생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제21권4호
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  • Pages.175-181
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  • 2014
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

일 지역 치매의심 노인군에서 갑상선관련 호르몬, 인지기능, 우울증, 주관적 기억저하의 연관성

Thyroid Hormones, Cognitive Impairment, Depression and Subjective Memory Complaint in Community-Dwelling Elders with Questionable Dementia in Korea

  • 이성남 (건국대학교 의학전문대학원 정신건강의학교실) ;
  • 진하영 (순천향대학교 천안병원 정신건강의학과) ;
  • 문석우 (건국대학교 의학전문대학원 정신건강의학교실)
  • Lee, Sung Nam (Department of Neuropsychiatry, Konkuk University School of Medicine) ;
  • Jin, Ha Young (Department of Clinical Psychology, Soonchunhyang University Cheonan Hospital) ;
  • Moon, Seok Woo (Department of Neuropsychiatry, Konkuk University School of Medicine)
  • 투고 : 2014.08.25
  • 심사 : 2014.10.13
  • 발행 : 2014.11.30
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초록

Objectives It was the aim to examine the association of the thyroid-related hormones with cognitive function, depression, and subjective memory impairment in community-dwelling elders with questionable dementia. Methods The sample consisted of 399 community residents with 'questionable dementia' aged 60 or over in whom serum thyroid-related hormones [thyroid stimulating hormone (TSH) and thyroxine] had been assayed. Cognitive impairment was defined using the Korean version of the Consortium Establish a Registry for Alzheimer's Disease. Depression was diagnosed using the Korean version of Geriatric Depression Scale and subjective memory complaint (SMC) was checked using the subjective memory complaints questionnaire (SMCQ). Age, gender, education, and the presence of apolipoprotein E {\varepsilon}4 were included as covariates. Results There was a significant positive association between verbal fluency test (VFT) score and serum TSH levels (p = 0.01). There was a significant negative association between SMCQ total score and word list memory test (WLMT)(p = 0.002) or word list recall test (WLRT) score (p = 0.013). Conclusions Lower serum TSH levels were associated with semantic memory (VFT), and we found that SMC was associated with episodic memory (WLMT and WLRT) in this sample.

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