• 한국사회복지학
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• 제41권
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• pp.173-200
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• 2000

The purpose of this study is to examine the variables that may influence the level of family adaptation to schizophrenic patients using the Family Resiliency Model. The Family Resiliency Model is the most current extension of family stress Model. According to the Family Resiliency Model, The level of family adaptation in the face of a crisis situation is determined by a number of interacting components. The subjects are 151 family members with schizophrenic patient. The result from the research were as follows: 1) The following variables significantly correlated with the family adaptation: income of the family, educational level of the family, intimacy between family and patient, knowledge on schizophrenia, recognition of prognosis on schizophrenia. 2) The factors that compose the Family Resiliency Model significantly correlated with the level of family adaptation. 3) The result of stepwise multiple regression analysis indicated that factors which predict the level of family adaptation were the family control, the quality of family communication, and the support from the extended family, these findings give us significant practical implications for social work intervention.

• 동의생리병리학회지
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• 제19권5호
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• pp.1443-1445
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• 2005

The causes of schizophrenia are multifactorial and stress-diathesis model is one of the supporitive causes. This study is aimed for Sasang Constitutional tendency of schizophrenic patients. 20 Subjects are recruited from Gunsan Mental Health Center. They agreed with this study in advance and visited Daeya Public Health Center to interview with Sasang Constitutional Specialist. Their Sasang Constitution types are determined by QSCC II and interview with specialist. Taeumin and Soyangin are prevelant among the 20 cases of schizophrenic subjects visiting Public Health Center; 10 subjects are Taeumin, 9 subjects are Soyangin and 1 subject is Soeumin.

• 대한간호학회지
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• 제35권6호
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• pp.1125-1134
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• 2005

Purpose: This research investigated the daily experiences of patients' lives to develop a formal theory that explains the lives of schizophrenic patients. Method: A grounded theory method(Strauss & Corbin, 1998) guided the data collection and analysis. Thirteen patients who were diagnosed with schizophrenia in regional communities participated. Result: The experiences of chronic schizophrenic patients are defined as "escaping from a fallen mine" comparing their suffering to that of entrapped miners trying to free themselves from a collapsed mine tunnel with much difficulty and without hope. In observing participant's time lines of having lived with chronic schizophrenia, it advances with 'surrender', 'collapse', 'reaching out', 'rising', 'preparing to spring up', and 'starting anew'. Conclusion: The results of this study indicate that the experience of a chronic schizophrenic patient is like that of a miner caught under a fallen mine channel, who, without external help cannot escape the depths 'Of the mine, but at the same time must have conviction and hope of rescue and avert fear to cooperate with outside help. The result indicates that family members, doctors and nurses as well as an institute's persistent and active support is most critical for the patient's adjustment to social life.

• 생물정신의학
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• 제13권3호
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• pp.191-201
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• 2006

Objectives : The purpose of this study was to investigate whether the cognitive functions would be correlated with psychotic symptoms and whether antipsychotic treatments would affect the cognitive functions after 8 weeks. Methods : The thirty-five schizophrenic patients were conducted in this study. The psychopathology was measured using PANSS. The memory function, executive function, and sustained attention were measured using Memory Assessment Scale(MAS), Wisconsin Card Sorting Test(WCST), and Vigilance(VIG) and Cognitrone(COG) in Vienna Test System. After 8 weeks of antipsychotic treatment, we retested the cognitive tests. Results : 1) The cognitive tests after the 8 week's treatment showed significant improvements in memory and executive function in the schizophrenic patients. On the other side, sustained attention did not show improvement. 2) The change of PANSS were correlated with perseverative response, perseverative error and total correct in WCST at baseline. WCST scores at baseline were correlated with negative symptoms, but not positive ones. Conclusion : These study suggests that 1) the impaired sustained attention could be a vulnerability marker in schizophrenia, 2) memory & executive function deficit could be reversible after treatment, and 3) medication might have a benefit in improving the cognitive functions in schizophrenia. Furthermore, the data supports that the better premorbid executive function was, the more favorable was the treatment response in schizophrenic patients. Finally, this study indicates that executive function might be an index of treatment improvement.

• 생물정신의학
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• 제5권2호
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• pp.215-218
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• 1998

The $5-HT_{2A}$ receptor is of great interest for research into schizophrenia and psychopharmacology in light of the observation that schizophrenic patients has 5-HT cortical-subcortical imbalance and atypical antipsychotic clozpine has $5-HT_{2A}$ antagonists properties. An significant association between schizophrenia and the T102C polymorphism of the gene for $5-HT_{2A}$receptor has been reported. In this study, we investigated an association between schizophrenia and the T102C polymorphism of the gene for $5-HT_{2A}$ receptor in Korean schizophrenic patients. The subjects consisted of 139 schizophrenic patients and 88 normal controls. Genomic DNA was amplified by PCR and digested with MsPI. The uncutt product identified allele 1(nucleotide sequence TCT) ; digested products of 216bp and 156bp identified allele 2(nucleotide sequence TCC). The allele frequencies and the genotypic distribution of $5-HT_{2A}$ receptor gene were not significantly different between schizophrenic patients and normal controls. Since allele frequencies of the T102C polymorphism may differ between individuals of different ethnic backgrounds, it needs to be conducted in an advanced research.

