• 한국동물학회지
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• 제8권1호
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• pp.1-7
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• 1965

The short-necked clam is distributed widely in Korean tidal flats and it is a much an important bivalve quantitatively as to control the production of the tidal flat. The shell of this clam tends to show remarkable morphological variations depending on the habitat. Under a seemingly favorable condition for the growth , the color pattern of shell of the clam is clear and obvious and having less weight and elongated shape, the ratios of shell length to both height and width are small . On the contrary , when the environment appears to be an unfavorable one, the shell is found to be heavy and stunted with smudgy color pattern. If this correlation between could be a basis for the judgement in suitability of growth environment for the clam. In the Ikawazu Bay, Japan, it is revealed that the elongated shell is produced from the coast outside of the Bay (1) , the stunted from the esturay (2) and the intermediate from the floodgate area (3) and the middle of the Bay (4). Followings are the results obtained from the morphological investigation of the claim in this Bay. 1. Relationship between the shell length and the largest shell rib length is linear and between the shell length and the shell width is also linear but with a critical point at the shell length of 17-20 mm. The ratio between the width and the largest rib length at a given shell length increases with the order of 1, 3, 4, and 2. 2. A gradual decreases of the ratio of the shell length to the largest rib length is observed when the former is less than 17-18 mm, and this ratio increases with the shell of longer. Also there is a different range of this ratio in each different location ; the greatest range in 2, the smallest in 1 and 4 being in between. 3. A similar biometric finding is apparent with the ratio between the length and width of the shell and the order in value is 2, 4, 1 and 3. 4. The ratios between the length and the largest rib length of elongated and stunted shell are 0.84-0.86 and 0.89-0.92, respectively , and those between the length and width are 0.40-0.51 and 0.49-0.58, respectively. 5. Generally , the elongated short necked clam shells are products of the tidal flat of good circulation of sea water with high salinity and smaller fluctuations of salinity and temperature within a day. The stunted shells are produced for tidal flats of opposite of above conditions.

• Animal Bioscience
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• 제35권10호
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• pp.1461-1478
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• 2022

The maintenance of poultry gut health is complex depending on the intricate balance among diet, the commensal microbiota, and the mucosa, including the gut epithelium and the superimposing mucus layer. Changes in microflora composition and abundance can confer beneficial or detrimental effects on fowl. Antibiotics have devastating impacts on altering the landscape of gut microbiota, which further leads to antibiotic resistance or spread the pathogenic populations. By eliciting the landscape of gut microbiota, strategies should be made to break down the regulatory signals of pathogenic bacteria. The optional strategy of conferring dietary fibers (DFs) can be used to counterbalance the gut microbiota. DFs are the non-starch carbohydrates indigestible by host endogenous enzymes but can be fermented by symbiotic microbiota to produce short-chain fatty acids (SCFAs). This is one of the primary modes through which the gut microbiota interacts and communicate with the host. The majority of SCFAs are produced in the large intestine (particularly in the caecum), where they are taken up by the enterocytes or transported through portal vein circulation into the bloodstream. Recent shreds of evidence have elucidated that SCFAs affect the gut and modulate the tissues and organs either by activating G-protein-coupled receptors or affecting epigenetic modifications in the genome through inducing histone acetylase activities and inhibiting histone deacetylases. Thus, in this way, SCFAs vastly influence poultry health by promoting energy regulation, mucosal integrity, immune homeostasis, and immune maturation. In this review article, we will focus on DFs, which directly interact with gut microbes and lead to the production of SCFAs. Further, we will discuss the current molecular mechanisms of how SCFAs are generated, transported, and modulated the pro-and anti-inflammatory immune responses against pathogens and host physiology and gut health.

• 유통과학연구
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• 제8권3호
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• pp.17-26
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• 2010

세계경제 및 환경의 변화에 따라 농산물의 불안정적인 수급으로 인한 문제점이 노출되고 있으며, 우리나라의 경우 농산물의 안정적인 확보를 위하여 국가 전략적 차원에서의 해외농업투자의 필요성이 요구되고 있다. 하지만 정부차원의 지원 미진, 해외 농업에 대한 정보 및 기술 미비, 개발자금 확보의 어려움, 장기간의 투자금 회수기간, 사후관리 미흡 등의 이유로 성과를 이루지 못하고 있는 실정이며, 특히 해외 농산물의 국내 반입 시 관세의 장벽, 물류 유통비용 등으로 가격 경쟁력이 떨어지고 있어 국내에 반입되지 못하고 있는 실정이다. 이에 본 연구에서는 우리나라의 해외농업투자의 기본개념 및 실태를 살펴보고 해외농업투자의 필요성과 고려사항, 문제점 등을 도출하여 해외에서 재배된 농산물의 경쟁력을 위한 유통 측면에서의 개선방안을 정부의 간접적인 지원, 유통 현대화 및 유통정보기능 강화, 유통시설, 수송루트, 하역업무개선, 경쟁력 확보를 위한 정부의 정책적 지원, 교육 훈련을 통한 전문인력 양성 등 다섯 가지 측면에서 제시하였다.

