• Bulletin of the Korean Chemical Society
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• v.33 no.2
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• pp.489-491
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• 2012

An $^{125}I$-labeled resveratrol derivative 1 was synthesized. It was purified by reverse phase HPLC. Radiochemical purity of the product was more than 98%, and the yield was 35% (decay-corrected). Its biodistribution in tumorbearing mice was studied. The results showed that the highest radioactivity was located in intestine and stomach. The biodistribution profile suggests that compound 1 can be effectively used as a promising imaging probe for intestine and stomach.

• Nuclear Engineering and Technology
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• v.49 no.8
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• pp.1752-1757
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• 2017

The aim of this study is to evaluate the radioactivity levels and radiological impacts of representative black sand samples collected from different locations in the Rashid area, Egypt. These samples were prepared and then analyzed using the high-resolution gamma ray spectroscopy technique with a high-purity germanium detector. The activity concentration ($A_c$), minimum detectable activity, absorbed gamma dose rate, external hazard index ($H_{ex}$), annual effective dose rate equivalent, radium equivalent, as well as external and internal hazard index ($H_{ex}$ and $H_{in}$, respectively) were estimated based on the measured radionuclide concentration of the $^{238}U$($^{226}Ra$) and $^{232}Th$ decay chains and $^{40}K$. The activity concentrations of the $^{238}U$, $^{232}Th$ decay series and $^{40}K$ of these samples varied from $45.11{\pm}3.1Bq/kg$ to $252.38{\pm}34.3Bq/kg$, from $64.65{\pm}6.1Bq/kg$ to $579.84{\pm}53.1Bq/kg$, and from $403.36{\pm}20.8Bq/kg$ to $527.47{\pm}23.1Bq/kg$, respectively. The activity concentration of $^{232}Th$ in Sample 1 has the highest value compared to the other samples; this value is also higher than the worldwide mean range as reported by UNSCEAR 2000. The total absorbed gamma dose rate and the annual effective dose for these samples were found to vary from 81.19 nGy/h to 497.81 nGy/h and from $99.86{\mu}Sv/y$ to $612.31{\mu}Sv/y$, which are higher than the world average values of 59 nGy/h and $70{\mu}Sv/y$, respectively. The $H_{ex}$ values were also calculated to be 3.02, 0.47, 0.63, 0.87, 0.87, 0.51 and 0.91. It was found that the calculated value of $H_{ex}$ for Sample 1 is significantly higher than the international acceptable limit of <1. The results are tabulated, depicted, and discussed within national and international frameworks, levels, and approaches.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.147-152
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• 2021

C-11 Radiolabeled amino acid-based radiopharmaceuticals such as [¹¹C]MET for brain tumor PET imaging have limitations due to their short half-life (20 min). F-18 radiolabeled amino acid derivatives have been developed to overcome for the short half-life, one of which is [¹⁸F]FET. Brain tumor imaging using [¹⁸F]FET showed high uptake in tumor region and no non-specific uptake in inflammatory tissue, which was useful in discriminating the difference between inflammation and tumor especially. In this study, [¹⁸F]FET was synthesized using an automatic synthesis module and quality tests were carried out including enantiomeric purity analysis with reference compounds. Radiochemical yield was 50.3 ± 4.9% (n=7, decay-corrected) with molar activity of 76 ± 17 GBq/mmol. The radiochemical purity of >99%. Enantiomeric purity of [¹⁸F]FET using chiral HPLC analysis showed >99%, which was confirmed by co-injection with the L-FET and D-FET authentic standards. [¹⁸F]FET was prepared with high radiochemical yield and molar activity including no racemate mixture.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.8 no.1
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• pp.3-8
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• 2022

Alteration of the mGluR5 density is closely related to various brain diseases including schizophrenia, depression, Parkinson's disease, and Alzheimer's disease. Therefore, mGluR5 is considered as a valuable imaging biomarker for brain disease and many radiopharmaceuticals have been developed so far. Among them, [¹⁸F]FPEB has favorable pharmacokinetic characteristics, and this is the most frequently used radiopharmaceutical for preclinical and clinical studies. In the present study, we want to introduce the optimized radiosynthetic method for the routine production of [¹⁸F]FPEB using a GE TRACERlabTM FXFN pro module. In addition, the entire process was monitored with a webcam to solve the problems arising from the synthetic process. As a result, [¹⁸F]FPEB was prepared by nucleophilic substitution from its nitro- precursor at 120℃ for 20 min in dimethyl sulfoxide. Radiochemical yield was 13.7 ± 5.1% (decay-corrected, n = 91) with the molar activity of 84 ± 17 GBq/µmol at the end of synthesis. The radiochemical purity was determined to be above 96%. The manufactured [¹⁸F]FPEB injection for quality controls were carried out in accordance with an KIRAMS approved protocol, as per ICH and USP guidelines.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.6 no.2
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• pp.61-68
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• 2020

