• Journal of applied mathematics & informatics
• /
• v.31 no.5_6
• /
• pp.651-659
• /
• 2013

A graph is $s$-regular if its automorphism group acts regularly on the set of its $s$-arcs. In this paper, the cubic $s$-regular graphs of order 12p, 36p, 44p, 52p, 66p, 68p and 76p are classified for each $s{\geq}1$ and each prime $p$. The number of cubic $s$-regular graphs of order 12p, 36p, 44p, 52p, 66p, 68p and 76p is 4, 3, 7, 8, 1, 4 and 1, respectively. As a partial result, we determine all cubic $s$-regular graphs of order 70p except for $p$ = 31, 41.

• Journal of Cancer Prevention
• /
• v.23 no.4
• /
• pp.153-161
• /
• 2018

Imbalance of protein homeostasis (proteostasis) is known to cause cellular malfunction, cell death, and diseases. Elaborate regulation of protein synthesis and degradation is one of the important processes in maintaining normal cellular functions. Protein degradation pathways in eukaryotes are largely divided into proteasome-mediated degradation and lysosome-mediated degradation. Proteasome is a multisubunit complex that selectively degrades 80% to 90% of cellular proteins. Proteasome-mediated degradation can be divided into 26S proteasome (20S proteasome + 19S regulatory particle) and free 20S proteasome degradation. In 1980, it was discovered that during ubiquitination process, wherein ubiquitin binds to a substrate protein in an ATP-dependent manner, ubiquitin acts as a degrading signal to degrade the substrate protein via proteasome. Conversely, 20S proteasome degrades the substrate protein without using ATP or ubiquitin because it recognizes the oxidized and structurally modified hydrophobic patch of the substrate protein. To date, most studies have focused on protein degradation via 26S proteasome. This review describes the 26S/20S proteasomal pathway of protein degradation and discusses the potential of proteasome as therapeutic targets for cancer treatment as well as against diseases caused by abnormalities in the proteolytic system.

• Korean journal of communication and information
• /
• v.67
• /
• pp.62-87
• /
• 2014

The purpose of this study is to understand the social and cultural implication of the activities of taking 'selfies' and the use of Social Network Service(SNS)s through the personal story of a 20s female researcher. She analyzes her own digital photography activities based on the experience of the use of Cyworld photo albums for three years and the use of pictures in iPhone album for fifteen months. The other researcher(40s male) cooperates to answer the questions about how to understand the digital photography activities. We understand the digital photography activities including digital cameras, social network services and smart phones as acts of personal identity configuration and acts of making the personal documentary. As a result, digital photos are used more for archive purpose rather than for document purpose. Also, we found that the digital photography activities can be understood as the interactions between human and non-human actors in the perspective of Actor-Network Theory (ANT).

• Journal of the Korean Society of Costume
• /
• v.58 no.1
• /
• pp.61-78
• /
• 2008

Comedy costumes worn on the comedians/gag men express the information of the performances such as character's era, place, social rank, present environment, age, sex, occupation, emotion, relationships between the characters, importance and mood in visual language. The comic is found when these informations are reversed, revealed, exaggerated or distorted. To analyse the TV comedy costumes, 5 subordinate concepts of the comic which are Body, Gender, Age, T.P.O.(Time, Place, Occasion) and Role could be identified, and the results from the analysis focused on (10 shows were selected from each of the first and second half of the years from 2003 to 2007) are as follows: Distorted and ugly body implies the resistance against the ideal body. Reversed or confused sex are usually expressed as men dressed in women, and these mean breaking the dichotomy between male and female, and coexistence of the masculinity and feminity, and satirizing the social custom restricting women by moral rules. It could be recognized that the way of men's dressing in women have been changing keeping pace with the times. The discord between age and costume was often expressed with children's wear and childish props. This implies the liberation from the age role. The comic expressed from the inadequate costume for T.P.O. usually appeared with the costumes 20-30years behind the times. When there were discordance with the acts and acts expected from the outfit(appearance) also made an ironical laugh. The comics acquired by vulgarization and exaggeration of the characteristics of role(figures/occupation) were from the imitation and deformation of the objects in stereotypes, and through this dissolving the custom was under way.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.23 no.3
• /
• pp.402-413
• /
• 1999

The objectives of this study were to investigate the relationships among the degree of delinquency and clothing buying behavior information search and fashion involvement and to examine the causal relationships of adolescent delinquency demographic variables and fashion involvement on information search. Subjects for this study were 537 high school students(male ; 225, female : 312) in Seoul Korea. the results of the study were as follow. 1. Four factors of adolescent's delinquency derived by factor analysis : F. 1 'general position delinquency' F. 2 'school-norm delinquency' F3. 'personal delinquency' : F.4 'sexual delinquency'. 2. There were partially significant correlations between the degree of adolescent's delinquency and information search and fashion involvement. There were significant relationships between degree of delinquency and degree of clothing purchasing frequency. companion while shopping and source of clothing expenses. 3. In the case of male students fashion involvement and sexual delinquency had a direct effect on information search(R2 =.278) General position delinquency and allowance had a indirect effect on information search through Father's level of education had a direct effect on allowance. the present findings provide that in general the more allowance students received the higher the general position delinquency for both males and females, The higher the general position delinquency the higher the degree of fashion involvement and information search. Therefore it can be concluded that relatively mild delinquency acts such as drinking. smoking and going to discothque have more influence on fashion involvement and information search that serious delinquency acts such as violence and robbery.

