• 한국지반공학회논문집
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• 제24권4호
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• pp.67-78
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• 2008

본 연구에서는 시멘트의 고결효과를 정량적으로 파악하기 위하여 낙동강하상모래와 소량의 포틀랜드시멘트를 혼합하여 고결된 모래에 대하여 일축압축시험 및 배수조건과 비배수 조건의 삼축압축시험을 수행하였다. 시멘트혼합율의 증가에 따라 첨두강도 및 탄성계수는 증가하였고 시멘트의 결합력에 의하여 다일레이션 및 과잉간극수압이 억제되었으나 시멘트 결합력의 파괴 후 증가된 모래입자크기에 의하여 증가하였다. 그리고 배수조건의 응력-변형률 곡선은 연화거동이 나타났지만 비배수조건에서는 증가된 부(-)의 과잉간극수압에 의한 유효응력의 증가로 경화거동을 나타냈다. 각 조건에 대한 강도증가량의 예측을 위하여 선형을 가정한 다중회귀분석을 실시한 결과 제시된 경험식의 결정계수는 $0.81{\sim}0.91$로 나타나 신뢰성이 높은 것으로 평가되었으며 건조밀도의 경우 고결된 모래의 입도조건을 동시에 고려할 수 있어 고결된 모래의 강도를 결정하는데 중요한 변수로 분석되었다.

• BMB Reports
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• 제56권6호
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• pp.347-352
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• 2023

The protein family of poly (ADP-ribose) polymerases (PARPs) is comprised of multifunctional nuclear enzymes. Several PARP inhibitors have been developed as new anticancer drugs to combat resistance to chemotherapy. Herein, we characterized PARP4 mRNA expression profiles in cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines. PARP4 mRNA expression was significantly upregulated in cisplatin-resistant ovarian cancer cell lines, and this upregulation was associated with the hypomethylation of specific cytosine-phosphate-guanine (CpG) sites (cg18582260 and cg17117459) on its promoter. Reduced PARP4 expression was restored by treating cisplatin-sensitive cell lines with a demethylation agent, implicating the epigenetic regulation of PARP4 expression by promoter methylation. Depletion of PARP4 expression in cisplatin-resistant cell lines reduced cisplatin chemoresistance and promoted cisplatin-induced DNA fragmentation. The differential mRNA expression and DNA methylation status at specific PARP4 promoter CpG sites (cg18582260 and cg17117459) according to cisplatin responses, was further validated in primary ovarian tumor tissues. The results showed significantly increased PARP4 mRNA expressions and decreased DNA methylation levels at specific PARP4 promoter CpG sites (cg18582260 and cg17117459) in cisplatin-resistant patients. Additionally, the DNA methylation status at cg18582260 CpG sites in ovarian tumor tissues showed fairly clear discrimination between cisplatin-resistant patients and cisplatin-sensitive patients, with high accuracy (area under the curve = 0.86, P = 0.003845). Our findings suggest that the DNA methylation status of PARP4 at the specific promoter site (cg18582260) may be a useful diagnostic biomarker for predicting the response to cisplatin in ovarian cancer patients.

• Advances in nano research
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• 제15권1호
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• pp.59-65
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• 2023

In this present article, the mechanical behavior of single-walled black phosphorene nanotubes (SW-αPNTs) is simulated using molecular dynamics (MD). The proposed model is subjected to the axial loading and the effects of morphological parameters, such as the mono-vacancy defect and strain rate on the tensile behavior of the zigzag and armchair SW-αPNTs are studied as a pioneering work. In order to assess the accuracy of the MD simulations, the stress-strain response of the current MD model is successfully verified with the efficient quantum mechanical approach of the density functional theory (DFT). Along with reproducing the DFT results, the accurate MD simulations successfully anticipate a significant variation in the stress-strain curve of the zigzag SW-αPNTs, namely the knick point. Predicting such mechanical behavior of SW-αPNTs may be an important design factor for lithium-ion batteries, supercapacitors, and energy storage devices. The simulations show that the ultimate stress is increased by increasing the diameter of the pristine SW-αPNTs. The trend is identical for the ultimate strain and stress-strain slope as the diameter of the pristine zigzag SW-αPNTs enlarges. The obtained results denote that by increasing the strain rate, the ultimate stress/ultimate strain are respectively increased/declined. The stress-strain slope keeps increasing as the strain rate grows. It is worth noting that the existence of mono-atomic vacancy defects in the (12,0) zigzag and (0,10) armchair SW-αPNT structures leads to a drop in the tensile strength by amounts of 11.1% and 12.5%, respectively. Also, the ultimate strain is considerably altered by mono-atomic vacancy defects.

