• 대한방사선기술학회지:방사선기술과학
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• 제34권4호
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• pp.305-314
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• 2011

분진에 노출된 집단의 흉부 디지털영상에서 진폐 소견에 따라 흉부 저선량 CT영상에서 발견된 소견을 비교 분석하였다. 2007년 4월부터 2008년 8월 사이 일개 진폐정밀건강진단기관에 내원한 진폐정밀건강진단 대상자 남자 328명에 대해 저선량 CT촬영을 실시하였고, 진폐 판독경험이 많은 1명의 영상의학과 전문의가 판독하였다. 흉부 디지털영상의 진폐 소견은 국제노동기구 흉부 영상 분류법(ILO, 2000)따라 아날로그 표준 사진을 참조하여 2명의 영상의학과 전문의가 합의 판독한 결과로부터 얻었고, 소음영의 병형에 따라 진폐 소견이 없는군(87명, 26.5%)과 있는군(241명, 73.5%)으로 분류하였다. 진폐 소견이 있는군에서 나이(60.9 vs. 65.0, p<0.001)와 분진노출기간(17.0 vs. 19.2, p=0.024)이 통계학적으로 유의하게 높았지만, 흡연력은 차이가 없었다. 전체 대상자 328명 중 245명(74.7%)이 저선량 CT영상에서 13 종류의 소견이 발견되었다. 진폐 소견이 없는군 보다 있는군에서 관상동맥 석회화 소견이 통계학적으로 의미 있게 높은 빈도를 보였고(25.3% vs. 36.9%, p=0.049), 벌집모양 소견도 높은 빈도를 보였다(1.2% vs. 6.2%, p=0.079). 하지만, 저선량 CT영상에서 진폐 소음영을 시사하는 작은 결절은 진폐 소견이 없는 군에서 더 높은 빈도를 보여 흉부 디지털영상이 민감도가 낮았다. 이상의 결과에서 분진 노출에 의한 진폐 소견이 저선량 CT영상의 관상동맥 석회화 소견과 유의한 관련성을 보였지만, 독립적인 위험요인임을 규명하기 위해서는 관상동맥 혈관 조영술을 이용한 전향적인 추가 연구가 필요할 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제40권3호
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• pp.274-282
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• 1993

연구배경 : 국내에서 폐흡충의 발생은 과거에 비하여는 현저하게 감소되었으나, 국내의 일부 가정에서 감염된 민물게로 게장을 만들어 먹음으로 아직도 이 질환이 산발적으로 발생되고 있는 실정이다. 환자 진단시 그 환자와 같이 음식을 먹은 병력이 있는 가족 구성원들도 역시 이환 가능성이 높으므로 비록 그 당시 증상이 없더라도 이들에 대한 검사 및 치료도 중요하다고 사료된다. 방법 : 폐흡충증으로 확진된 환자 74예를 대상으로 환자의 성별 및 연령분포, 과거력 및 임상증상, 검사실 소견, 방사선학적 소견등을 분석하였으며, 치료후에도 추적이 가능하였던 13예의 환자에서는 특이 항체(ELISA)의 변동을 관찰하였다. 또 가족적으로 진단된 가족 구성원들간의 임상증세 및 방사선학적 소견등에 유사성이 있는지 여부를 확인하여 보았다. 결과 : 남녀비는 약 2.2:1 이었다. 가장 많은 연령층은 40~49세였다. 민물게장을 먹은 병력은 총 대상 환자 중 58예 (78%)에서는 뚜렷하였고, 7예(10%)에서는 불명확하였으나, 9예(12%)에서는 이를 먹은 기억은 없다고 하였다. 내원시 환자의 증상은 63예(85%)에서는 호흡기 증상을 호소하였고, 11예(15%)에서는 호흡기 증상은 없었다. 폐흡충 충란은 피검예 74예중 29예(39%)에서 발견되었으며 45예(61%)는 충란을 발견하지는 못하였다. 환자 74예중 53예(72%)에서 비정상적인 흉부 X-선소견을 보였고, 21예(28%)에서는 정상 소견으로 판독되었다. 흉부 X-선의 비정상적인 소견중 폐실질성 병변은 40예(75%), 늑막성 변화는 33예(63%)에서 관찰되었다. 결론 : 폐흡충증으로 확진된 7예의 환자들의 가족에서 환자와 함께 민물게장등의 음식을 먹은 가족구성원 13예에 모두에서 피내반응검사와 혈청 특이항체 양성소견을 보여, 이들이 환자와 같이 폐흡충증에 이환되었음을 확인하였다.

