• Title/Summary/Keyword: Reproducibility evaluation

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The Effect of Breathing Biofeedback on Breathing Reproducibility and Patient's Dose in Respiration-gated Radiotherapy (호흡연동 방사선 치료에서 호흡생체자기제어 방식이 호흡 재현성 및 선량에 미치는 영향 평가)

  • An, Sohyun;Yeo, Inhwan;Jung, Jaewon;Suh, Hyunsuk;Lee, Kyung Ja;Choi, Jinho;Lee, Kyu Chan;Lee, Rena
    • Progress in Medical Physics
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    • v.24 no.3
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    • pp.135-139
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    • 2013
  • We evaluated the effect of two kinds of breathing biofeedback technique such as audio-instruction and audio-visual biofeedback on breathing reproducibility and the CTV coverage during repeated treatment regimes in respiration-gated radiotherapy. In this study, the breathing data of nineteen lung cancer patients acquired from Medical College of Virginia (MCV) during five weeks were used. The dose evaluation algorithm was programmed in MATLAB. In the result, the CTV coverage was decreased as 30.0% due to the breathing irreproducibility for free-breathing. For audio-visual biofeedback, the CTV coverage was improved as 20.0% because patients can learn how control their breathing stably. And the audio-instruction was effective to preserve the breathing reproducibility.

Use of autonomous maximal smile to evaluate dental and gingival exposure

  • Wang, Shuai;Lin, Hengzhe;Yang, Yan;Zhao, Xin;Mei, Li;Zheng, Wei;Li, Yu;Zhao, Zhihe
    • The korean journal of orthodontics
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    • v.48 no.3
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    • pp.182-188
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    • 2018
  • Objective: This study was performed to validate the autonomous maximal smile (AMS) as a new reference for evaluating dental and gingival exposure. Methods: Digital video clips of 100 volunteers showing posed smiles and AMS at different verbal directives were recorded for evaluation a total of three times at 1-week intervals. Lip-teeth relationship width (LTRW) and buccal corridor width (BCW) were measured. LTRW represented the vertical distance between the inferior border of the upper vermilion and the edge of the maxillary central incisors. Intraclass correlation coefficients (ICCs) for reproducibility, and the m-value (minimum number of repeated measurements required for an ICC level over 0.75), were calculated. Results: LTRW and BCW of the AMS were 1.41 and 2.04 mm, respectively, greater than those of the posed smile (p < 0.05), indicating significantly larger dental and gingival exposure in the AMS. The reproducibility of the AMS (0.74 to 0.77) was excellent, and higher than that of the posed smile (0.62 to 0.65), which had fair-to-good reproducibility. Moreover, the m-value of the AMS (0.88 to 1.05) was lower than that of the posed smile (1.59 to 1.85). Conclusions: Compared to the posed smile, the AMS shows significantly larger LTRW and BCW, with significantly higher reproducibility. The AMS might serve as an adjunctive reference, in addition to the posed smile, in orthodontic and other dentomaxillofacial treatments.

Efficiency test Evaluation Method for Nebulizer & Medicinal Nonventilatory Nebulizer (의료용 흡입기 및 분무기의 성능 평가 연구)

  • Kim, S.M.;Jeong, J.H.;Lee, J.H.;Rho, S.G.
    • Journal of Biomedical Engineering Research
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    • v.30 no.5
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    • pp.438-443
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    • 2009
  • Nebulizer is designed to atomize medicinal fluid for patient with small particles(0.5-$5{\mu}m$) and also able to deliver particles from devices to the lungs when patient inhales air. Several particle size measurements are currently used to size aerosol particles. The most commonly used test is the cascade impactor method in as a standard. But, other methods for comparative particle size distribution data such as the particle size range and reproducibility are acceptable. Therefore, in this study a new test methode is suggested for nonventilatory nebulizer evaluation equipment.

