-square test and multiple logistic regression analysis were used. Results: Of all subjects, 31.3% was reported subjective experience of memory impairment. The odds ratios (ORs; 95% confidence interval (CI)) for subjective memory impairment according to age were statistically significant at 1.9 (0.9-4.3) in patients in 60s and 2.2 (1.1-4.7) in patients in beyond 70s compared to those in 50s. The OR (95% CI) of ex-smoker compared to the non-smoker was 0.3 (0.8-0.9). The OR (95% CI) of depressive symptom compared to no depressive symptoms was 4.9 (95% CI: 1.8-13.7). Conclusion: In this study, subjective memory impairment in patients with diabets mellitus was associated with age, smoking, and depressive symptoms. Based on the results of this study, subjective memory impairment should be detected early through periodic cognitive function evaluation for elderly patients with diabetes mellitus, and a program for healthy cognitive function should be included in diabetes management program.

• 한국산학기술학회논문지
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• 제20권8호
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• pp.83-92
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• 2019

본 연구는 주관적 기억장애를 호소하는 65세 이상 노인을 대상으로 스스로 경험하는 깜빡 잊어버리는 건망증에 대한 경험을 분석하기 위한 포커스그룹 면담을 적용한 질적연구이다. 본 연구 대상자는 D시의 일개 노인복지관에서 인지기능향상 프로그램에 참여하는 65세 이상 노인 남녀 10명을 대상으로 수행하였다. 연구대상자는 주관적 기억장애를 호소하며, 건망증을 경험한 노인으로 자신의 의사표현을 자유롭게 잘 할 수 있는 노인으로 하였으며, 총 3-4명 씩 3그룹으로 나누어 진행하였고 각 그룹 당 40~60분의 면담을 진행하였다. 본 연구 결과 '인간관계에서의 곤란함', '일상생활에서의 불편감/안전위험성 노출', '표현할 수 없는 양가감정', '건망증을 이겨내기 위한 가족의 노력', '자신만의 건망증 예방 노하우' 5개의 주제어가 도출되었다. 본 연구에 참여한 주관적 기억장애를 호소하는 노인들은 치매가 아닌 것에 대한 안도감과 치매로의 이환에 대한 불안감을 동시에 가지고 있었고, 건망증을 스스로 이겨내기 위한 각자의 방법을 수행하고 있었다. 본 연구를 바탕으로 추후, 주관적 기억장애를 호소하는 노인들의 각자의 방법과 요구도를 반영한 기억력 향상 중재개발이 이루어져야 할 것으로 사료된다.

• 생물정신의학
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• 제21권4호
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• pp.175-181
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• 2014

Objectives It was the aim to examine the association of the thyroid-related hormones with cognitive function, depression, and subjective memory impairment in community-dwelling elders with questionable dementia. Methods The sample consisted of 399 community residents with 'questionable dementia' aged 60 or over in whom serum thyroid-related hormones [thyroid stimulating hormone (TSH) and thyroxine] had been assayed. Cognitive impairment was defined using the Korean version of the Consortium Establish a Registry for Alzheimer's Disease. Depression was diagnosed using the Korean version of Geriatric Depression Scale and subjective memory complaint (SMC) was checked using the subjective memory complaints questionnaire (SMCQ). Age, gender, education, and the presence of apolipoprotein E {\varepsilon}4 were included as covariates. Results There was a significant positive association between verbal fluency test (VFT) score and serum TSH levels (p = 0.01). There was a significant negative association between SMCQ total score and word list memory test (WLMT)(p = 0.002) or word list recall test (WLRT) score (p = 0.013). Conclusions Lower serum TSH levels were associated with semantic memory (VFT), and we found that SMC was associated with episodic memory (WLMT and WLRT) in this sample.

• 한국노년학
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• 제38권4호
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• pp.853-869
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• 2018

