• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.293.1-293.1
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• 2016

Various materials including conductive, dielectric, and semi-conductive materials, constitute suitable candidates for printed electronics. Metal nanoparticles (e.g. Ag, Cu, Ni, Au) are typically used in conductive ink. However, easily oxidized metals, such as Cu, must be processed at low temperatures and as such, photonic sintering has gained significant attention as a new low-temperature processing method. This method is based on the principle of selective heating of a strongly absorbent film, without light-source-induced damage to the transparent substrate. However, Cu nanoparticles used in inks are susceptible to the growth of a native copper-oxide layer on their surface. Copper-oxide-nanoparticle ink subjected to a reduction mechanism has therefore been introduced in an attempt to achieve long-term stability and reliability. In this work, a flash-light sintering process was used for the reduction of an inkjet-printed Cu(II)O thin film to a Cu film. Using a photographic lighting instrument, the intensity of the light (or intense pulse light) was controlled by the charged power (Ws). The resulting changes in the structure, as well as the optical and electrical properties of the light-irradiated Cu(II)O films, were investigated. A Cu thin film was obtained from Cu(II)O via photo-thermal reduction at 2500 Ws. More importantly, at one shot of 3000 Ws, a low sheet resistance value ($0.2527{\Omega}/sq.$) and a high resistivity (${\sim}5.05-6.32{\times}10^{-8}{\Omega}m$), which was ~3.0-3.8 times that of bulk Cu was achieved for the ~200-250-nm-thick film.

• 대한기계학회논문집
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• 제19권4호
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• pp.968-980
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• 1995

Al/Al$_{2}$O$_{3}$/C hybrid metal matrix composites are fabricated by the direct squeeze infiltration method. From the microstructure of Al/Al$_{2}$O$_{3}$/C composites, uniform distribution of reinforcements and good bondings are found. Optimum processing conditions for preforms and squeeze castings are suggested. Mechanical properties, such as elastic modulus, elongation, 0.2% offset yield strength and ultimate tensile strength are obtained. Through the abrasive were test and wear surface analsis, wear behavior and its mechanism of AC2B aluminum and Al/Al$_{2}$O$_{3}$/C composites can be characterized under various sliding speed conditions. Tensile strenght elongation of Al/Al$_{2}$O$_{3}$/C composites are decreased with increasing the addition of carbon fiber. On the contrary, elastic modulus of Al/Al$_{2}$O$_{3}$/C composites is slightly improved compared with that of the unreinforced matrix alloy. The addition of carbon fiber to al/al$_{2}$O$_{3}$/C composites gives rise to improvement of the wear resistance. Specially, carbon chopped fibers play an important role in interfering sticking between the counter material and metal matirix composites. Al/Al$_{2}$O$_{3}$/C composites are suitable to high speed due to solid lubication of carbon. And wear model of Al/Al$_{2}$O$_{3}$/C composites is suggested by the examination of worn surfaces.

• Biomolecules & Therapeutics
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• 제17권4호
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• pp.370-378
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• 2009

N-myc downstream-regulated gene 2 (NDRG2) has recently been found to be a tumor suppressor gene. Although it has been reported that NDRG2 expression in breast cancer cells decreases cell proliferation by inhibiting STAT3 activation via SOCS1 induction, the molecular mechanism of chemotherapeutic agent-induced apoptosis is not well known. To elucidate the effect of NDRG2 on the apoptotic pathway induced by doxorubicin, we established stable cell lines expressing NDRG2 and investigated the effect of NDRG2 expression on the doxorubicin-induced apoptosis. While STAT3 activation was remarkably inhibited by NDRG2 overexpression, the expression level of p21 was increased by NDRG2 expression. We confirmed that NDRG2-expressing cells treated with doxorubicin suppressed STAT3 activation and upregulated p21 expression. NDRG2 expression considerably enhanced TUNEL positive apoptotic cells, poly-ADP ribose polymerase (PARP) cleavage, release of cytochrome c to cytosol, and caspase-3 activity in doxorubicin-induced apoptosis. Bid expression in a resting state and after treatment with doxorubicin increased in MDA-MB-231-NDRG2 cells compared to MDA-MB-231-mock cells. Meanwhile, Bcl-$x_L$ expression decreased in MDA-MB-231-NDRG2 cells compared to MDA-MB-231-mock cells in a resting state and in doxorubicin-treated cells. Collectively, these data suggest that suppression of STAT3 activation by NDRG2 influences the sensitivity to doxorubicin-induced apoptosis of breast cancer cells and this may provide a potential therapeutic benefit to overcome the resistance against doxorubicin in breast cancer.

