• Journal of Nutrition and Health
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• 제26권7호
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• pp.899-906
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• 1993

사람의 혈중 셀레늄의 농도는 식품의 셀레늄 함유량과 생리적 이용도에 따른다. 그러므로 특히 토양중 셀레늄의 농도가 낮은 나라에서는 식이 형태에 따라 셀레늄의 섭취량과 혈중 셀레늄 농도의 차이를 볼 수 있다. 본 실험에서는 평균 독일 식이(average German diet)를 하는 건강한 성인 여자 175명과 wholesome nutrition을 지켜온 243명을 대상으로 셀레늄의 영양상태를 살펴보았다. 평균 독일 식이군에서 평균 전혈 셀레늄의 농도와 혈장 셀레늄의 농도는 84.79$\mu\textrm{g}$/l, 혈장 셀레늄의 농도는 75.02$\mu\textrm{g}$/l 이었고, wholesome nutrition군에서 전혈 셀레늄의 농도와 혈장 셀레늄의 농도가 각각 78.62$\mu\textrm{g}$/l 와 63.95$\mu\textrm{g}$/l로 두 식이군 간에 전혈 셀레늄 농도와 혈장 셀레늄 농도에서 모두 유의적인 차이를 나타내었다. 그리고 셀레늄의 혈중 농도에 영향을 주는 요인을 알아보기 위하여 BMI, 나이, 하루 식품 섭취량과의 상관 관계를 조사해 보았다. BMI와 나이는 전혈, 그리고 혈장 셀레늄 농도와 유의적인 상관관계를 찾아볼 수 없었으며, 하루 식품 섭취량과의 상관 관계에서는 wholesome nutrition군에서 전혈 셀레늄 농도에서 모두 생선 섭취량과 유의적인 상관 관계를 나타내었다.

• 생물환경조절학회지
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• 제15권4호
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• pp.346-351
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• 2006

토양에 비료 형태로 투여한 셀레늄 농도와 처리기간이 마늘의 생육에 미치는 영향을 구명하고자 본 실험을 수행하였다. 셀레늄의 농도가 높고 처리기간이 길수록 생체중은 대조구에 비하여 감소하였다. 셀레늄의 처리농도가 높고 처리기간이 길수록 3주 후 셀레늄의 함량은 구보다는 엽초에 많이 축적되었다 그러나 처리 6주 후에는 구>엽초>뿌리 순으로 셀레늄의 함량이 높았다. 셀레늄 처리 후 토양에 잔류하고 있는 셀레늄의 함량은 대조구와 차이가 없었다.

• Asian-Australasian Journal of Animal Sciences
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• 제22권12호
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• pp.1661-1666
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• 2009

The objective of this study was to determine the effect of Se-enriched bean sprout, Se-enriched yeast and sodium selenite on productivity, egg quality and egg Se concentrations in laying hens. Using a Completely Randomized Design, 144 Rohman laying hens at 71 weeks of age were divided into four groups. Each group consisted of four replicates and each replicate contained nine hens. The dietary treatments were T1: control diet, T2: control diet plus 0.3 mg Se/kg from sodium selenite, T3: control diet plus 0.3 mg Se/kg from Se-enriched yeast, T4: control diet plus 0.3 mg Se/kg from Se-enriched bean sprout. The results showed that there was no significant difference (p>0.05) in feed intake, egg production and egg quality among treatments. Selenium supplementation from Seenriched yeast and Se-enriched bean sprout markedly increased (p<0.05) egg Se concentration as compared to the control and sodium selenite groups. The results indicated that Se-enriched bean sprout could be used as an alternative Se source in diets of laying hens.

