This study examined the correlation between safety practices and safety knowledge, safety awareness and safety efficacy, and the factors influencing the safety practices of in-home child-care providers. The participants were 199 in-home child-care providers who worked at two cities in G province. Using a structured-questionnaire, the data were collected from December 2019 to January 2020. The data were analyzed using the IMB/SPSS 25.0 program. The collected data were analyzed using descriptive statistics (frequency, percent, mean, and SD), a t-test, ANOVA, Scheff test, Pearson Correlation Coefficient, and multiple regression. The mean score for safety knowledge, safety awareness, safety efficacy, and safety practices were 0.64 (SD, 0.09), 1.92 (SD, 0.37), 4.18 (SD, 0.51), and 2.55 (SD, 0.36), respectively. Safety practices were positively correlated with the safety knowledge (r=.14, p=.042), safety efficacy (r=.43, p<.001), and sub-factors of safety efficacy, self-regulation (r=.32, p<.001), enlisting social support (r=.40, p<.001), and controlling the environment (r=.39, p<.001). Enlisting social support and controlling the environment, sub-factors of safety efficacy were influenced safety practices significantly and explained 20.0% of the variance. Based on these findings, it will be necessary to develop a program that can enhance their safety efficacy for safety practices of in-home child-care providers.