• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제31권5호
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• pp.363-369
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• 2005

Purpose: To determine the role of Insulin-like Growth Factor-I (IGF-I) in the regulation of Vascular Endothelial Growth Factor (VEGF) expression in MG-63 cells and then to find the mechanism b which this regulation occurs. Materials and methods: MG-63 cells were grown to confluence in 60-mm dishes. To determine the effects of IGF-I on expression of VEGF mRNA according to time and concentration, the cells were treated with 10 nM IGF-I, following isolation of total RNA and Northern blot analysis after 1, 2, 4, 8, 12, 24 hours and after 2 hours of treatment with 0.5, 2, 10, 25, 50 nM IGF-I respectively, isolation of total RNA and Northern blot analysis were followed. To determine the mechanism of action of IGF-I, inhibitors such as hydroxyurea $(76.1\;{\mu}g/ml)$, actinomycin D $(2.5\;{\mu}g/ml)$, cycloheximide $(10\;{\mu}g/ml)$ were added 1 hour after treatment of 10 nM IGF-I. Results: 1. the expression of VEGF mRNA was increased with treatment of IGF-I. 2. The expression of VEGF mRNA was increased according to time-and concentration dependent manner of IGF-I. 3. The effect of IGF-I was decreased by hydroxyuera, actinomycin D, but not by cycloheximide. Conclusion: IGF-I regulate the expression of VEGF mRNA in the level of DNA synthesis and transcription. These results could suggest that IGF-I plays an important role in angiogenesis in the process of new bone formation and remodeling.

• 한국콘텐츠학회논문지
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• 제18권9호
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• pp.684-695
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• 2018

본 연구는 보건 복지전공 대학생 사회적 지지가 대학생활적응에 어떠한 영향을 미치는지를 알아보고, 사회적 지지와 대학생활적응 사이에 학업스트레스가 매개역할을 하는지를 검증하는데 목적이 있다. 본 연구를 위해 경상남도 G지역과 J지역 대학에서 보건 복지계열을 전공하는 대학생을 임의표본추출방식을 통해 연구 대상을 선정하였으며, 구조화된 설문지를 활용, 자기기입식 방식을 통해 자료를 수집하였으며, 최종 229명을 분석 대상으로 분석하였다. 그 분석 결과는 다음과 같다. 첫째, 대학생의 사회적지지 요인과 학업스트레스 요인이 대학생활적응에 통계적으로 유의미한 영향을 미치는 것으로 나타났다. 둘째, 학업스트레스가 사회적 지지 요인과 대학생활적응 간에 부분매개효과 있는 것으로 나타났다. 즉 학업스트레스는 보건 복지전공 대학생의 대학생활적응에 영향을 미치는 사회적 지지 요인에 대해 완충역할을 하고 있는 것으로 나타났으며, 대학생의 친구, 가족, 교수 등의 다양한 사회적 지지 체계의지지 수준을 향상시킴으로써 학업스트레스 정도를 낮추면 대학생의 대학생활적응 수준이 더욱 향상시킬 수 있는 결과이다.

• 한국콘텐츠학회논문지
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• 제18권3호
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• pp.530-541
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• 2018

본 연구는 지역사회 거주 노인들의 사회적 배제 요인이 심리적복지감에 어떠한 영향을 미치는지를 알아보고, 사회적배제 요인과 심리적복지감 사이에 사회적 지지가 매개역할을 하는지를 검증하는데 목적이 있다. 본 연구를 위해 전라북도 소재 노인복지관에 등록되어 있는 노인을 대상으로 구조화된 설문지를 통해 자료를 수집하였으며, 260명의 설문내용으로 연구한 결과는 다음과 같다. 첫째, 노인의 사회적 배제 요인과 사회적지지 요인은 심리적복지감에 통계적으로 유의미한 영향을 미치는 것으로 나타났다. 둘째, 사회적지지 요인이 사회적배제 요인과 심리적복지감 간에 부분매개효과 있는 것으로 나타났다. 종합적인 연구결과 사회적지지 요인은 노인의 심리적복지감에 영향을 미치는 사회적 배제 요인에 대해 완충역할을 하고 있는 것으로 나타났으며, 사회 배제적 상황에 놓여 있는 노인이라 할지라도 가족을 포함하여 이웃, 지역사로부터 사회적지지가 이루어진다면 심리적복지감이 유지될 수 있다는 것을 알 수 있는 결과이다.

