• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.211-226
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• 2019

Pig CD45, the leukocyte common antigen, is encoded by the PTPRC gene and CD45 is a T cell-type specific tyrosine phosphatase with alternative splicing of its exons. The CD45 is a coordinated regulator of T cell antigen receptor (TCR) signal transduction achieved by dephosphorylating the phosphotyrosine of its substances, including $CD3{\zeta}$ chain of TCR, Lck, Fyn, and Zap-70 kinase. A dysregulation of CD45 is associated with a multitude of immune disease and has been a target for immuno-drug discovery. To characterize its key structural features with the effects of regulating TCR signaling, this study predicted the unknown structure of pig CD45RO (the smallest isoform) and the complex structure bound to the ITAM (REEpYDV) of $CD3{\zeta}$ chain via homology modeling and docking the peptide, based on the known human CD45 structures. These features were integrated into the structural plasticity of extracellular domains and functional KNRY and PTP signature motifs (the role of a narrow entrance into ITAM binding site) of the tyrosine phosphatase domains in a cytoplasmic region from pig CD45RO. This contributes to the selective recognition of phosphotyrosine from its substrates by adjusting the structural stability and binding affinity of the complex. The characterized features of pigCD45RO can be applied in virtual screening of the T-cell specific immunomodulator.

• Journal of Korea Multimedia Society
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• v.6 no.3
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• pp.469-480
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• 2003

The accurate user- authentication technology is being raised as one of the most important in this current society, which is, so called, information society. Most authentication technology is used to identify users by using the special characteristics of users. This paper has established an e-commerce shopping mall based on conventional e-commerce systems. It also suggested and established the user authentication interface that uses the mouse gesture, which is the new authentication of what users have. The user authentication interface using the mouse gesture generates the status of recognition directly on the screen by comparing the stored pattern values with the unique pattern values that users entered. When users purchase products through the shopping mall and enter their another signature information together with payment information, security can be more increased. Experimental results show that our mouse gesture interface may be useful to provide more security to e-commerce server.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.10
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• pp.7211-7218
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• 2015

Tens of thousands of malicious codes are generated on average in a day. New types of malicious codes are surging each year. Diverse methods are used to detect such codes including those based on signature, API flow, strings, etc. But most of them are limited in detecting new malicious codes due to bypass techniques. Therefore, a lot of researches have been performed for more efficient detection of malicious codes. Of them, visualization technique is one of the most actively researched areas these days. Since the method enables more intuitive recognition of malicious codes, it is useful in detecting and examining a large number of malicious codes efficiently. In this paper, we analyze the relationships between malicious codes and Native API functions. Also, by applying the word cloud with text mining technique, major Native APIs of malicious codes are visualized to assess their maliciousness. The proposed malicious code analysis method would be helpful in intuitively probing behaviors of malware.

• Fisheries and Aquatic Sciences
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• v.1 no.2
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• pp.227-231
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• 1998

The teleosts represent ancient real-bony vertebrates in phylogeny and resemble major genetic patterns to higher vertebrates. In the present study, we have defined the single family of insulin-like growth factors (IGFs) from flounder (Paralichthys olivaceus), compared to the prototype of IGFs observed in the Agnathan hagfish. In flounder, IGFs are clearly diverged into two major types including type I and II, and they are structurally similar by displaying a multidomain structure consisting of five functional regions as previously found in other vertebrates. However, flIGF-I appears to be more basic (pI 8.03) than the flIGF-II (pI 5.34) in the fully processed form for the B to D domain region. The flIGF-I seems to contain an evolutionary conserved Asn-linked glycosylation in E domain, which is not found in flIGF­II. The most interesting feature is that flIGF-II appeared to be structurally close to hagfish IGF in secondary structures, particularly in Band D domains. This could tell us an idea on the molecular divergence of IGFs from the Agnatha to teleosts during the vertebrate phylogeny. It also support, in part, a notion regarding on how IGF-II is appeared as more embryonic during development. Nonetheless, the biologically active B to D domain region of flIGF-II shows significant sequence homology of $65.6\%$ to flIGF-Is and contains the evolutionary conserved insulin-family signature, as well as a reserved recognition site (Lys) in D domain, necessary to generate proteolytic cleavage for E-peptide. A significant structural difference was found in E domain in which flIGF-I possesses two potential alternative splicing donor site at $Val^{17,\;24}$ of E domain. Therefore, it seems so far that IGF-I sorely produces spliced variants due to the spliced E-peptide moiety while IGF-II appears to be maintained in a single type during evolution. IGF-II, however, may be also possible to transcribe unidentified variants, depending on the physiological conditions of tissues in vertebrates in vivo.