• 대한간호학회지
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• 제35권8호
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• pp.1485-1492
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• 2005

Purpose. The present study aims to verify the effectiveness of the reality therapy for patients with schizophrenia. Methods. It is designed as a quasi-experimental study by which a nonequivalent control group pretest-posttest is conducted. The test was conducted with 30 patients with schizophrenia who were hospitalized at a mental hospital in South Korea. Fifteen of the patients participated in the reality therapy program while another 15 in the control group. The effects are measured by marking scores in the areas of the locus of control, self-esteem, and problem-focused stress coping of each participant. Results. The general characteristics and dependent variables related to outcome variables were controlled to be equal between the two groups. It turns out that the internal locus of control, self-esteem, and problem-focused stress coping are statistically significant. Conclusion. Findings show that the reality therapy caused positive changes in terms of the internal locus of control, self-esteem, and problem-focused stress coping of the observed schizophrenic patients.

• 대한약리학회지
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• 제18권2호
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• pp.27-32
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• 1982

만성 정신분렬병 환자에서 성(性)에 따른 혈소판 MAO 활성도의 변화양상을 분석하고 이에 관련하여 혈장 Testosterone 및 Estradiol농도의 변화를 검토하고자, 135명의 정상대조군과 78명의 만성 정신분렬병 환자를 대상으로 하여 혈소판 MAO활성도와 혈장 Testosterone 및 Estradiol농도를 측정한 결과는 다음과 같다. 1) 만성 정신분렬병 환자에서 혈소판 MAO활성도는 남녀 모두 그 정상대조군에 비하여 낮은 사람이 더 많았다. 2) 혈소판 MAO활성도의 남녀간의 차이는 정상대조군에서는 없었지만 만성 정신분렬병 환자가 여자 환자에 비해 혈소판 MAO활성도가 낮은 사람이 더 많았다. 3) 남자 정신분렬병 환자에서는 혈장 Estradiol농도만 정상대조군에 비하여 저하되어 있었고, 여자 정신분렬병 환자에서는 혈장 Testosterone농도만 정상대조군에 비하여 저하되어 있었다.

• 생물정신의학
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• 제3권1호
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• pp.75-82
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• 1996

Object : The aim of this study was to evaluate the changes of positive stmtoms. negative symptoms, and depressive symptoms after fluoxetine trial in haloperidol-stabilized schizophrenic in-patients. Method : Fluoxetine(20mg/day) was added for 6weeks to stable doses of haloperidol given to 32 schizophrenic in-patients. The subjects was divided into positive and negative schizophrenics by PANSS. The authors checked PANSS. HRSD at baseline, the 2nd week. the 4th week, the 6th week of treatment. Result were as follows : 1) In all subjects, positive and depressive symptoms were significantly improved. 2) As time went on, positive and negative symptoms were not significantly improved in positive and negative schizophrenics. 3) As time went on, depressive symptoms were not significantly improved in positive and negative schizophrenics. Conclusion : We suggested that fluoxetine may be useful in the treatment of positive symptoms in schizophrenia and, It may be due to the effect on the serotonin system and the interaction between serotonin and dopamine system.

• 생물정신의학
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• 제3권2호
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• pp.162-169
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• 1996

An association study with korean schizophrenic patients(N=75) and normal controls(N=87) was performed to find the relationship between D6S274 polymorphism and schizophrenia using polymerase chain reaction. Nine different alleles of a dinucleotide polymorphism on D6S273 locus were observed in both group. When we compared the frequencies of alleles between schizophrenics and normal controls, there was no significant difference between two groups. To increase homogeneity of schizophrenic group, we divided schizophrenic group by clinical phenotypes such as DSM-IV diagnostic subtype, family history, negative and positive symptoms(PANSS), soft neurologic signs(NES-K). Then we compared the frequencies of alleles among subgroups of clinical phenotypes. there was only significant difference between two subgroups on soft neurologic signs(p<0.05). Although our findings fail to provide on evidence of association between schizophrenia and D6S274 locus, follow-up investigation of this locus may be needed in homogeneous subtypes of schizophrenia and schizophrenic pedigrees.

• 대한간호학회지
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• 제3권1호
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• pp.1-4
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• 1972

A study designed to provide effective nursing care for schizophrenic patient was carried out to 22 patients who were admitted to the psychiatric in-patient service, St. Malays Hospital, Catholic Medical Center. The main purpose of the study was to provide effective means of discriminating the effects of nursing care for schizophrenic patients. The experimental group sampled consisted of 10 male and female patients who have been given patient-centered nursing care while the control group consisted of 12 male and female patients who have been given only routine care. The administration of the WBI manual in both groups obtained the changes in the psychopathological behavior of them. The result were found to be as follows. 1. The greater number of the patient in both groups were below 30 years of age (70%). 2. Uptill 15 days after admission there was no difference between the change of the psychopathological behavior the subject group and that of the control. 3. There as a difference between the change of the psychopathological behavior of the subject group and that of the control uptill 30 days after. admission(p<0.08).