• 대한토목학회논문집
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• 제28권1A호
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• pp.25-37
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• 2008

역량스펙트럼 방법은 그래픽적인 방법으로 간단하게 지진해석을 수행한다. 개발 초기에 역량스펙트럼 방법은 빌딩구조물에 주로 사용되었으나 최근에는 교량구조물에도 사용할 수 있도록 확장되었다. 역량스펙트럼 방법은 비탄성 정적해석으로부터 구한 역량곡선과 유효감쇠 혹은 강도감소계수를 사용하여 선형탄성 설계스펙트럼을 감소시켜 구한 요구도 스펙트럼에 기반을 두고 있다. 본 논문에서는 감소된 요구도 스펙트럼은 강도감소계수에 대한 몇 개의 제안식을 사용하여 구한 비탄성 요구도 스펙트럼을 사용한다. 역량스펙트럼 해석에 대한 강도감소계수의 영향은 세가지 종류의 대칭 및 비대칭 교량에 대하여 평가하였다. 몇 개의 강도감소계수를 적용한 역량스펙트럼 방법의 정확성을 평가하기 위하여, 역량스펙트럼 방법에 의한 최대변위를 8개의 인공지진에 의한 비탄성 시간이력해석 결과와 비교하였다. 강도감소계수 제안식 중 SJ 제안식에 의한 역량스펙트럼 해석의 최대변위가 비탄성 시간이력해석 결과와 가장 일치하는 결과를 나타냄을 알 수 있었다.

• 한국식생활문화학회지
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• 제21권6호
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• pp.638-643
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• 2006

This study was performed to determine the effect of Takju(Korean turbid rice wine) lees on the serum glucose level in streptozotocin-induced diabetic rats. 24 Sprague-Dawley male rats were divided into three groups: normal control(NC), diabetic control(DC) and diabetic rats(DS) were fed on experimental diet and water ad libitum for 4 weeks. DS diet was containing 20% Takju lees. Body weight gain and food Efficiency Ratio(FER) were significantly lower in DC and DS than NC. DS tended to have higher weight, weight gain and FEF than DC nevertheless food intake. Therefore Takju lees could possibly complement casein as a protein source. Gastrointestianl transit time in DS significantly decreased than NC while not significantly than DC. Serum lipid profiles and AST. ALT and amylase were not significantly different between diabetic DC and DS. Blood glucose was measured at fasting state and 30, 60, 90 and 120 minute by oral glucose tolerance test, DS tended to lower the mean(${\pm}$ SE) incremental blood glucose concentrations than DC and was significantly low at 120 min. But incremental AUG(area under the curve) of postprandial glucose response was not significantly different. In conclusion, in spite of high contents of carbohydrate Takju lees perhaps have a benefit effect on the diabetes.

• Journal of Veterinary Science
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• 제24권5호
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• pp.54.1-54.13
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• 2023

Background: Porcine reproductive and respiratory syndrome virus (PRRSV) vaccines do not provide full cross-protection, mainly due to the virus genetic variability. Despite this, vaccines based on modified-live PRRSV (PRRSV-MLV) reduce the disease impact. Objectives: To assess the efficacy of two commercial vaccines-one based on PRRSV1 (PRRSV1-MLV) and another on PRRSV2 (PRRSV2-MLV)-against a Japanese PRRSV2 field strain. Methods: Two groups of three-week-old piglets were vaccinated (G1: PRRSV1-MLV; G2: PRRSV2-MLV) and two were kept as non-vaccinated (INF and CTRL). One month later, G1, G2, and INF were challenged with a PRRSV2 field strain. Results: After the challenge, clinical signs were only observed in INF. Moreover, the highest rectal temperatures and values for the area under the curve (AUC) were observed in INF. Regarding viral detection, both AUC and the proportion of positive samples in blood were higher in INF. In G1, viremic animals never reached 100%. At necropsy (21 d after the challenge), differences for titers among groups were only found in tonsils (G1 < G2 and INF). One animal (belonging to G1) was negative in all tissues. Regarding humoral responses, G1 and G2 seroconverted after vaccination, as detected in the corresponding enzyme-linked immunosorbent assay. Specific neutralizing antibodies (NA) against PRRSV1-MLV were already detected at 14 d after vaccination in G1, showing a significant booster after the challenge, while PRRSV2-MLV NA were detected in G2 at the end of the experiment. Conclusions: Despite genetic differences, PRRSV1-MLV has been demonstrated to confer partial protection against a Japanese PRRSV2 strain, at least as good as PRRSV2-MLV.

• 한국안전학회지
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• 제38권5호
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• pp.1-7
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• 2023

This study analyzes the operational characteristics of 311 aged and non-aged residual current circuit breakers (RCCBs) in low-voltage consumer contexts. It investigates the influence of external temperature and harmonics based on the rated current multiples. To simulate temperature variations, a convectional oven was used around the circuit breakers. Additionally, the generation of harmonic reference signals and data measurement for overcurrent experiments were conducted using NI SCXI, myDAQ, and LabVIEW. An observation revealed that as the ambient temperature increased, the operating time of RCCBs decreased in the time delay region. This was attributed to the faster response or bending of the bimetal, which is the tripping element. However, aged RCCBs encountered challenges with tripping outside the protective curve. The operating time of the circuit breakers exhibited an acceleration influenced by the order and content of harmonic currents, potentially leading to malfunctions. Aged RCCBs demonstrated faster operating times than their non-aged counterparts. However, the difference in operating time varied based on the manufacturer's and operating environment of the RCCBs. Frequent malfunctions of RCCBs can result in power outages. In cases where these circuit breakers fail to operate, they can lead to secondary damages, including electrical fires and shocks. Consequently, it is imperative to consider the operating environment of RCCBs and provide appropriate replacement cycles to mitigate these risks.

