• Journal of Pharmaceutical Investigation
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• 제22권1호
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• pp.1-10
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• 1992

The use of erythrocyte as drug carrier has been reviewed, Carrier erythrocytes have proven to offer many advantages for delivery of therapeutic agents, especially in the treatment of inherited enzyme deficiency and cancer. Carrier erythrocytes are biodegradable and nonimmunogenic. Encapsulated drugs may be protected from premature degradation, inactivation and excretion. Carrier erythrocytes may be used as a slow-release system. Targeting of encapsulated drugs directly to a site of action is another possibility. Methods for encapsulating drugs into erythrocytes, the fate of carrier erythrocytes in vivo, the strategies of targeting carrier erythrocytes to special organs and in vivo applications of erythrocytes have been discussed. The encapsulation of drugs in erythrocytes has shown attractive possibilites in future use.

• Journal of Plant Biology
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• 제38권4호
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• pp.343-348
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• 1995

Treatment of Pisum sativum tissue with the protein kinase inhibitor staurosphorine resulted in impairment of 3H-indoleacetic acid transport in etiolated stem segments. The transport inhibitiion was accompanied by an increase in net uptake of labeled auxin in the tissue. The magnitude of auxin accumulation in tissue treated with the phytotropin N-1-naphthylphthalaic acid (NPA) which specifically blocks the efflux of auxin in the plasma membrane was reduced by the protein kinase inhibitor, suggesting that inhibition of protein phosphorylation could lead to hindrance of the auxin-exporting function of NPA receptors. The flavonoid genistein which is also known to inhibit protein kinase likewise reduced NPA-induced auxin accumulation. However, the flavonoid did not bring about auxin accumulation by itself, nor did it inhibit auxin transport. In view of the finding that the flavonoid also competes with NPA for a common binding site, a mechanism for the flavonoid effect on the NPA action will be proposed.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2012년도 춘계 학술논문 발표대회
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• pp.191-192
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• 2012

The BIM(Building Information Modeling) introduction of the construction and maintenance at the design phase through the life cycle of the building until it is destroyed, I will bring big changes in the process. If you are building a small action by a variety of variables difficult to manage on-site construction, but, BIM remodeling of the building by applying a small improvement in the quality of imported building and construction delays, such as design changes or re-construction by removing the elements of economic 04 to make. Since the early stages of applying BIM to complement the introduction part, but the future seems to lead to changes in the built environment, academics and practitioners of the construction industry seem to have an active research.

• Molecules and Cells
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• 제28권4호
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• pp.403-406
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• 2009

Rev is an essential regulatory protein for HIV-1 replication. Rev (11-20) is known as the significant region regarding the function of a nuclear entry inhibitory signal (NIS) of Rev. In this study, anticandidal effects and mechanism of action of Rev (11-20) were investigated. The result exhibited that Rev (11-20) contained candidacidal activities. To understand target site(s) of Rev (11-20), the intracellular localization of the peptide was investigated. The result showed that Rev (11-20) rapidly accumulated in the fungal cell surface. The cell wall regeneration test also indicated that Rev (11-20) exerted its anticandidal activity to fungal plasma membrane rather than cell wall. The fluorescent study using 1,6-diphenyl-1,3,5-hexatriene (DPH) further confirmed the membrane-disruption mechanism(s) of Rev (11-20). The present study suggests that Rev (11-20) possesses significant potential regarding therapeutic agents for treating fungal diseases caused by Candida species in humans.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2013년 춘계학술대회
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• pp.445-456
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• 2013

According to Department of labor guideline "2012-104 (2012.9.26.)" This study is to suggest the basic information and the improvement for the application of risk assessment on a construction site by group interview & survey of construction worker who is the practice of the subject and then numerical analysis about awareness and action plan of Safety and health. The result of group interview and survey of construction worker, most of construction worker feel the danger during the work. Then construction worker analysis results that risk assessment helps to change & raise awareness of safety and reduce an industrial disaster. Easy Safety management activity such as TBM & safety education active will be necessary for safe worksite and then I suggest the TBT(tool box talk) active which combines TBM & safety education.

