• Proceedings of the KIEE Conference
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• summer
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• pp.36-38
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• 2004

This paper presents an application of parallel hybrid Genetic Algorithm-Tabu Search (GA-TS) algorithm to search an optimal solution of a recokiguration in distribution system. In parallel hybrid CA-TS, after CA operations, stings which are not emerged in the past population are selected in the reproduction procedure. After reproduction operation, if there are many strings which are in the past population, we add new random strings into the population, if there's no improvement for the predetermined iteration, local search procedure is executed by TS for the strings with high fitness function value. To show the usefulness of the proposed method, developed algorithm has been tested and compared on a distribution system in the reference paper.

• Korea journal of population studies
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• v.11 no.1
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• pp.185-196
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• 1988

This study considers inter-jurisdictional fiscal externalities between a central city and suburbs, rigorously examines. and empirically tests the suburban-exploitation-of-central-cities hypothesis. Using micro-migra4ion data, house-holds 'intra-metropolitan migration between 1985 and 1990 Is examined based on a random utility model. It is found that efficient population distribution between a central city and suburbs can be achieved when local government stake into account inter-jurisdictional externalities. External aids from the federal and state governments should be given to public services such as education, welfare, health, and employee retirement services, if they intend to arrest central city decline. Regional tax sharifs can be another way of dealing with these externalities.

• Journal of the Korean Institute of Rural Architecture
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• v.21 no.3
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• pp.61-68
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• 2019

Dramatic increase of population migrating from suburban area to metropolitan area which started in 1990s resulted in the increase of aging population among this area. Centralized population also causes decreased number of students in suburban areas which in turn affects environmental facilities such as school and brings social issue. Additionally, compared to the alternative analysis and data regarding internal spatial arrangement of high school, there are not enough data or information on external spatial arrangement and how to construct such space. Therefore, the main purpose of this thesis is to provide fundamental data which can be used as a reference in improving educational environment of suburban high school by analyzing and investigating various factors including location, accessibility, facility status, and external spatial arrangement based on arrangement type of 8 normal high schools located across Jeju Island where the trend of decreasing number of students is prominent. Following is the result of such investigation. Despite the fact that high schools from suburban areas in Jeju Island possess diversity based on local characteristic, construction of external space is rather inconsistent as the plans regarding external space is not organized. Therefore, there is a need for preparing external spaces appropriate for each school based on the number of students and the characteristic of gymnasium.

• Spatial Information Research
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• v.8 no.1
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• pp.171-182
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• 2000

Random sampling or systematic sampling method is commonly used to assess the accuracy of classification results. In remote sensing, with these sampling method, much time and tedious works are required to acquire sufficient ground truth data. So , a more effective sampling method that can retain the characteristics of the population is required. In this study, fractal analysis is adopted as an index for reference sampling . The fractal dimensions of the whole study area and the sub-regions are calculated to choose sub-regions that have the most similar dimensionality to that of whole-area. Then the whole -area s classification accuracy is compared to those of sub-regions, respectively, and it is verified that the accuracies of selected sub regions are similar to that of full-area . Using the above procedure, a new kind of reference sampling method is proposed. The result shows that it is possible to reduced sampling area and sample size keeping up the same results as existing methods in accuracy tests. Thus, the proposed method is proved cost-effective for reference data sampling.

• Korean Journal of Clinical Pharmacy
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• v.19 no.1
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• pp.50-60
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• 2009