Aggregated neurofibrillary tangles (NFTs) are a pathological hallmark in Alzheimer's disease (AD) and many radiopharmaceuticals targeting NFTs have been developed so far. Among these, [¹⁸F]flortaucipir (TAUVID^TM) is the first approved radiopharmaceutical in the Food and Drug Administration (FDA) to image tau pathology. In the present study, we describe the optimized radiosynthetic method for the routine production of [¹⁸F] flortaucipir using a commercialized automation module (i.e. GE TRACERlab^TM FX_FN pro). [¹⁸F]Flortaucipir was prepared by nucleophilic substitution from its N-tert-butoxycarbonyl protected nitro precursor, tertbutyl 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole-5-carboxylate, at 130℃ for 10 min in dimethyl sulfoxide. The mean radiochemical yield was 20 ± 4.3% (decay-corrected, n = 47) with the molar activity of 218 ± 32 GBq/µmol at the end of synthesis. The radiochemical purity was determined to be above 95%. The overall production time including quality control is approximately 100min. The final produced [¹⁸F]flortaucipir injection meets the USP criteria for quality control. Thus, this fully automated system is validated for clinical use.

• Journal of Radiation Protection and Research
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• v.44 no.4
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• pp.128-148
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• 2019

Massive environmental monitoring has been conducted continuously since the Fukushima Daiichi Nuclear Power accident in March of 2011 by different monitoring methods that have different features together with migration studies of radiocesium in diverse environments. These results have clarified the characteristics of radiological environments and their temporal change around the Fukushima site. At three months after the accident, multiple radionuclides including radiostrontium and plutonium were detected in many locations; and it was confirmed that radiocesium was most important from the viewpoint of long-term exposure. Radiation levels around the Fukushima site have decreased greatly over time. The decreasing trend was found to change variously according to local conditions. The air dose rates in environments related to human living have decreased faster than expected from radioactive decay by a factor of 2-3 on average; those in pure forest have decreased more closely to physical decay. The main causes of air dose rate reduction were judged to be radioactive decay, movement of radiocesium in vertical and horizontal directions, and decontamination. Land-use categories and human activities have significantly affected the reduction tendency. Difference in the air dose rate reduction trends can be explained qualitatively according to the knowledge obtained in radiocesium migration studies; whereas, the quantitative explanation for individual sites is an important future challenge. The ecological half-lives of air dose rates have been evaluated by several researchers, and a short-term half-life within 1 year was commonly observed in the studies. An empirical model for predicting air dose rate distribution was developed based on statistical analysis of an extensive car-borne survey dataset, which enabled the prediction with confidence intervals. Different types of contamination maps were integrated to better quantify the spatial data. The obtained data were used for extended studies such as for identifying the main reactor that caused the contamination of arbitrary regions and developing standard procedures for environmental measurement and sampling. Annual external exposure doses for residents who intended to return to their homes were estimated as within a few millisieverts. Different forms of environmental data and knowledge have been provided for wide spectrum of people. Diverse aspects of lessons learned from the Fukushima accident, including practical ones, must be passed on to future generations.

• Journal of radiological science and technology
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• v.39 no.4
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• pp.637-642
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• 2016

In this study, we prepared and characterized a acrylate based UV-curable plastic scintillator. It was used co-polymers TMPTA, DHPA and Ultima $Gold^{TM}$ LLT organic scintillator. The emission spectrum of the plastic scintillator was located in the range of 380~520 nm, peaking at 423 nm. And the scintillator is more than 50% transparent in the range of 400~800 nm. The emission spectrum is well match to the quantum efficiency of photo-multiplier tube and the fast decay time of the scintillation is 12 ns, approximately. This scintillation material provides the possibility of combining 3D printing technology, and then the applications of the plastic scintillator may be expected in human dosimetry etc.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.275-278
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• 2002

