• Title/Summary/Keyword: Stress Based Evaluation

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Neuronal Cell Protective Effect of Dendropanax morbifera Extract against High Glucose-Induced Oxidative Stress (High Glucose로 유도된 산화 스트레스에 대한 황칠나무 잎 추출물의 뇌신경세포 보호 효과)

  • Kim, Jong Min;Park, Seon Kyeong;Guo, Tian Jiao;Kang, Jin Yong;Ha, Jeong Su;Lee, Du Sang;Kwon, O-Jun;Lee, Uk;Heo, Ho Jin
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.45 no.7
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    • pp.938-947
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    • 2016
  • Antioxidant activities and neuroprotective effects of ethyl acetate fraction from Dendropanax morbifera (EFDM) against high glucose-induced oxidative stress and neurotoxicity were investigated to confirm their physiological activities. An 80% ethanolic extract of D. morbifera showed the highest contents of total phenolic compounds as well as 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities. The extract was fractionated using several solvents, and the ethyl acetate fraction showed the highest activities in ferric reducing/antioxidant power and malondialdehyde inhibitory assays. To evaluate the neuroprotective effect based on antioxidant activities, cell viability was assessed using PC12 and MC-IXC cells in $H_2O_2$- and high glucose-induced cytotoxic assays, respectively. EFDM evidently showed neuroprotective effects in all cells (neuron-like PC12 cells and human brain-originated neuroblastoma MC-IXC cells). Inhibitory effect of the extract on acetylcholinesterase (AChE) as an acetylcholine-hydrolyzing enzyme was performed to examine the effect on cognitive function. EFDM presented an AChE inhibitory effect. Finally, high-performance liquid chromatography analysis showed that the major phenolic compound of EFDM is probably a rutin.

Estimation for Red Pepper(Capsicum annum L.) Biomass by Reflectance Indices with Ground-Based Remote Sensor (지상부 원격탐사 센서의 반사율지수에 의한 고추 생체량 추정)

  • Kim, Hyun-Gu;Kang, Seong-Soo;Hong, Soon-Dal
    • Korean Journal of Soil Science and Fertilizer
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    • v.42 no.2
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    • pp.79-87
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    • 2009
  • Pot experiments using sand culture were conducted in 2004 under greenhouse conditions to evaluate the effect of nitrogen deficiency on red pepper biomass. Nitrogen stress was imposed by implementing 6 levels (40% to 140%) of N in Hoagland's nutrient solution for red pepper. Canopy reflectance measurements were made with hand held spectral sensors including $GreenSeeker^{TM}$, $Crop\;Circle^{TM}$, and $Field\;Scout^{TM}$ Chlorophyll meter, and a spectroradiometer as well as Minolta SPAD-502 chlorophyll meter. Canopy reflectance and dry weight of red pepper were measured at five growth stages, the 30th, 40th, 50th, 80th and 120th day after planting(DAT). Dry weight of red pepper affected by nitrogen stress showed large differences between maximum and minimum values at the 120th DAT ranged from 48.2 to $196.6g\;plant^{-1}$, respectively. Several reflectance indices obtained from $GreenSeeker^{TM}$, $Crop\;Circle^{TM}$ and Spectroradiometer including chlorophyll readings were compared for evaluation of red pepper biomass. The reflectance indices such as rNDVI, aNDVI and gNDVI by the $Crop\;Circle^{TM}$ sensor showed the highest correlation coefficient with dry weight of red pepper at the 40th, 50th, and 80th DAT, respectively. Also these reflectance indices at the same growth station was closely correlated with dry weight, yield, and nitrogen uptake of red pepper at the 120th DAT, especially showing the best correlation coefficient at the 80th DAT. From these result, the aNDVI at the 80th DAT can significantly explain for dry weight of red pepper at the 120th DAT as well as for application level of nitrogen fertilizer. Consequently ground remote sensing as a non-destructive real-time assessment of plant nitrogen status was thought to be a useful tool for in season nitrogen management for red pepper providing both spatial and temporal information.

