• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.957-961
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• 2014

Purpose: With regard to the protective effect of vitamin D against colorectal cancer (CRC), we evaluated genetic variants that might influence vitamin D metabolism: vitamin D receptor (VDR), vitamin D binding protein (GC), vitamin D 25-hydroxylase (CYP2R1), and vitamin D 25-hydroxy 1-alpha hydroxylase (CYP27B1). Materials and Methods: A total of 657 subjects, including 303 cases with CRC and 354 controls were enrolled in this case-control study. All 657 were genotyped for the four gene variants using PCR-RFLP methods. Results: In this study, no significant difference was observed for VDR (rs2238136), GC (rs4588), CYP2R1 (rs12794714), and CYP27B1 (rs3782130) gene variants in either genotype or allele frequencies between the cases with CRC and the controls and this lack of difference remained even after adjustment for age, BMI, sex, smoking status, NSAID use, and family history of CRC. Furthermore, no evidence for effect modification of the variants and CRC by BMI, sex, or tumor site was observed. Conclusions: Our findings do not support a role for VDR, GC, and CYP27B1 genes in CRC risk in our Iranian population. Another interesting finding, which to our knowledge has not been reported previously, was the lack of association with the CYP2R1 gene polymorphism. Nonetheless, our findings require confirmation and possible roles of vitamin D metabolism-related genes in carcinogenesis need to be further investigated.

• Preventive Nutrition and Food Science
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• v.7 no.2
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• pp.133-138
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• 2002

To examine the cholesterol-towering effects of extruded products made with cassava starch (CS) and blends of cassava starch with either resistant starch (CS-RS) or oat fiber (CS-OF) hamsters were fed with diets containing a high-cholesterol (2%) and high-fat (17%) diet for 20 days. Hamsters fed with a diet containing no cholesterol were used as a control. Total cholesterol (TC) levels in the CS-RS and CS-OF groups were significantly (p>0.05) lower compared to the CS group by 11.5% and 8.5%, respectively. Also, the diets containing fibers decreased the value of low-density lipoproteins plus very low-density lipoproteins fraction by 32.4% (CS-RS diet) and 51.7% (CS-OF), respectively, as compared to the CS diet. Total lipid values were significantly (p<0.05) lower in hamsters fed the CS-RS diet (916 mg/dL) and CS-OF diet (964 mg/dL) as compared to those fed the CS diet (1661 mg/dL). The results obtained in this study suggest that extruded products containing cassava starch blended with either resistant starch or oat fleer, could prevent health problems associated with high levels of cholesterol and hypertriglyceridemia induced by a high cholesterol and fat diet.

• Journal of Broadcast Engineering
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• v.12 no.6
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• pp.641-648
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• 2007

The decoding structure of up-to-date ATSC DTV receivers is well optimized, and it seems that 14.6 dB is the unbreakable minimum SNR in the AWGN channel. But the SNR satisfying the Shannon capacity of DTV receivers is 11.76 dB, So, the SNR gab between the 14.6 dB and the 11.76 dB is about 2.8 dB. In order to approach the Shannon capacity we propose a recursive trellis decoder which uses reliable feedback data obtained by an RS decoder. The performance enhancement of about 0.8 dB can be achieved in case of the AWGN channel.

• Genomics & Informatics
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• v.12 no.4
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• pp.231-235
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• 2014

Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily G, member 2 (ABCG2) gene as being possibly causal. We investigated an association between the single-nucleotide polymorphism (SNP) rs2725220 in the ABCG2 gene and uric acid levels in the Korean population. A total of 991 subjects in Seoul City were used for a replication study with ABCG2 SNP rs2725220. The rs2725220 SNP in the ABCG2 gene was associated with mean uric acid levels (effect per allele 0.25 mg/dL, p < 0.0001). Subjects with the GC/CC genotype had a 1.78-fold (range, 1.22- to 2.62-fold) higher risk of having abnormal uric acid levels (${\geq}7.0mg/dL$) than subjects with the GG genotype. When analyzed by gender, the association with ABCG2 was stronger in men than in women. The association with ABCG2 was much stronger in male subjects with body mass index (BMI) ${\geq}26.4$ (odds ratio, 5.09; 95% confidence interval, 2.41 to 10.8) than in male subjects with BMI < 26.4. This study clearly demonstrates that genetic variations in ABCG2 influence uric acid levels in Korean adults.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2001.04a
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• pp.223-232
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• 2001

This paper describes Genetic Algorithm-Based Relay Search Method, RS-GA, which is developed in this study to search the multiple design variables in the design space. The RS-GA based on Simple-GA consists of some functions to search many variables from some wide variable space. It repeats a Simple-GA, that is the convergence process of the Simple-GA, which makes many time reiteration itself. From the results of the numerical studies, it was actually found that RS-GA can search all peak-variable from the 2D functions including 5 peaks. Finally, RS-GA applied for design-strengthening problems in composite plate girder bridges using the external prestressing technique is also verified.