• Journal of Korean Neurosurgical Society
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• 제63권2호
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• pp.137-152
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• 2020

In spite of the developing endovascular era, large (15-25 mm) and giant (>25 mm) wide-neck cerebral aneurysms remained technically challenging. Intracranial flow-diverting stents (FDS) were developed to address these challenges by targeting aneurysm hemodynamics to promote aneurysm occlusion. In 2011, the first FDS approved for use in the United States market. Shortly thereafter, the Pipeline of Uncoilable or Failed Aneurysms (PUFS) study was published demonstrating high efficacy and a similar complication profile to other intracranial stents. The initial FDA instructions for use (IFU) limited its use to patients 22 years old or older with wide-necked large or giant aneurysms of the internal carotid artery (ICA) from the petrous segment to superior hypophyseal artery/ophthalmic segment. Expanded IFU was tested in the Prospective Study on Embolization of Intracranial Aneurysms with PipelineTM Embolization Device (PREMIER) trial. With further post-approval clinical data, the United States FDA expanded the IFU to include patients with small or medium, wide-necked saccular or fusiform aneurysms from the petrous ICA to the ICA terminus. However, IFU is more restrictive in South Korea than in United States. Several systematic reviews and meta-analyses have sought to evaluate the overall efficacy of FDS for the treatment of cerebral aneurysms and consistently identify FDS as an effective technique for the treatment of aneurysms broadly with complication rates similar to other traditional techniques. A growing body of literature has demonstrated high efficacy of FDS for small aneurysms; distal artery aneurysms; non-saccular aneurysms posterior circulation aneurysms and complication rates similar to traditional techniques. In the short interval since the Pipeline Embolization Device was first introduced, FDS has been firmly entrenched as a powerful tool in the endovascular armamentarium. As new FDS are developed, established FDS are refined, and delivery systems are improved the uses for FDS will only expand further. Researchers continue to work to optimize the mechanical characteristics of the FDS themselves, aiming to optimize deploy ability and efficacy. With expanded use for small to medium aneurysms and posterior circulation aneurysms, FDS technology is firmly entrenched as a powerful tool to treat challenging aneurysms, both primarily and as an adjunct to coil embolization. With the aforementioned advances, the ease of FDS deployment will improve and complication rates will be further minimized. This will only further establish FDS deployment as a key strategy in the treatment of cerebral aneurysms.

• Journal of Korean Neurosurgical Society
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• 제60권6호
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• pp.635-643
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• 2017

Objective : Acute basilar artery occlusion (BAO) is associated with severe neurological dysfunction and high mortality rates. The benefits of mechanical thrombectomy in BAO have not been explored in recent clinical trials. Therefore, we analyzed outcomes of stent retriever mechanical thrombectomy for BAO, and compared with anterior circulation occlusions (ACO). Methods : In total, 161 consecutive patients (24 BAO, 137 ACO) who underwent mechanical thrombectomy with the stent retriever between January 2013 and August 2016 enrolled in our study. All patients underwent clinical assessment with the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin scale (mRS). Radiological results were used to evaluate thrombolysis in cerebral infarction (TICI) scores and successful recanalization was defined by TICI 2b or 3. Results : Mean NIHSS scores at 24 hours and 30 days were significantly higher in the BAO group than the ACO group (p=0.021, p=0.001). mRS at 90 days was significantly higher in the BAO group (4.2) compared with the ACO group (3.0) (p=0.003). The BAO group (2.0) performed fewer stent retriever passages than the ACO group (2.7) (p=0.049). There were no significant differences between the two groups in terms of complications, but the BAO patients experienced a higher mortality (16.6%) rate than ACO patients (5.8%) (p=0.001). In subgroup analysis of BAO, patients with short procedure times achieved successful recanalization (p=0.001) and successfully recanalized patients exhibited more favorable mRS at 90 days (p=0.027). Conclusion : In our study, mechanical thrombectomy of BAO patients showed worse clinical outcome and higher mortality rate than ACO patients. However, mechanical thrombectomy with a stent retriever in BAO is an effective treatment, because successfully recanalized patients showed good clinical outcome in BAO patients.