본 연구는 전립선비대증을 가진 노인을 대상으로 주관적 기억장애에 영향을 미치는 요인을 파악하는 것을목적으로 하였다. 연구대상은 일 광역시 두 개 종합병원 비뇨기과 외래에서 전립선비대증을 진단받은 노인 179명이며, 하부요로증상, 수면장애, 일상생활 수행능력에 따른 주관적 기억장애의 차이를 파악하기 위하여 t-test, one-way ANOVA를 실시하였고, $Scheff{\acute{e}}$ test로 사후검정을 하였다. 또한, 제 변수와의 상관관계는 Pearson's correlation-coefficient로 분석하였고, 주관적 기억장애에 영향을 미치는 요인은 stepwise multiple regression으로 분석하였다. 본 연구결과 하부요로증상(${\beta}=.52$, p<.001), 일상생활 수행능력(${\beta}=.18$, p=.005)이 주관적 기억장애와 관련 있으며, 두 변수는 주관적 기억장애를 30.0% 설명하였다. 이 연구결과를 바탕으로 다음과 같은 점을 논의하였다. 첫째, 전립선비대증에 의한 하부요로증상은 주관적 기억장애의 위험성을 증가시킬 수 있다. 둘째, 하부요로증상 치료가 미뤄지는 이유는 연령이 증가할수록 하부요로증상을 노화에 따른 자연스런 생리현상으로 인식하기 때문이다. 셋째, 하부요로증상을 예방하기 위하여 조기 검진과 시기적절한 중재가 권고된다. 이를 바탕으로 전립선비대증을 가진 노인의 하부요로증상을 완화시킬 수 있는 간호중재 프로그램 개발과 주관적 기억장애를 사정, 평가, 중재할 수 있는 간호사 양성을 위한 교육 프로그램 개발을 제언한다.

• 디지털융복합연구
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• 제17권2호
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• pp.283-292
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• 2019

초기의 인지 감퇴를 판단하는 요소로 의미지식 및 의미 연관관계의 범주별 손상 유무가 주목을 받고 있다. 본 연구에서는 정상 및 주관적 기억장애, 경도인지장애 노인을 대상으로 의미연상과제를 사용하여 인지 감퇴의 정도에 따라 관찰되는 의미 하위범주별 수행과 오류유형의 차이를 살펴보고자 하였다. 연구 결과, 의미연상과제 범주별 정반응 점수와 반응시간에서 세 군 간 유의한 차이를 보였으며, 하위범주 중, '기능'에서 가장 높은 수행력을, '상위'와 '부분/전체'에서 가장 낮은 수행력을 보였다. 또한, 오류유형별 산출 횟수는 정상에서 경도인지장애 노인으로 갈수록 유의하게 높아졌으며, 무반응은 주관적 기억장애 노인부터 유의하게 증가하였다. 결론적으로, 인지 감퇴가 진행될수록 의미연결망에서 범주별 손상의 정도와 과정이 다르므로, 기억장애 노인의 인지적 감퇴를 확인하고 추적 관찰하기 위한 지표로 의미연상과제 수행력을 활용할 수 있을 것이다.

• Journal of Ginseng Research
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• 제47권6호
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• pp.735-742
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• 2023

Background: Gintonin is a new material of ginseng that acts through the ginseng-derived lysophosphatidic acid (LPA) receptor ligand. The gintonin-enriched fraction (GEF) inhibits amyloid plaque accumulation in the cortex and hippocampus, improves cognitive dysfunction by increasing acetylcholine levels, and promoted hippocampal neurogenesis in an animal model of Alzheimer's disease. We evaluated the effect of the GEF on the cognitive performance of subjects with subjective memory impairment (SMI). Methods: In this eight-week, randomized, assessor- and participant-blinded, placebo-controlled study, participants with SMI were assigned to three groups receiving placebo, GEF 300 mg/day or GEF 600 mg/day. The Korean versions of the Alzheimer's Disease Assessment Scale (K-ADAS), Mini-Mental State Examination (K-MMSE), and Stroop color-word test (K-SCWT) were also evaluated along with the safety profiles. Results: One hundred thirty-six participants completed the study. After eight weeks, we analyzed intergroup differences in primary or secondary outcome score changes. When we compared the GEF group with the placebo group, we observed significant improvements in the K-ADAS and K-SCWT scores. The GEF group did not show a significant improvement in K-MMSE and BDI scores compared to the placebo group. No adverse events were observed in the gintonin and placebo groups for eight weeks. Conclusion: The GEF is safe and effective in improving subjective cognitive impairment related to both the K-ADAS and K-SCWT in this study. However, further large-scale and randomized controlled studies are warranted to secure other cognitive function tests besides the K-ADAS and K-SCWT, and to confirm the findings of the current study.

• 대한간호학회지
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• 제45권1호
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• pp.118-128
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• 2015

Purpose: Evidence suggests that some patients with breast cancer experience cognitive difficulties following chemotherapy. This longitudinal study was done to examine the prevalence of cognitive impairment and trajectory of cognitive function over time in women with breast cancer, who received adjuvant chemotherapy. Methods: Participants were 137 patients with breast cancer. They completed neuropsychological tests and the Functional Assessment of Cancer Therapy-Cognitive Function before adjuvant therapy (pretest), toward the end of adjuvant therapy (posttest), and 6 months after the completion of adjuvant therapy (follow-up test). Of the patients, 91 were treated with adjuvant chemotherapy and 46 patients who did not receive chemotherapy made up the comparison group. A reliable-change index and repeated-measure ANOVA were used for statistical analyses. Results: At the posttest point, over 30% of patients showed complex cognitive impairment and reported greater difficulty in subjective cognitive function. At the follow-up test point, 22.0% of patients exhibited complex cognitive impairment and 30.8% of patients complained of subjective cognitive impairment. Repeated-measure ANOVA showed significant decreases after receiving chemotherapy followed by small improvements 6 months after the completion of chemotherapy in cognitive domains of change for attention and concentration, memory, executive function, and subjective cognitive function. Conclusion: These results suggest that chemotherapy in patients with breast cancer may be associated with objective and subjective cognitive impairments. Further studies are needed to explore the potential risk factors and predictor of chemotherapy-related cognitive changes. Also nursing interventions for prevention and intervention of cognitive impairments should be developed and tested.