• 한국병원경영학회지
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• 제11권3호
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• pp.42-55
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• 2006

The present study is designed to develop surveying tools to measure stressors of and social supports for Radiological Technologists which may play a role to alleviate their stresses caused from their job environments. For this purpose, an analysis of reliability by factors of personal stressors was conducted on 890 radiologists who are working at 44 general hospitals in 16 cities and provinces across the country. The results of the analysis may be summed up as follows: Six factors in 2 concerned fields turned out to be major tools for use as items of questionnaires to measure social supports for and organizational culture of Radiological Technologists. The factors determined to be applicable for survey with reliability coefficient of more than 0.7 measured by factors for internal coherence included social supports on the job(0.90), off-the-job social supports(0.81), job satisfaction(0.80), devotion for job by length of service(0.81) and emotional devotion for job(0.80), all deemed to be appropriate as survey items. In the verifying process of the results, it was found that normative devotion for job(0.61) showed lower reliability as its statistical coefficient was analyzed to be less than 0.7. It seemed, therefore, necessary to reconstruct items or re-select such ones only that can maintain internal coherence in order to analyze appropriateness of related measuring tools, or to develop new measuring tools. Although the outcomes of this study can be used to verify reliability and appropriateness of concerned concepts to assess stresses caused during the job performance of Radiological Technologists, it may be improper to adopt them to measure all types of social supports and stresses that occur generally under the job environment. It is desired, however, to compare and analyze the findings of the present study with others and to utilize them as basic data for further development of tools that can maintain internal coherence in terms of reliability and appropriateness in spite of changing social environments.

• Journal of Korean Neurosurgical Society
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• 제42권2호
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• pp.92-96
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• 2007

Objective : The authors have speculated that metastatic brain lesions from renal cell carcinoma (RCC) show diverse radiological patterns and tumor responses after Gamma knife surgery (GKS), and have hypothesized that these can be predicted from tumor radiological characteristics. The goal of the current study was to identify the radiological characteristics of RCC brain metastases and the predictors of initial radiosurgical response after GKS. Methods : A retrospective analysis was performed on 48 lesions in 18 patients with RCC brain metastasis treated by GKS. The radiological characteristics of these lesions in magnetic resonance images (MRI) were classified into 3 categories according to enhancement patterns in T1-weighted images and signal intensity characteristics in T2-weighted images. Responses to GKS were analyzed according to these categories, and in addition, other potential predictive factors were also evaluated. Results : MRI findings in the three categories were diverse, though numbers of the lesion were comparable. At 2-month MRI follow-ups after GKS, response rate was 54% and the local tumor control rate 83%. T2 signal intensity was found to be the principal predictive factor of response to GKS, namely negative predictive factor. Other variables such as age, sex, tumor volume, dose, duration from initial diagnosis to GKS, and previous systemic therapies failed to show significant relationships with treatment response by multivariate analysis. Conclusion : Careful evaluation of the radiological characteristics of brain metastases from RCC is important prior to GKS because MRI heterogeneity has predictive value in terms of determining initial tumor response.

• 대한디지털의료영상학회논문지
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• 제16권1호
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• pp.49-59
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• 2014

For this study, this researcher conducted a questionnaire survey of college students as juniors who were majoring in radiology at universities located in Daegu and Gyeongbuk. The distribution and collection of the questionnaire copies were made from April 2nd to 30th, 2013 when the researcher explained the purpose of this study to those students and asked them to fill in the documents. Out of the distributed coies, 220 were finally collected and analyzed. The findings of this study can be summarized as follows. 1. Concerning conventional images of the radiological technologists, the male college students of radiology were most affirmative about 'being rational and logical' and 'doing business with putting patients first' while, the female ones of the same major, 'being accurate in doing business' and 'being reliable'. 2. Regarding social images of the radiological technologists. the male college students of radiology were most affirmative about 'being highly intellectual' while, the female ones of the same major, 'being attractive in profession'. 3. In terms of professional images of the radiologist, the college students, irrespective of gender, were most affirmative about 'having highly professional skills' and 'having expertise'. 4. In relation to personal images of the radiologist, both the male and female college students of radiology were most affirmative about 'being kind', but most negative about 'being egocentric'. 5. The radiology students' perceived images of the radiological technologists, and their self-esteem were statistically, significantly correlated with each other. Among those images, conventional ones were found most correlated with self-esteem.

• Nuclear Engineering and Technology
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• 제55권12호
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• pp.4576-4582
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• 2023

The Korea retrospective dosimetry (KREDOS)-electron paramagnetic resonance (EPR) group undertook an intercomparison investigation utilizing hydroxyapatite. This analysis involved four institutions: the Korea Institute of Radiological and Medical Sciences, Dongnam Institute of Radiological and Medical Sciences, Korean Association for Radiation Application, and Radiation Health Institute of Korea Hydro & Nuclear Power. Following the irradiation of the hydroxyapatite sample, the recorded build-up was analyzed. To validate the reliability of the EPR dosimetry findings and enhance its operational performance, a hydroxyapatite dose-response curve was plotted and dosimetry was performed for a blind sample. The proficiency of each laboratory was assessed by employing an interlaboratory comparison methodology. This involved a comparative analysis of the measurement results by calculating the relative bias, z-score, and En value. The results submitted by the participating laboratories demonstrated satisfactory ratings for doses of 1.006, 3.999, and 6.993 Gy. Following the second intercomparison, efforts to optimize their hydroxyapatite-EPR dosimetry systems are underway in the participating laboratories. The current assessment of hydroxyapatite dose yielded the foundational data required to establish the parameters of dental dosimetry. In future, the third intercomparison experiment will be conducted for exploring other materials.

