• 한국생물공학회:학술대회논문집
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• 2005.04a
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• pp.570-573
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• 2005

The spray method was chiefly used to prepare alginate microspheres. Additionally due to formation at mild conditions, the alginate microspheres were coated with chitosan. The particle size of alginate microspheres increased when the sodium alginate increased. Release pattern of OVA in alginate microspheres was evaluated at PBS buffer(pH 7.4) and HCl buffer(pH 1.2). Release rate of OVA from chitosan/alginate microsphere was also lower than that with the concentration of alginate in the microspheres, the amount of OVA released from alginate microspheres increased from alginate micorsphere. Therefore, the alginate microspheres can be prepared by spray rozzle for a protein drug delivery. OVA release from the alginate microspheres was controlled by a coating with chitosan.

• Polymer(Korea)
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• v.38 no.4
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• pp.434-440
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• 2014

We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres$^{(R)}$). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.

• Polymer(Korea)
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• v.33 no.6
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• pp.596-601
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• 2009

We prepared nanoparticles containing insoluble aceclofenac by the method of solid dispersions using spray dryer to improve solubility of aceclofenac. We used PVP-K30 as a water soluble carrier for the solid dispersion and poloxamer as a surfactant. Characterization of aceclofenac solid dispersion was performed by SEM, DSC, XRD and FT-IR. The results of SEM, DSC and XRD demonstrated that aceclofenac is amorphous in solid dispersion. The formation of salt by hydrogen bond between aceclofenac and PVP K-30 was confirmed by FT-IR. The dissolution rate measured in intestinal juice showed the method of solid dispersion improved aceclofenac solubility as compared with a conventional drug($Airtal^{(R)}$). In conclusion, the method of solid dispersion using spray dryer would improve solubility of aceclofenac in oral administration.

• Polymer(Korea)
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• v.32 no.3
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• pp.193-198
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• 2008

Sibutramine is a highly crystalline and poorly water soluble drug as the appetite depressant for obesity treatment. In order to increase water solubility of sibutramine, microspheres including sibutramine were prepared by solid dispersion method using a spray dryer. The crystallinity and morphology of the prepared microspheres were confirmed by SEM and XRD. The morphology of micro spheres has gradually changed into spherical shape as increasing evaporation rate of solvent. According to XRD analysis, crystallinity of sibutramine in micro spheres was decreased by below 10%. Release behavior of microspheres was investiaged at pH 1.2, pH 6.8, and solubility of the sibutramine was significantly different depending on pH. The hard capsule showed fast release of sibutramine comparing with the tablet. These results demonstrated that the pharmaceutical preparation is able to control the release behaviors.

• Journal of Microbiology and Biotechnology
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• v.27 no.4
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• pp.768-774
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• 2017

Horseradish peroxidase (HRP) catalyzes the oxidation of aromatic compounds by hydrogen peroxide via insoluble polymer formation, which can be precipitated from the wastewater. For HRP immobilization, poly(lactic-co-glycolic acid) (PLGA) fine carrier supports were produced by using the Nano Spray Dryer B-90. Immobilized HRP was used to remove the persistent 2,4-dichlorophenol from model wastewater. Both extracted (9-16 U/g) and purified HRP (11-25 U/g) retained their activity to a high extent after crosslinking to the PLGA particles. The immobilized enzyme activity was substantially higher in both the acidic and the alkaline pH regions compared with the free enzyme. Optimally, 98% of the 2,4-dichlorophenol could be eliminated using immobilized HRP due to catalytic removal and partly to adsorption on the carrier supports. Immobilized enzyme kinetics for 2,4-dichlorophenol elimination was studied for the first time, and it could be concluded that competitive product inhibition took place.

• Food Science of Animal Resources
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• v.30 no.4
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• pp.551-559
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• 2010

Among the food constituents, proteins differ in coagulation properties as compared to other constituents in food system. Especially milk protein coagulate through different pathways thus this coagulability can be used for manufacture of various dairy products or as a determinant of dairy product analysis. These milk coagulation methods include organic solvent, isoelectric point, trichloroacetic acid, Ca-sensitive casein, heavy metal ion and rennet coagulation. The coagulation experiment was performed using above parameters at $0^{\circ}C$ and $25^{\circ}C$ to find the dehydration conditions before coagulating for precheese powder making. After different chemical treatments, there was no coagulation at $0^{\circ}C$ rather at $25^{\circ}C$ whatever the mode of coagulation methods was. The appearance of precipitate with coagulation methods was quite different from above mentioned methods of coagulation illustrated by scanning electron microscope. These powders were used for fabrication of camembert cheese by renneting coagulation at $0^{\circ}C$, showing the possibility of cheese materials and of food additives for fabrication of products.

