• 한국콘텐츠학회논문지
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• 제12권10호
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• pp.237-253
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• 2012

본 연구는 이혼한 부부들이 현실적으로 이혼 후 대안의 하나로 고려해보거나 혹은 실행하는 재결합에 대하여 사이버상에서 이루어지는 이혼 후 재결합과 관련된 논의의 내용을 살펴보고자 하였다. 이를 위해 이혼 후 재결합과 관련된 인터넷 웹사이트에서 이혼 후 재결합을 고민 중인 다양한 일곱 가지 사례들을 택하여 각각의 사례들에 대해 사이버공동체 성원들이 재결합을 지지 혹은 반대하는 의견을 중심으로 이혼 후 재결합에 대한 인식을 살펴보았다. 그 결과 사이버공동체 성원들은 다양한 이유에서 이혼 후 재결합에 대해 지지하였다. 즉, 재결합에 대한 준비나 전배우자의 이혼 후 이성관계의 포용, 이혼이유의 성찰과 전배우자의 약점을 감싸주려는 노력이 전제되었을 때 그리고 혼인 신고 없이 재결합을 해보는 것, 자녀를 위해서는 재혼보다 재결합이 나을 것이라는 생각, 전배우자와의 이혼 후 성적 관계가 이루어진 경우 이혼 후 재결합을 지지하며 긍정적으로 인식하였다. 반면에 사이버공동체 성원들이 이혼 후 재결합에 대해 부정적으로 인식하며 반대하는 이유도 있었다. 즉, 시간이 갈수록 재결합의지가 약화될 것이라는 예측과 이혼한 전배우자에 대한 용서가 어려운 점, 전배우자의 무반성적이고 믿을 수 없는 태도, 외도로 인한 이혼의 경우 전배우자의 외도 재발의 우려, 재결합에 대한 전배우자의 진정성 결여, 성급한 재결합 결정으로 인한 후유증에 대한 염려, 이전의 갈등 해결 이 선행되지 않은 재결합으로 인한 재이혼의 문제, 전배우자의 단점 불변에 대한 생각 등으로 이혼 후 재결합에 대해 부정적으로 인식하였다. 아직 재결합을 하지 않고 재결합을 고민 중인 사례들에 대해 사이버공동체 성원들의 찬반 의견과 조언이 다양했던 반면, 자녀를 위해 이미 재결합을 결정한 사례에 대해서는 대부분의 사이버공동체 성원들은 재결합을 지지하며 긍정적으로 인식하였다. 이러한 연구의 결과는 이혼 후 재결합에 대한 학문적 논의와 사회적 관심이 미흡한 상황에서 이혼증가로 익명성이 보장된 사이버공간상에서 이혼 후 재결합을 둘러싼 논의들이 활발히 이루어지고 있음을 보여주며 아울러 이혼 후 재결합에 대한 사이버공동체 참여자들의 인식을 통해 추후로 이혼 후 재결합의 성패요인에 대한 학문적, 실천적 논의를 확장시켜 가는데 일조할 수 있을 것이다.

• IMMUNE NETWORK
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• 제1권1호
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• pp.36-44
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• 2001

Background : Peritoneal metastasis is one of the maj or types of the stomach cancer recurrence and the role of the adhesion molecules is thought to be very much important in this event. Retinoic acid (RA) has been known to induce the growth inhibition and differentiation of various malignancies, and apoptpsis and the change of expression of adhesion molecules have been reported to be involved in the action of RA. Methods : We studied the adhesion abilities of SNU-1, SNU-5, and SNU-6 cells to the peritoneal endothelial cells as well as the expression of the adhesion molecules (CD44, ICAM-1) in Western blot analysis. And also we studied the expression of apoptosis and the change of expression patterns of the various isoforms of CD44 and the change of the adhsion abilities of the cell line cells after RA treatment. Results: CD44 was expressed in SNU-5 and -16, together with an isoform in SNU-16. ICAM-1 was not expressed in any of the cell line cells tested. After the treatment of RA in the concentration range of $1-5{\times}10^{-5}M$ to three stomach cancer cell lines, growth inhibition, apoptosis and the change of expression of the CD44 were noted. After RA treatment, the expression of CD44H was weakly increased in SNU-1, and was markedly increased in SNU-5. In SNU-16, the expression of CD44H was decreased while that of CD44E were markedly increased. The adhesibility of cells to peritoneal cells was increased in relation with the increase of the CD44H expression, which shows the fact that the adhesibility of tumor cells to peritoneal mesothelial cells is mediated by CD44H recognizing hyaluronic acid. Conclusion : RA induces growth inhibition of stomach cancer cell line cells and increase the adhesiblity of stomach cancer cell line cells to peritoneal mesothelium. It is believed that RA decreases the metastatic ability of stomach cancer cells by upregulating the CD44H expression.