• BMB Reports
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• 제43권7호
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• pp.461-467
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• 2010

Natural products with non-toxic and environmentally friendly properties are good resources for skin-whitening cosmetic agents when compared to artificial synthetic chemicals. Here, we investigated the effect of glyceollin produced to induce disease resistance responses of soybean to specific races of an incompatible pathogen, phytophthora sojae, on melanogenesis and discussed their mechanisms in melanin biosynthesis. We found that glyceollin inhibits melanin synthesis and tyrosinase activity in B16 melanoma cells without cytotoxicity. To elucidate the mechanism of the effect of glyceollin on melanogenesis, we conducted western blot analysis for melanogenic enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2. Glyceollin inhibited tyrosinase and TRP-1 protein expression. Additionally, glyceollin effectively inhibited intracellular cAMP levels in B16 melanoma cells stimulated by $\alpha$-melanocyte stimulating hormone ($\alpha$-MSH). These results suggest that the whitening activity of glyceollin may be due to the inhibition of cAMP involved in the signal pathway of $\alpha$-MSH in B16 melanoma cells.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.67.1-67
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• 2003

Phytophthora blight is a devastating disease of pepper and occurs almost anywhere peppers are grown. Phytophthora blight is caused by Phytophthora capsici and this pathogen can infect every part of the plant by moving inoculum in the soil, by infecting water on surface, by aerial dispersal to sporulating lesions. Management of Phytophthora blight currently relies on cultural practices, crop rotation, and use of selective fungicides. Since these treatments are a short-term management, a classical breeding for development of resistant pepper against the Phytophthora is an alternative. So far some of the resistant cultivars have been on the market, but those are limited regionally and commercially. Therefore, ultimately an elite line resistant against this disease should be developed, if possible, by biotechnology. We have set out a series of work recently in order to develop Phytophthora resistant pepper cultivar. For the first time, the cDNA microarray analysis was peformed using an EST chip that holds around 5000 pepper EST clones to identify genes responsive to Phytophthora infection. Total RNA samples were obtained from Capsicum annuum PI201234 after inoculating P. capsici to roots and soil and exposed to the chip. .Around 900 EST clones were up-regulated and down-regulated depending on the two RNA sample tissues, leaf and root. From those, we have found 55 transcription factors that may be involved in gene regulation of the disease defense mechanism. Further and in detail information will be provided in the poster.

• 한국세라믹학회지
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• 제39권1호
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• pp.99-107
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• 2002

임피던스 측정법은 시멘트 페이스트의 수화 진행 시 미세구조의 연속적인 변화를 분석하는데 유용한 수단으로 이용되어 왔다. 본 실험에서는 고로슬래그의 첨가량과 분말도를 달리하여 보통 포틀랜드 시멘트에 첨가한 후 나타나는 페이스트의 초기 수화거동을 임피던스 측정법을 이용하여 관찰하였다. 고로 슬래그가 시멘트에 치환 첨가되면, 수화 초기에는 $R_{t (s+1)}$(고상과 액상에 의한 저항)과 $R_{t(int)}$의 증가폭이 감소하였다. 이것은 고로 슬래그를 포함한 시멘트의 수화가 초기재령에서는 늦게 진행되고 있음을 보여준다. 고로 슬래그의 첨가량이 증가할 수록 $R_{t(s+1)}$이 감소하였으며, 수화 72시간에 출현하는 반원의 직경, $R_{t(int)}$ 역시 고로 슬래그의 첨가량이 증가할 수록 감소하고 있다. 그러나, 첨가된 고로 슬래그의 분말도가 클수록 수화 초기부터 $R_{t(s+1)}$과 $R_{t(int)}$의 수치가 증가하였다.

• 콘크리트학회논문집
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• 제16권6호
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• pp.785-794
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• 2004

이 논문은 휨과 전단이 동시에 작용하고 있는 철근콘크리트 보에서 전단은 휨모멘트의 변화율(V=dM/dx)이라는 기본 관계식에 근거한 새로운 트러스모델링기법을 제안하는 것이다. 이 새로운 모델의 핵심은 보의 경간에서 내부 모멘트 팔길이의 변화를 고려함으로써, 보의 전단 저항 메커니즘을 아치작용과 보작용이라는 두 기본 성분의 합으로 표현할 수 있게 한 것이다. 이두 작용에 의한 전단 저항 구성비는 상호 변형 적합조건을 적용하여 계산하였는데, 이 때 수정압축장이론과 CEB/FIP MC-90의 인장강화효과 공식을 이용하였다. 이렇게 함으로써 전단과 모멘트 관계식 V=dM/dx을 수치적으로 복제할 수 있는 새로운 트러스모델을 결정하였다.