Highly variable drugs (within-subject variability greater than 30%) have been difficult to meet current regulatory acceptance criteria using a reasonable number of study subjects. In this study, we reviewed previous studies presenting alternative approaches for bioequivalence evaluation of highly variable drugs, and focused on an approach for widening the bioequivalence acceptance limits using within-subject variability. We discussed the suggested five solutions for highly variable drug including the deletion of $C_{max}$ of the bioequivalence criteria, direct expansion of bioequivalence limit, multiple dose studies in steady state, bioequivalence assessment on the metabolite, add-on study, and widening the bioequivalence acceptance limits based on reference variability. The methods for widening of bioequivalence limits based on reference variability are scaled average bioequivalence containing within-subject variability on reference drug (${\sigma}_{WR}$), population bioequivalence derived from total variability on reference drug (${\sigma}_{TR}$) and test drug (${\sigma}_{TT}$), and individual bioequivalence derived from subject by formulation interaction variability (${\sigma}_D$) and within subject variability on reference drug (${\sigma}_{WR}$) and test drug (${\sigma}_{TR}$). To apply these methods, the switching variability (${\sigma}_0$) will have to be set by the regulatory authorities. The proposals of bioequivalence evaluation approach for the highly variable in Korea are presented for both of new drug and reevaluation drug.

• Journal of Oral Medicine and Pain
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• v.38 no.4
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• pp.367-372
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• 2013

To diagnose sensory nerve damage, patient values for thermal stimuli as quantitative sensory test (QST) can be compared with the values of the general population (absolute reference data) or to values measured at contralateral unaffected side (relative reference data). It is well know that relative reference data are more sensitive for detecting sensory abnormality than absolute reference data. However it is still lack of the studies for comparisons between relative and absolute data. This study aimed to evaluate the validity of relative reference data and compare the sensitivities of the two approaches in the orofacial region. In 19 young Korean women as normal subjects, quantitative somatosensory thermotest were done in the forehead, cheek, mentum, lower lip and tongue tip bilaterally. After we get the standard deviations (SD) of average reference data and relative reference data, the ratios SD absolute data/SD relative data were calculated. Our study showed that relative reference data for side to side comparisons in the same patient have the high ratios than the absolute reference data, i.e. the side to side comparisons with relative reference data exhibit gain in sensitivity in assessment of sensory abnormality.

• Health Policy and Management
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• v.7 no.1
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• pp.155-182
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• 1997

Objectives : This study was designed to compare North Korea and South Korea in measures of the quality of life (physical quality of life index and human development index) and to investigate the impact of selected medical and socioeconomic factors on PQL variables. Data and Methods : The World Bank, the United Nations Development Programme, and Population Reference Bureau were the principal sources of statistical data of 121 countries. Variables included infant mortality, life expectancy at birth, literacy rate, secondary school enrollment (male and female), GNP per capita, population per doctor, daily calorie supply per capita, and a composite PQL index. The Ordinary Least Square model was employed for cross-countries analysis. Findings : Both countries under quite different political and economic systems saw big improvememts in the quality of life, reducing mortality and prolonging life expectancy during the past three decades. In recent decad, however, North Korea has experienced abrupt exacerbation in the quality of life. Significant improvements in infant mortality of the population wer attributable mainly to GNP per capita and the secondary school enrollemt of female. The principal predictors of life expectancy at birth were population per doctor, infant mortality, and literacy rate. The secondary school enrollment of female and population per doctor were significantly associated with improvements in the physical quality of life index (PQLI). Conclusion : The results of this study confirmed a point illustrated by other studies : The association between quality of life as a measure of health status and socioeconomic factors was strong and positive. The important contribution of educational attainment in general, female education level in particular to improvements in the quality of life deserves good news for building an integrated health care system in the reunified Korea, taking into account the high level of education two koreas are enjoying. Meanwhile, when a sharp drop in the quality of life has been observed in North Korea under serious economic difficulties and food shortage in recent decade, the significant contribution of economic development to improvements in the quality of life poses bad nows for reunifying Korean health care in economic terms.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9899-9903
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• 2014