• Journal of Nutrition and Health
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• 제24권6호
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• pp.506-515
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• 1991

Serum concentration of selenium were measured ; Studying 36 patients with Hepatoma. 19 with Hepatitis 15 with Liver cirrhosis and 67 Normal control to discover the correlation between serum selenum and cancer. And it have tested also the serum protein and albumin to compare the nutrition status by researching the same persons above The results of those two experiments are as follow : 1) The mean of each group of patients resulting from mearsuing the serum protein content showing 6.91$\pm$0.10g/dl in the patients with hepatoma 7.05$\pm$0.17g/dl in the ones with hepatitis 6.42$\pm$0.13g/dl in the ones with liver cirrhosis and 7.46$\pm$0.06g/dl in the normal control is all being within the normal range such as 6.0-0.8(g/dl) while the distribution is revealin 10.5%, 13.3% in the patients with hepatitis and liver cirrhosis which are below the normal range and 47.2%, 96.9%, 80.0% in the low range of normal one ; therefore in could see that patientsw compared with normal control are in low level in the serum protein content 2) The mean based on the consquence of serum albumin measurement is 3.74$\pm$0.11g/dl. 4.26$\pm$0.13g/dl 4.73$\pm$0.06g/dl in the patients with hepatoma hepatits and normal control which are in between the normal range such as 3.5-5.5(g/dl) except the patients with liver cirrhosis(3/05$\pm$0.12g/dl) while the distribution of the patients with hepatoma an liver cirrhosis is showing 27.8% 73.3% which are below the normal one and 55.5%, 52.6% and 26.7% in the patients with hepatoma hepatits and liver cirrhosis which are in the low area of normal range ; as a result It could find that patients. compared with the normal control are in low level in serum albumin measurement. 3) The mean consulting the serum concentration is 430.86$\pm$26.06$\mu\textrm{g}$/1, 192.37$\pm$18.15$\mu\textrm{g}$/1 186.73$\pm$23.99$\mu\textrm{g}$/1, 196.94$\pm$8.94$\mu\textrm{g}$/1 in the patients with hepatoma hepatitis liver cirrhosis and noramal control ; it shows 2.19 times increasing of serum selenium concentra-tion in the patients with hepatoma 'compared with the normal control and patients with hepatoma spread out at a still higher range in serum selenium concentration test. 4) The serum selenium concentration is not quite dependent on sexes and doesn't show any correlation with age, serum protein, serum albumin. The nutrition status of patients, rested on the results of those experiments, stays in low level, which is caused by that they are in low stage of serum protein and serum albu¬min. In serum selenium concentration, patients with hepatitis and liver cirrhosis, specially, show the condition as good as normal control's; while patients with hepatoma are indicating a significant increasing compared with the three groups, which can be reasoned into that there is a possibility for the patients to take selenium and chemotherapy or radiation treatment, and have high serum selenium concentration by poor excreting of seleno methionine, which is caused by low serum protein content And another thing can be reasoned is that the difference in origination mechanism hetween korean and western people. As a result, It showed that the correlation between serum selenium and seses, age, serum protein, and serum albumin neither exists nor affects on each other.

• 한국환경보건학회지
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• 제18권1호
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• pp.95-104
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• 1992

The influence of selenium to several toxic effects of cadmum, including lethality has been shown following pretreatment with cadmium, zinc and seleniurm Five groups of rats, each consisting of 16 rats, were studied and each group was divided into four subgroups, 4 rats for each subgroup. After subcutaneous pretreatment during 5 days with saline, CdCl$_{2}$ (0.5mg/kg, ZnCl$_{2}$ (13.0mg/kg) and $Na_{2}SeO_{3}$(1.0mg/kg), rats were given intraperitioneal administration of various dosage of or cadium of cadmium and selenium. After giving the challenge dose, cadmium and metallothionein(MT) concentrations were determined in liver and kidney The concentration of cadmium in liver and kideny increased proportionally to the increase of challenge dosage. The simultaneous administration of cadmium and selenium significantly more decrease cadmium concentrations in liver and kidney than those of the administration of cadmium only. However, MT concentrations in liver and kideny were increased by the pretreatment of cacmium, zinc and selenium. Our results suggest that increasing cadmium concentrations, gradully accumulating in the tissues of liver and kidney as a result of the pretreatment, served to induced the synthesis of MT, thus making them resistant to the challenge from cadmium.

