YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Preparation and Evaluation of Coated-Peonja Dry Elixir for Masking the Bitterness

쓴맛이 차폐된 편자 고형엘릭실제의 제조 및 평가

  • Published : 1997.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Peonjahwan composed of crude herb, and materials and tissue of animals is a considerably bitter and poorly water-soluble oriental medicine for the treatment of hepatitis. Peonja dry elixir and Eudragit-coated peonja dry elixir were prepared using spray-dryer to mask the bitterness and enhance the release of ingredients from peonjahwan. The bitterness of peonja dry elixir and Eudragit-coated peonja dry elixir reduced to 1/2 and 1/4 of that from peonja powder, respectively. Furthermore, the release rate of bound bilirubin from dry elixir was significantly higher than that from peonja powder.

Keywords

References

  1. 편자캅셀-편자환. Medical index (6th) 김병수(외)
  2. Int. J. Pharm. v.106 Preparation and evaluation of a dry elixir for the enhancement of the dissolution rate of poorly water-soluble drugs. Kim, C. K.;Choi, J. Y.;Yoon, Y. S.;Kong, J. P.;Choi, H. G.;Kong, J. Y.;Lee, B. J.
  3. Int. J. Pharm. v.120 Preparation and evaluation of flurbiprofen dry elixir as a novel dosage form using a spray drying technique. Kim, C. K.;Yoon, Y. S.
  4. J. Microencapsul. v.1 Development of digoxin dry elixir as a novel dosage form using a spray drying technique. Kim, C. K.;Yoon, Y. S.
  5. Zipeprol 내용액제의 고미교정에 관한 연구, 약학회지 v.31 김종국;최한곤
  6. 우황청심원중 우황 정량법. 의약품 기준 및 시험방법(Ⅰ)(추보 6), 약업신문사 이성우(외)