• 대한간호학회지
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• 제30권5호
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• pp.1279-1291
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• 2000

The main objectives of this study were to analyze the concept of hope, so to provide basic data to develop a valid instrument to measure hope, and to develop hope enhancing nursing intervention a program for cancer patients. The hybrid model approach was applied in three phases, the theoretical phase, the empirical phase, and the analytic phase. The study was developed on universal attributes explaining generalized hope and specific hope, which were revealed in a comprehensive review of the literature. In the empirical phase, eight cancer patients undergoing chemotherapy were interviewed to reveal causes, motivation, and their resource of hope according to The Hope Assessment Guide (Farren, Herth, & Popovich, 1995). In the analytical phase, the results of the two previous stages of the study were compared. The results were as follows : In the theoretical phase, six dimensions of hope emerged; affective, cognitive, behavioral, affiliative, temporal and contextual dimension. The antecedent of hope was loss, crisis, uncertainity, and stress. The consequences were renewal, development of new methods, safety, peace and transcendental competence. In the empirical phase, these six dimensions emerged as theoretical phases were verified and specified as these descriptive terms: feeling, intention, expectation, activity, relation, future- orientation, reality and goal-setting. The antecedent factor of hope was occurrence or recurrence of cancer. The consequence of hope was ability to cope with real condition, feeling of safety and comfort, peace, development of new strategy and recovery of disease. The major content of hope in this phase was related to specific hope, but it was also influenced on by general hope. In the analytic phase, general and specific hope was renamed as trait and state hope. All attributes emerged at the empirical phases, and also emerged at the theoretical phase. However, cognitive and contextual dimensions were revised and specified. In conclusion, the concept of hope is divided into trait hope and state hope, and state hope is an anticipatory expectation that occurs at the time of a stressful stimulus, such as being diagnosed with cancer. Hope is a multidimensional dynamic energized mental state which has the dimensions of affective, cognitive, behavioral, affiliative, temporal and contextual. There should be further studies to develope the state and trait hope scale according to definition and attributes of hope investigated in this study. In addition, considering results of the empirical phase, the family is very a important factor as a resource of hope, so it is necessary to consider family in implementing a nursing intervention program to enhance hope.

• 대한골관절종양학회지
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• 제12권1호
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• pp.30-36
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• 2006

목적: 유상피 육종은 매우 드물며 예후 예측이 힘든 육종이다. 본 연구는 병기, 잔존 종양의 유무, ezrin 발현과 유상피 육종의 임상 양상과의 관계를 분석하였다. 대상 및 방법: 23예를 대상으로 하였다. 전 예에서 수술을 시행하였으며 보조적 치료로 15예는 화학요법을, 6예는 방사선 치료를 하였다. 15예에서 면역조직화학 염색을 하였다. 분석한 인자는 병기, 보조적 요법, 국소 재발, 잔여 종양, 면역조직화학 결과, 절제연이었다. 결과: 15예의 병기 II및 III 환자의 무병 생존율은 129 개월에 47.4%, 8예의 병기 IV환자의 실질 생존율은 80개월에 37.5%였다. 재 절제한 병리 표본에 잔존 종양의 존재 유무가 무병생존에 유의한 인자였다(P=0.03). 보조적 요법의 유무가 치료 결과와 상관은 없었다. 병기 IV와 국소 재발한 예에서 Ezrin 발현이 호발하는 경향이 있었다. 결론: 잔존 종양의 유무가 예후에 중요하였으며 보조적 치료는 결과에 영향을 미치지 못하였다. Ezrin 발현과 예후 사이의 상관 관계를 알기 위해 좀더 많은 증례 분석이 요구된다.

• 한국콘텐츠학회논문지
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• 제17권10호
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• pp.472-482
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• 2017

본 연구에서는 최근 7개년(2011~2017학년도)의 수학교과내용학 기출문항 가운데 이산수학 문항을 분석대상 문항으로 분류하고, 수학과 임용시험 문항 분석틀을 기반으로 분류된 문항을 분석하였다. 그 결과 첫째, 한국교육과정평가원이 제시한 이산수학 평가 영역 및 평가 내용 요소가 고르게 출제될 필요가 있다. 둘째, 인지적 방법의 활용에 대한 전략적 지식인 메타인지적 지식(Metacognitive Knowledge)을 측정하는 문항도 출제되어야 한다. 셋째, 이산수학의 출제 비중은 문항 수로는 비율이 3.8%~6.8%이고, 배점에 따른 비율은 이 보다 낮은 2.2%~6.3% 사이로 출제되었다. 넷째, 모든 문항이 평가 목표에 적합하고 교육과정을 성실하게 이행한 예비 수학교사라면 해결 할 수 있도록 적정한 난도가 유지된 것으로 분석된다. 다섯째, 임용시험 문항과 각 사범대학 수학교육과에 개설된 이산수학 교육과정의 세는 방법, 점화관계와 생성함수, 그래프 등의 내용요소가 일치하고 있어 예비 교사의 학습 동기 부여에 기여하고 있다는 결론과 시사점을 얻었다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.807-813
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• 2016

