• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4725-4732
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• 2012

Aim: The incidence of stomach cancer in Mizoram is highest in India. We have conducted a population based matched case-control study to identify environmental and genetic risk factors in this geographical area. Methods: A total of 102 histologically confirmed stomach cancer cases and 204 matched healthy population controls were recruited. GSTM1 and GSTT1 genotypes were determined by PCR and H. pylori infections were determined by ELISA. Results: Tobacco-smoking was found to be an important risk factor for high incidence of stomach cancer in Mizoram. Meiziol (local cigarette) smoking was a more important risk factor than other tobacco related habits. Cigarette, tuibur (tobacco smoke infused water) and betel nut consumption synergistically increased the risk of stomach cancer. Polymorphisms of GSTM1 and GSTT1 genes were not found to be directly associated with stomach cancer in Mizoram. However, they appeared to be effect modifiers. Persons habituated with tobacco smoking and/or tuibur habit had increased risk of stomach cancer if they carried the GSTM1 null genotype and GSTT1 non-null genotype. Conclusion: Tobacco smoking, especially meiziol is the important risk factor for stomach cancer in Mizoram. GSTM1 and GSTT1 genes modify the effect of tobacco habits. This study is a first step in understanding the epidemiology of stomach cancer in Mizoram, India.

• Journal of agricultural medicine and community health
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• v.47 no.4
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• pp.268-274
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• 2022

Objectives: The purpose of this study was to identify the individual and regional risk factors on depression using community-based data in Jeollabuk-do. Methods: This cross-sectional study obtained data from the Community Health Survey 2018 in Jeollabuk-do. The dependent variable was depression measured by Patient Health Questionnaire-9 (PHQ-9). The prevalence of depression was defined if total score of PHQ-9 was 10 or higher. A multilevel analysis was conducted to consider individual and regional level independent variables that could be risk factors for depression. Results: In the individual level, female gender and smokers had significantly higher odds ratios (ORs) for depression of 1.58 and 1.72, respectively. Subjects with economic activity, higher income and higher education had significantly lower ORs of 0.53, 0.41 and 0.66. In the regional level, higher greening rates and lower levels of PM2.5 had statistically lower ORs at the significance level of 10%. Conclusion: By conducting this study, risk factors associated with depression were identified in individual- and regional-level. This study suggests that health projects are needed to control regional level risk factors including community networks for mental health management in addition to the traditional individual level risk factors.

• Journal of the Korean Association of Geographic Information Studies
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• v.14 no.3
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• pp.68-77
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• 2011

Flood disasters on the metropolis where population and facilities were densely concentrated cause an enormous damage, therefore it is important to find risk and vulnerable area for floods, and then mid-long term disaster reduction plan should be established by the results. However, there is no rational method which reflects urban characteristics to estimate the regional safety for flood. so it is necessary to develop the standardized method of regional safety assesment due to urban flood. The proposed regional safety assesment model in this study was combined risk and mitigation score which consisted of three and two element, and 12 assesment factors which effect flood disasters were selected. And then the integrated regional safety was estimated by subtracting mitigation score from risk score. GIS tool was used to estimate the factor assesment and integrated regional safety. Developed regional safety assesment model was applied in Seoul to evaluate the suitability.

• Journal of Korea Water Resources Association
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• v.55 no.8
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• pp.589-601
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• 2022

Although drought is a natural phenomenon, its damage occurs in combination with regional physical and social factors. Especially, related to the supply and demand of various waters, drought causes great socio-economic damage. Even meteorological droughts occur with similar severity, its impact varies depending on the regional characteristics and water supply system. Therefore, this study assessed regional drought risk considering regional socio-economic factors and water supply system. Drought hazard was assessed by grading the joint drought management index (JDMI) which represents water shortage. Drought vulnerability was assessed by weighted averaging 10 socio-economic factors using Entropy, Principal Component Analysis (PCA), and Gaussian Mixture Model (GMM). Drought response capacity that represents regional water supply factors was assessed by employing Bayesian networks. Drought risk was determined by multiplying a cubic root of the hazard, vulnerability, and response capacity. For the drought hazard meaning the possibility of failure to supply water, Goesan-gun was the highest at 0.81. For the drought vulnerability, Daejeon was most vulnerable at 0.61. Considering the regional water supply system, Sejong had the lowest drought response capacity. Finally, the drought risk was the highest in Cheongju-si. This study identified the regional drought risk and vulnerable causes of drought, which is useful in preparing drought mitigation policy considering the regional characteristics in the future.