Nasopharyngeal carcinoma (NPC) is an uncommon disease in most countries but occurs with much greater frequency in southern China. This study aimed to examine the secular trends of NPC in urban Guangzhou over the time period of 2000-2011 using data from the Guangzhou Cancer Registry. Age-adjusted annual incidence rates of NPC were calculated by the direct method using the WHO World Standard Population (1960) as the reference. The average annual percentage change (AAPC) was used as an estimate of the trend. A total of 7,532 new cases of NPC and 3,449 related deaths were registered. In both genders, the peak incidence occurred in the 50- to 59-year age group, and this age distribution pattern remained similar throughout. The AAPC in NPC incidence rates was -3.26% (95% CI: -5.4%--1.1) for males and -5.74% (95% CI: -8.9%--2.5) for females, resulting in a total decrease of 39.3% (from 22.14 to 13.44 per 100,000 population) for males and 48.6% (from 10.1 to 5.18 per 100,000 population) for females over this 12-year period. The AAPCs in NPC mortality rates were -4.62% (95%CI: -3.5%--5.7) for males and -6.75% (95% CI: -5.2%--8.3) for females, resulting in a total decrease of -46.1% (from 12.1 to 6.54 per 100,000 population) for males and 51.7% (from 4.14 to 2.00 per 100,000 population) for females. The age-adjusted incidence and mortality rates of NPC declined during 2000-2011 in urban Guangzhou but remained high. Future efforts to improve prevention, early detection and treatment strategies are needed.

• Korea journal of population studies
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• v.12 no.1
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• pp.19-29
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• 1989

It is well known that vital statistics is of great importance as basic data for establishing various range of national policies. Especially, vital statistics is important among demographic information for monitoring and evaluating the population policy, for constructing life table, for making population projection, and for studying various aspects of the society. In principle, the production of vital statistics is based on the registration system. It is, however, still observed that there are some limitations in utilizing fully the registration system due to the inherent problems such as problems in its coverage, accuracies and timeliness. Thus, as an alternative, many countries conduct survey on vital statistics in order to supplement the registration system and obtain in-depth data. Korea is no exception in this aspect. The National Bureau of Statistics carries out the so-called Continuous Demographic Survey. This is a kind of multi-round retrospective survey, covering 32, 000 households and having reference period of one month. The survey has also characteristics of multi-subject sample. Thus, surveys on economic activity status of population, house-hold income & expenditure, and social indicators are together conducted with the same sample. It is, however, found that the survey itself tends to have some quality problems. Especially, the quality problems connected with field data collection are summarized as coverage error, non-response error and response error. Although it is inevitable not to be free from these errors, we should make all our efforts to reduce the errors. The probable schemes pointed out in this paper are as follows : 1) the strengthening formal quality control activities, 2) the review of the survey method, i. e., the combining interview method with mail-sending and mail-back method or pick-up method, 3) well documentation for various cases found in every stage of data collection, and 4) the strengthening the analytical activities. It is, also, emphasized that sincerity of planners and interviewers is the most important factor among other things.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.9
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• pp.1393-1400
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• 2018

Objective: This study was carried out to assess the haplotype diversity and population dynamics in cattle populations of Ethiopia. Methods: We sequenced the complete mitochondrial cytochrome b gene of 76 animals from five indigenous and one Holstein Friesian${\times}$Barka cross bred cattle populations. Results: In the sequence analysis, 18 haplotypes were generated from 18 segregating sites and the average haplotype and nucleotide diversities were $0.7540{\pm}0.043$ and $0.0010{\pm}0.000$, respectively. The population differentiation analysis shows a weak population structure (4.55%) among the populations studied. Majority of the variation (95.45%) is observed by within populations. The overall average pair-wise distance ($F_{ST}$) was 0.049539 with the highest ($F_{ST}=0.1245$) and the lowest ($F_{ST}=0.011$) $F_{ST}$ distances observed between Boran and Abigar, and Sheko and Abigar from the indigenous cattle, respectively. The phylogenetic network analysis revealed that all the haplotypes detected clustered together with the Bos taurus cattle and converged to a haplogroup. No haplotype in Ethiopian cattle was observed clustered with the reference Bos indicus group. The mismatch distribution analysis indicates a single population expansion event among the cattle populations. Conclusion: Overall, high haplotype variability was observed among Ethiopian cattle populations and they share a common ancestor with Bos taurus.