Evaluation of Perfusion and Image Quality Changes by Reconstruction Methods in 13N-Ammonia Myocardial Perfusion PET/CT (13N-암모니아 심근관류 PET/CT 검사 시 영상 재구성 방법에 따른 관류량 변화와 영상 평가)

  • Do, Yong Ho;Lee, Hong Jae;Kim, Jin Eui
    • The Korean Journal of Nuclear Medicine Technology
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    • v.18 no.1
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    • pp.69-75
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    • 2014
  • Purpose: The aim of this study was to evaluate changes of quantitative and semi-quantitative myocardial perfusion indices and image quality by image reconstruction methods in $^{13}N$-ammonia ($^{13}N-NH_3$) myocardial perfusion PET/CT. Materials and Methods: Data of 14 (8 men, 6 women) patients underwent rest and adenosine stress $^{13}N-NH_3$ PET/CT (Biograph TruePoint 40 with TrueV, Siemens) were collected. Listmode scans were acquired for 10 minutes by injecting 370MBq of $^{13}N-NH_3$. Dynamic and static reconstruction was performed by use of FBP, iterative2D (2D), iterative3D (3D) and iterative TrueX (TrueX) algorithm. Coronary flow reserve (CFR) of dynamic reconstruction data, extent(%) and total perfusion deficit (TPD) (%) measured in sum of 4-10 minutes scan were evaluated by comparing with 2D method which was recommended by vendor. The image quality of each reconstructed data was compared and evaluated by five nuclear medicine physicians through a blind test. Results: CFR were lower in TrueX 18.68% (P=0.0002), FBP 4.35% (P=0.1243) and higher in 3D 7.91% (P<0.0001). As semi-quantitative values, extent and TPD of stress were higher in 3D 3.07%p (P=0.001), 2.36%p (P=0.0002), FBP 1.93%p (P=0.4275), 1.57%p (P=0.4595), TrueX 5.43%p (P=0.0003), 3.93%p (P<0.0001). Extent and TPD of rest were lower in FBP 0.86%p (P=0.1953), 0.57%p (P=0.2053) and higher in 3D 3.21%p (P=0.0006), 2.57%p (P=0.0001) and TrueX 5.36%p (P<0.0001), 4.36%p (P<0.0001). Based on the results of the blind test for image resolution and noise from the snapshot, 3D obtained the highest score, followed by 2D, TrueX and FBP. Conclusion: We found that quantitative and semi-quantitative myocardial perfusion values could be under- or over-estimated according to the reconstruction algorithm in $^{13}N-NH_3$ PET/CT. Therefore, proper dynamic and static reconstruction method should be established to provide accurate myocardial perfusion value.

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Preliminary Study on the Development of a Performance Based Design Platform of Vertical Breakwater against Seismic Activity - Centering on the Weakened Shear Modulus of Soil as Shear Waves Go On (직립식 방파제 성능기반 내진 설계 Platform 개발을 위한 기초연구 - 전단파 횟수 누적에 따른 지반 강도 감소를 중심으로)

  • Choi, Jin Gyu;Cho, Yong Jun
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.30 no.6
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    • pp.306-318
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    • 2018
  • In order to evaluate the seismic capacity of massive vertical type breakwaters which have intensively been deployed along the coast of South Korea over the last two decades, we carry out the preliminary numerical simulation against the PoHang, GyeongJu, Hachinohe 1, Hachinohe 2, Ofunato, and artificial seismic waves based on the measured time series of ground acceleration. Numerical result shows that significant sliding can be resulted in once non-negligible portion of seismic energy is shifted toward the longer period during its propagation process toward the ground surface in a form of shear wave. It is well known that during these propagation process, shear waves due to the seismic activity would be amplified, and non-negligible portion of seismic energy be shifted toward the longer period. Among these, the shift of seismic energy toward the longer period is induced by the viscosity and internal friction intrinsic in the soil. On the other hand, the amplification of shear waves can be attributed to the fact that the shear modulus is getting smaller toward the ground surface following the descending effective stress toward the ground surface. And the weakened intensity of soil as the number of attacking shear waves are accumulated can also contribute these phenomenon (Das, 1993). In this rationale, we constitute the numerical model using the model by Hardin and Drnevich (1972) for the weakened shear modulus as shear waves go on, and shear wave equation, in the numerical integration of which $Newmark-{\beta}$ method and Modified Newton-Raphson method are evoked to take nonlinear stress-strain relationship into account. It is shown that the numerical model proposed in this study could duplicate the well known features of seismic shear waves such as that a great deal of probability mass is shifted toward the larger amplitude and longer period when shear waves propagate toward the ground surface.