• Journal of Korean Society of Water and Wastewater
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• v.33 no.4
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• pp.269-279
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• 2019

This study would present a risk analysis method to evaluate stable tap water supply in a multi-regional water supply system and propose a measure for the evaluation of the effect of the conjunctive operation of the multi-regional water supply system using this. Judging from the vulnerability for the crisis response of the entire N. multi-regional water supply system, as compared to the result of Scenario 1 in which no conjunctive pipes were operated, it was found that in Scenario 2, in which conjunctive pipes were partially operated, the vulnerability of crisis response decreased by about 30.6%, and as compared to Scenario 3, the vulnerability of crisis response decreased by 86.2%. In setting a plan for stable tap water supply in N multi-regional water supply system, using the estimated value and the method for the evaluation of the vulnerability of crisis response by pipe, by interval and by line, it is judged that this can be utilized as a basis for the judgment of the evaluation of the operation or the additional installation of conjunctive pipes.

• Journal of agricultural medicine and community health
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• v.49 no.2
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• pp.111-120
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• 2024

Objective: This study aimed to analyze the correlation between factors affecting health risk behaviors of rural residents according to regional scale. Methods: Restricted-access data from the 2016~2021 Korea National Health and Nutrition Examination Survey and the multivariate probit model were used. As for health risk behaviors, smoking, drinking, lack of aerobic exercise, low level of healthy eating index, unvaccination, and non-participation in health examination were considered. Results: Controlling for individuals' socio-demographic characteristics, in general, correlation coefficients between unobservable factors affecting health risk behaviors were significant. However, the magnitude and statistical significance of the correlation coefficients varied by regional scale (dong/eup/myeon). This suggests that rural residents engage in health risk behaviors due to their different characteristics compared with urban dwellers, which also varies by whether residents are located in eup or myeon area. Conclusion: It is necessary to differentiate health care services between urban and rural areas in terms of type of service and programs based on the relationship between unobservable factors affecting each type of health risk behaviors.

• Nutrition Research and Practice
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• v.14 no.5
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• pp.519-531
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• 2020

BACKGROUND/OBJECTIVES: Regional disparities in dietary factors might be related to regional disparities in cardiometabolic health. Therefore, this study investigated the associations of cardiometabolic risk factors and dietary factors with regional types in Korean adults. SUBJECTS/METHODS: Based on data from the 2007-2017 Korea National Health and Nutrition Examination Survey, the study included 39,781 adults aged ≥ 19 years who completed the dietary survey and a health examination. Healthy and unhealthy dietary factors (fat, sodium, fruit, and vegetable intakes) were evaluated using 1-day 24-h dietary recall method, as well as the use of nutrition labels with a questionnaire. RESULTS: Of the participants, 48.7%, 36.0%, and 15.2% lived in metropolitan, urban, and rural areas, respectively. Adults living in urban and rural had higher odds ratios (ORs) for obesity (OR for urban, 1.07; 95% confidence interval (CI), 1.01-1.14; OR for rural, 1.14; 95% CI, 1.05-1.24) than adults living in metropolitan areas; these associations were significantly observed in middle-aged adults. Compared to metropolitan residents, rural residents had lower ORs for hypertension in middle-aged (OR, 0.86; 95% CI, 0.76-0.96) and metabolic syndrome in older adults (OR, 0.78; 95% CI, 0.67-0.91). Regarding urban residents, a lower OR for diabetes in middle-aged adults (OR, 0.85; 95% CI, 0.74-0.97) and a higher OR for hypertension in older adults (OR, 1.19; 95% CI, 1.02-1.39) were observed. Overall rural residents had higher ORs of excessive carbohydrate, low fruit, and high salted-vegetable intakes than metropolitan residents. Low fruit intake was positively associated with obesity, metabolic syndrome, and hypertension, after adjustment for regional type and other confounders in total participants. CONCLUSIONS: These findings indicate that cardiometabolic risk and unhealthy dietary factors differ among regional types and age groups within Korea. Nutritional policy and interventions should consider regional types for prevention and management of cardiometabolic risk factors.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10653-10658
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• 2015