• 대한방사선기술학회지:방사선기술과학
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• 제28권1호
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• pp.45-53
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• 2005

전국 16개 시도의 44개 3차 의료기관에 근무하는 방사선사의 직무환경에서 발생되는 스트레스원과 개인적인 관련요인을 분석한 결과는 다음과 같다. 근무환경에서 스트레스원에 영향을 주는 개인적인 관련요인은 직위, 직무만족도, 신체화 증상이고, 역할관련에서는 직무만족도와, 신체적 증상이며, 직무안정성에 있어서는 직위와 직무만족도가 많은 영향을 주는 요인으로 나타났다. 직무자율성에서 영향을 주는 요인은 연령, 직위, 직무만족도이고, 직무부담에서는 직무만족도, 행동적 증상이며, 직무갈등에서는 직장동료, 직속상관, 직무만족도, 신체적 증상이 영향을 많이 주고 있는 것으로 나타났다.

• Tuberculosis and Respiratory Diseases
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• 제58권6호
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• pp.554-561
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• 2005

The clinical and radiographic findings of lung cancer have been well established many journals. Even if the radiographic findings of lung cancer show a typical pattern, the specific cell type of lung cancer sometimes needs to be determined prior to a pathological diagnosis. For example, the usual finding of a squamous cell carcinoma is similar to other cancer types such as an adenocarcinoma or a small cell carcinoma but with a lower incidence. Therefore, it should not be used to make a diagnosis of the cell type prior to a pathological diagnosis. Many unusual findings of lung cancer, so called atypical pattern have been reported, but atypical findings are widely accepted. The more important thing is not to diagnose a specific cell type of cancer but to differentiate it from other benign conditions such as tuberculosis, fungal infections or organizing pneumonia. This paper presents typical information of the cell type of lung cancer along with the atypical radiographic findings.

• Molecules and Cells
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• 제38권4호
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• pp.327-335
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• 2015

Piperlongumine, a natural alkaloid isolated from the long pepper, selectively increases reactive oxygen species production and apoptotic cell death in cancer cells but not in normal cells. However, the molecular mechanism underlying piperlongumine-induced selective killing of cancer cells remains unclear. In the present study, we observed that human breast cancer MCF-7 cells are sensitive to piperlongumine-induced apoptosis relative to human MCF-10A breast epithelial cells. Interestingly, this opposing effect of piperlongumine appears to be mediated by heme oxygenase-1 (HO-1). Piperlongumine upregulated HO-1 expression through the activation of nuclear factor-erythroid-2-related factor-2 (Nrf2) signaling in both MCF-7 and MCF-10A cells. However, knockdown of HO-1 expression and pharmacological inhibition of its activity abolished the ability of piperlongumine to induce apoptosis in MCF-7 cells, whereas those promoted apoptosis in MCF-10A cells, indicating that HO-1 has anti-tumor functions in cancer cells but cytoprotective functions in normal cells. Moreover, it was found that piperlongumine-induced Nrf2 activation, HO-1 expression and cancer cell apoptosis are not dependent on the generation of reactive oxygen species. Instead, piperlongumine, which bears electrophilic ${\alpha},{\beta}$-unsaturated carbonyl groups, appears to inactivate Kelch-like ECH-associated protein-1 (Keap1) through thiol modification, thereby activating the Nrf2/HO-1 pathway and subsequently upregulating HO-1 expression, which accounts for piperlongumine-induced apoptosis in cancer cells. Taken together, these findings suggest that direct interaction of piperlongumine with Keap1 leads to the upregulation of Nrf2-mediated HO-1 expression, and HO-1 determines the differential response of breast normal cells and cancer cells to piperlongumine.

• 대한방사선기술학회지:방사선기술과학
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• 제31권4호
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• pp.323-327
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• 2008

자기양담낭은 담낭 벽에 칼슘이 침착되는 드문 질환이며, 만성담낭염에 의해 벽에 석회화가 일어나거나 결석에 의해 담낭관이 폐색되면서 발생하는 것으로 보고 되고 있다. 자기양담낭은 일반적으로 담낭암을 동반하므로 담낭암을 예방하기 위해 일차적으로 담낭 절제술이 시행된다. 저자들은 증상이 없는 석회화된 담낭을 초음파 검사와 복부 단순방사선검사 및 복부 전산화단층검사를 통해 확인하였고 문헌고찰과 함께 보고하고자 한다.