• Journal of the Korean Institute of Rural Architecture
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• v.14 no.2
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• pp.11-18
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• 2012

Carlos Jimenez's 'House and Studio' was self-designed to fully function as both a home and workplace. Since its establishment in 1983, the installation has been continuously updated for almost 30 years solely under the guidance of the owner's life occurrences and routine needs. The additions and alterations succeeding the building's erection were executed to incorporate small yet symbolic fragments of the resident's memories and life episodes. The particularity of the 'House and Studio' can be compared with other residential remodeling and expansion projects in regards to certain key aspects. These means of comparison include, but are not limited to, building strictly under the direction of a master plan of development vs. allowing natural adaptations that comply with the resident's needs, rapid development vs. gradual advancement, the ornamenting by exposing showy features vs. the enhancing by addition of modest natural components, sustainability vs. sustenance, systematic room divisions vs. ambiguous spatial organization, possession as a materialized asset vs. preservation as a recollection of memories, and finally the recognition as one example of signature architecture vs. the witnessing of a maturing animated shelter. The given propositions can be further explained with the comprehension of Erich Fromm's theory of the 'Having' mode and 'Being' mode, two mechanisms that categorize the essence of human life. The 'Having' mode is described by the human greed for wealth, power, and influence, whereas the 'Being' mode is comprised of compassion, joy, and productivity. Fromm's thesis applies to the general sense of human life, but the ideas can be narrowed to accommodate the architectural standpoint. In architecture, the 'Having' mode can be translated to be the conspicuous form-oriented and self-contained object. The 'Being' mode, on the other hand, is transposed as the more natural form, incorporating the needs of the owner before commercialization. The growth of Jimenez's 'House and Studio' can be perceived as an architectural suggestion to the overcoming of human indifference caused by fixation on the 'Having' mode.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.4
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• pp.15-23
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• 2021

In most hacking attacks, hackers intrudes inside for a long period of time and attempts to communicate with the outside using a circumvent connection to achieve purpose. research in response to advanced and intelligent cyber threats has been mainly conducted with signature-based detection and blocking methods, but recently it has been extended to threat hunting methods. attacks from organized hacking groups are advanced persistent attacks over a long period of time, and bypass remote attacks account for the majority. however, even in the intrusion detection system using intelligent recognition technology, it only shows detection performance of the existing intrusion status. therefore, countermeasures against targeted bypass rwjqthrwkemote attacks still have limitations with existing detection methods and threat hunting methods. in this paper, to overcome theses limitations, we propose a model that can detect the targeted circumvent connection remote attack threat of an organized hacking group. this model designed a threat hunting process model that applied the method of verifying the origin IP of the remote circumvent connection, and verified the effectiveness by implementing the proposed method in actual defense information system environment.

• Journal of Sensor Science and Technology
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• v.31 no.1
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• pp.24-30
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• 2022

Distributed fiber-optic acoustic·vibration sensing technology is becoming increasingly popular in many industrial and academic areas such as in securing large edifices, exploring underground seismic activity, monitoring oil well/reservoir, etc. Long-range perimeter intrusion detection exemplifies an application that not only detects intrusion, but also pinpoints where it happens and recognizes kinds of threats made along the perimeter where a single fiber cable was installed. In this study, we developed a distributed fiber-optic sensing device that measures a distributed acoustic·vibration signature (pattern) for intrusion detection. In addition, we demontrate the proposed deep learning algorithm and how it classifies various intrusion events. We evaluated the sensing device and deep learning algorithm in a practical testbed setup. The evaluation results confirm that the developed system is a promising intrusion detection system for long-distance and seamless recognition requirements.

