Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Changes of Positive Symptoms, Negative Symptoms and Depressive Symptoms after Adjuntive Fluoxetine Trial in Schizophrenic Patients

정신 분열증 환자에서 Fluoxetine 투여에 따른 양성증상, 음성 증상 및 우울 증상의 변화

  • Choi, Won (Department of Neuropsychiatry, School of Medicine, Soonchunhyang University) ;
  • Jung, Han Yong (Department of Neuropsychiatry, School of Medicine, Soonchunhyang University) ;
  • Han, Sun Ho (Department of Neuropsychiatry, School of Medicine, Soonchunhyang University)
  • 최원 (순천향대학교 의과대학 신경정신과학교실) ;
  • 정한용 (순천향대학교 의과대학 신경정신과학교실) ;
  • 한선호 (순천향대학교 의과대학 신경정신과학교실)
  • Published : 1996.06.30
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Abstract

Object : The aim of this study was to evaluate the changes of positive stmtoms. negative symptoms, and depressive symptoms after fluoxetine trial in haloperidol-stabilized schizophrenic in-patients. Method : Fluoxetine(20mg/day) was added for 6weeks to stable doses of haloperidol given to 32 schizophrenic in-patients. The subjects was divided into positive and negative schizophrenics by PANSS. The authors checked PANSS. HRSD at baseline, the 2nd week. the 4th week, the 6th week of treatment. Result were as follows : 1) In all subjects, positive and depressive symptoms were significantly improved. 2) As time went on, positive and negative symptoms were not significantly improved in positive and negative schizophrenics. 3) As time went on, depressive symptoms were not significantly improved in positive and negative schizophrenics. Conclusion : We suggested that fluoxetine may be useful in the treatment of positive symptoms in schizophrenia and, It may be due to the effect on the serotonin system and the interaction between serotonin and dopamine system.

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