• Molecules and Cells
• /
• v.38 no.2
• /
• pp.122-129
• /
• 2015

DBM-2198, a six-membered azasugar nucleotide (6-AZN)-containing phosphorothioate (P = S) oligonucleotide (AZPSON), was described in our previous publication [Lee et al. (2005)] with regard to its antiviral activity against a broad spectrum of HIV-1 variants. This report describes the mechanisms underlying the anti-HIV-1 properties of DBM-2198. The LTR-mediated reporter assay indicated that the anti-HIV-1 activity of DBM-2198 is attributed to an extracellular mode of action rather than intracellular sequence-specific antisense activity. Nevertheless, the antiviral properties of DBM-2198 and other AZPSONs were highly restricted to HIV-1. Unlike other P = S oligonucleotides, DBM-2198 caused no host cell activation upon administration to cultures. HIV-1 that was pre-incubated with DBM-2198 did not show any infectivity towards host cells whereas host cells pre-incubated with DBM-2198 remained susceptible to HIV-1 infection, suggesting that DBM-2198 acts on the virus particle rather than cell surface molecules in the inhibition of HIV-1 infection. Competition assays for binding to HIV-1 envelope protein with anti-gp120 and anti-V3 antibodies revealed that DBM-2198 acts on the viral attachment site of HIV-1 gp120, but not on the V3 region. This report provides a better understanding of the antiviral mechanism of DBM-2198 and may contribute to the development of a potential therapeutic drug against a broad spectrum of HIV-1 variants.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.49 no.5
• /
• pp.425-435
• /
• 2021

It is imperative to examine the regulatory trends of leading overseas aviation authorities to accelerate the effort to integrate emerging new air vehicle concepts such as UAS and eVTOL into the existing national airspace system. Whilst EASA seems to react swiftly in relation to regulatory framework by proposing new sets of customised special conditions to cope with a growing demand to introduce new aircraft concepts, understanding of such movement lags behind mainly due to the complexity of EASA's regulation structure, not to mention EU's legal system. Witnessing this situation, this paper reviewed the legal system of the EU which forms the basis of EASA's regulation system together with its own recently published UAS regulations so as to contribute towards the improvement of the aviation regulatory framework.

• BMB Reports
• /
• v.55 no.6
• /
• pp.287-292
• /
• 2022

The acute response to hypoxia is mainly driven by hypoxia-inducible factors, but their effects gradually subside with time. Hypoxia-specific histone modifications may be important for the stable maintenance of long-term adaptation to hypoxia. However, little is known about the molecular mechanisms underlying the dynamic alterations of histones under hypoxic conditions. We found that the phosphorylation of histone H3 at Ser-10 (H3S10) was noticeably attenuated after hypoxic challenge, which was mediated by the inhibition of aurora kinase B (AURKB). To understand the role of AURKB in epigenetic regulation, DNA microarray and transcription factor binding site analyses combined with proteomics analysis were performed. Under normoxia, phosphorylated AURKB, in concert with the repressor element-1 silencing transcription factor (REST), phosphorylates H3S10, which allows the AURKB-REST complex to access the MDM2 proto-oncogene. REST then acts as a transcriptional repressor of MDM2 and downregulates its expression. Under hypoxia, AURKB is dephosphorylated and the AURKB-REST complex fails to access MDM2, leading to the upregulation of its expression. In this study, we present a case of hypoxia-specific epigenetic regulation of the oxygen-sensitive AURKB signaling pathway. To better understand the cellular adaptation to hypoxia, it is worthwhile to further investigate the epigenetic regulation of genes under hypoxic conditions.

• The Korean Society of Law and Medicine
• /
• v.9 no.2
• /
• pp.77-107
• /
• 2008

In Republic of Chaina (Taiwan), Natural Death Act named "Anning Huauhe Yiliao Tiaoli" which means palliative and hospice care act was enacted in year of 2000. And enforced in the same year. Many scholars say that Taiwan's Act took Many U.S.A.'s acts such as 'Federal Patient Self-Determination Act 1990', 'California Natural Death Act 1976' and 'Washington Natural Death Act 1979' for a model. Taiwan's Act adopts a few outstanding systems - 'advance declarations' including 'living will' and 'durable power of attorney for health care', 'family-determination system' for a patient who is in a persistent unconscious state. This paper disusses this Act. 'The content is as follow: 1. A background of legislation. 2. The purpose of legislation. 3. The concept of terms. 4. Patient's self-determination. 5. Subrogated determination by family. 6. Keeping documents. 7. Punitive provision. 8. The relationship with euthanasia. 9. Controversial issues.

• Journal of applied mathematics & informatics
• /
• v.30 no.3_4
• /
• pp.455-462
• /
• 2012

The cyclic group $Cn={\langle}(12{\cdots}n){\rangle}$ acts on the set ($^{[n]}_k$) of all $k$-subsets of [$n$]. In this action of $C_n$ the number of orbits of size $d$, for $d|n$, is $$O^{n,k}_d=\frac{1}{d}\sum_{\frac{n}{d}|s|n}{\mu}(\frac{ds}{n})(^{n/s}_{k/s})$$. Stanton and White[7] generalized the above identity to construct the orbit polynomials $$O^{n,k}_d(q)=\frac{1}{[d]_{q^{n/d}}}\sum_{\frac{n}{d}|s|n}{\mu}(\frac{ds}{n})[^{n/s}_{k/s}]{_q}^s$$ and conjectured that $O^{n,k}_d(q)$ have non-negative coefficients. In this paper we give a combinatorial proof for the positivity of coefficients of the orbit polynomial $O^{n,3}_d(q)$.