• Journal of Korean Society of Transportation
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• v.3 no.1
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• pp.76-85
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• 1985

The significant role of transportation system for economic development process has been recognized, but the argument that transportation improvements stimulate economic development has brought sometimes no resonance in lacking of a plausible theory on the conditions and process of economic development by transportation investment. This paper reviews the theory on regional differentiation of transportation system and shows why and how the installation of a new transportation system or the improvements of the old transportation quality differentiate the spatial order of economic activities. It presents the interaction between the change of transportation quality with introducing of definition "transportation value" as tool of its determination and economic activities following the regional differentiation process, which result means regional defferentiation of niveau of economic development.

• Korean Institute of Interior Design Journal
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• v.21 no.1
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• pp.280-288
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• 2012

The purpose of this study is to deduct influence factors by analyzing preferences for public design that can increase user satisfaction through differentiated identity of regions. The study methods are as follows. First, consider a concept and semantic change of public design through the relevant literatures and precedent studies and then understand application status of domestic and overseas public design. Second, extract design elements for regional differentiation through precedent studies and reclassify regional resources that have an effect. Third, understand the necessity level of public design for regional differentiation by targeting experts and research the extracted design element and the degree of reflection about regionality. Lastly, understand a correlation between design elements and influence factors about territorial regionality of public design based on the researched contents, and analyze the degree of reflection between each other. As a result of this study, a plan that used 'material' and 'color' had high preference on the aspect of design elements and this is an important element that can show regional differentiation of regions. public design of showing regional differentiation. Thus, it is considered that various methods of using 'material' and 'color' must be planned. 'Public space' among design territories was most effective, and the following was 'public facility'. In particular, 'public space' has high preference of using 'natural resources' and 'industrial resources', and therefore an effect of a plan that uses these is judged to be positive. This study can use these results as basic data that suggested the standard for utilization of regional factors for regional differentiation of public design.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.80-104
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• 1996

The development of routine techniques for the isolation and in vitro maintenance of conducting airway epithelial cells in a differentiated state provides an ideal model to study the factors involved in the regulation of the expression of mucocilicary differentiation. Several key factors and conditions have been identified. These factors and conditions include the use of biphasic culture technique to achieve mucociliary differentiation and the use of such stimulators, the thickness of collagen gel substratum, the calcium level, and vitamin A, and such inhibitors, the growth factors EGF and insulin, and steroid hormones, for mucous cell differentiation. Using the defined culture medium, the life cycle of the mucous cell population in vitro was investigated. It was demonstrated that the majority of the mucous cell population in primary cultures is not involved in DNA replication. However, the mucous cell type is capable of self-renewal in culture and this reproduction is vitamin A dependent. furthermore, differentiation from non-mucous cell type to mucous cell type can be demonstrated by adding back a positive regulator such as vitamin A to the “starved” culture. Cell kinetics data suggest that vitamin A-dependent mucous cell differentiation in culture is a DNA replication-independent process and the process is inhibited by TGF-${\beta}$1.

• Journal of the Korean association of regional geographers
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• v.11 no.2
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• pp.211-232
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• 2005

Recently, Korean agriculture and rural areas face a huge crisis due to the change in the market environment of agricultural products under WTO and FTA. Thus, rural policy needs to break from the agriculture-centered sectoral perspective and to develop the various potentials in rural areas. The transformation of rural policy is also required from the aspect of increasing regional differentiation in rural areas. In this context, the paper aims to classify the regional types of rural areas and analyse their features in geographical location, population, farming, public finance and so an. The result of analysis shows that rural areas can be classified into 5, 9 or 15 regional types by stages. This implies that there is significant regional differentiation ill rural areas. However, there is regional polarization as much as differentiation in rural areas. In this point, rural policy should catch up regional polarization as well as diversity in rural areas.

• Journal of the Economic Geographical Society of Korea
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• v.8 no.2
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• pp.285-299
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• 2005

The economic reform in China since 1978 has been increasingly sped up and deepened. The recent development of private enterprises, especially, has significant economic and political implications, whereas its regional differentiation has considerable impacts on both the development potential of certain regions and overall regional growth pattern. This study aims to understand the regional pattern of private enterprise growth as well as the institutional change which has structured the growth process. The development of private enterprises turned out to be closely tied to the marketization strategy of dual-track system and policy needs to reduce the unemployment level in both urban and 겨ral China. The regional pattern of the private enterprise growth can be characterized as ever-increasing spatial differentiation. Based on the basic statistical analysis results, it is argued that the private enterprise growth is closed related with the marketization level of the regional economy. Therefore, the strategy of developing private sector will be more important in shaping the regional development path as well as potential.

• Journal of Distribution Research
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• v.8 no.2
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• pp.21-39
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• 2003

The objective of this study is examining regional differentiation of private brand customer. Factors found to influence private brand purchase intention included familiarity with private brand, perceived value, store loyalty, perceived risk, perceived quality variation between national and private brand products. For testing the research model, data were collected in Seoul and Busan. The hypothetical paths included in model are supported. There are regional differentiations in 1) negative relation of perceived quality variation and perceived value, 2) positive relation of familiarity and purchase intention, and 3) positive relation of store royalty and purchase intention.

