• Journal of Radiopharmaceuticals and Molecular Probes
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• v.3 no.1
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• pp.32-37
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• 2017

Cis-(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tertrahydro-N-methyl-1-naphthalenamine (sertraline) hydrochloride from among selective serotonin reuptake inhibitors (SSRIs) is a treatment of major depression. For the differential diagnosis by metabolizing serotonin in a patient with neurological disorders, the radiolabeled $^{11}C$-sertraline was developed for non-invasive positron emission tomography in living brain and use the evaluation of new drug for SSRIs. We release the results of a fast and easy radiolabeling method applied a one-step loop method with $[^{11}C]CH_3OTf$ for routine clinical applications of $^{11}C$-sertraline. 1 mg of a precursor for $^{11}C$-sertraline in 0.1 mL DMF and $5{\mu}L$ of 1N NaOH, were injected into the loop of semi-prep high-performance liquid chromatography (HPLC). $[^{11}C]CH_3OTf$ was passed through the loop at room temperature (RT). The $^{11}C$-sertraline was separated by the semi-preparative HPLC. $^{11}C$-sertraline was eluted at 28.0 min was collected and evaluated by analytical HPLC and mass spectrometer. The total radiolabeling efficiency of $^{11}C$-sertraline was $30.7{\pm}8.7%$. The specific activity was $64.8{\pm}51.4GBq/{\mu}mol$. The radiochemical and chemical purities were higher than 99%. The mass spectrum of the product showed m/z peaks at 307.1 (M+1), indicating the mass of sertraline. By the one-step loop method with $[^{11}C]CH_3OTf$, $^{11}C$-sertraline could be quickly and easily prepared for clinical application.

• Structural Engineering and Mechanics
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• v.45 no.5
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• pp.677-691
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• 2013

A semi-analytical finite strip method is developed for analyzing the post-buckling behavior of rectangular composite laminated plates of arbitrary lay-up subjected to progressive end-shortening in their plane and to normal pressure loading. In this method, all the displacements are postulated by the appropriate harmonic shape functions in the longitudinal direction and polynomial interpolation functions in the transverse direction. Thin or thick plates are assumed and correspondingly the Classical Plate Theory (CPT) or Higher Order Plate Theory (HOPT) is applied. The in-plane transverse deflection is allowed at the loaded ends of the plate, whilst the same deflection at the unloaded edges is either allowed to occur or completely restrained. Geometric non-linearity is introduced in the strain-displacement equations in the manner of the von-Karman assumptions. The formulations of the finite strip methods are based on the concept of the principle of the minimum potential energy. The Newton-Raphson method is used to solve the non-linear equilibrium equations. A number of applications involving isotropic plates, symmetric and unsymmetric cross-ply laminates are described to investigate the through-thickness shearing effects as well as the effect of pressure loading, end-shortening and boundary conditions. The study of the results has revealed that the response of the composite laminated plates is particularly influenced by the application of the Higher Order Plate Theory (HOPT) and normal pressure loading. In the relatively thick plates, the HOPT results have more accuracy than CPT.

• Journal of Korea Spatial Information System Society
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• v.11 no.2
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• pp.45-53
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• 2009

The fast progress on multimedia data acquisition technologies has enabled collecting vast amount of videos in real time. Although the amount of information gathered from these videos could be high in terms of quantity and quality, the use of the collected data is very limited typically by human-centric monitoring systems. In this paper, we propose a framework for analyzing long traffic video using series of content-based analyses tools. Our framework suggests a method to integrate theses analyses tools to extract highly informative features specific to a traffic video analysis. Our analytical framework provides (1) re-sampling tools for efficient and precise analysis, (2) foreground extraction methods for unbiased traffic flow analysis, (3) frame property analyses tools using variety of frame characteristics including brightness, entropy, Harris corners, and variance of traffic flow, and (4) a visualization tool that summarizes the entire video sequence and automatically highlight a collection of frames based on some metrics defined by semi-automated or fully automated techniques. Based on the proposed framework, we developed an automated traffic flow analysis system, and in our experiments, we show results from two example traffic videos taken from different monitoring angles.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.17 no.2
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• pp.105-116
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• 1999

Owing to the rapid development of computer system and the introduction of image processing technique, recent photogrammetric studies have been concentrated on the automation of photogrammetric orientation work that have been carried out by skilled professionals in analog and/or analytical pbotogrammetric field. To automate the whole photogrammetric work, the automation of the orientation processes including interior, relative and absolute orientation should be preceded. This study aims to automate interior orientation and relative orientation process. For this purpose, we applied Hough transform to interior orientation process and object space matching technique to relative orientation process. As the result of this study, we can present a method to automate interior and relative orientation process that has been semi-automatically operated in most commercial digital photogrammetric workstations currently available.

• Structural Engineering and Mechanics
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• v.63 no.4
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• pp.471-480
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• 2017

This paper investigates free vibration characteristics of a rotating functionally graded (FG) beam in hygro environments. In the present study, material properties of the FG beam vary continuously through thickness direction according to the power-law which approximates material properties of FG beam. The governing differential equations of motion are derived based on Euler-Bernoulli beam theory and using the Hamilton's principle which solved utilizing a semi-analytical technique called the Differential Transform Method (DTM). In order to verify the competency and accuracy of the current analysis, a comparative study with previous researches are performed and good agreement is observed. Influences of Several important parameters such as power-law exponent, hygro environment, rotational speed and slenderness ratio on natural frequencies are investigated and discussed in detail. It is concluded that these effects play significant role on dynamic behavior of rotating FG beam in the hygro environments. Numerical results are tabulated in several tables and figures that can be serving as benchmarks for future analyses of rotating FG beams in the hygro environments.