• 한국환경농학회지
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• 제28권2호
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• pp.179-185
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• 2009

새싹채소의 종자발아와 생장에 미치는 셀레늄 농도 처리(삽입) 효과와 흡수특성을 구명하기 위하여, 대표적인 채소류인 배추, 상추, 청경채 및 을 이용하여 다양한 셀레늄 농도 (0, 1, 5, 10, 25, 50, 100 mg $L^{-1}$ 를 처리하였다. 종자발아는 배추, 청경채 및 갓에서 처리 농도가 증가함에 따라 억제되었지만, 상추의 경우 큰 영향을 받지 않았다. 싹의 생장에 미치는 셀레늄의 효과는 배추, 상추, 청경채 및 갓의 경우, 지상부 길이, 뿌리 길이, 생체중 및 엽록소 함량 등의 생육특성에 있어서 낮은 처리 농도 (1 mg $L^{-1}$)에서 오히려 약간의 생장 촉진 효과를 보이거나 거의 차이가 없었다. 5 mg $L^{-1}$ 이상의 농도 처리 시에는 농도가 높아짐에 따라 심각한 생육 억제 현상을 보였다. 식물체내의 셀레늄의 흡수 특성은 셀레늄을 각각 1${\sim}$25 mg $L^{-1}$ 처리 시 배추는 0.11${\sim}$1.15, 상추는 0.16${\sim}$0.61, 청경채는 0.13${\sim}$1.31 그리고 갓은 0.14${\sim}$1.13 mg $g^{-1}$dw 범위에서 셀레늄 처리농도가 높아짐에 따라 점진적으로 증가하였다. 따라서 본 연구의 결과에 의하여 1${\sim}$5 mg $L^{-1}$ 범위의 낮은 농도의 셀레늄 처리가 셀레늄 함유된 기능성 새싹채소의 생산을 위한 기초 자료로 활용 될 것으로 판단된다.

• Asian-Australasian Journal of Animal Sciences
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• 제19권6호
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• pp.865-871
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• 2006

Signs of dental discolouration, difficulty in mastication, bony exostosis and debility were observed in cattle from Qingtongxia Ningxia, China where fluoride concentration in drinking water, soil, fodder, serum, bone, teeth, haircoat and urine were significantly higher than the corresponding health site. The problem of fluorosis in beef cattle is attributable to water containing toxic levels of fluoride. The objective of this paper was therefore to evaluate the influence of fluoride on erythrocyte parameters in cattle under high fluoride and low selenium conditions, as well as the protective efficacy of selenium exposure in feedstuff for bovine endemic fluorosis. Sixteen 6 to 7 year-old high fluoride beef cattle were randomly allotted into two groups each with eight cows: high fluoride control group, and supplemented with 0.25 mg/kg selenium per day for 83 days respectively. In addition, eight 6 to 7 year-old normal control beef cattle were selected from a non-high fluoride site. Blood samples were collected on day 0, 30 and 83 for erythrocyte parameters analysis and scanning electronic microscopy. The results indicated that erythrocytes, hemoglobin, packed cell volume values and $Na^+-K^+$ ATPase activity from affected cattle on the high fluoride site were significantly reduced during the period as compared with the corresponding samples of normal control cattle, a great number of echinocytes were present in peripheral blood, and subsequent anaemia. However, affected cattle exposed to selenium revealed increasable erythrocyte parameters, the extent of elevation in these values being dependent on the duration of supplementation with selenium. These findings suggest that fluoride exposure can cause erythrocyte damage, whereas selenium supplementation can antagonize fluoride-induced generation of free radicals and cumulative effects of lipid peroxidation in erythrocytes. Selenium supplementation may help to alleviate the possible hazards associated with bovine endemic fluorosis.

• 환경생물
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• 제21권3호
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• pp.297-302
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• 2003

This study was designed to determine whether selenium (Se) nutrition affects pulmonary glutathione peroxidase and alveolarization in the neonatal rat. Twenty-four female Sprague Dawley rats were bred and fed a semipurified Se-deficient (0.04 ppm, Se-) or a Se-adequate (0.5 ppm, Se+) diet through pregnancy and lactation. Pulmonary DNA synthesis was slightly higher in Se+ pups than in Se- pups on d 6 and d 9 of lactation, but significant difference was not found. As pulmonary alveolarization progressed, mean air space size decreased and internal surface area and lung volume increased. No difference in pulmonary alveolarization was found between Se- and Se+ pups by age. Pulmonary Se concentration was higher in Se+ pups than in Se- pups at all age. Glutathione peroxidase activity in lung tissur reflected Se status and was lower in Se- pups than in Se+ pups. In conclusion, selenium has no significant effect on alveolarization of neonatal lungs. but it is necessary for adequate supply of pulmonary antioxidant, glutathione peroxidase.

