• BMB Reports
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• v.37 no.1
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• pp.1-10
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• 2004

DNA and RNA quantifications are widely used in biological and biomedical research. In the last ten years, many technologies have been developed to enable automated and high-throughput analyses. In this review, we first give a brief overview of how DNA and RNA quantifications are carried out. Then, five technologies (microarrays, SAGE, differential display, real time PCR and real competitive PCR) are introduced, with an emphasis on how these technologies can be applied and what their limitations are. The technologies are also evaluated in terms of a few key aspects of nucleic acids quantification such as accuracy, sensitivity, specificity, cost and throughput.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.11
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• pp.180-187
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• 2003

A CAD-based seamless design system for MEMS named DS/MEMS was developed which performs coupled-field analysis, optimal and robust design. DS/MEMS has been developed by means of integrating commercial codes and inhouse code-SolidWorks, FEMAP, ANSYS and CA/MEMS. This strategy results in versatility that means to include various analysis model, corresponding analyses and approximated design sensitivity analysis and user friendliness that design variables are taken to be selectable directly from a CAD model, that the problem is formulated under a window environment and that the manual job during optimization process is almost eliminated. DS/MEMS works on a parametric CAD platform, integrating CAD modeling, analysis, and optimization. Nonlinear programming algorithms, the Taguchi method, and response surface method are made available for optimization. One application problem is taken to illustrate the proposed methodology and show the feasibility of DS/MEMS as a practical tool.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.15 no.6 s.99
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• pp.660-666
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• 2005

Recently, the need for subminiature storage systems has increased with the diversification of portable devices. An actuator for small optical disk drives has to satisfy performance requirements such as higher access speed, lower power consumption, and smaller size. In this paper, we proposed the miniaturized rotary type VCM actuator that had an effective focusing mechanism and secured sufficient bandwidth for small form factor (SFF) optical disk drive (ODD). Initial model was designed by electromagnetic (EM) and structural analyses. Such a model was improved using design of experiments (DOE) procedure based on a Blu-ray disk (BD) 1x specifications.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.5
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• pp.942-948
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• 2011

This paper deals with characteristic analysis of axial flux permanent magnet (AFPM) machines with axially magnetized PM rotor using quasi-3-D analysis modeling. On the basis of magnetic vector potential and a two-dimensional (2-D) polar-coordinate system, the magnetic field solutions due to various PM rotors are obtained. In particular, 3-D problem, that is, the reduction of magnetic fields near outer and inner radius of the PM is solved by introducing a special function for radial position. And then, the analytical solutions for back-emf and torque are also derived from magnetic field solutions. The predictions are shown in good agreement with those obtained from 3-D finite element analyses (FEA). Finally, it can be judged that analytical solutions for electromagnetic quantities presented in this paper are very useful for the AFPM machines in terms of following items : initial design, sensitivity analysis with design parameters, and estimation of control parameters.

• Journal of the Korean Operations Research and Management Science Society
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• v.34 no.1
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• pp.11-28
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• 2009

Intelligent investment in setup cost reduction and process reliability improvement is crucial to an emerging integrated lean six sigma practice today. This study examines a cost-minimizing problem of jointly determining production lot size, setup cost reduction, and process reliability improvement decisions for a manufacturer with an imperfect production process. We develop models for previously untapped discrete shipping in a supply chain context as well as continuous shipping and solve them optimally using differential calculus and nonlinear programming. We also conduct analytic and numerical sensitivity analyses to provide various important managerial insights into practices.

• Steel and Composite Structures
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• v.15 no.4
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• pp.451-466
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• 2013

This paper deals with the multi-objective optimization of tire reinforcement structures such as the tread belt and the carcass path. The multi-objective functions are defined in terms of the discrete-type design variables and approximated by artificial neutral network, and the sensitivity analyses of these functions are replaced with the iterative genetic evolution. The multi-objective optimization algorithm introduced in this paper is not only highly CPU-time-efficient but it can also be applicable to other multi-objective optimization problems in which the objective function, the design variables and the constraints are not continuous but discrete. Through the illustrative numerical experiments, the fiber-reinforced tire belt structure is optimally tailored. The proposed multi-objective optimization algorithm is not limited to the tire reinforcement structure, but it can be applicable to the generalized multi-objective structural optimization problems in various engineering applications.

• Architectural research
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• v.17 no.1
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• pp.41-48
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• 2015

Early investigations focused mainly on manipulating the confinement effect to develop a reinforced concrete column with lateral hoops. Based on this legacy model, Li's model incorporated the additional confinement effect of a steel jacket. However, recent experiments on plain concrete cylinders with steel jackets revealed relatively large discrepancies in the estimates of strength enhancement and the post-peak behavior. Here, we describe a modified constitutive law for confined concrete with an unbonded external steel jacket in terms of three regions for the loading stage. We used a two-phase heterogeneous concrete model to simulate the uniaxial compression test of a $150mm{\times}300mm$ concrete cylinder with three thicknesses of steel jackets: 1.0 mm, 1.5 mm, and 2.0 mm. The proposed constitutive model was verified by a series of finite element analyses using a finite element program. The damaged plasticity model and extended Drucker-Prager model were applied and compared in terms of the level of pressure sensitivity for confinement in 3D. The proposed model yielded results that were in close agreement with the experimental results.

• Steel and Composite Structures
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• v.15 no.5
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• pp.567-583
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• 2013

Experimental studies and finite element analyses have been carried out to establish the effect of tendon damage on the structural behavior of concrete filled tubular tied arch girder (CFTA girder). The damage of tendon is considered in different stages by varying the number of damaged cables in the tendon. Static and dynamic structural parameters are observed at each stage. The results obtained from the experiments and numerical studies have been compared to validate the studies. The tendons whose damage can significantly affect the stiffness of the CFTA girder are identified by performing the sensitivity analysis. The locations in the girder which are sensitive to the tendon damage are also identified.

• KIEE International Transactions on Power Engineering
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• v.5A no.4
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• pp.390-395
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• 2005

The most widely used index for the vulnerable area investigation has been the reactive power margin or sensitivity analysis. But we can only obtain the results of these analyses if the results of load flow are convergent in severe contingencies. Otherwise these methods are not adoptable. This paper presents a good index for overcoming severe contingencies, though the power flow equation is unsolvable using the branch parameter continuation power flow. In simulation, the Korea Electric Power Corporation (KEPCO) Systems are applied.

• International Journal of Reliability and Applications
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• v.17 no.1
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• pp.85-105
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• 2016

In this paper accelerated life testing is incorporated in quality control technique of acceptance sampling plan to induce early failures in high reliability products.Stress under accelerated condition can be applied in constant-stress, step-stress and progressive-stress or combination of such loadings. A ramp-stress results when stress is increased linearly (from zero) with time. In this paper optimum failure-censored ramp-stress accelerated life test sampling plan for log-logistic distribution has been formulated with cost considerations. The log-logistic distribution has been found appropriate for insulating materials. The optimal plans consist in finding optimum sample size, sample proportion allocated to each stress, and stress rate factor such that producer's and consumer's interests are safeguarded. Variance optimality criterion is used when expected cost per lot is not taken into consideration, and bilevel programming approach is used in cost optimization problems. The methods developed have been illustrated using some numerical examples, and sensitivity analyses carried out in the context of ramp-stress ALTSP based on variable SSP for proportion nonconforming.