• Journal of Physiology & Pathology in Korean Medicine
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• v.37 no.6
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• pp.185-192
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• 2023

The purpose of this study is to analyze trends in domestic and international clinical research studies on pharmacopuncture treatment for fractures. We searched five online databases (PubMed, CNKI, RISS, KISS, and OASIS), and selected a total of 13 clinical research studies from Korea and China. Selected studies were analyzed according to publication year, subject, intervention, treatment method, evaluation scale, adverse event, risk of bias, etc. A total of 10 case studies and 3 randomized controlled trials were included. The study subjects were more often female, and the most common type of fracture was vertebral compression fracture. In Korea, herbal medicine preparations and bee venom were used for pharmacopuncture solution, whereas in China, both herbal medicine preparations and Western medicine preparations were used. All studies commonly used local acupoint needling, and in most cases, the treatment period for case study was less than 1 month, and the observation period of randomized controlled trials was diverse. The most frequently used evaluation scale was numeric rating scale, adverse events were mentioned in only three studies, and no adverse events were reported. Overall risk of bias of all included randomized controlled trials was judged "some concerns". According to this study, pharmacopuncture treatment for fractures was found to be relatively effective and safe, but research that complements the limitations of this study is needed.

• Journal of Korean Home Economics Education Association
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• v.30 no.3
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• pp.151-173
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• 2018

The purposes of this study was to identify the magnitude and direction of the effects of Practical Reasoning Instruction (PRI) on students' achievements in Home Economics classes using the meta-analysis method and to examine whether the effects of PRI vary across publication status, study design, year of the studies, school level, gender of students, type of students' achievements, content area, location where the interventions of PRI were conducted, and duration. Thirty-four primary studies with 44 effect sizes were analyzed with calculation method of Becker(1988). A funnel plot method result revealed no publication bias. The results of this meta-analysis are as follows. First, PRI was more effective than traditional instruction on students' achievements. A summary statistic was 0.60 with a standard error of .074, which means that an increase of about two-third of a standard deviation beyond what would be expected from traditional instruction was gained from PRI intervention. Second, categorical and regression analyses were employed to find the sources of variance and moderators that predict the effects of PRI. The moderator analyses revealed no statistically significant effects of publication status, study design, school level, gender of students, type of students' achievements, and duration. Content area, location where the interventions of PRI were revealed to be moderators. It was concluded that PRI was effective in improving students' achievements regardless of publication status, study design, year of the studies, school level, gender of students, type of student achievement, and duration.

• Journal of the Korea Society of Computer and Information
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• v.22 no.4
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• pp.115-122
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• 2017

The purpose of this study was to evaluate the effect of job satisfaction on turnover intention and organizational commitment in nurses through a systematic literature review and meta-analysis. For the study purpose, 26 studies were selected through a systematic process of using several databases and used to estimate the effect size of correlation between 3 variables. Meta-analysis was applied by usingcrandom effects model, and effect sizes on three types were calculated. Results are as follows. First, the effect size of correlation between job satisfaction and turnover intention is -.58. Second, the effect size of correlation between job satisfaction and organizational commitment is .77. Third, for the organizational commitment and turnover intention relationship, the effect of correlation is -0.68. Furthermore, publication bias analysis were assessed the results by using the funnel plot, Egger's regression test, fail-safe N, and trim-and-fill test. Based on these results, implications for the study were discussed.

• Clinical and Experimental Pediatrics
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• v.60 no.7
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• pp.203-207
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• 2017

Chorioamnionitis is an inflammation in the fetal membranes or placenta. When chorioamnionitis develops, fetal lungs are exposed to inflammatory cytokines and mediators via amniotic fluid. Because inflammation plays a pivotal role in the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, fetal lung inflammation induced by chorioamnionitis has been considered to be one of the major pathogenetic factors for BPD. Although there have been a number of studies that demonstrated the relationship between chorioamnionitis and BPD, there are still controversies on this issue. The controversies on the relationship between chorioamnionitis and BPD arise from not-unified definitions of chorioamnionitis and BPD, different study populations, and the proportion of contribution between inflammation and infectious microorganisms. The publication bias also contributes to the controversies. Clinical trials targeting chorioamnionitis or microorganisms that cause chorioamnionitis will answer on the actual relationship between chorioamnionitis and BPD and provide a novel prophylactic strategy against BPD based on that relationship.

• Korean Journal of Adult Nursing
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• v.17 no.5
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• pp.783-792
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• 2005

Purpose: This study was conducted to meta-analyze the effects of hardiness on health-related variables. Method: After review of 19 studies performed by Korean nurses, research variables, statistical data(r or F), and other methodological data were extracted and coded. Research variables were categorized under 5 groups such as health-related behavior, well-being, adaptation, stress, and support according to conceptual similarity. Using SAS program, 20 research variables and 34 effect sizes were calculated after eliminating heterogeneous data by Q-test, Results: Effects of hardiness on whole research variables was .512 and ranged from .322 to .643 by categories. The greatest effect was obtained from well-being category, whereas the smallest effect from stress category. All effect sizes were statistically significant. But fail-safe numbers were small and failed to achieve reasonable tolerance level. Conclusion: Results of meta-analysis indicated that hardiness has a moderate effect on health-related variables. But for improving the reliability of the results by minimizing publication bias, the more hardiness studies should be done.

• The Journal of the Korean dental association
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• v.52 no.8
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• pp.478-490
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• 2014

Recently, importance of meta-analysis is increasing in the field of dentistry, since it is not easy to settle controversies arising from conflicting studies. Meta-analysis is the statistical method of combining results from two or more individual studies that have been done on the same topic. Merits of meta-analysis include an increase in power, an improvement in precision, and the ability to address solution not provided by individual studies. However, it might mislead researchers when variation across studies and publication bias are not carefully taken into consideration. The purpose of this study is to help understand meta-analysis by making use of individual results in dental research paper.