• Journal of Nutrition and Health
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• 제44권2호
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• pp.112-118
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• 2011

We investigated the selenium (Se) nutrition status in Korean infants. The mean serum Se concentration in infants was 66.9 ${\mu}g/L$, and it increased with increasing in infant age: 57.6 ${\mu}g/L$ at 0-5 months, 71.8 ${\mu}g/L$ at 6-11 months, and 75.5 ${\mu}g/L$ at 12-24 months. Serum glutathione peroxidase (GPx) activity also increased with infant age. Serum Se concentration in infants was positively correlated with serum GPx activity (r = 0.565, p < 0.01). At 0-5 months, human milk-fed infants tended to have higher Se concentrations and GPx activity than those of formula-fed infants, but the result was not significant. With the introduction of supplemental feeding at 6-24 months of age, serum Se concentration was not different between the groups. Therefore, human milk feeding seemed to be more appropriate for infant Se nutrition than infant formula feeding during the first 6 months of life, but supplemental feeding became more important later to maintain good Se nutrition status.

• Journal of Animal Science and Technology
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• 제48권6호
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• pp.897-906
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• 2006

본 연구는 셀레늄강화 한우고기 생산을 위하여 셀레늄강화 버섯폐배지(Se-SMC)가 함유된 셀레늄사료(사료내 셀레늄함량: 0.9ppm)를 활용하여 급여사양기간(2개월, 3개월, 4개월)을 달리 하였을 때, 비육후기 거세한우의 조직 내 셀레늄 함량과 혈중 글루타치온 과산화효소(GSH-Px) 활성에 미치는 영향을 조사하여 최대 포화축적기간을 제시하고자 실시하였다. 본 연구에 사용된 비육후기 거세한우는 30두로 각 급여기간(2개월: 평균 체중 677kg, 3개월: 평균 체중 610kg 및 4개월: 평균 체중 524kg)에 대한 대조구 및 Se-SMC 급여구로 나누어 처리구당 5두씩 배치하여 총 6처리구로 구분하여 실시하였다. 대조구와 Se-SMC 급여구에 사용된 실험사료는 0.1과 0.9ppm의 셀레늄을 각각 함유하였다. 각 급여기간이 종료되면 도축하여 후지와 간을 채취하였으며 이를 셀레늄 함량분석에 이용하였다. 그리고 혈중 셀레늄 농도 및 글루타치온 과산화효소활성을 분석하기 위하여 도축 시에 채혈을 실시하였다. 건물섭취량은 Se-SMC 급여 및 급여기간에 의하여 유의한 차이가 나타나지 않았다. 또한 일당증체량은 대조구 및 Se-SMC 급여구간 그리고 급여기간 간에 유의한 차이가 나타나지 않았을 뿐만 아니라 총증체량 또한 각 급여기간내 대조구와 Se-SMC 급여구 간에 유의한 차이가 나타나지 않았다. Se-SMC 급여는 혈중 셀레늄농도를 유의하게 증가시켰으나(P<0.001), 급여기간에 따른 혈중셀레늄 농도에는 유의한 영향을 미치지 않았다. 아울러 혈중 GSH-Px 활성은 혈중 셀레늄농도에서 나타난 양상과 유사한 경향을 나타내었고, 급여기간에 의한 효과는 나타나지 않았다. 후지내 셀레늄 함량은 급여기간(P<0.05)이 증가함에 따라, 그리고 Se-SMC 급여(P<0.001)에 의하여 유의하게 증가하였다. 하지만, Se-SMC의 3개월 급여군과 4개월 급여군 간에는 유의한 차이가 나타나지 않았다. 간내 셀레늄 함량은 Se-SMC의 급여기간이 증가함에 따라 다소 증가하는 경향을 나타내었으나 유의한 효과는 나타나지 않았다. 하지만, 동일한 급여기간 내 Se-SMC는 대조구에 비하여 유의하게 높았다(P<0.01).이상의 결과로부터 근육내 셀레늄 축적을 위한 적정 Se-SMC 급여기간은 후지와 간내 셀레늄 함량을 고려할 때 약 2 내지 3개월의 급여가 충분할 것으로 사료된다.