Evaluation of flash drought characteristics using satellite-based soil moisture product between North and South Korea (위성영상 기반 토양수분을 활용한 남북한의 돌발가뭄 특성 비교)

  • Lee, Hee-Jin;Nam, Won-Ho;Jason A. Otkin;Yafang Zhong;Xiang Zhang;Mark D. Svoboda
    • Journal of Korea Water Resources Association
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    • v.57 no.8
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    • pp.509-518
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    • 2024
  • Flash drought is a rapid-onset drought that occurs rapidly over a short period due to abrupt changes in meteorological and environmental factors. In this study, we utilized satellite-based soil moisture product from the Advanced Microwave Scanning Radiometer-2(AMSR2) ascending X-band to calculate the weekly Flash Drought Intensity Index (FDII). We also analyzed the characteristics of flash droughts on the Korean Peninsula over a 10-year period from 2013 to 2022. The analysis of monthly spatial distribution patterns of the irrigation period across the Korean Peninsula revealed significant variations. In North Korea (NK), a substantial increase in the rate of intensification (FD_INT) was observed due to the rapid depletion of soil moisture, whereas South Korea (SK) experienced a significant increase in drought severity (DRO_SEV). Additionally, regional time series analysis revealed that both FD_INT and DRO_SEV were significantly high in the Gangwon province of both NK and SK. The estimation of probability density by region revealed a clear difference in FD_INT between NK and SK, with SK showing a higher probability of severe drought occurrence primarily due to the high values of DRO_SEV. As a result, it is inferred that the occurrence frequency and damage of flash droughts in NK are higher than those in SK, as indicated by the higher density of large FDII values in the NK region. We analyzed the correlation between DRO_SEV and the Evaporative Stress Index (ESI) across the Korean Peninsula and confirmed a positive correlation ranging from 0.4 to 0.6. It is concluded that analyzing overall drought conditions through the average drought severity holds high utility. These findings are expected to contribute to understanding the characteristics of flash droughts on the Korean Peninsula and formulating post-event response plans.

Evaluation of the Minimum Shear Reinforcement Ratio of Reinforced Concrete Members (철근콘크리트 부재의 최소전단보강근비의 평가)

  • Lee Jung-Yoon;Yoon Sung-Hyun
    • Journal of the Korea Concrete Institute
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    • v.16 no.1 s.79
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    • pp.43-53
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    • 2004
  • The current Korean Concrete Design Code(KCI Code) requires the minimum and maximum content of shear s in order to prevent brittle and noneconomic design. However, the required content of the steel reinforcement In KCI Code is quite different to those of the other design codes such as fib-code, Canadian Code, and Japanese Code. Furthermore, since the evaluation equations of the minimum and maximum shear reinforcement for the current KCI Code were based on the experimental results, the equations can not be used for the RC members beyond the experimental application limits. The concrete tensile strength, shear stress, crack inclination, strain perpendicular to the crack, and shear span ratio are strongly related to the lower and upper limits of shear reinforcement. In this research, an evaluation equation for the minimum content of shear reinforcement is theoretical proposed from the Wavier's three principals of the mechanics of materials.

Fatigue Field Test of Variable Message Sign Structure and Evaluation of AASHTO Specifications (가변정보판이 설치된 지주구조물에 대한 피로 시험 및 AASHTO설계기준 적용성 평가)

  • Park, Jong Sup
    • Journal of Korean Society of Steel Construction
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    • v.18 no.1
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    • pp.11-22
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    • 2006
  • Message Signs (VMS) structures offer an increase in traffic safety through their ability to relay massages to motorists for warnings of hazards ahead, traffic congestion, accidents, and lane closings. The geometry of these signs sometimes results in the significant cyclic loading of the supports structure due to wind gusts, which can result from passing trucks or from natural wind. This study presents the results of analytical and experimental investigations of VMS structures. The commercially available softwareGTSTRUDL (2003) was used to perform space-frame structural analyses of these welded tubular structures. Fatigue evaluations were performed using stress ranges from field measurements and from structural analyses. Based on the results of the structural analyses that were conducted, where fatigue design loadings that had been derived from AASHTO Specifications for Structural Supports for Highway Signs, Luminaries, and Traffic Signals (2001) were used, the structures that had been studied were found not to have infinite fatigue life. According to the limited measurements that were made in this study, the fatigue design loadings derived from AASHTO Specifications (2001) appear to be conservative, but they are not overly conservative. The results of this study should be used to make a reasonable design of VMS structures, and to maintain their standards.

