• Title/Summary/Keyword: Safe region

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Phosphodiesterase-5 Inhibitor Attenuates Anxious Phenotypes and Movement Disorder Induced by Mild Ischemic Stroke in Rats

  • Yu, Yeon Hee;Kim, Seong-Wook;Kang, Juhyeon;Song, Yejin;Im, yHyuna;Kim, Seo Jeong;Yoo, Dae Young;Lee, Man-Ryul;Park, Dae-Kyoon;Oh, Jae Sang;Kim, Duk-Soo
    • Journal of Korean Neurosurgical Society
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    • v.65 no.5
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    • pp.665-679
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    • 2022
  • Objective : Patients with mild ischemic stroke experience various sequela and residual symptoms, such as anxious behavior and deficits in movement. Few approaches have been proved to be effective and safe therapeutic approaches for patients with mild ischemic stroke by acute stroke. Sildenafil (SIL), a phosphodiesterase-5 inhibitor (PDE5i), is a known remedy for neurodegenerative disorders and vascular dementia through its angiogenesis and neurogenesis effects. In this study, we investigated the efficacy of PDE5i in the emotional and behavioral abnormalities in rats with mild ischemic stroke. Methods : We divided the rats into four groups as follows (n=20, respectively) : group 1, naïve; group 2, middle cerebral artery occlusion (MCAo30); group 3, MCAo30+SIL-pre; and group 4, MCAo30+SIL-post. In the case of drug administration groups, single dose of PDE5i (sildenafil citrate, 20 mg/kg) was given at 30-minute before and after reperfusion of MCAo in rats. After surgery, we investigated and confirmed the therapeutic effect of sildenafil on histology, immunofluorescence, behavioral assays and neural oscillations. Results : Sildenafil alleviated a neuronal loss and reduced the infarction volume. And results of behavior task and immunofluorescence shown possibility that anti-inflammation process and improve motor deficits sildenafil treatment after mild ischemic stroke. Furthermore, sildenafil treatment attenuated the alteration of theta-frequency rhythm in the CA1 region of the hippocampus, a known neural oscillatory marker for anxiety disorder in rodents, induced by mild ischemic stroke. Conclusion : PDE5i as effective therapeutic agents for anxiety and movement disorders and provide robust preclinical evidence to support the development and use of PDE5i for the treatment of mild ischemic stroke residual disorders.

A Study on Information System for Safe Transportation of Emergency Patients in the Era of Pandemic Infectious Disease (팬데믹 감염병 시대에 안전이송을 위한 정보시스템 연구)

  • Seungyong Kim;Incheol Hwang;Dongsik Kim
    • Journal of the Society of Disaster Information
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    • v.18 no.4
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    • pp.839-846
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    • 2022
  • Purpose: To secure the safety of firefighters who are dispatched to emergency activities for patients with suspected infectious diseases during an epidemic, and to identify the current status of suspected infectious disease patients by region based on the information collected at the site, and manage firefighting infectious diseases that can be controlled and supported I want to develop a system. Method: Develop a smartphone app that can classify suspected infectious disease patients to check whether an infectious disease is suspected, and develop a disposable NFC tag for patient identification to prevent infection from suspected infectious disease patients. Develop a management system that collects and analyzes data related to emergency patients with suspected infectious disease input from the field and provides them to relevant business personnel to evaluate whether the transport of emergency patients with suspected infectious disease is improved. Result: As a result of the experiment, it was possible to determine whether an infectious disease was suspected through the algorithm implemented in the smartphone app, and the retransfer rate was significantly reduced by transferring to an appropriate hospital. Conclusion: Through this study, the possibility of improving emergency medical services by applying ICT technology to emergency medical services was confirmed. It is expected that the safety of paramedics will be actively secured.

APPLICATION OF WIFI-BASED INDOOR LOCATION MONITORING SYSTEM FOR LABOR TRACKING IN CONSTRUCTION SITE - A CASE STUDY in Guangzhou MTR

  • Sunkyu Woo;Seongsu Jeong;Esmond Mok;Linyuan Xia;Muwook Pyeon;Joon Heo
    • International conference on construction engineering and project management
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    • 2009.05a
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    • pp.869-875
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    • 2009
  • Safety is a big issue in the construction sites. For safe and secure management, tracking locations of construction resources such as labors, materials, machineries, vehicles and so on is important. The materials, machineries and vehicles could be controlled by computer, whereas the movement of labors does not have fixed pattern. So, the location and movement of labors need to be monitored continuously for safety. In general, Global Positioning System(GPS) is an opt solution to obtain the location information in outside environments. But it cannot be used for indoor locations as it requires a clear Line-Of-Sight(LOS) to satellites Therefore, indoor location monitoring system could be a convenient alternative for environments such as tunnel and indoor building construction sites. This paper presents a case study to investigate feasibility of Wi-Fi based indoor location monitoring system in construction site. The system is developed by using fingerprint map of gathering Received Signal Strength Indication(RSSI) from each Access Point(AP). The signal information is gathered by Radio Frequency Identification (RFID) tags, which are attached on a helmet of labors to track their locations, and is sent to server computer. Experiments were conducted in a shield tunnel construction site at Guangzhou, China. This study consists of three phases as follows: First, we have a tracking test in entrance area of tunnel construction site. This experiment was performed to find the effective geometry of APs installation. The geometry of APs installation was changed for finding effective locations, and the experiment was performed using one and more tags. Second, APs were separated into two groups, and they were connected with LAN cable in tunnel construction site. The purpose of this experiment was to check the validity of group separating strategy. One group was installed around the entrance and the other one was installed inside the tunnel. Finally, we installed the system inner area of tunnel, boring machine area, and checked the performance with varying conditions (the presence of obstacles such as train, worker, and so on). Accuracy of this study was calculated from the data, which was collected at some known points. Experimental results showed that WiFi-based indoor location system has a level of accuracy of a few meters in tunnel construction site. From the results, it is inferred that the location tracking system can track the approximate location of labors in the construction site. It is able to alert the labors when they are closer to dangerous zones like poisonous region or cave-in..

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A Study on the Status and Performance of Cultural Heritage in the Demilitarized Zone on the Korean Peninsula (한반도 비무장지대 문화유산의 실태조사 현황과 성과 고찰)

  • HWANGBO Kyung
    • Korean Journal of Heritage: History & Science
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    • v.57 no.2
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    • pp.28-50
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    • 2024
  • A fact-finding survey of the Demilitarized Zone can be said to be a very meaningful academic survey linked to previous index surveys of protected military areas and municipal and excavation surveys of ruins and military sites on Mount Dora. Not a few ruins were first discovered in this survey, and the locations, structures, and restoration artifacts of the previously investigated ruins were confirmed differently, raising the need for a detailed investigation. In particular, it is noteworthy that various relics from the Paleolithic Age to the Joseon Dynasty were recovered from relics dispersion sites such as Josan-ri and Cheorwon Gangseo-ri in Paju, and Hoengsan-ri Temple Site is also a Buddhist relic in the Demilitarized Zone. However, in the case of some graveyards and relics sites in the Paju region, it was an opportunity to understand the reality that they are not safe from cultivation and development, and the ruins of Cheorwon Capital Castle, Seongsanseong Fortress, Jorangjin Bastion, and Gangseo-ri Bastion were damaged during the construction of military facilities, and an urgent investigation is needed. Also, farmland and hilly areas around the ruins of Jangdan, Gunnae-myeon, and Gangsan-ri have not been properly investigated for buried cultural assets due to small-scale development. Therefore, it is an important time for the relevant authorities and agencies to cooperate more closely to establish special management and medium- to long-term investigation measures for the cultural heritage in the Demilitarized Zone based on the results of this fact-finding investigation.

Development and Application of an Informal Elementary Science Education Program Emphasizing 'Participation and Action' ('참여와 실천' 차원을 강조한 비형식 초등 과학교육 프로그램의 개발 및 적용)

  • Kim, Hyunguk;Shin, Chaeyeon;Park, Jiwon;Song, Jinwoong
    • Journal of Korean Elementary Science Education
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    • v.43 no.2
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    • pp.337-352
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    • 2024
  • This study develops an informal science education program based on a creative design for the promotion of participation and action and explores the validity and effectiveness of the program. The program consists of three mini-projects, namely, The Martian: Surviving from the Mars, So Good to Have Seonjeongneung, and Designing a Sunshine Restaurant, with distinct topics focusing on the localization and contextualization of the region in which the program was implemented to encourage students' participation and action. The researchers selected three topics for each mini-project through discussions and revisions. The program is designed for 42 lessons across the three mini-projects and offers a presentation session in which students present their learnings from the program, constructed to facilitate personal contextualization. Participants included 15 elementary school students from Grades 5 and 6 who took surveys before and after the program. The pre-post surveys comprised two dimensions, 'Participation and Action' and 'Positive Experience about Science,' to examine the effectiveness of the program. At the end of the survey, we added a self-descriptive question that allows students to freely write down their feelings and thoughts. We checked the students' thoughts. The effectiveness of the program was illustrated by the largest increase in the "safe society" category, whereas there was little increase in other categories under the 'participation and Action' dimension in the Korean Science Education Standards. 'Science-related Self-concept' exhibited the largest increase, whereas the other categories displayed little increase from the 'Positive Experience about Science' dimension category.

Cost-Benefit and Spatial Effects of CCTV on Crime Prevention (방범용 CCTV 설치로 인한 경제적·공간적 효과분석)

  • HEO, Sun-Young;MOON, Tae-Heon;KIM, Ju-Young
    • Journal of the Korean Association of Geographic Information Studies
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    • v.21 no.3
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    • pp.63-75
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    • 2018
  • The purpose of this study is to analyze the effects of CCTV installation empirically in the economic and spatial aspects(crime displacement and diffusion effects of crime control benefits), targeting S city in Korea. In terms of economic effects, caused by CCTV installation(2012 and 2013), cost benefit analysis was conducted by means of CCTV installation costs, crime cases, and crime costs per case. The result shows that there is positive effect of 1.34(34%) in 2012. This is slightly higher than the previous study results in Korea(cost effectiveness 1.32), but a little lower than the USA cases(cost effectiveness 1.49). In the case areas in S city, the result proves that the new CCTV has gained economic profit through the crime reduction, compared to the installation expences. However, the cases in 2013 shows no economic profit effect. Secondly, an analysis was conducted in the spatial aspect(crime displacement and diffusion effects of crime control benefits) by using the analysis tool of crime displacement value called WDQ. The results are summarized as follows: The total crimes in three regions had crime diffusion effect but it was less than the direct effect, while in one region, displacement effect was found, but they were less than direct effect. In the case of theft and violence, CCTV had a positive effect, except for one region. The results of the analysis were totally different. Judging from this difference, it may conclude that the effects of CCTV are different by the types of crimes and the places of crimes. The results of this study is meaningful in that it examined and evaluated the effects of the CCTV by scientific and rational measurement tools where previous studies are not many. In addition, it has policy implication for the validity of CCTV and making effective installation plan for crime reduction and prevention.

Caffeinated Food Consumption Patterns and Level among High School Students in Yongin Region (용인지역 고등학생의 카페인 함유 식품의 소비 패턴 및 소비 수준)

  • Park, Eun Jeong;Kim, Seong Yeong
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.46 no.9
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    • pp.1128-1136
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    • 2017
  • Previous studies of the caffeine consumption pattern were limited primarily to beverages containing caffeine. Therefore, this study examined the caffeine consumption patterns and levels in beverages and foods containing caffeine among high school students (n=310) in the Yongin region. The participants included 171 boys (55.2%) and 139 girls (44.8%). The daily mean caffeine intake of the respondents was 41.27 mg (0.651 mg/kg) and 36.47 mg (0.696 mg/kg) in boys and girls, respectively. Among the caffeinated food groups, coffee had the highest caffeine intake group in both boys (18.95 mg) and girls (26.28 mg). Girls consumed large amounts of caffeine in the form of Americano-style coffee (20.04 mg), whereas boys consumed more canned coffee (6.77 mg) than girls (2.43 mg, P<0.01). Carbonated soft drinks were the second most prevalent source of caffeine intake in both groups, even though boys (14.29 mg) consumed larger amounts of caffeine than girls (5.85 mg, P<0.001). Multiple regression analysis investigating the major contributing food group to daily total caffeine intake also showed that the highest standardized coefficient was in coffee regardless of gender (boys 0.492, P<0.001 and girls 0.944, P<0.001), followed by carbonated soft drinks and energy drinks. Approximately 95% of high school students consumed normal levels of caffeine, whereas 3.5% of boys and 5.8% of girls consumed excessive amounts based on the standard limit of Korea Food and Drug Administration (<2.5 mg/kg/d) for adolescents. The daily mean caffeine intake of the excess group was 5.38 mg/kg and 6.96 mg/kg in boys and girls, respectively. Consequently, safe daily caffeine intake needs to be determined throughout continuous national management guidelines and nutritional education.

Effects of Growth Period and Cumulative Temperature on Flowering, Ripening and Yield of Soybean by Sowing Times (파종시기별 생육일수 및 적산온도 변화가 콩의 개화, 등숙 및 수량에 미치는 영향)

  • Lee, Jae Eun;Jung, Gun Ho;Kim, Sung Kook;Kim, Min Tae;Shin, Su Hyeon;Jeon, Weon Tai
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.64 no.4
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    • pp.406-413
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    • 2019
  • The purpose of this research was to analyze the effect of different sowing times on the flowering and maturing of major soybean cultivars by varying day length and temperature in the central plain region. The average of growth period and cumulative temperature in five test cultivars by sowing times were 121 days and 2,972℃ on June 1, respectively and gradually decreased to 85 days, 2,042℃, respectively on July 20. Analysis of the flowering response according to the sowing times showed that flowering was greatly influenced by the decrease of photoperiod until the sowing on July 10, and the minimum number of days for flowering were 27 days, 36 days, respectively in early and mid-rate maturing type in the central plain region. Daepung 2 is classified to the same ecotype with Daewonkong, the total number of growing days was not different between two cultivars, but ripening period (R2-R6) was longer by 5 days and yield was higher by 11% in Daepung 2. The maturity rate was also high and safe enough to maintain more than 90% through the entire sowing times. This ecological characteristic can be usefully applied as a section index for breeding environmental stress resistant and high yielding soybean varieties. The yield of 4 domestic cultivars (except TI196944) sowing on July 20 were 85~92% levels compared to sowing on June 20.