• 한국식품영양학회지
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• 제36권6호
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• pp.462-470
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• 2023

The aim of this study was to investigate the hypoglycemic effects of saengshik in Sprague-Dawley (SD) rats and to explore the potential of three commercially available saengshik products (BS, LS, WS) as an alternative diabetic meal. Blood glucose levels were measured at 30, 60, 90, 120, and 150 minutes after the ingestion of experimental materials. In experiment 1, the amount of experimental materials remained the same. We measured blood glucose-related biomarkers as the area under the blood glucose response curve (AUC), glycemic index (GI), maximum concentration (Cmax), and time to reach maximum concentration (Tmax). AUC and Cmax of the experimental group showed significant differences compared to the control group, while GI and Tmax did not show significant differences among the groups but were lower in the experimental group compared to the control group. In experiment 2, carbohydrates were adjusted to the same amount. We measured blood glucose-related biomarkers in the same manner as Experiment 1 and obtained similar results. These hypoglycemic effects appear to be attributed to phytochemicals and dietary fiber found in whole, unrefined grains. These results suggest that saengshik exerts hypoglycemic effects by modulation of glucose-related biomarkers.

• Korean Journal of Radiology
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• 제24권7호
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• pp.626-639
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• 2023

Objective: To investigate the association of clinical, pathologic, and magnetic resonance imaging (MRI) variables with progressive disease (PD) during neoadjuvant chemotherapy (NAC) and distant metastasis-free survival (DMFS) in patients with triple-negative breast cancer (TNBC). Materials and Methods: This single-center retrospective study included 252 women with TNBC who underwent NAC between 2010 and 2019. Clinical, pathologic, and treatment data were collected. Two radiologists analyzed the pre-NAC MRI. After random allocation to the development and validation sets in a 2:1 ratio, we developed models to predict PD and DMFS using logistic regression and Cox proportional hazard regression, respectively, and validated them. Results: Among the 252 patients (age, 48.3 ± 10.7 years; 168 in the development set; 84 in the validation set), PD was occurred in 17 patients and 9 patients in the development and validation sets, respectively. In the clinical-pathologic-MRI model, the metaplastic histology (odds ratio [OR], 8.0; P = 0.032), Ki-67 index (OR, 1.02; P = 0.044), and subcutaneous edema (OR, 30.6; P = 0.004) were independently associated with PD in the development set. The clinical-pathologic-MRI model showed a higher area under the receiver-operating characteristic curve (AUC) than the clinical-pathologic model (AUC: 0.69 vs. 0.54; P = 0.017) for predicting PD in the validation set. Distant metastases occurred in 49 patients and 18 patients in the development and validation sets, respectively. Residual disease in both the breast and lymph nodes (hazard ratio [HR], 6.0; P = 0.005) and the presence of lymphovascular invasion (HR, 3.3; P < 0.001) were independently associated with DMFS. The model consisting of these pathologic variables showed a Harrell's C-index of 0.86 in the validation set. Conclusion: The clinical-pathologic-MRI model, which considered subcutaneous edema observed using MRI, performed better than the clinical-pathologic model for predicting PD. However, MRI did not independently contribute to the prediction of DMFS.

• Earthquakes and Structures
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• 제26권3호
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• pp.175-189
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• 2024

Aiming at studying the plastic hinge (PH) evolution regularities and failure mode of rocking wall moment frame (RWMF) structure in earthquakes, the whole-working history analysis of seismic performance state of RWMF structure based on co-operation performance and PH evolution was carried out. Building upon the theoretical analysis of the elastic internal forces and deformations of RWMF structures, nonlinear finite element analysis (FEA) methods were employed to perform both Pushover analysis and seismic response time history analysis under different seismic coefficients (δ). The relationships among PH occurrence ratios (R_ph), inter-story drifts and δ were established. Based on the plotted curve of the seismic performance states, evaluation limits for the R_ph and inter-story drifts were provided for different performance states of RWMF structures. The results indicate that the R_ph of RWMF structures exhibits a nonlinear evolution trend of "fast at first, then slow" with the increasing of δ. The general pattern is characterized by the initial development of beam hinges in the middle stories, followed by the development towards the top and bottom stories until the beam hinges are fully formed. Subsequently, the development of column hinges shifts from the bottom and top stories towards the middle stories of the structure, ultimately leading to the loss of seismic lateral capacity with a failure mode of partial beam yield, demonstrating a global yielding pattern. Moreover, the limits for the R_ph and inter-story drifts effectively evaluate the five different performance states of RWMF structures.