Background: A very high incidence of lung cancer is observed in Mizoram and Manipur, North East India. We conducted a population based case control study to establish associations of p53 codon 72 polymorphisms and interactions with environmental factors for this high incidence. Material and Methods: A total of 272 lung cancer cases and 544 controls matched for age (${\pm}5years$), sex and ethnicity were collected and p53 codon 72 polymorphism genotypes were analyzed using a polymerase chain based restriction fragment length polymorphism assay. We used conditional multiple logistic regression analysis to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: p53 Pro/Pro genotype was significantly associated with increased risk of lung cancer in the study population (adjusted OR=2.14, CI=1.35-3.38, p=0.001). Interactions of the p53 Pro/Pro genotype with exposure to wood smoke (adjusted OR=3.60, CI=1.85-6.98, p<0.001) and cooking oil fumes (adjusted OR=3.27, CI=1.55-6.87, p=0.002), betel quid chewing (adjusted OR=3.85, CI=1.96-7.55, p<0.001), tobacco smoking (adjusted OR=4.42, CI=2.27-8.63, p<0.001) and alcohol consumption (adjusted OR=3.31, CI=1.10-10.03, p=0.034) were significant regarding the increased risk of lung cancer in the study population. Conclusions: The present study provided preliminary evidence that a p53 codon 72 polymorphism may effect lung cancer risk in the study population, interacting synergistically with environmental factors.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.717-723
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• 2014

Background: This study was carried out to investigate the interaction of p53 codon 72 polymorphism, dietary and tobacco habits with reference to risk of stomach cancer in Mizoram, India. A total of 105 histologically confirmed stomach cancer cases and 210 age, sex and ethnicity matched healthy population controls were included in this study. Materials and Methods: The p53 codon 72 polymorphism was detected by PCR-RFLP and sequencing. H. pylori infection status was determined by ELISA. Information on various dietary and tobacco related habits was recorded with a standard questionnaire. Results: This study revealed that overall, the Pro/Pro genotype was significantly associated with a higher risk of stomach cancer (OR, 2.54; 95%CI, 1.01-6.40) as compared to the Arg/Arg genotype. In gender stratified analysis, the Pro/Pro genotype showed higher risk (OR, 7.50; 95%CI, 1.20-47.0) than the Arg/Arg genotype among females. Similarly, the Pro/Pro genotype demonstrated higher risk of stomach cancer (OR, 6.30; 95%CI, 1.41-28.2) among older people (>60 years). However, no such associations were observed in males and in individuals <60 years of age. Smoke dried fish and preserved meat (smoke dried/sun dried) consumers were at increased risk of stomach cancer (OR, 4.85; 95%CI, 1.91-12.3 and OR, 4.22; 95%CI, 1.46-12.2 respectively) as compared to non-consumers. Significant gene-environment interactions exist in terms of p53 codon 72 polymorphism and stomach cancer in Mizoram. Tobacco smokers with Pro/Pro and Arg/Pro genotypes were at higher risk of stomach cancer (OR, 16.2; 95%CI, 1.72-153.4 and OR, 9.45; 95%CI, 1.09-81.7 respectively) than the non-smokers Arg/Arg genotype carriers. The combination of tuibur user and Arg/Pro genotype also demonstrated an elevated risk association (OR, 4.76; 95%CI, 1.40-16.21). Conclusions: In conclusion, this study revealed that p53 codon 72 polymorphism and dietary and tobacco habit interactions influence stomach cancer development in Mizoram, India.

• Journal of the Korean association of regional geographers
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• v.8 no.2
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• pp.247-255
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• 2002

In recent decades, the characteristics of natural hazard has been changed and the global cost of natural disasters has increased substantially. There are several trends in society and nature that suggest this pattern may continue, with more frequent mega-disasters occurring in the future. In particular, risk perception that is at odds with the "real" risk underlies the process of risk transference increases long-term vulnerability. Therefore investigating the correct risk transference and adjustments according to regional socio-economic structure can mitigate and reduce environmental, so called man-made hazard.