Economic Evaluation of Measurement System by Principal Component Analysis (주성분 분석을 이용한 측정시스템의 경제적 평가)

  • Kang, Chung-Oh;Byun, Jai-Hyun
    • Journal of Korean Institute of Industrial Engineers
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    • v.24 no.2
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    • pp.211-221
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    • 1998
  • It is very important to have a satisfactory measurement system, since it is useless to try to improve the manufacturing process without an adequate measurement system. Therefore, evaluation of the measurement system is the first step for the quality improvement of the manufacturing process. To estimate the measurement error we must conduct a controlled gage repeatability and reproducibility(gage R&R) study. Many manufacturers use a gage or instrument to measure multiple dimensions for the overall quality of the manufactured parts. In this case, it is necessary to estimate the gage R&R for multiple dimensions. When a gage measures a large number of dimensions of a part, it is very time-consuming and costly to measure all the dimensions. In this paper we propose the use of the principal component analysis method to identify a few principal components out of the original multivariate measurement capability to explain most of the measurement system variation pattern.

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Evaluation of Color Change According to Coloring Time of Dental Zirconia Block (치과용 지르코니아 블럭의 착색시간에 따른 색조변화 관찰)

  • Choi, Sung-Min;Nam, Sang-Yong
    • Journal of Technologic Dentistry
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    • v.33 no.3
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    • pp.219-224
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    • 2011
  • Purpose: The current study focused on investigating color change of dental zirconia block with respect to the block coloring time. Methods: Three types of dental zirconia blocks(Zirtooth, Pearl-HT, D-Max) were tinted with coloring agent under four different time condition (0 minutes, 1 minutes, 10 minutes, 30 minutes). The quantitative evaluation of the tinted dental zirconia blocks was conducted with spectrophotometer. Results: The Zirtooth and D-Max blocks showed lower H value. The Pearl-HT blocks showed poor reflectivity(L value). Conclusion: The study of color change of zirconia block, which consists the substructure of all ceramic Crown, is applicable for deciding appropriate coloring condition when fabricating one layer ceramic Crown or double layer ceramic Crown.

Evaluation of Cancer Treatment Using FDG-PET (FDG-PET을 이용한 암 치료 효과의 평가)

  • Ryu, Jin-Sook
    • The Korean Journal of Nuclear Medicine
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    • v.36 no.1
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    • pp.64-73
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    • 2002
  • FDG-PET has potential as an effective, non-invasive tool to measure tumor response to anticancer therapy. The changes in tumor FDG uptake may provide an early, sensitive guide to the clinical and subclinical response of tumors to cancer treatment, as well as functional assessment of residual viable tumor. This may allow the evaluation of subclinical response to anticancer drugs in early clinical trials and improvements in patients management. However, monitoring tumor responses with FDG-PET is still in its infancy. The methods of measurement of FDG uptake are currently diverse and timing with respect to anti cancer therapy variable. Therefore, there is a need for larger-scale trials along with standardized methodology and a collection of reproducibility data. The recent guideline from the European group seems to be the most comprehensive. In future, the combination of morphological and metabolic images may improve the quantitative nature of these measurements by relating tumor viability to total tumor mass. More data on sensitivity and specificity of FDG-PET technique are needed along with continued advancement of PET methodology.

Comparison of the Tactile Sensation of Worsted Fabrics With and Without Reference (기준 직물 제시와 비제시 방법에 따른 소모직물의 촉감 평가 비교)

  • 김동옥;김은애
    • Journal of the Korean Society of Clothing and Textiles
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    • v.28 no.3_4
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    • pp.452-459
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    • 2004
  • The purpose of this study was to evaluate the effect of reference fabric for the tactile sensation of worsted fabrics. As specimens, 32 worsted fabrics for spring/fall suits were selected. A series of subjective evaluation for roughness, harshness, coarseness, smoothness, warmth, bulkiness and softness were performed with 20 trained panels. The panels were selected by the test of consistency and trained for 3 weeks to enhance the reproducibility and consistency. Subjective evaluation was performed using 9 points Semantic Differential Scales with and without reference fabric. Results showed that the sensations were very similar between the results for the test of with or without reference. However the standard deviations of ratings for the with-reference were much less than that of without-reference which means the use of reference fabric can reduce the subjective error or can reduce the number of panels to test.

