• Title/Summary/Keyword: Prior Test

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Chronic Administration of Catechin Decreases Depression and Anxiety-Like Behaviors in a Rat Model Using Chronic Corticosterone Injections

  • Lee, Bombi;Sur, Bongjun;Kwon, Sunoh;Yeom, Mijung;Shim, Insop;Lee, Hyejung;Hahm, Dae-Hyun
    • Biomolecules & Therapeutics
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    • v.21 no.4
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    • pp.313-322
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    • 2013
  • Previous studies have demonstrated that repeated administration of the exogenous stress hormone corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis and results in depression and anxiety. The current study sought to verify the impact of catechin (CTN) administration on chronic CORT-induced behavioral alterations using the forced swimming test (FST) and the elevated plus maze (EPM) test. Additionally, the effects of CTN on central noradrenergic systems were examined by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity in rat brains. Male rats received 10, 20, or 40 mg/kg CTN (i.p.) 1 h prior to a daily injection of CORT for 21 consecutive days. The activation of the HPA axis in response to the repeated CORT injections was confirmed by measuring serum levels of CORT and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Daily CTN administration significantly decreased immobility in the FST, increased open-arm exploration in the EPM test, and significantly blocked increases of TH expression in the locus coeruleus (LC). It also significantly enhanced the total number of line crossing in the open-field test (OFT), while individual differences in locomotor activities between experimental groups were not observed in the OFT. Taken together, these findings indicate that the administration of CTN prior to high-dose exogenous CORT significantly improves helpless behaviors, possibly by modulating the central noradrenergic system in rats. Therefore, CTN may be a useful agent for the treatment or alleviation of the complex symptoms associated with depression and anxiety disorders.

Factors Influencing Health Promoting Behaviors of University Students using Pender's Model (Pender 모형을 활용한 대학생의 건강증진 행위와 영향요인)

  • Kim, Hee-Kyung
    • Women's Health Nursing
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    • v.12 no.2
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    • pp.132-141
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    • 2006
  • Purpose: The purpose of this study was to supply basic data for a health promoting program and to elevate the level of it by examining whether university students' health promoting behaviors were related to health perception, health concept, self- esteem, perceived benefits of action, perceived barriers of action, perceived self-efficacy, activity-related affect, social support, preference, prior related behavior, and a plan for action. Method: Subjects were 192 university students in K city. Data collection method was a structured questionnaire. Data was analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation, and stepwise multiple regression. Result: The most powerful predictor was previous related behavior (36%). Altogether previous related behavior, health status, a plan for action, perceived self-efficacy and number of admissions were proven to account for 57% of health promoting behaviors. Conclusion: It suggested that prior related behavior, health status, a plan for action, perceived self-efficacy, and number of admissions should be considered when developing a students' health promoting program.

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A Study on the Wheel Wear Partern of KTX (고속철도 차륜의 마모유형에 관한 연구)

  • Hur Hyun-Moo;Seo Jung-won;Seo Sung-Il
    • Proceedings of the KSR Conference
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    • 2005.05a
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    • pp.415-420
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    • 2005
  • Korea High Speed Railway of which wheels have been excessively worn during the trial operation prior to opening was additionally applied with solid lubricant besides the existing oil lubricant in order to overcome such excessive wear. Therefore, it was shown that wear status has been improved in the test by which railway system including vehicles and tracks was stabilized during a year's commercial operation, comparing to that with excessive wear in the trial operation prior to opening to the public. In this connection, wheel's wear per mileage was analyzed, based on vehicles in service in order to make out the wheel's wear at present, from which the useful data relating to wheel maintenance could be obtained.

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A Study on the Lifetime Prediction of Device by the Method of Bayesian Estimate (베이지안 추정법에 의한 소자의 수명 예측에 관한 연구)

  • 오종환;오영환
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.19 no.8
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    • pp.1446-1452
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    • 1994
  • In this paper, Weibull distribution is applied to the lifetme distribution of a device. The method of Bayesian estimate used to estimate requiring parameter in order to predict lifetime of device using accelerated lifetime test data, namely failure time of device. The method of Bayesian estimate needs prior information in order to estimate parameter. But this paper proposed the method of parameter estimate without prior information. As stress is temperature, Arrhenius model is applied and the method of linear estimate is applied to predict lifetime of device at the state of normal operation.

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A Novel Oxidation Model with Photolysis for Degradation of Trichlorobenzenes (TCBs)

  • Kim, Jae-Hyoun
    • Environmental Analysis Health and Toxicology
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    • v.12 no.3_4
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    • pp.1-13
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    • 1997
  • First- and second-order kinetic oxidation rates of trichlorobenzenes (TCBs) were obtained and compared by a chemical activation system (CAS) which mimics mixed functional oxidase activity. The system consists of EDTA, ferrous sulfate, ascorbic acid, and $H_2O_2$ in potassium phosphdte buffer (monobasic at pH 7.4). The rate of transformation in CAS was enhanced in the presence and absence of catalase in the sequence 1, 2, 3-TCB < 1, 2, 4-TCB < 1, 3, 5-TCB. In general, the rates of degradation were greater in the test media with catalase. The effect of photolysis on the degradation of the TCBs with the CAS were examined. Sensitized photolysis with nitrite, Fenton's reagent, TiO$_2$ and triethylamine (TEA) studied in concert with the CAS demonstrated significant enhancement of the degradation rate of TCBs. Disappearance rates of TCBs in CAS with prior photolysis or prior photosensitization were at least 10-fold higher than the sum of the rate for each single experiment. This study proves that the combination of the CAS and photolysis can be used as a suitable technique for enhancing degradation of TCBs in aqueous systems.

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Independent Testing in Marshall and Olkin's Bivariate Exponential Model Using Fractional Bayes Factor Under Bivariate Type I Censorship

  • Cho, Kil-Ho;Cho, Jang-Sik;Choi, Seung-Bae
    • Journal of the Korean Data and Information Science Society
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    • v.19 no.4
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    • pp.1391-1396
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    • 2008
  • In this paper, we consider two components system which the lifetimes have Marshall and Olkin's bivariate exponential model with bivariate type I censored data. We propose a Bayesian independent test procedure for above model using fractional Bayes factor method by O'Hagan based on improper prior distributions. And we compute the fractional Bayes factor and the posterior probabilities for the hypotheses, respectively. Also we select a hypothesis which has the largest posterior probability. Finally a numerical example is given to illustrate our Bayesian testing procedure.

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A Study on Education Evaluation Method using Conditioned Fuzzy Number (조건부 퍼지수를 이용한 교육 평가 방법에 관한 연구)

  • 윤경희;김선희;원성현;정환묵
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 1995.10b
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    • pp.279-284
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    • 1995
  • In CAI, it is very important to evaluate the grade of understanding which students reach about the scope of problem which students are studying. In this paper, to find out students' learning achievement, we make students reply to test which the system presents and then lead evaluation result using fuzzy number about answer result. Besides, we define the degree of prior knowledge of studentsd as conditioned fuzzy number and use existing fuzzy accuracy production function begore the stage of using fuzzy number, Next, we apply conditioned fuzzy number to accuracy degree of answer produces by this function. