• 한국경영과학회:학술대회논문집
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• 한국경영과학회 2006년도 추계학술대회
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• pp.618-629
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• 2006

This Paper is about optimizing preventive maintenance period of connected (r,s) out of(m,n) : F lattice system that one of multi-component system, (m,n) matrix failure of whole system is occurrence when parts that belong in (r,s) matrix part procession of parts arranged with procession are breakdown all. The preventive maintenance about system is very important viewing from system reliability and operational expense viewpoint. Preventive maintenance that misses a time calls big loss by system failure and expense of frequent full equipment is paid excessively in preventive maintenance itself but expense is paid much in preventive maintenance itself and whole expense escalation can be achieved preferably. Through this research, reliability model is constructed that do expense by smallest under full equipment policy chosen through comparison of each full equipment policy and preventive maintenance expense full equipment cycle and r ,s value are made using simulated annealing algorithm and simulated annealing algorithm that converge fast in multi-component system certified most suitable to optimization decision

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.4937-4944
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• 2015

MicroRNAs (miRNAs) are emerging as critical regulators in carcinogenesis and tumor progression. Recently, miR-99a has been reported as a tumor suppressor gene in various human cancers, but its functions in the context of anaplastic thyroid cancer (ATC) remain unknown. In this study, we reported that miR-99a was commonly downregulated in ATC tissue specimens and cell lines with important functional consequences. Overexpression of miR-99a not only dramatically reduced ATC cell viability by inducing cell apoptosis and accumulation of cells at G1 phase, but also inhibited tumorigenicity in vivo. We then screened and identified a novel miR-99a target, mammalian target of rapamycin (mTOR), and it was further confirmed by luciferase assay. Up-regulation of miR-99a would markedly reduce the expression of mTOR and its downstream phosphorylated proteins (p-4E-BP1 and p-S6K1). Similar to restoring miR-99a expression, mTOR down-regulation suppressed cell viability and increased cell apoptosis, whereas restoration of mTOR expression significantly reversed the miR-99a antitumor activity and the inhibition of mTOR/p-4E-BP1/p-S6K1 signal pathway profile. In clinical specimens and cell lines, mTOR was commonly overexpressed and its protein levels were statistically inversely correlated with miR-99a expression. Taken together, our results demonstrated for the first time that miR-99a functions as a tumor suppressor and plays an important role in inhibiting the tumorigenesis through targeting the mTOR/p-4E-BP1/p-S6K1 pathway in ATC cells. Given these, miR-99a may serve as a novel prognostic/diagnostic and therapeutic target for treating ATC.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2021년도 학술발표회
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• pp.317-317
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• 2021

효율적인 물관리를 위한 댐 유입량 대한 연구는 필수적이다. 본 연구에서는 다양한 머신러닝 알고리즘을 통해 40년동안의 기상 및 댐 유입량 데이터를 이용하여 소양강댐 유입량을 예측하였으며, 그 중 고유량과 저유량예측에 적합한 알고리즘을 각각 선정하여 머신러닝 알고리즘을 결합한 CombML을 개발하였다. 의사 결정 트리 (DT), 멀티 레이어 퍼셉트론 (MLP), 랜덤 포레스트(RF), 그래디언트 부스팅 (GB), RNN-LSTM 및 CNN-LSTM 알고리즘이 사용되었으며, 그 중 가장 정확도가 높은 모형과 고유량이 아닌 경우에서 특별히 예측 정확도가 높은 모형을 결합하여 결합 머신러닝 알고리즘 (CombML)을 개발 및 평가하였다. 사용된 알고리즘 중 MLP가 NSE 0.812, RMSE 77.218 m3/s, MAE 29.034 m3/s, R 0.924, R2 0.817로 댐 유입량 예측에서 최상의 결과를 보여주었으며, 댐 유입량이 100 m3/s 이하인 경우 앙상블 모델 (RF, GB) 이 댐 유입 예측에서 MLP보다 더 나은 성능을 보였다. 따라서, 유입량이 100 m3/s 이상 시의 평균 일일 강수량인 16 mm를 기준으로 강수가 16mm 이하인 경우 앙상블 방법 (RF 및 GB)을 사용하고 강수가 16 mm 이상인 경우 MLP를 사용하여 댐 유입을 예측하기 위해 두 가지 복합 머신러닝(CombML) 모델 (RF_MLP 및 GB_MLP)을 개발하였다. 그 결과 RF_MLP에서 NSE 0.857, RMSE 68.417 m3/s, MAE 18.063 m3/s, R 0.927, R2 0.859, GB_MLP의 경우 NSE 0.829, RMSE 73.918 m3/s, MAE 18.093 m3/s, R 0.912, R2 0.831로 CombML이 댐 유입을 가장 정확하게 예측하는 것으로 평가되었다. 본 연구를 통해 하천 유황을 고려한 여러 머신러닝 알고리즘의 결합을 통한 유입량 예측 결과, 알고리즘 결합 시 예측 모형의 정확도가 개선되는 것이 확인되었으며, 이는 추후 효율적인 물관리에 이용될 수 있을 것으로 판단된다.