• 대한두경부종양학회지
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• 제20권2호
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• pp.177-180
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• 2004

Objectives: To completely excise a malignant tumor which invades carotid artery walls, the resection and reconstruction of the carotid artery is essentially required. In most of the cases, interposition graft using a saphenous vein has been performed, however the vessel caliber discrepancy between a common carotid artery and the saphenous vein can result in a problem on surgical technique. We have introduced and evaluated a new titanium hemoclip tailing method to overcome vessel caliber discrepancy in interposition saphenous vein graft for carotid artery resection in the treatment of head and neck cancers. Method: After carotid artery resection, the calibers of the proximal common carotid artery and the vein were compared, and an orifice of the common carotid artery was gradually reduced to a little larger than or the same size as the orifice of the vein by using the titanium hemostatic clip. Subsequently, the common carotid artery was connected to the vein through anastomosis. The same method was also applied to the distal anastomosis site. There after, the vessels were connected through the anastomosis, and a circulation was restored by releasing a vascular clamp. Then, a titanium hemostatic clip-applied redundant portion on the outside of carotid artery was sutured by the blanket edge suture method, using 6-0 Prolene. Results: We have experienced this method in two patients with recurrent squamous cell carcinoma and neuroblostoma, respectively. The interposition saphenous vein graft of these patients was found to maintain good patency on the follow up angiography after one year, and they had no specific vascular complication, such as atherosclerosis. Conclusion: This method made it possible to simply perform the interposition saphenous vein graft (ISVG) within a short time and, therefore, was very useful for shortening the duration to block circulation.

• 한국산학기술학회논문지
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• 제20권4호
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• pp.580-589
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• 2019

인도네시아는 전력 공급이 매우 부족한 현실에 처해 있으며, 이에 대한 해결책으로 화력발전소 건설 계획이 증가하고 있다. 화력발전소는 발전에 수반되는 엔진과 장비의 과열을 식히기 위해 냉각수 계통을 필요로 하며, 냉각수 계통 중 순환수 취수펌프장(circulating water pump chamber)은 일반적으로 ANSI (1998) 기준에 따라 설계된다. 본 연구에서는 인도네시아 K-석탄화력발전소의 순환수취수펌프장이 현장 여건상 ANSI (1998)의 확산각 설계기준 $20^{\circ}$를 만족시킬 수 없어, 수리적으로 안정된 흐름 및 구조물이 되도록 3차원 수치모형실험을 수행하였다. 수치모형으로 Flow-3D 모형을 이용하였다. Flow-3D 모형의 적용성을 검토하기 위해 Rodi (1997)의 사각형 구조물 주변에 형성되는 흐름 연구 결과와 금회 수치해석 결과를 비교하였다. 수치해석에서 도출된 종방향 유속 분포는 잘 일치함을 보여주고 있다. 순환수취수펌프장 내 설계유속을 만족시키기 위해 유속 저감에 유리한 사각형 형태의 배플을 적용하였다. 순환수취수펌프장으로 유입되는 유속이 1.5 m/s ~ 2.5 m/s로 분포되는 경우, 배플에서 분리흐름의 각도는 약 $15^{\circ}{\sim}20^{\circ}$로 발생하였다. 이를 고려하여 분리흐름 각도 이하로 하류에 배플을 배치함으로 Inlet bay 설계유속 0.5 m/s 이하를 만족시켰다.

• 한국습지학회지
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• 제23권1호
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• pp.67-73
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• 2021

도시화와 산업화로 인하여 불투수면적이 증가함에 따라 강우유출에 의한 비점오염원이 수계에 미치는 영향이 커지고 있다. 과거에는 비점오염원을 관리하기위해 장치형 시설(BMP)이 많이 사용되었으나 최근 LID(Low Impact Development)기술을 통해 자연적으로 처리하는 기술이 많이 활용되고 있다. 본 연구에서는 자연형 시설 중 식생체류지에서의 강우 모니터링을 실시한 데이터를 토대로 SWMM 모델을 통해 다양한 강우사상을 모의하였다. LID 모델링 연구의 특징으로 실데이터가 자연시설을 통해 얻은 결과이기 때문에 단기간 데이터로는 정확한 모델링 자료를 구축하기 어려워 정확한 모델을 구현하기가 힘들다는 특징이 있는데, 본 연구에서는 3년간 모니터링한 데이터를 통해 정밀한 모델을 구축하였다는 점에서 의의가 있다. 총 18회 모니터링한 실데이터를 모의하였으며, 유입량과 유출량, 오염물질 5개항목의 제거효율을 모의하였다. 성능평가를 실시한 결과 7개 항목 대부분이 우수한 지표를 나타내었으며, 상대적으로 TN과 TP 항목이 모의성능이 낮은 것으로 나타났다. 미래에는 우리나라도 상수도 시스템과 하수도 시스템이 실질적으로 통합되어 운영되는 통합물관리 시스템이 도입될 것으로 예상된다. 따라서, 본 연구결과는 미래형 통합물관리시스템에서 강우를 초기에 관리하는 단계에서 중요한 역할을 할 수 있을 것으로 판단되며, 설치예상지역의 강우유출저감 및 오염물질 저감 정도를 사전에 예측할 수 있으며, 이를 통해 식생체류지의 과다설계를 방지할 수 있을 것으로 기대된다.