• Korean Journal of Materials Research
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• v.29 no.7
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• pp.425-431
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• 2019

Generally, ceramic tiles for building construction are manufactured by dry forming process using granular powders prepared by spray drying process after mixing and grinding of mineral raw materials. In recent years, as the demand for large ceramic tiles with natural texture has increased, the development of granule powders with high packing ratio and excellent flowability has become more important. In this study, ceramic tile granule powders are coated with hydrophobically treated silica nanoparticles. The effects of hydrophobic silica coating on the flowability of granule powders and the strength of the green body are investigated in detail. Silica nanoparticles are hydrophobically treated with GPTMS(3-glycidoxypropyl trimethoxy silane), which is an epoxy-based silane coupling agent. As the coating concentration increases, the angle of repose and the compressibility decrease. The tap density and flowability index increase after silica coating treatment. These results indicate that hydrophobic treatment can improve the flowability of the granular powder, and prevent cracking of green body at high pressure molding.

• Proceedings of the Korea Society for Energy Engineering kosee Conference
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• 2000.11a
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• pp.193-198
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• 2000

분무건조장치는 Solution, Slurry, Emulsion, Colloidal Suspension 등의 액상원료를 미립화하여 표면적을 증가시켜 수열면적을 크게 하여 열풍과 직접 접촉함으로써 순간적으로 건조를 행하여 액상원료로부터 바로 분립상의 제품을 얻는 건조법이다. 분유를 비롯하여 Instant 식품류, 합성세제, 염료, 안료, Ceramic, 공해 폐액의 처리에 이르기까지 폭넓게 이용되고 있다. 분무건조기는 통기, 회전, 기류 건조기 등 다른 건조기에 비하여 고도의 설계 및 제작 기술을 요하며, 설계에 있어서 일부 이론적인 취급이 행해지고 있는 것은 사실이나 아직은 경험에 의존하고 있는 현실이다. 국내에서 제작되고 있는 분무건조기의 열효율은 25-33%로 선진국의 35-48%에 비해 매우 낮다. 국내에서 사용되고 있는 분무건조기의 92%는 덴마크, 일본 등에서 수입된 것이다.(중략)

• Proceedings of the Materials Research Society of Korea Conference
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• 2003.03a
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• pp.72-72
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• 2003

전기 및 전자산업의 발달과 더불어 규석 관련 제품에 대하여 고기능성 초미립 분말이 요구되고 있으며, 한편으로는 취급과 활용성이 우수한 형상인 구형 분말을 요구하고 있다. 본 연구에서는 평균 입도 1.0$\mu\textrm{m}$이하의 규석 초미립 분말 제조기술 개발과 유기용매 및 계면활성제 등을 첨가하여 형상이 구형인 기능성 분말과 항균, 항곰팡이 효과가 우수한 교질 상태의 실리카를 제조하여 기능성 재료 및 코팅용 실란 등에 활용이 가능하도록 물리적 단순공정을 통하여 평균 입도 1.0$\mu\textrm{m}$이하의 초미립 규석분말을 제조함으로써 고무, 타이어, 토너, 도료, EMC(epoxy molding compound) 등의 충전제, 이형제, 연마재 등으로 활용이 가능하게 하였으며 제조된 규석 초미립 분말은 분산성이 양호하도록 spray dryer 방법으로 건조하여 각 제품에 알맞은 적용이 용이하도록 하였다.

• YAKHAK HOEJI
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• v.41 no.5
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• pp.602-606
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• 1997

Peonjahwan composed of crude herb, and materials and tissue of animals is a considerably bitter and poorly water-soluble oriental medicine for the treatment of hepatitis. Peonja dry elixir and Eudragit-coated peonja dry elixir were prepared using spray-dryer to mask the bitterness and enhance the release of ingredients from peonjahwan. The bitterness of peonja dry elixir and Eudragit-coated peonja dry elixir reduced to 1/2 and 1/4 of that from peonja powder, respectively. Furthermore, the release rate of bound bilirubin from dry elixir was significantly higher than that from peonja powder.