• 콘크리트학회논문집
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• 제26권2호
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• pp.125-133
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• 2014

이 연구에서는 볼트접합 및 프리스트레스를 적용한 프리캐스트 콘크리트 보-기둥 외부접합부의 내진 및 구조적 성능을 평가하였다. 총 5개의 보-기둥 외부접합부 실험체를 제작하고 보 단부에 변위제어 방식으로 반복하중을 가하며 실험을 수행하였다. 이 연구의 결과를 근거로 다음과 같은 결론을 얻을 수 있었다. 완전 건식공법이 적용된 PC 접합부는 완전 습식공법이 적용된 RC 접합부보다 에너지소산이나 핀칭현상에 있어서 불리한 거동을 보였지만 이는 설계과정에서 의도된 현상이며, 횡변형 능력에 있어서는 우수한 결과를 보였다. 또한 층간변위비 4%까지 횡하중 저항성능의 손실이 발생하지 않았고 매설용너트에 항복이 집중되는 메커니즘을 보이는 점으로 미루어 볼 때 개발된 접합부는 외부접합부 횡저항시스템으로서 적합한 것으로 사료된다. 추가적인 프리스트레스는 PC 접합부의 과도한 핀칭현상 방지 및 접합부 균열제어에 효과적이었으며 PC 접합부의 전체적인 내진성능을 향상시켰다.

• Tuberculosis and Respiratory Diseases
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• 제38권4호
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• pp.357-371
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• 1991

To identify the pathogenetic role of reactive oxygen free radical-induced oxidation reaction in endotoxin-induced acute lung injury, we infused endotoxin into 8 domestic pigs; endotoxin only (n=3), pretreatment with dimethylthiourea (DMTU) (n=5). We observed the sequential changes in hemodynamic parameters, the concentration of plasma oxidized glutathione (GSSG) in pulmonary arterial and venous blood, and albumin content in bronchoalveolar lavage fluid (BALF). The results were as follows. 1) While cardiac output decreased, mean pulmonary arterial pressure, pulmonary vascular resistance, and alveolar-arterial oxygen difference increased over phase 1 (0-2 hr) and phase 2 (2-4.5 hr) by endotoxin, DMTU attenuated the above changes only during phase 2. 2) While the concentration of plasma GSSG increased significantly by endotoxin during phase 2, there were no significant differences between pulmonary arterial and venous GSSG contents during both phases. The increase in plasma GSSG content was attenuated by DMTU. 3) The content of BALF albumin was significantly lower in DMTU group than that of endotoxin group. These results suggest that reactive oxygen free radical-induced oxidation reaction may have an important pathogenetic role in endotoxin-induced acute lung injury in pigs, which seems to be greater during phase 2 rather than phase 1.

• 한국지반공학회논문집
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• 제30권10호
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• pp.55-65
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• 2014

최근 토석류의 이동 메커니즘에 대한 연구와 거동 예측을 위한 해석 프로그램의 개발이 활발히 진행중이다. 하지만, 토석류를 유체이동으로 간주하는 기존의 프로그램들은 수치적인 안정성과 모델링 그리고 다양한 경계조건의 적용에 대한 제약이 있다. 본 연구에서는 토석류의 유동현상에 대한 연속방정식과 힘평형 방정식에 대하여 깊이적분을 수행하였다. 토체의 두께 h, x와 y 흐름방향의 평균속도 $\bar{u}$, $\bar{v}$를 주변수로 채택하여 흐름이 없는 해석영역에 대한 수치적인 안정성을 확보하였다. DG기법에 의한 가중행렬을 산정하고 유동방향을 고려한 불연속 시험함수를 이용하여 Petrov-Galerkin 수식화를 수행하였다. 그리고 토석류의 유체 및 토립자의 특성을 동시에 고려할 수 있는 역학적 구성모델을 제시하였다. 단일경사 사면에서 사면경사, 토사 유발량, 저면 마찰 저항이 토석류 흐름특성에 미치는 영향을 비교 분석하였다. 그리고 수치해석을 통하여 사면 하부에 설치된 제방의 영향을 분석하였다. 개발된 해석프로그램을 활용하여 토석류 발생예상 지역의 다양한 위험인자에 대한 평가를 수행하고, 피해를 최소화하기 위한 시설물의 설계방안을 제안할 수 있을 것으로 판단된다.