• Journal of Plant Biotechnology
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• 제3권3호
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• pp.113-121
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• 2001

The use of a marker gene in a transformation process aims to give a selective advantage to the transformed cells, allowing them to grow faster and better, and to kill the non-transformed cells. In general, the selective gene is introduced into plant genome along with the genes of interest. In some cases, the marker gene can be the gene of interest that will confer an agronomic characteristic, such as herbicide resistance. In this review we list and discuss the use of the most common selective marker genes on plant transformation and the effects of their respective selective agents. These genes could be divided in categories according their mode of action: genes that confer resistance to antibiotics and herbicides; and genes for positive selection. The contention of the marker gene flow through chloroplast transformation is further discussed. Moreover, strategies to recover marker-free transgenic plants, involving multi-auto-transformation (MAT), co-transformation, site specific recombination and intragenomic relocation of transgenes through transposable elements, are also reviewed.

• 한국측량학회:학술대회논문집
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• 한국측량학회 2004년도 추계학술발표회 논문집
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• pp.423-428
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• 2004

Flooding is one of the main causes of loss of lives and properties among various natural disasters in Korea. Flood risk maps are currently being produced in Korea but the progress is slow considering the necessity to map at nationwide scale. In this study, GIS-based multi-criteria decision making process which is normally used for resource management and site analysis was applied to locate flood vulnerable areas. Past records of flooding maps were analysed to extract topographic characteristics of flooded areas. The extracted characteristics were then set as criteria for flooding analysis using the Fuzzy and Analytic Hierarchy Process(AHP) methodology. Results from this study showed that an improved phased action plan was possible, because the flood vulnerable areas are shown in varying degrees of uncertainty unlike the conventional Boolean type GIS layer superimposition analysis.

• 한국정보시스템학회지:정보시스템연구
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• 제16권4호
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• pp.157-176
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• 2007

Most of the Information Systems(IS) literature has focused on utilitarian or hedonic Information Technology(IT) to explain and predict IT adoption and use. This study investigates the relationships among individuals' beliefs and intention to use of movie website, which has both utilitarian and hedonic characteristics simultaneously. As a theoretical background, this study adopts Technology Acceptance Model(TAM) and Motivation Theory, in which the former is well-known as a theory of IT adoption and use in IS field, and the latter is famous for a theory of individual's behavior in organizational behavior field. With 153 responses, five hypotheses are tested by using structured equation model. The results show that perceived ease of use positively influences perceived usefulness and perceived enjoyment, and that all individuals' beliefs have a positive impact on intention to use of movie web-site. Based upon the study results, movie website's managers and professionals can plan and conduct their courses of action effectively for users' continuous visits on their operating website.

• 시큐리티연구
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• 제7호
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• pp.29-59
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• 2004

This is a study on hostage crisis and effective resolution of the crisis. First, we surveyed the theoretical guidance for our study: definition, patterns, of hostage crisis; psychology of hostage-takers. And we explores a great variety of hostage crisis cases to develop principles and methods for negotiation and subjugation. We suggest, throughout this study, some action program to be developed, as follow: First, we need to broaden and deepen the understanding on the issue of hostage-crisis by expanding educational opportunity on the issue, while raising hostage negotiators. Second, information sharing system among hostage management related offices, and complete training for SWAT team are required. Third, when a hostage-crisis is raised, police enforcement must corporate with mass-media in a way of close manner. Fourth, in a critical hostage crisis, the commander should appear on site for effective command. Lastly, the top-priority for the commander who is in charge of the crisis should be put on the security of hostage and hostage-taker, as well.

• Journal of applied mathematics & informatics
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• 제35권3_4호
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• pp.349-369
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• 2017

In last 30 years, mathematical tangle theory is applied to molecular biology, especially to DNA topology. The recent issues and research results of this topic are reviewed in this paper. We introduce a tangle which models an enzyme-DNA complex. The studies of 2-string tangle equations related to Topoisomerase II action and site-specific recombination is discussed. And 3-string tangle analysis of Mu-DNA complex, n-string tangle analysis ($n{\geq}4$) of DNA-enzyme synaptic complexes are also discussed.