• The Korean Journal of Emergency Medical Services
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• v.23 no.2
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• pp.33-42
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• 2019

Purpose: This study aimed to identify the effects of post-traumatic stress disorder intervention programs on firefighters through a meta-analysis. Methods: Seven studies were selected for meta-analysis. The overall average effect size, effect sizes for each intervention variables, and publication bias were analyzed using Comprehensive Meta-Analysis(CMA) version 2.0 (Biostat, Englewood, NJ, USA). Results: Post-traumatic stress disorder intervention programs were found to have a very low, not statistically significant effect (effect size=-.171, confidence interval=-0.361~0.019, Z=-1.768, p>.05). However, these programs was less than 50 (effect size=-.622). Conclusion: The results of this study suggest that further research on the effects of post-traumatic stress disorder intervention among firefighters is needed in order to develop more effective programs.

• The Korean Journal of Emergency Medical Services
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• v.27 no.1
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• pp.31-41
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• 2023

Purpose: This study was conducted to analyze variables related to paramedic students' major satisfaction comprehensively and present development plans to improve major satisfaction. Methods: Five studies were selected for analysis. The overall average effect size, effect sizes for each related variable, and publication bias were analyzed using Comprehensive Meta-Analysis (CMA) version 2.0 (Biostat, Englewood, NJ, USA). Results: Various known variables related to major satisfaction were found to have little correlation, and paramedic students' major satisfaction were highly correlated variables, such as major commitment (ES=.781), and department adaptation (ES=.722). Conclusion: Research should be continuously conducted to examine additional variables correlated with the major satisfaction of paramedic students.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8653-8658
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• 2016

Background: Heparanase is believed to be involved in gastric carcinogenesis. However, the clinicopathologic features of gastric cancer with high heparanase expression remain unclear. Aim : The purpose of this study was to comprehensively and quantitatively summarize available evidence for the use of heparanase mRNA and protein expression to evaluate the clinicopathological associations in gastric cancer in Asian patients by meta-analysis. Materials and Methods: Relevant articles listed in MEDLINE, CNKI and the Cochrane Library databases up to MARCH 2015 were searched by use of several keywords in electronic databases. A meta-analysis was performed to clarify the impact of heparanase mRNA and protein on clinicopathological parameters in gastric cancer. Combined ORs with 95%CIs were calculated by Revman 5.0, and publication bias testing was performed by stata12.0. Results: A total of 27 studies which included 3,891 gastric cancer patients were combined in the final analysis. When stratifying the studies by the pathological variables of heparanase mRNA expression, the depth of invasion (633 patients) (OR=4.96; 95% CI=2.38-1.37; P<0.0001), lymph node metastasis (639 patients) (OR=6.22; 95%CI=2.70-14.34, P<0.0001), and lymph node metastasis (383 patients) (OR=6.85; 95% CI=2.04-23.04; P=0.002) were all significant. When stratifying the studies by the pathological variables of heparanase protein expression, this was the case for depth of invasion (1250 patients) (OR=2.76; 95% CI=1.52-5.03; P=0.0009), lymph node metastasis (1178 patients) (OR=4.79 ; 95% CI=3.37-6.80, P<0.00001), tumor size (727 patients) (OR=2.06 ; 95% CI=1.31-3.23; P=0.002) (OR=2.61; 95% CI=2.09-3.27; P=0.000), and TNM stage (1233 patients) (OR=6.85; 95% CI=2.04-23.04; P=0.002). Egger's tests suggested publication bias for depth of invasion, lymph node metastasis, lymph node metastasis and tumor size of heparanase mRNA and protein expression. Conclusions: This meta-analysis suggests that higher heparanase expression in gastric cancer is associated with clinicopathologic features of depth of invasion, lymph node metastasis and TNM stage at mRNA and protein levels, and of tumor size only at the protein level. Egger's tests suggested publication bias for these clinicopathologic features of heparanase mRNA and protein expression, and which may be caused by shortage of relevant studies. As a result, although abundant reports showed heparanase may be associated with clinicopathologic features in gastric cancer, this meta-analysis indicates that more strict studies were needed to evaluate its clinicopathologic significance.

• Journal of The Korean Society of Clinical Toxicology
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• v.13 no.2
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• pp.103-110
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• 2015

Purpose: The purpose of this study is to evaluate the effectiveness and the adverse events of high dose insulin/euglycemia therapy in acute calcium channel blocker (CCB) poisoning. Methods: We developed a systematic search strategy and applied it to 4 electronic reference databases. We searched medical journals as well as the bibliographies of relevant articles. All forms of literature relevant to human use of high dose insulin for acute CCB poisoning were included. The literature search was conducted by two investigators in August, 2015 with publication language restricted to English and Korean. Case reports were divided between CCB overdose alone and multi-drug overdose including CCB. The effect and adverse event of high dose insulin and clinical outcome of each case were analyzed. Results: Among 55 searched studies, 20 studies were included. A prospective study, a retrospective study, a systematic review study, and 17 case reports were identified. Case reports consisted of 11 CCB alone and 12 multidrug overdose cases including CCB. Although most cases described significant clinical improvements, one of them showed no beneficial effect. Several adverse events including hypoglycemia and hypokalemia were reported. No significant sequalae from adverse events was reported. Conclusion: Although there were many case reports demonstrating successful use of high dose insulin for CCB poisoning, the effect cannot be estimated due to a possibility of publication bias. Therefore, high dose insulin/euglycemia therapy might be considered adjunctive therapy in cases of CCB intoxication refractory for standard therapy.