• Structural Engineering and Mechanics
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• v.61 no.2
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• pp.231-244
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• 2017

The aim of this study is to develop a semi-analytical method to investigate fluid-structure coupling of concentric double shells with different lengths and elastic behaviours. Co-axial shells constitute a cylindrical circular container and a baffle submerged inside the stored fluid. The container shell is made of functionally graded materials with mechanical properties changing through its thickness continuously. The baffle made of steel is fixed along its top edge and submerged inside fluid such that its lower edge freely moves. The developed approach is verified using a commercial finite element computer code. Although the model is presented for a specific case in the present work, it can be generalized to investigate coupling of shell-plate structures via fluid. It is shown that the coupling between concentric shells occurs only when they vibrate in a same circumferential mode number, n. It is also revealed that the normalized vibration amplitude of the inner shell is about the same as that of the outer shell, for narrower radial gaps. Moreover, the natural frequencies of the fluid-coupled system gradually decrease and converge to the certain values as the gradient index increases.

• Structural Engineering and Mechanics
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• v.50 no.6
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• pp.773-796
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• 2014

This paper deals with free vibration analysis of continuous grading fiber reinforced (CGFR) and bi-directional FG annular sector plates on two-parameter elastic foundations under various boundary conditions, based on the three-dimensional theory of elasticity. The plates with simply supported radial edges and arbitrary boundary conditions on their circular edges are considered. A semi-analytical approach composed of differential quadrature method (DQM) and series solution is adopted to solve the equations of motion. Some new results for the natural frequencies of the plate are prepared, which include the effects of elastic coefficients of foundation, boundary conditions, material and geometrical parameters. Results indicate that the non-dimensional natural frequency parameter of a functionally graded fiber volume fraction is larger than that of a discrete laminated and close to that of a 2-layer. It results that the CGFR plate attains natural frequency higher than those of traditional discretely laminated composite ones and this can be a benefit when higher stiffness of the plate is the goal and that is due to the reduction in spatial mismatch of material properties. Moreover, it is shown that a graded ceramic volume fraction in two directions has a higher capability to reduce the natural frequency than conventional one-dimensional functionally graded material. The multidirectional graded material can likely be designed according to the actual requirement and it is a potential alternative to the unidirectional functionally graded material. The new results can be used as benchmark solutions for future researches.

• Journal of The Korean Astronomical Society
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• v.31 no.1
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• pp.27-37
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• 1998

We have made semi-analytical studies to investigate the configurations of caustics and the probability distribution of the flux factor K for the binary microlensing including external shears. A parametric equation of critical curve is derived in a 4th order complex polynomial. We present the topological dependencies of the caustics for selected gamma parameters (0, 0.3, 0.6, 1.3, 2.0, and 2.5) and convergence terms (0., 0.4, 0.8, 1.2, 1.6, and 2.0). For the purpose of analyzing the efficiency of High Amplification Event (HAE) on each caustics, we examine the probability distribution of the flux factor by a Monte Carlo method. Changing the separation of the binary system from 0.8 to 1.3 (in normalied unit), we examine the probability distribution of the K-values in various gamma parameters. The relationship between gamma parameters, seperations and their probabilties of the flux factor K have been studied. Our results show that the relatively higher K values (K>1.5) are increased as increasing the separation of the binary system. We therfore conclude that, in the N-body microlensing, the probabilities of higher HAEs are inversely proportional to the star density as well. We also point out that the present research might be used as a preliminary step toward investigating heavy N-body microlensing simulations.

• Structural Engineering and Mechanics
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• v.50 no.1
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• pp.53-71
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• 2014

A semi-analytical method is developed to consider free vibrations of a functionally graded elastic plate resting on Winkler elastic foundation and in contact with a quiescent fluid. Material properties are assumed to be graded distribution along the thickness direction according to a power-law in terms of the volume fractions of the constituents. The fluid is considered to be incompressible and inviscid. In the analysis, the effect of an in-plane force in the plate due to the weight of the fluid is taken into account. By satisfying the compatibility conditions along the interface of fluid and plate, the fluid-structure interaction is taken into account and natural frequencies and mode shapes of the coupled system are acquired by employing energy methods. The results obtained from the present approach are verified by those from a finite element analysis. Besides, the effects of volume fractions of functionally graded materials, Winkler foundation stiffness and in-plane forces on the dynamic of plate are elucidated.

• Nuclear Engineering and Technology
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• v.28 no.1
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• pp.27-35
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• 1996

In this paper, an unsteady analytical model for the thermal stratification in the pressurizer surge line of PWR plant has been proposed to investigate the temperature profile, flow characteristics, and thermal stress in the pipe. In this model, the interface level, between hot and cold fluid, is assumed to be a function of time while the other models had developed for time independent or steady state. The dimensionless governing equations are solved by using a SIMPLE (Semi-Implicit Method for Pressure Linked Equations) algorithm. The analysis result for an example shows that the maximum dimensionless temperature difference is about 0.78 between hot and cold sections of pipe wall and the maximum thermal stress by thermal stratification is calculated about 276 MPa at the dimensionless time 27.0 under given conditions.