• Proceedings of the Korean Society of Medical Physics Conference
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• 1999.11a
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• pp.178-181
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• 1999

• Journal of Institute of Control, Robotics and Systems
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• v.14 no.2
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• pp.205-211
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• 2008

This paper describes the method aimed at establishing the equipment measuring the parameter of Cable Network by Best proper Cable Modem and PDA through RS232 interface. In this paper, we propose our creative experimental configuration and develope the Cable Modem (DOCSIS 2.0) superior more performing than the referred Cable Modem (DOCSIS 1.0, 1.1) and the measuring equipment of HFC network compositing of Cable Modem and PDA through RS232 interface. This equipment analyzes Upstream (U/S) and Downstream (D/S) Signal quality and generates the signal of Upstream by CW signal. The paper also provides the experimental results to check the Best Proper Cable Modem and the displayed screen for parameters for SNR, BER and the demodulated IQ diagram of 256QAM through LCD of PDA. Henceforth, it'll be possible to support a variety of the functions for E-mail, Internet, the speed test of WEB connection and the transmission of the measured result real time by PDA.

• Korean Journal of Biological Psychiatry
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• v.13 no.4
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• pp.289-298
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• 2006

Objectives : Autism is a complex neurodevelopmental spectrum disorder with a strong genetic component. Previous neurochemical and genetic studies suggested the possible involvement of glutamate N-methyl-D-aspartate(NMDA) receptor in autism. The aim of study was to investigate the association between the NMDA2B receptor gene(GRIN2B) and autism spectrum disorders(ASD) in the Korean population. Methods : The patients with ASD were diagnosed with Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule based on DSM-IV diagnostic classification. The present study was conducted with the detection of four single nucleotide polymorphisms(SNPs) in GRIK2 and family-based association analysis of the single nucleotide polymorphisms in Korean ASD trios using transmission disequilibrium test (TDT). Results : One hundred twenty six patients with ASD and their biological parents were analyzed. 86.5% were male and 85.1% were diagnosed as autistic disorder. The mean age was $71.9{\pm}31.6$ months(range : 26-185 months). We found that rs1805247 showed significantly preferential transmission(TDT ${\chi}^2$=12.8, p<0.001) in ASD. Conclusion : One SNP in GRIN2B gene was significantly associated with ASD in the Korean population. This result suggests the possible involvement of glutamate NMDA receptor gene in the development of ASD.

• Journal of Satellite, Information and Communications
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• v.8 no.2
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• pp.94-98
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• 2013

A report of security problems and simultaneous operation limits of Standard tone currently used for FTS introduces the development of a next generation FTS. In this paper, BER performance by modulations and channel coding methods for EFTS are compared. Simulation results show that coherent modulations have better BER performance than noncoherent modulations. However the environments of a lunching vehicle may cause serious problems in achieving and maintaining synchronization and the increasing complexity of coherent systems also increases reliability problems. Therefore noncoherent systems are suitable for FTS even though BER performace of noncoherent systems is lower than coherent systems. Noncoherent DPSK has better BER performance than noncoherent CPFSK. However the PEP of noncoherent DPSK is 0.8dB higher than noncoherent CPFSK. Therefore a transmitter of noncoherent DPSK has more output power than noncoherent CPFSK. Convoltional code has better BER performance than RS code. However RS code has a tendency of steeply decreasing BER near the wanted $E_b/N_0$.

• Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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• 2003.02a
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• pp.140-142
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• 2003

We have designed a SFQ (Single Flux Quantum) D2 Cell and Inverter(NOT) for a superconducting ALU (Arithmetic Logic Unit). To optimize the circuit, we have used Julia, XIC and Lmeter for simulations and layouts. We obtained the circuit margin of larger than $\pm$25%. After layout, we drew chip for fabrication of SFQ D2 Cell and Inverter. We connected D2 Cell and Inverter to jtl, DC/SFQ, SFQ/DC and RS flip-flop for measurement.