The Study on Applicability of Manufactured Lead(II) Iodide Dosimeter for Dose Measurement in Brachytherapy (방사선근접치료 분야의 선량 측정을 위해 제조된 Lead(II) Iodide 선량계의 적용가능성 연구)

  • Yang, Seung-Woo;Han, Moo-Jae;Park, Sung-Kwang
    • Journal of the Korean Society of Radiology
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    • v.15 no.6
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    • pp.789-794
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    • 2021
  • Brachytherapy is a treatment in which radioactive isotopes are placed inside the body to intensively irradiate the tumor with radiation. Because brachytherapy uses a radioisotope source with a high dose rate, it is very important to know the exact location and dose of the source. However, in clinical practice, it is evaluated inaccurately with the naked eye through rulers and autoradiographs. Therefore, in this study, a dosimeter that can be used for brachytherapy was developed using a lead(II) iodide (PbI2) material, and the applicability was evaluated by analyzing the reproducibility, linearity, and PID items. As a result of reproducibility evaluation, the RSD value was 1.41%, satisfying the evaluation criteria of 1.5%. As a result of the linearity evaluation, the R2 value was 0.9993, which satisfies the evaluation criterion of 0.9990. As a result of PID evaluation, it showed only a difference of 0.06 cm compared with the theoretical value of the inverse square law of distance at the 50% dose reduction point. The dosimeter manufactured in this experiment shows results that satisfy the standard in all evaluations, so it is judged that the possibility of applying the dosimeter in the radiation brachytherapy area is sufficient.

Evaluation Method for Measurement System and Process Capability Using Gage R&R and Performance Indices (게이지 R&R과 성능지수를 이용한 측정시스템과 공정능력 평가 방법)

  • Ju, Youngdon;Lee, Dongju
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.42 no.2
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    • pp.78-85
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    • 2019
  • High variance observed in the measurement system can cause high process variation that can affect process capability badly. Therefore, measurement system analysis is closely related to process capability analysis. Generally, the evaluation for measurement system and process variance is performed separately in the industry. That is, the measurement system analysis is implemented before process monitoring, process capability and process performance analysis even though these analyses are closely related. This paper presents the effective concurrent evaluation procedure for measurement system analysis and process capability analysis using the table that contains Process Performance (Pp), Gage Repeatability & Reproducibility (%R&R) and Number of Distinct Categories (NDC). Furthermore, the long-term process capability index (Pp), which takes into account both gage variance and process variance, is used instead of the short-term process capability (Cp) considering only process variance. The long-term capability index can reflect well the relationship between the measurement system and process capability. The quality measurement and improvement guidelines by region scale are also described in detail. In conclusion, this research proposes the procedure that can execute the measurement system analysis and process capability analysis at the same time. The proposed procedure can contribute to reduction of the measurement staff's effort and to improvement of accurate evaluation.

Validation of One-Step Real-Time RT-PCR Assay in Combination with Automated RNA Extraction for Rapid Detection and Quantitation of Hepatitis C Virus RNA for Routine Testing in Clinical Specimens

  • KIM BYOUNG-GUK;JEONG HYE-SUNG;BAEK SUN-YOUNG;SHIN JIN-HO;KIM JAE-OK;MIN KYUNG-IL;RYU SEUNG-REL;MIN BOK-SOON;KIM DO-KEUN;JEONG YONG-SEOK;PARK SUE-NIE
    • Journal of Microbiology and Biotechnology
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    • v.15 no.3
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    • pp.595-602
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    • 2005
  • A one-step real-time quantitative RT-PCR assay in combination with automated RNA extraction was evaluated for routine testing of HCV RNA in the laboratory. Specific primers and probes were developed to detect 302 bp on 5'-UTR of HCV RNA. The assay was able to quantitate a dynamic linear range of $10^7-10^1$ HCV RNA copies/reaction ($R^2=0.997$). The synthetic HCV RNA standard of $1.84{\pm}0.1\;(mean{\pm}SD)$ copies developed in this study corresponded to 1 international unit (IU) of WHO International Standard for HCV RNA (96/790 I). The detection limit of the assay was 3 RNA copies/reaction (81 IU/ml) in plasma samples. The assay was comparable to the Amplicor HCV Monitor (Monitor) assay with correlation coefficient r=0.985, but was more sensitive than the Monitor assay. The assay could be completed within 3 h from RNA extraction to detection and data analysis for up to 32 samples. It allowed rapid RNA extraction, detection, and quantitation of HCV RNA in plasma samples. The method provided sufficient sensitivity and reproducibility and proved to be fast and labor-saving, so that it was suitable for high throughput HCV RNA test.