• Toxicological Research
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• 제14권3호
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• pp.293-300
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• 1998

Previous studies have shown that the heterocycles including thiazoles are efficacious in inducing phase phase II metabolizing enzyme as well as certain cytochrome P450s and that the inductin of these matabolizing enzymes by the heterocyclic agents is highly associated with their hepatotoxicity. In the present study, the effects of benzylisothiazole (BIT), which has a isothiazole moiety, on the expression of microsomal epoxide hydrolase (mEH), major glutathione S-transerases and cytochrome P450s were studied in the rat liver in association with its hepatotoxicity. Treatment of rats with BIT(1.17 mmol/kg, 1~3d) resulted in substantial increases in the mEH. rGSTA2, rGSTA2, rGSTM1 and rGSTM2 mRNA levels, whereas rGSTA3 and rGSTA5 mRNA levels were increased to much lesser extents. A time-course study showed that the mRNA levels of mEH and rGSTs were greater at 24hr after treatment than those after 3 days of consecutive treatment. Relative changes in mEH and rGST mRNA levels were consistent with those in the proteins, as assessed by Western immunoblot analysis. Hepatic cytochrom P450 levels were monitored after BIT treatment under the assumption that metabolic activation of BIT may affect expression of the enzymes in conjunction with hepatotoxicity. Immunoblot analysis revealed that cytochrome P450 2B1/2 were 3-to 4-fold induced in rats teatd with BIT(1.17 mmol/kg/day.3days), whereas P450 1A2, 2C11 and 3A1/2 levels were decreased to 20~30% of those in unteatd rats. P450 2E1 was only slightly decreased by BIT. Thus, the levels of several cytochrome P450s were suppressed by BIT treatment. Rats treated with BIT at the dose of 1.17mmol/kg for 3 days exhibited extensive multifocal nodular necrosis with moderate to extensive diffuse liver cell degeneration. No notable toxicity was observed in the kidney. These results showed that BIT induces mEH and rGSTs in the liver with increases in the mRNA levels, whereas the agent significantly decreased major cytochrome P450s. The changes in the detoxifying enzymes might be associated with the necrotic liver after consecutive treatment.

• 대한전자공학회논문지SD
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• 제37권12호
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• pp.1-9
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• 2000

미세구조 N-채널 MOSFET의 게이트-소스 전압에 의존하는 유효 채널 캐리어 이동도와 소스 및 드레인 기생저항의 정확한 분리 추출을 위해서 새로운 ERM-방법을 제안하였다. ERM-방법은 선형영역에서 동작하는 게이트 길이가 다른 두개의 소자($W_m/L_m=30{\mu}m/0.6{\mu}m, 30{\mu}m/1{mu}m$)에 적용되었고 유효 채널 캐리어 이동도를 모델링하고 추출하는 과정에서 게이트-소스 전압에 의존하는 소스 및 드레인 기생저항의 영향을 고려하였다. ERM-방법으로 추출된 특성변수들을 사용한 해석적 모델식과 소자의 측정데이터를 비교해본 결과 오차가 거의 없이 일치하는 것을 확인하였다. 따라서, ERM-방법을 사용하면 대칭구조 및 비대칭구조 소자의 유효 채널 캐리어 이동도, 소스 및 드레인 기생저항과 다른 특성변수들을 정확하고 효율적으로 추출할 수 있을 것으로 기대된다.

• 한국정보통신학회논문지
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• 제17권5호
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• pp.1138-1144
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• 2013

최대주기를 갖는 수열들의 상호상관함수에 대한 연구는 수십년간 이루어져 왔다. 본 논문에서는 n=2m을 만족하고 최대주기 $2^n-1$을 가지면서 Niho type의 데시메이션 $d=2^{m-2}(2^m+3)$에 대하여 비선형수열$S_a^r(t)=Tr_1^m\{[Tr_m^n(a{\alpha}^t+{\alpha}^{dt})]^r\}$의 상호상관함수 값을 구한다. 특히, $d{\equiv}1(mod\;2^m-1)$을 만족하는 d를 Niho type의 데시메이션 이라고 한다. 그리고 위상이동차 ${\tau}=(2^m+1)k(0{\leq}k{\leq}2^m-2)$인 경우에 대하여 $S_a^r(t)$의 상호상관함수 값의 분포를 분석하고 실험 결과를 제시한다.

