Korean Journal of Environmental Biology (환경생물)

Korean Society of Environmental Biology (한국환경생물학회)
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Effect of Selenium on Pulmonary Glutathione Peroxidase and Alveolarization of Neonatal Rats

  • Published : 2003.09.01
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Abstract

This study was designed to determine whether selenium (Se) nutrition affects pulmonary glutathione peroxidase and alveolarization in the neonatal rat. Twenty-four female Sprague Dawley rats were bred and fed a semipurified Se-deficient (0.04 ppm, Se-) or a Se-adequate (0.5 ppm, Se+) diet through pregnancy and lactation. Pulmonary DNA synthesis was slightly higher in Se+ pups than in Se- pups on d 6 and d 9 of lactation, but significant difference was not found. As pulmonary alveolarization progressed, mean air space size decreased and internal surface area and lung volume increased. No difference in pulmonary alveolarization was found between Se- and Se+ pups by age. Pulmonary Se concentration was higher in Se+ pups than in Se- pups at all age. Glutathione peroxidase activity in lung tissur reflected Se status and was lower in Se- pups than in Se+ pups. In conclusion, selenium has no significant effect on alveolarization of neonatal lungs. but it is necessary for adequate supply of pulmonary antioxidant, glutathione peroxidase.

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References

  1. Nutr. Metab. v.24 Selenium in premature infants Amin,S.;S.Y.Chen;P.J.Collipp;M.Castro-Magana;V.T.Maddaiah;S.W.Klein https://doi.org/10.1159/000176279
  2. Biol. Trace. Element Res. v.7 Tissue selenium accretion in premature and full-tern human infants and children Bayliss,P.A.;B.E.Buchanan;R.G.V.Hancock;S.H.Zlotkin https://doi.org/10.1007/BF02916547
  3. Annu. Rev. Physiol. v.46 Fetal and postnatal development of the lung Burri,P.H. https://doi.org/10.1146/annurev.ph.46.030184.003153
  4. Anat. Rec. v.180 The postnatal growth of the rat lung.: Ⅲ. Morphology Burri,P.H. https://doi.org/10.1002/ar.1091800109
  5. Korean J. Nutr. v.27 Effect of maternal selenium nutrition on pulmonary selenium, glutathione peroxidase, and phos-pholipid levels in meonatal rats Kim,H.Y.P.
  6. J. Nutr. v.122 Selenium repletion protects neonatal rat lungs from hyperoxia Kim,H.Y.P.;M.F.Picciano;M.A.Wallig
  7. Pediatr. Res. v.29 The role of selenium in the development of neonatal rat lung Kim,H.Y.P.;M.F.Picciano;M.A.Wallig;J.A.Milner https://doi.org/10.1203/00006450-199105010-00006
  8. J. Pediatr. v.114 Selenium deficiency in low birth weight neonates: an unrecognized problem Lockitch,G.;B.Jacobson;G.Quigley;P.Dison;M.Pendray https://doi.org/10.1016/S0022-3476(89)80154-4
  9. J. Biol. Chem. v.193 Protein measurement with the Folin phenol reagent Lowry,O.H.;N.J.Rosebrough;A.L.Farr;R.J.Randall
  10. J. Chin. Invest. v.76 Postnatal development of alveoli Massaro,D.;N.Teich;S.Maxwell;G.D.Massaro;P.Whitney https://doi.org/10.1172/JCI112103
  11. J. Chromatogr. v.225 Improved method for selenium determination in biological samples by gas chromatography McCarthy,T.P.;B.Brodie;J.A.Milner;R.F.Bevill https://doi.org/10.1016/S0378-4347(00)80238-8
  12. Nutrient Requirements of Laboratory Animals(3rd ed.) Nutrient requirements of the laboratory rat National Research Council
  13. J. Dev. Physiol. v.6 Preparation of the respiratory system for the early neonatal period Maloney,J.E.
  14. J. Lab. Clin. Med. v.70 Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase Paglia,D.E.;W.N.Valentine
  15. Biochim. Biophys. Acta. v.947 Metabolic and developmental aspects of the pulmonary surfactant system Post,M.;L.M.G. Van Golge https://doi.org/10.1016/0304-4157(88)90011-1
  16. J. Nutr. v.116 Evidence for increased selenium requirement for the rat during pregnancy and lactation Smith,A.M.;M.F.Picciano
  17. Pediatr. Clin. North Am. v.33 Respiratory Distress Syndrome Stark,A.R.;I.D.Frantz
  18. Principles and procedures of statistics: A biometrical approach(2nd ed.) Steel,R.G.D.;J.H.Torrie
  19. Thorax v.36 Adaptive response to pneumonectomy in puppies Thurlbeck,W.M.;W.Galaugher;J.Mathers
  20. Biol. Neonate. v.58 Glutathione peroxidase and selenium levels in the preterm infant Tubman,T.R.J.;H.S.Halliday;D.McMaster https://doi.org/10.1159/000243284
  21. Morphometry of the human lung Weibel,E.R.
  22. Respiratory physiology(3rd ed.) West,J.B.
  23. Proc. Exp. Biol. Med. v.147 Stimulation of DNA synthesis in mouse lung following intraperitoneal injection of butylated hydroxytoluene Witsci,H.P.;W.Saheb
  24. Annu. Rev. Physiol. v.53 Regulation of pulmonary surfactant secretion and clearance Wright,J.R.;L.G.Dobbs https://doi.org/10.1146/annurev.ph.53.030191.002143