• 인터넷정보학회논문지
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• 제23권3호
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• pp.21-33
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• 2022

본 논문은 기업비밀 노출로 초래될 손실을 현격히 줄일 안전 비밀조각 공유 시스템을 제안한다. 본 연구 시스템은 중앙서버 방식이 아닌 효율적 P2P 분산 시스템을 제안한다. 최근 비트코인 유통 시스템도 역시 P2P 분산 방식을 사용하고 있다. 본 연구는 기능이 단순하고 확장성이 높고 전송 효율적인 토렌트 P2P 분산 구조와 그 프로토콜을 사용하여 토렌트 파일조각 대신 임계 샤미르(Shamir) 비밀조각의 보안 유통을 설계한다. 본 연구는 임계 샤미르 비밀조각 공유기법 (Threshold Shamir Secret Sharing Scheme)을 시스템에 적용하고. 동시에 다중 협동장치의 서명기법을 사용하여 안전하고 강력한 다중인증방식의 사용자 인증을 수행한다. 안전한 비밀 데이터 유통도 공개키로 암호화 교환된 임시키의 대칭암호방식의 효율적 암호화로 전송을 한다. 짧은 유효기간의 임시키는 세션 동안 생성되고 세션 마감후 소멸하므로 키 노출에서 안전하다. 특별히 본 제안한 시스템의 특징은 임계 분산기법을 효율적 토렌트 P2P 분산 시스템에 구조적 변경없이 효과적으로 적용한다. 동시에 본 시스템은 효율적인 임시키 대칭암호방식으로 비밀파일 유통에 기밀성을 보장하고 임시키는 공개키 암호방식으로 안전하게 교환된다, 본 시스템은 외부 유출 기기도 사용자로 동적 등록이 가능하다. 이 확장성으로 기밀성과 인증성을 동적으로 등록된 사용자에게도 적용할 수 있다.

• The Korean Journal of Physiology and Pharmacology
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• 제18권5호
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• pp.411-418
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• 2014

Vascular remodelling is an adaptive mechanism, which counteracts pressure changes in blood circulation. Nicotine content in cigarette increases the risk of hypertension. The exact relationship between nicotine and vascular remodelling still remain unknown. Current study was aimed to determine the effect of clinically relevant dosage of nicotine (equivalent to light smoker) on aortic reactivity, oxidative stress markers and histomorphological changes. Twelve age-matched male Sprague-Dawley rats were randomly divided into two groups, i.e.: normal saline as control or 0.6 mg/kg nicotine for 28 days (i.p., n=6 per group). On day-29, the rats were sacrificed and the thoracic aorta was dissected immediately for further studies. Mean arterial pressure (MAP) and pulse pressure (PP) of nicotine-treated vs. control were significantly increased (p<0.05). Nicotine-treated group showed significant (p<0.05) increase tunica media thickness, and decrease in lumen diameter, suggesting vascular remodelling which lead to prior hypertension state. The phenylephrine (PE)-induced contractile response in nicotine group was significantly higher than control group ($ED_{50}=1.44{\times}10^5M$ vs. $4.9{\times}10^6M$) (p<0.05~0.001). However, nicotine-treated rat showed significantly lower endothelium-dependent relaxation response to acetylcholine (ACh) than in control group ($ED_{50}=6.17{\times}10^7M$ vs. $2.82{\times}10^7M$) (p<0.05), indicating loss of primary vascular function. Malondialdehyde (MDA), a lipid peroxidation marker was significantly higher in nicotine group. Superoxide dismutase (SOD) enzymatic activity and glutathione (GSH) were all reduced in nicotine group (p<0.05) vs. control, suggesting nicotine induces oxidative imbalance. In short, chronic nicotine administration impaired aortic reactivity, probably via redox imbalance and vascular remodelling mechanism.