• 여성건강간호학회지
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• 제7권1호
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• pp.80-92
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• 2001

The labor participation rate of women are increasing, especially for married and 30 and over aged women in Korea. Marital role quality might be regarded as an influencing factor on quality of life or health status. The purpose of this study is to investigate influencing factors on quality of marital role for Korean employed women with husband. Data were collected from 323 mothers of students at 3 kindergartens, 2 elementary schools, 3 middle schools, 4 high schools in metropolitan area, during 1998.8~1998.12. they were dual-earner couples, and were employed over one year. Response rate is 62.3%. Quality of marital role was measured using Role Quality Scale developed by Park, June & Kim(1999). This instrument is based on Role Rewards and Concerns Scale of Barnett et al.(1993) for quality of marital role. Quality of marital role is made of 19 items and the subfactors are doing households, satisfaction with husband, and relationship with husband The scale has good internal consistency (Cronbach $\alpha$= 0.90). The findings of this study show that age, monthly average household income, husband's occupation, husband's attitude for wife's employment, and the perceived equity for labor division between couples are significant variables for quality of marital role. But education, career years, working hours per week, occupation, monthly average wage, and marital years are not significant. 33.81% of the variance in quality of martal role were accounted for by these variables.

• 기본간호학회지
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• 제18권1호
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• pp.107-115
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• 2011

Purpose: The purpose of this study was to investigate the relationship between professional self-concept, role conflict and job satisfaction of emergency department (ER) nurse. Method: Data were collected from a convenience sample of 200 ER nurses who worked in one of 9 hospitals in 5cities. The instrument for this study was a structured questionnaire on professional self-concept, role conflict and job satisfaction. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficient, and multiple regression. Results: The mean score for professional self-concept was 2.52 (0.28), for role conflict, 3.37 (0.55), and for job satisfaction, 2.71 (0.35). There were significant differences on three variables according to total career, and satisfaction with nursing. There was a significant positive correlation between professional self-concept and role conflict, job satisfaction. Role conflict showed a significant negative correlation with job satisfaction. Conclusion: The results of this study indicate that the important role-related variables of professional self-concept, role conflict and job satisfaction of ER nurses are significantly related, and that as, role conflict is an important factor for job satisfaction of ER nurses, strategies to decrease role conflict need to be developed.

• 지역사회간호학회지
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• 제10권2호
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• pp.387-399
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• 1999

The purpose of this study is to identify the relationships of job stressor. coping strategies. and stress responses of manufactoring workers. Data were collected through self-reported questionnaires from 262 of the manufacturing workers in a local electronic company from July to August. 1999. For data analysis. Cronbach's a. Factor Analysis. Descriptive statistics. ANOVA. and Pearson's correlation coefficient with SPSS/PC+ 7.5 version program were used. The results were as follows: 1. Regard to the stress responses and coping strategies by sociodemographic variables. 'the overall stress responses' showed significant differences by sex. age. marrital state. The use of 'control coping strategy' showed significant differences by sex and the type of work. The use of 'avoid coping strategy' showed significant differences by sex. age. married state. year of career. and income. 2. The average scores of 'the job characteristics and participation in decision making factor'. 'the physical environmental factor'. and 'the role and leadership factor' were 2.66. 2.59. 2.59 in order. The average scores for 'the avoid coping strategy' and 'the control coping strategy' were 3.03. 2.97. The average scores for 'the overall. psychosoical. and physical stress responses' were 2.18. 2.18. 2.23. 3. The 'control coping strategy' was negatively related to 'the job characteristics and participation in decision making factor'. 'the role and leadership factor'. 'the psychosocial stress responses'. and 'the overall responses'. 'The control coping strategy' was positively related to all of 'the job stressors'. 'the physical stress responses', and' the overall stress responses'. 'The physical environment factor' was positively related to all of 'the stress reponses'. 'the role and leadership factor'. and 'the job characteristics and participation in decision making factor'. According to the results of this study, the suggestions were as follows: 1. The coping strategies of manufacturing workers in the specific job stress situation should be considered to future studies. 2. In order to applying the stress management program in the workplace. The organizational intervention focused on 'the job characteristics and participation in decision making' will be needed. 3. To support and use of 'control coping strategy' of the workers. the organizational efforts should be required.