• The Journal of the Korea Contents Association
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• v.16 no.5
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• pp.242-250
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• 2016

This study was conducted to investigate whether Stroop-related cognitive task will be affected according to the preceding affective valence factored by matchedness in response time(RT) and whether facial recognition will be indexed by specific event-related potentials(ERPs) signature in normal person as in patients suffering from affective disorder. ERPs primed by subliminal(30ms) facial stimuli were recorded when presented with four pairs of affect(positive or negative) and cognitive task(matched or mismatched) to get ERP effects(N2 and P300) in terms of its amplitude and peak latency variations. Behavioral response analysis based on RTs confirmed that subliminal affective stimuli primed the target processing in all affective condition except for the neutral stimulus. Additional results for the ERPs performed in the negative affect with mismatched condition reached significance of emotional-face specificity named N2 showing more amplitude and delayed peak latency compared to the positive counterpart. Furthermore the condition shows more positive amplitude and earlier peak latency of P300 effect denoting cognitive closure than the corresponding positive affect condition. These results are suggested to reflect that negative affect stimulus in subliminal level is automatically inhibited such that this effect had influence on accelerating detection of the affect and facilitating response allowing adequate reallocation of attentional resources. The functional and cognitive significance with these findings was implied in terms of subliminal effect and affect-related recognition modulating the cognitive tasks.

• Journal of the Korean Applied Science and Technology
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• v.40 no.6
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• pp.1298-1308
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• 2023

This study collected 245 questionnaires from college students in Gyeonggi-do and analyzed them using SPSS statistical packages, with the aim of identifying the status of hair loss perception due to the relationship between stress and hair loss received by college students and analyzing the correlation between stress and hair loss perception by type. As a result of the study, it was analyzed that the biggest problem caused by hair loss was 'loss of confidence', and in particular, people who were stressed about career/employment and studies were analyzed to consider the problem of 'loss of confidence' the most serious. As a result of cross-analysis of the general characteristics of awareness and the 'most recent stress' item, and as a result of correlation analysis between stress by type and hair loss status that constitutes hair loss awareness, it was analyzed that all types of stress affect hair loss in college students. Among them, career/employment stress and academic stress were found to be the most influential stress, and in the event of hair loss, it was analyzed that they were more willing to engage in hair loss treatment for career/employment, study, and appearance before interpersonal relationships or economic problems. Therefore, this study is of great significance in that it classified stress by type and analyzed the correlation through empirical research methods by specifying the contents of hair loss recognition into three categories: hair loss status, hair loss management, and hair loss treatment.

• Journal of the Korean Institute of Intelligent Systems
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• v.26 no.5
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• pp.375-382
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• 2016

In this paper, we presents a signatures verification by using the nonlinear quantization histogram of polar coordinate based on multi-dimensional adjacent pixel intensity difference. The multi-dimensional adjacent pixel intensity difference is calculated from an intensity difference between a pair of pixels in a horizontal, vertical, diagonal, and opposite diagonal directions centering around the reference pixel. The polar coordinate is converted from the rectangular coordinate by making a pair of horizontal and vertical difference, and diagonal and opposite diagonal difference, respectively. The nonlinear quantization histogram is also calculated from nonuniformly quantizing the polar coordinate value by using the Lloyd algorithm, which is the recursive method. The polar coordinate histogram of 4-directional intensity difference is applied not only for more considering the corelation between pixels but also for reducing the calculation load by decreasing the number of histogram. The nonlinear quantization is also applied not only to still more reflect an attribute of intensity variations between pixels but also to obtain the low level histogram. The proposed method has been applied to verified 90(3 persons * 30 signatures/person) images of 256*256 pixels based on a matching measures of city-block, Euclidean, ordinal value, and normalized cross-correlation coefficient. The experimental results show that the proposed method has a superior to the linear quantization histogram, and Euclidean distance is also the optimal matching measure.