The recognition of the natural background radiation is important not only for radiological education but also for the promotion of people's scientific view about radiation. We made a "room" on the web showing natural background radiation as part of a VRM (Virtual Radiation Museum). The "room" shows the video images of the tracks of charged particles from natural background radiation, alpha and beta ray track from known sources using a Large Scale Diffusion Cloud Chamber. The purpose of this study is to make clear the origin of a kind of track (named A-track) which is thick and easy to recognize with the length less than several cm in the cloud chamber, and to make numerical explanation of its counting rate. The study was carried out using a Large Scale Diffusion Cloud Chamber (Phywe, Germany) installed in the Niigata Science Museum. The Model RNC (Pylon Electronics, Canada) was used as Rn-222 source. Ra-226 activity in RNC was 111.6 Bq calibrated with NIST protocol. Rn-222 gas was injected into the cloud chamber. Continuous video recording with use of Digital Handycam (SONY, Japan) was carried out for 360 min. after injection of Rn-222 gas. The number of alpha-ray track (alpha track) in the video images was analyzed. The growth and decay curve of the total activity of Rn-222 and its alpha emitting progeny were calculated and compared with the count of the alpha tracks. As a result the alpha tracks formed by Rn-222 injection resemble A-Tracks. The relationship between A-track in the cloud chamber and atmospheric Rn is discussed.

• Bulletin of the Korean Chemical Society
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• v.26 no.1
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• pp.91-96
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• 2005

O-(3-[$^{18}$F]Fluoropropyl)-L-tyrosine (L-[$^{18}$F]FPT) was synthesized by nucleophilic radiofluorination followed by acidic hydrolysis of protective groups and evaluated with 9 L tumor bearing rat. L-[$^{18}$F]FPT is an homologue of O-(2-[$^{18}$F]fluoroethyl)-L-tyrosine (L-[$^{18}$F]FET) which recently is studied as a tracer for tumor imaging using positron emission tomography (PET). [$^{18}$F]FPT was directly prepared from the precursor of O-(3-ptoluenesulfonyloxypropyl)- N-(tert-butoxycarbonyl)-L-tyrosine methyl ester. FPT-PET image was obtained at 60 min in 9 L tumor bearing rats. The radiochemical yield of [$^{18}$F]FPT was 0-45% (decay corrected) and the radiochemical purity was more than 95% after HPLC purification. The total time elapsed for the synthesis of [$^{18}$F]FPT was 100 min from EOB (End-of-bombardment). A comparison of uptake studies between [$^{18}$F]FPT and [$^{18}$F]FET was performed. In biodistribution, [$^{18}$F]FPT showed similar pattern with [$^{18}$F]FET in various tissues, but [$^{18}$F]FPT showed low uptake in brain. Furthermore, [$^{18}$F]FPT showed higher tumor-to-brain ratio than [$^{18}$F]FET. In conclusion, [$^{18}$F]FPT seems to be more useful amino acid tracer than [$^{18}$F]FET for brain tumors imaging with PET.

• Journal of the Korean Society of Safety
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• v.31 no.5
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• pp.22-27
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• 2016

The Electrostatic Charge Prevention Technology is a core factor that highly influences the yield of Ultra High Resolution Flat Panel Display and high-integrated semiconductor manufacturing processes. The corona or x-ray ionizations are commonly used in order to eliminate static charges during manufacturing processes. To develop such a revolutionary x-ray ionizer that is free of x-ray radiation and has function to control the volume of ion formation simultaneously is a goal of this research and it absolutely overcomes the current risks of x-ray ionization. Under the International Commission on Radiological Protection, it must have a leakage radiation level that should be lower than a recommended level that is $1{\mu}Sv/hour$. In this research, the new generation of x-ray ionizer can easily control both the volume of ion formation and the leakage radiation level at the same time. In the research, the test constraints were set and the descriptions are as below; First, In order not to leak x-ray radiation while testing, the shielding box was fully installed around the test equipment area. Second, Implement the metallic Ring Electrode along a tube window and applied zero to ${\pm}8kV$ with respect to manage the positive and negative ions formation. Lastly, the ion duty ratio was able to be controlled in different test set-ups along with a free x-ray leakage through the metallic Ring Electrode. In the result of experiment, the maximum x-ray radiation leakage was $0.2{\mu}Sv/h$. These outcome is lower than the ICRP 103 recommended value, which is $1{\mu}Sv/h$. When applying voltage to the metallic ring electrode, the positive decay time was 2.18s at the distance of 300 mm and its slope was 0.272. In addition, the negative decay time was 2.1s at the distance of 300 mm and its slope was 0.262. At the distance of 200 mm, the positive decay time was 2.29s and its slope was 0.286. The negative decay time was 2.35s and its slope was 0.293. At the distance of 100 mm, the positive decay time was 2.71s and its slope was 0.338. The negative decay time was 3.07s and its slope was 0.383. According to these research, the observation was shown that these new concept of ionizer is able to minimize the leakage radiation level and to control the positive and negative ion duty ratio while ionization.