• International Journal of Stem Cells
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• v.15 no.3
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• pp.247-257
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• 2022

Background and Objectives: Although human-induced pluripotent stem cells (hiPSC) can be efficiently differentiated into cardiomyocytes (CMs), the heterogeneity of the hiPSC-CMs hampers their applications in research and regenerative medicine. Retinoic acid (RA)-mediated signaling pathway has been proved indispensable in cardiac development and differentiation of hiPSC toward atrial CMs. This study was aimed to test whether RA signaling pathway can be manipulated to direct the differentiation into sinoatrial node (SAN) CMs. Methods and Results: Using the well-characterized GiWi protocol that cardiomyocytes are generated from hiPSC via temporal modulation of Wnt signaling pathway by small molecules, RA signaling pathway was manipulated during the differentiation of hiPSC-CMs on day 5 post-differentiation, a crucial time point equivalent to the transition from cardiac mesoderm to cardiac progenitor cells in cardiac development. The resultant CMs were characterized at mRNA, protein and electrophysiology levels by a combination of qPCR, immunofluorescence, flow cytometry, and whole-cell patch clamp. The results showed that activation of the RA signaling pathway biased the differentiation of atrial CMs, whereas inhibition of the signaling pathway biased the differentiation of sinoatrial node-like cells (SANLCs). Conclusions: Our study not only provides a novel and simple strategy to enrich SANLCs but also improves our understanding of the importance of RA signaling in the differentiation of hiPSC-CMs.

• Journal of the Korean association of regional geographers
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• v.9 no.2
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• pp.119-134
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• 2003

This paper analyzes Wu Ha-Youngs Cheonilrok in order to reconstruct the regional characteristics of farming in the late 18th-century Korean countryside. The projected objective is approached through the examination of various indices drawn from the volume such as environment, distribution of arable lands, major crops, agricultural techniques, and productivity. The main finding of this research is that unlike todays homogenous picture of agriculture, quite significant differences of agrarian practices existed across the country in the past. The regional differentiation was attributable foremost to natural environment. To elaborate, landform, climate and soil influenced the distribution and use of land plots, the kinds of main crops produced, and the agricultural productivity. The region-specific agricultural techniques result from the cumulative processes of trial and error against the given environment. Other social and economic conditions which include population, skill of the peasants, size of landownership, and irrigation facilities sustained the regional differentiation of agriculture.

• Nutrition Research and Practice
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• v.15 no.5
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• pp.579-590
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• 2021

BACKGROUND/OBJECTIVES: Petasites japonicus Maxim (P. japonicus) has been used as an edible and medicinal plant and contains many bioactive compounds. The purpose of this study is to investigate the effect of P. japonicus on osteogenesis. MATERIALS/METHODS: The leaves and stems of P. japonicus were separated and extracted with hot water or ethanol, respectively. The total phenolic compound and total polyphenol contents of each extract were measured, and alkaline phosphatase (ALP) activity of each extract was evaluated to determine their effect on bone metabolism. To investigate the effect on osteoblast differentiation of the aqueous extract of P. japonicus leaves (AL), which produced the highest ALP activity among the tested extracts, collagen content was measured using the Sirius Red staining method, mineralization using the Alizarin Red S staining method, and osteocalcin production through enzyme-linked immunosorbent assay analysis. Also, real-time reverse transcription polymerase chain reaction was performed to investigate the mRNA expression levels of Runt-related transcriptional factor 2 (Runx2) and Osterix. RESULTS: Among the 4 P. japonicus extracts, AL had the highest values in all of the following measures: total phenolic compounds, total polyphenols, and ALP activity, which is a major biomarker of osteoblast differentiation. The AL-treated MC3T3-E1 cells showed significant increases in induced osteoblast differentiation, collagen synthesis, mineralization, and osteocalcin production. In addition, mRNA expressions of Runx2 and Osterix, transcription factors that regulate osteoblast differentiation, were significantly increased. CONCLUSIONS: These results suggest that AL can regulate osteoblasts differentiation, at least in part through Runx2 and Osterix. Therefore, it is highly likely that P. japonicus will be useful as an alternate therapeutic for the prevention and treatment of osteoporosis.

• Journal of the Korean association of regional geographers
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• v.10 no.3
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• pp.592-605
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• 2004

The research analyzes data on housing(apartments) value and educational level(45$\sim$59 aged) in Seoul. The results of the research show that: since the economic crisis of 1997 out of which Korea was rescued by the IMF, it is evident that the spatial process of increasing residential segregation and the regional differentiation of housing price are inextricably interrelated. Through time-series analysis for the education level by the administrative unit of Dong in Seoul, already in 1990 the residential segregation by the educational groups was observed, it is acknowledged that this residential segregation has been reproduced continuously. The rate of residence of the highly educated groups in an administrative Dong is closely related to the variation of the housing value within the Dongs. The housing value in the period 1997$\sim$2003 has risen sharply in the regions where highly educated groups are spatially concentrated. That of other regions have stagnated or have risen marginally thus, the regional differences of the housing value have greatly increased. The differentiation of housing price reflects the residential segregation.