Single Carbon Fiber/Acid-Treated CNT-Epoxy Composites by Electro-Micromechanical Technique and Wettability Test for Dispersion and Self-Sensing (젖음성 시험과 전기-미세역학 시험법과 통한 단 카본섬유/산처리된 CNT-에폭시 나노복합재료의 분산과 자체-감지능)

  • Jang, Jung-Hoon;Wang, Zuo-Jia;GnidaKouong, Joel;Gu, Ga-Young;Park, Joung-Man;Lee, Woo-Il;Park, Jong-Kyoo
    • Journal of Adhesion and Interface
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    • v.10 no.2
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    • pp.90-97
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    • 2009
  • Dispersion and self-sensing evaluation for single-carbon fiber reinforced in three different acid-treated CNT-epoxy nanocomposites were investigated by electro-micromechanical techniques and wettability tests. Self-sensing based on contact resistivity exhibited more noise for single carbon fiber/acid-treated CNT-epoxy composites than it did for untreated CNT. However, the apparent modulus was higher the acid treated case than the untreated case which is attributed to better stress transfer. The interfacial shear strength (IFSS) between carbon fibers and the CNT-epoxy was lower than that between carbon fiber and neat epoxy due to the increased viscosity associated with the addition of the CNT. The CNT-epoxy nanocomposite exhibited more hydrophobicity than did neat epoxy. Change in the thermodynamic work of adhesion was consistent with changes in the IFSS but disproportional to that of the apparent modulus. The optimum condition of acid treatment on the need can be obtained instead of the maximum condition.

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Determination of Ozone Tolerance on Environmental Tree Species Using Standard Index (표준화 지수를 이용한 환경수목의 오존 내성 결정)

  • Han, Sim-Hee;Kim, Du-Hyun
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.11 no.1
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    • pp.3-12
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    • 2009
  • Ozone tolerance of tree species was determined by standard index of physiological damages and biochemical defense responses under short-term ozone exposure. At the end of 150ppb $O_3$ fumigation, photosynthetic characteristics and antioxidative enzyme activities were analyzed in the leaves of five species(Koelreuteria paniculata, Firmiana simplex, Styrax japonica, Fraxinus rhynchophylla, Viburnum sargentii). Injury index was determined by the effect of ozone on photosynthetic parameters and malondialdehyde(MDA) content, and tolerance index was calculated using the rate of increase in superoxide dismutase(SOD), ascorbate-peroxidase(APX), glutathione reductase(GR) and catalase(CAT) activities. Apparent quantum yield(AQY), carboxylation efficiency(Ce) and photo-respiration rate(PR) decreased in the leaves of five species with increasing ozone exposure time. These parameters were considered as an appropriate indicator for stress evaluation. Antioxidative enzyme activities showed various results depending on the tree species, exposure time, and enzyme types. SOD activity of K. paniculata increased with ozone exposure time, and that of F. rhynchophylla increased only after 6 hours of ozone exposure. CAT activity of $O_3$-exposed F. simplex was lower than the control. Based on standard index, ozone tolerance ability of five species was determined as two tolerant species(F. rhynchophylla > K. paniculata) and three sensitive species(S. japonica > F. simplex > V. sargentii).

Seismic Techniques for the Integrated Assessment of Structural Integrity of Concrete Runway (콘크리트 활주로 건전도상태의 종합평가를 위한 비파괴 탄성파기법)

  • Joh Sung-Ho;Kang Tae-Ho;Cho Mi-Ra;Suh Young-Chan;Kwon Soo-Ahn
    • Journal of the Korean Geotechnical Society
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    • v.21 no.4
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    • pp.51-63
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    • 2005
  • Concrete pavement may suffer from material deterioration or structural problems, which lead to surface cracks and deflection of a concrete pavement. Degraded concrete pavement, when it is still under operation, should be recovered by an urgent maintenance to avoid the discontinued service leading to the significant traffic problems and economic loss. Seismic techniques are good tools to assess the structural integrity of concrete runway. It is because seismic techniques can evaluate engineering properties nondestructively and quickly and the evaluation can be extended to subgrade. In this study, a series of numerical simulations of stress-wave propagation were performed to verify feasibility of seismic techniques as an assessment tool. Based on the results of the numerical simulation, a framework of using seismic techniques was presented fur the nondestructive integrated assessment fur structural integrity of concrete runway. And the presented framework was applied to $\bigcirc\bigcirc$ concrete runway with surface cracks, which required urgent maintenance, to identify the causes of the surface cracks. The results obtained from the structural integrity assessment were compared with the measurements of the cores collected from the same runway for verification of the presented framework.