• 미생물학회지
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• 제29권5호
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• pp.284-289
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• 1991

the nucleotide sequence of the 3' terminal 568 bases of the 18S rRNA gene from Mucor racemosus was determined. The 3' end of the structural gene was identified by comparison with the published sequence for the Saccharomyces cerevisiae gene. The M. racemosus gene was found to share 83.8% homology with that of S. cerevisiae and 71-81% homology with those of human, mouse, maize, Xenopus laevis and Tetrahymena thermophila. The known methylation sites in X. laevis and human were also highly conserved in M. racemosus and located within most conserved regions of 18S RNA gene throughout evolution.

• 대한수학회지
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• 제50권6호
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• pp.1271-1290
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• 2013

Let M be a fixed left R-module. For a left R-module X, we introduce the notion of M-prime (resp. M-semiprime) submodule of X such that in the case M=R, it coincides with prime (resp. semiprime) submodule of X. Other concepts encountered in the general theory are M-$m$-system sets, M-$n$-system sets, M-prime radical and M-Baer's lower nilradical of modules. Relationships between these concepts and basic properties are established. In particular, we identify certain submodules of M, called "primeM-ideals", that play a role analogous to that of prime (two-sided) ideals in the ring R. Using this definition, we show that if M satisfies condition H (defined later) and $Hom_R(M,X){\neq}0$ for all modules X in the category ${\sigma}[M]$, then there is a one-to-one correspondence between isomorphism classes of indecomposable M-injective modules in ${\sigma}[M]$ and prime M-ideals of M. Also, we investigate the prime M-ideals, M-prime submodules and M-prime radical of Artinian modules.

• East Asian mathematical journal
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• 제25권4호
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• pp.441-447
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• 2009

Jat and Choudhari defined a near-ring R with left bipotent or right bipotent condition in 1979. Also, we can dene a near-ring R as subcommutative if aR = Ra for all a in R. From these above two concepts it is natural to investigate the near-ring R with the properties aR = $Ra^2$ (resp. $a^2R$ = Ra) for each a in R. We will say that such is a near-ring with (1,2)-potent condition (resp. a near-ring with (2,1)-potent condition). Thus, we can extend a general concept of a near-ring R with (m,n)-potent condition, that is, $a^mR\;=\;Ra^n$ for each a in R, where m, n are positive integers. We will derive properties of near-ring with (1,n) and (n,1)-potent conditions where n is a positive integer, any homomorphic image of (m,n)-potent near-ring is also (m,n)-potent, and we will obtain some characterization of regular near-rings with (m,n)-potent conditions.

• 한국농림기상학회지
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• 제9권3호
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• pp.203-208
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• 2007

본 연구에서는 동시에 여러 지점을 측정할 수 있는 open flow 시스템을 이용하여 소나무 줄기에서 발생하는 호흡을 겨울과 여름 두 시기에 측정하였다. 연구결과, 줄기의 목부조직에서 호흡속도($R_{stem}$)는 겨울에 $0.25-0.55{\mu}mol\;m^{-2}s^{-1}$, 여름에 $1.25-1.63{\mu}mol\;m^{-2}s^{-1}$의 범위를 나타냈다. 시기별 측정된 수목(15개체)간 $R_{stem}$의 변화성은 변동계수로 나타낼 수 있으며, 그 결과 여름과 겨울이 모두 23%로 시기에 따른 차이를 보이지 않았다. 이러한 변동계수 값에 근거하면 $R_{stem}$ 이 95% 신뢰수준에서 실제 값과의 차이가 10%와 20%보다 적기 위해서는 샘플링 수가 각각 최소 24개와 6개가 필요한 것으로 확인되었다. 또한 겨울과 여름의 온도와 개체간 평균 $R_{stem}$의 상관관계에서, $Q_{10}$ 값은 겨울이 1.49, 여름이 1.45로 계절간에 큰 차이를 나타내지 않았다. 그러나 $R_{20}$(줄기 온도 $20^{\circ}C$일 때의 $R_{stem}$)은 겨울($0.61{\mu}mol\;m^{-2}s^{-1}$)보다 여름($1.23{\mu}mol\;m^{-2}s^{-1}$)이 두 배 정도 컸다.