Triple-negative breast cancers constitute about 15% of all cases, but despite their higher response to neoadjuvant chemotherapy, the tumors are very aggressive and associated with a poor prognosis as well as a higher risk of early recurrence. This study was retrospectively performed on 101 patients with stage II and III invasive breast cancer who received 6-8 cycles of neo-adjuvant chemotherapy. Out of the total, 23 were in the triple negative breast cancer subgroup. Nuclear Ki-67 expression in both the large cohort group (n=101) and triple negative breast cancer subgroup (n=23) and its relation to the pathological response were evaluated. The purpose of the study was to identify the predictive value of nuclear protein Ki-67 expression among patients with invasive breast cancers, involving the triple negative breast cancer subgroup, treated with neoadjuvant chemotherapy in correlation to the rate of pathological complete response. The proliferation marker Ki-67 expression was highest in the triple negative breast cancer subgroup. No appreciable difference in the rate of Ki-67 expression in triple negative breast cancer subgroup using either a cutoff of 14% or 35%. Triple negative breast cancer subgroup showed lower rates of pathological complete response. Achievement of pathological complete response was significantly correlated with smaller tumor size and higher Ki-67 expression. The majority of triple negative breast cancer cases achieved pathological partial response. The study concluded that Ki-67 is a useful tool to predict chemosensitivity in the setting of neoadjuvant chemotherapy for invasive breast cancer but not for the triple negative breast cancer subgroup.

• 한국안전학회지
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• 제35권4호
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• pp.64-73
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• 2020

As Korean government and safety-related organizations make continuous efforts to reduce the number of industrial accidents, accident rate has steadily declined since 2010, thereby recording 0.48% in 2017. However, the number of fatalities due to industrial accidents was 1,987 in 2017, which means that more efforts should be made to reduce the number of industrial accidents. As an essential activity for enhancing the system safety, accident analysis can be effectively used for reducing the number of industrial accidents. Accident analysis aims to understand the process of an accident scenario and to identify the plausible causes of the accident. Accident analysis offers useful information for developing measures for preventing the recurrence of an accident or its similar accidents. However, it seems that the current practice of accident analysis in Korean manufacturing companies takes a simplistic accident model, which is based on a linear and deterministic cause-effect relation. Considering the actual complexities underlying accidents, this would be problematic; it could be more significant in the case of human error-related accidents. Accordingly, it is necessary to use a more elaborated accident model for addressing the complexity and nature of human-error related accidents more systematically. Regarding this, HFACS(Human Factors Analysis and Classification System) can be a viable accident analysis method. It is based on the Swiss cheese model and offers a range of causal factors of a human error-related accident, some of which can be judged as the plausible causes of an accident. HFACS has been widely used in several work domains(e.g. aviation and rail industry) and can be effectively used in Korean industries. However, as HFACS was originally developed in aviation industry, the taxonomy of causal factors may not be easily applied to accidents in Korean industries, particularly manufacturing companies. In addition, the typical characteristics of Korean industries need to be reflected as well. With this issue in mind, we developed HFACS-K as a method for analyzing accidents happening in Korean industries. This paper reports the process of developing HFACS-K, the structure and contents of HFACS-K, and a case study for demonstrating its usefulness.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1889-1894
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• 2013

Background: Basaloid squamous cell carcinoma of the esophagus (BSCCE) is a rare and distinctive tumor with no standard treatment. This study aimed to explore treatment in relation to prognosis of the disease. Methods: A total of 142 patients with BSCCE that underwent treatment in our hospital from March 1999 to July 2010 were retrospectively analyzed. All patients received surgery, 42 postoperative radiotherapy and 28 patients chemotherapy. Results: There were 26 patients included in stage I, 60 in stage II, 53 in stage III and 3 in stage IV. The clinical symptoms and macroscopic performances of BSCCE did not differ from those of typical esophageal squamous cell carcinoma. Among 118 patients receiving endoscopic biopsy, only 12 were diagnosed with BSCCE. The median survival time (MST) of the entire group was 32 months, with 1-, 3- and 5-year overall survival (OS) of 81.4%, 46.8% and 31.0%, respectively. The 5-year OS of stage I and II patients was significantly longer than that of stages III/IV, at 60.3%, 36.1% and 10.9%, respectively (p<0.001, p=0.001). The MST and 5-year OS were 59.0 months and 47.4% in patients with tumors located in the lower thoracic esophagus, and 27.0 months and 18.1% in those with lesions in the upper/middle esophagus (p=0.002). However, the survival was not significantly improved in patients undegoing adjunctive therapy. Multivariate analysis showed TNM stage and tumor location to be independent prognostic factors. Furthermore, distant metastasis was the most frequent failure pattern, with a median recurrence time of 10 months. Conclusion: BSCCE is an aggressive disease with rapid progression and a propensity for distant metastasis. It is difficult to make a definitive diagnosis via preoperative biopsy. Multidisciplinary therapy including radical esophagectomy with extended lymphadenectomy should be recommended, while the effectiveness of radiochemotherapy requires further validation for BSCCE.