• 복식문화연구
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• 제11권3호
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• pp.340-351
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• 2003

The purpose of this study was to examine the effect of clothing type and hair style on men’s impression formation. The experimental design was 4×2×2×2 (clothing type×hair style×perceiver’s age×perceiver’s role) factorial design with between-subjects design. The stimuli of color photographs of male in his 20's model and semantic differential scale were used. The data were obtained from questionnaires completed by 881 men and women in the metropolitan area of Seoul. The SPSS package was used for data analysis which includes factor analysis, t-test, and Cronbach’s a to measure the reliability. This study showed the following results. Four factors were derived to account for the dimensions of impression formation. These were dignity, activity, individual character, and social intercourse. Men evaluated individual character factor higher than women did. Dignity factor was evaluated higher by students, while social intercourse factor was evaluated higher by office workers. The clothing type of shirts/pants was evaluated to be more active and more sociable than of jacket/pants. Men wanted to exhibit natty image and women did elegant image through clothes.

• 한국의류학회지
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• 제32권11호
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• pp.1659-1668
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• 2008

The purpose of this study was to examine the impact of advertising expressive factors on brand equity and to investigate the role of brand personality as a factor mediate variable. The subject used for this study were 352 female university students. The data was analyzed by descriptive analysis, correlation analysis and confirmatory factor analysis using SPSS program and Amos program. As the result, model fit index showed $X^2$=57.824, df=19, GFI=0.969, CFI=0.959, NFI=0.942, and RMSEA=0.076, providing good model fit. Out of the advertising expressive factors, sophistication and model preference factors gave impact on brand personality. Also, among advertising expressive factors, novelty, sophistication, model preference, information factors affected brand equity. Finally, brand personality influenced on brand equity. Brand equity was affected directly by advertising expressive factors. It was also affected by brand personality which is a mediate factor between advertising expressive factors and brand equity. The results of this study would provide advertising strategy for fashion brand.

• Genomics & Informatics
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• 제6권2호
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• pp.72-76
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• 2008

Hypoxia-inducible factor $1{\alpha}\;(HIF1{\alpha})$ is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis. The oxygen-dependent degradation (ODD) domain of $HIF1{\alpha}$ is responsible for the negative regulation of $HIF1{\alpha}$ in normoxia. The interactions of the $HIF1{\alpha}$ ODD domain with partner proteins such as von Hippel-Lindau tumor suppressor (pVHL) and p53 are mediated by two sequence motifs, the N- and C-terminal ODD(NODD and CODD). Multiple sequence alignment with $HIF1{\alpha}$ homologs from human, monkey, pig, rat, mouse, chicken, frog, and zebrafish has demonstrated that the NODD and CODD motifs have noticeably high conservation of the primary sequence across different species and isoforms. In this study, we carried out molecular dynamics simulation of the structure of the $HIF1{\alpha}$ CODD motif in complex with the p53 DNA-binding domain (DBD). The structure reveals specific functional roles of highly conserved residues in the CODD sequence motif of $HIF1{\alpha}$ for the recognition of p53.

• The Korean Journal of Physiology and Pharmacology
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• 제23권5호
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• pp.411-417
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• 2019

Humanin (HN) is a mitochondrial peptide that exhibits cytoprotective actions against various stresses and diseases. HN has been shown to induce the phosphorylation of AMP-activated protein kinase (AMPK), which is a negative regulator of receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL). However, the role of HN in osteoclastogenesis or other skeletal disorders remains unknown. Here, we examined whether HN regulates osteoclastogenesis via AMPK activation using bone marrow-derived macrophage (BMM) cultures. Our results show that HN inhibited RANKL-induced osteoclast formation and reduced the expression of genes involved in osteoclastogenesis, including nuclear factor of activated T-cells cytoplasmic 1, osteoclastassociated receptor, cathepsin K, and tartrate-resistant acid phosphatase. Moreover, HN increased the levels of phosphorylated AMPK protein; compound C, an AMPK inhibitor, recovered HN-induced osteoclast differentiation. In addition, we found that HN significantly decreased the levels of RANKL-induced reactive oxygen species in BMMs. Therefore, these results indicate that HN plays an important role in osteoclastogenesis and may function as an inhibitor of bone disorders via AMPK activation.