Heading Ecology of Rice Varieties Adaptable to the Temperature and Day-Length Conditions in North Korean Regions (북한 지역 기온과 일장 환경 적응 벼 품종의 출수생태 특성 분석)

  • Woonho Yang;Shingu Kang;Dae-Woo Lee;Mi-jin Chae
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.68 no.4
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    • pp.236-245
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    • 2023
  • We investigated the basic vegetative phase (BVP), photoperiod-sensitivity (PS), and thermo-sensitivity (TS) of 40 rice varieties to characterize their heading ecology that is adaptable to North Korean rice production areas. The ranges were 12 - 43 days for BVP, 0 - 74 days for PS, and 15 - 33 days for TS, depending on the variety. The number of days from transplanting to the heading stage (DTH) was significantly correlated with PS in the 13 major rice production regions where all 40 varieties (including early-, middle-, and mid-late-maturing varieties) were tested. DTH was significantly correlated with BVP and TS but not with PS in the 10 low-temperature regions where only 28 early-maturing varieties were tested. The heading ecology of the adaptable varieties for each region could be characterized by an exponential equation between the BVP and PS of varieties that headed at the border of the safe marginal heading date (SMHD) for each of the seven regional environments (Kaesong, Haeju, Yongyon, Singye, Sariwon, Nampo, and Pyongyang). A PS of 25 - 30 days or less was an additional adaptive trait in the Sariwon and Pyongyang environments. The varieties that reached the heading stage not later than the SMHD in six regional environments (Anju, Kusong, Sinuiju, Changjon, Wonsan, and Supung) and those that reached the heading stage not later than the late marginal heading date (LMHD) in four regional environments (Hamhung, Pyonggang, Huichon, and Kanggye) had both a PS of 26 days or less and a BVP of 25 - 28 days or less. In the Yangdok, Sinpo, and Chunggang environments, varieties that reached the heading stage not later than the LMHD for each region had a BVP of 15 - 20 days or less. The results suggested that a shortened BVP trait should be introduced to existing early-maturing rice varieties to reduce the duration of growth period to reach the heading stage.

A Study on Piracy Matters and Introduction of the Privately Contracted Armed Security Personnel on Board Ships (해적사건 대응을 위한 무장경비원제도 도입방안에 관한 연구)

  • Roh, Ho-Rae
    • Korean Security Journal
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    • no.41
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    • pp.293-326
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    • 2014
  • Piracy is a worldwide issue, but the deteriorating security situation in the seas off Somalia, the Gulf of Aden and the wider Western Indian Ocean between 2005 and 2012 and in the increasing number of attacks in the Gulf of Guinea are a major problem. The depth of concern for the problem internationally is amply demonstrated by the levels of co-operation and coordination among naval and other forces from several countries that have assembled in the west Indian Ocean region and the Gulf of Aden to escort ships carrying humanitarian aid to Somalia and to protect vulnerable shipping. Notwithstanding this unprecedented effort, the vast sea area in which the pirates now operate makes it difficult to patrol and monitor effectively, particularly with the limited resources available. More resources, in the form of naval vessels and aircraft, are needed and at every opportunity the IMO encourages Member Governments to make greater efforts to provide the additional naval, aerial surveillance and other resources needed through every means possible. IMO provide interim guidance and recommendations to be taken into account when considering the use of PCASP(privately contracted armed security personnel) if and when a flag State determines that such a measure would be lawful and, following a full risk assessment, appropriate. The interim guidance and recommendations of IMO are not intended to endorse or institutionalize the use of armed guards. Therefore, they do not represent any fundamental change of policy by the Organization in this regard. It is for each flag State, individually, to decide whether or not PCASP should be authorized for use on board ships flying their flag. If a flag State decides to permit this practice, it is up to that State to determine the conditions under which authorization will be granted. Therefore, Korea should be introduced rationally PCASP for safe shipping. PCASP on board ships is much the same to special guard personnel of security services industry act. Act plan of Oceans and fisheries ministry on PCASP collides with special guard personnel system of National Police Agency. Rather than new law making, PCASP regukations have to be included in security services industry act. Management Agency of PCASP is to not Oceans and fisheries ministry, but Central Headquarters Korea Coast Guard of Public Safety and Security Ministry because of specialty and closely connection.

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