• 부모자녀건강학회지
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• 제6권1호
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• pp.70-81
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• 2003

The otitis media has the highest rate of occurrence in 6-36 month after birth, and relatively high rate of occurrence to six years old. It is one of major cause for hearing loss problem because of its high rate of recurrence. The researcher observed at bed that feeding posture and feeding habit at night have some relationship with occurrence of otitis media. I found that medical research in this area was very weak, and it caused her to concentrate her research on the topic. This paper was undertook a retrospective case-control study to find out the relationship between the mode of feeding and the occurrence of otitis media among the otitis media patients and the healthy persons. As the controling groups, the researcher chose fifty eight mothers whose children received the treatment of otitis media(6-36 months after birth) from the pediatrics clinic of two general hospitals in Seoul, as the patient group, and forty five mothers who consulted with their child to well baby clinic at the general hospital and kindergarten in Seoul as the control group. The results of the survey can be summarized as followed : 1. "Otitis media patient group may have more lying posture mothers while feeding than the healthy control group". The first hypothesis is supported by the fact that the children who have lying posture feeding habit mothers are more easily exposed to otitis media than those who have sitting posture feeding habit mothers as the analysis show : $X^2=8.142$, p = .017 2. "Otitis media patient group may have higher rate of sleeping habit with milk bottle on the month at night than the healthy control group does". The second hypothesis was supported by the fact that the patients group has higher rate of expected sleeping habit than the healthy group dose as the analysis show : $X^2=4.35$, p = .037 3. "Otitis media can be found more in the artificial feeding group than in the healthy children group". The hypothesis is rejected by the analysis, $X^2=1.550$, p = .416. Though the hypothesis is not supported by this research, we need to encourage mothers to feed mother's breast milk on the ground that healthy group has mother's milk feeding tendency, and the best food for infants is their mother's milk, and psychological-sociological effects of breast feeding os quite good for children. It will improve the health of infants. It can be summarized as follows : Otitis media is more concerned with posture of feeding and night feeding habits than feeding modes. On the basis of this survey, feeding education problem for mothers of infants need to be developed. In the education, sitting-embracing posture of feeding, mother's breast feeding, and prohibition of children's lying posture feeding at night need to be emphasized.

• 전자공학회논문지
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• 제50권10호
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• pp.188-198
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• 2013

일반적으로 최대평탄 하프밴드 필터들은 다른 필터들에 비해 넓은 주파수 영역을 가지고 있다. 이것은 필터의 주파수 응답을 직접적으로 제어하기 위한 필터 차수의 여분이 없이 단지 $z={\pm}1$에서 최대 가능한 제로 수를 갖도록 설계된 것으로 독립된 파라미터가 없기 때문이다. 본 논문에서는 천이 대역폭 직접 제어가 가능한 FIR 하프밴드 필터들의 설계를 위한 새로운 방법을 제안하였다. 제안된 방법은 필터의 0번째 계수인 $h_0$를 파라미터화한 일반화된 라그랑지 하프밴드 다항식(g-LHBP)을 기반하고 있으며, $h_0$를 제어함으로써 요구되는 주파수 응답을 갖는 필터를 설계하는 방식이다. 이때 $h_0$는 g-LHBP 재귀관계의 이론적 분석을 통하여 천이대역의 경사도 파라미터로 모델링하였다. 또한, 이 방식은 요구된 필터 특성(:천이대역의 경사도와 대역 평탄도 사이의 균형) 선택과 관련된 설계 파라미터들(:필터 계수들)의 직접적인 계산을 위한 명확한 공식을 제공한다. 설계 예시들은 제안된 방식이 최대평탄 하프밴드 필터들 보다 상대적으로 날카로운 천이대역 경사도를 가진 하프밴드 필터의 설계에 적합한 솔루션임을 보여준다.