• Journal of Ginseng Research
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• 제48권3호
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• pp.245-252
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• 2024

Ginseng is a traditional herbal medicine used for prevention and treatment of various diseases as a tonic. Recent scientific cohort studies on life prolongation with ginseng consumption support this record, as those who consumed ginseng for more than 5 years had reduced mortality and cognitive decline compared to those who did not. Clinical studies have also shown that acute or long-term intake of ginseng total extract improves acute working memory performance or cognitive function in healthy individuals and those with subjective memory impairment (SMI), mild cognitive impairment (MCI), or early Alzheimer's disease (AD) dementia who are taking AD medication(s). Ginseng contains various components ranging from classical ginsenosides and polysaccharides to more recently described gintonin. However, it is unclear which ginseng component(s) might be the main candidate that contribute to memory or cognitive improvements or prevent cognitive decline in older individuals. This review describes recent clinical contributors to ginseng components in clinical tests and introduces emerging evidence that ginseng components could be novel candidates for cognitive improvement in older individuals, as ginseng components improve SMI cognition and exhibits add-on effects when coadministered with early AD dementia drugs. The mechanism behind the beneficial effects of ginseng components and how it improves cognition are presented. Additionally, this review shows how ginseng components can contribute to SMI, MCI, or early AD dementia when used as a supplementary food and/or medicine, and proposes a novel combination therapy of current AD medicines with ginseng component(s).

• 대한간호학회지
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• 제42권5호
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• pp.644-658
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• 2012

Purpose: The purpose of this study was to evaluate the cognitive effects of chemotherapy in patients with breast cancer. Methods: Using several databases, prospective studies were collected up to August 2011. Of 2,106 publications identified, 12 met the inclusion criteria, and 8 studies were used to estimate the effect size of chemotherapy on cognitive impairment. Results: Twelve studies were done since 2005 and most of the research was performed in Europe or North America. Eight studies were used to generate effect size across the cognitive domains of attention/concentration, verbal and visual memory, executive function, visuospatial skill, language, and subjective cognitive function. Each of the cognitive domains showed small effect sizes (-0.02 ~ -0.26), indicating diminished cognitive function for the chemotherapy group compared with non-chemotherapy groups. Conclusion: Finding suggests that breast cancer patients who undergo chemotherapy may experience mild cognitive decline. Further study is needed to generate knowledge and guideline for interventions to address chemotherapy related cognitive impairment in these patients.

• 대한통합의학회지
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• 제12권2호
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• pp.111-119
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• 2024

Purpose : This study aimed to demonstrate the effects of visiting cognitive activities using brain training on cognition, subjective memory complaints and depression among elderly participants residing in community living in Gwangmyeong city. Methods : Over a 14-month period (October 2022 to December 2023), four brain training instructors visited the homes of older adults and conducted the intervention using a brain training kit. The participants included 32 elderly individuals aged 65 years and older, who were living in Gwangmyeong city. The assessments were conducted by an occupational therapist, a nurse and a social worker at the Gwangmyeong dementia relief center. These assessments included the following the subjective memory complaints questionnaire (SMCQ), short geriatric depression scale-Korean (SGDS-K), a cognitive impairment screening test (CIST), the consortium to establish a registry for Alzheimer's disease-Korean (CERAD-K). The participants were divided into three groups (A: 20-30 points, B: 10-19 points, C: 1-9 points) based on the CIST score. For data analysis, descriptive statistics and wilcoxon signed-rank test were performed using SPSS 24.0, and the statistical level was at a=.05. Results : The results of the intervention showed that the SMCQ score of group A improved significantly (p<.05), the CIST score of group B also improved significantly (p<.05). However, the SGDS-K score of group C improved, but did not demonstrate statistical significance (p=.080). Conclusion : The visiting cognitive activities using brain training produced significant effects on cognition, depression, and subjective memory disorders, depending on the cognitive level of the elderly participants. In the future, it will be necessary to demonstrate the effects according to cognitive level in various aspects with more elderly people.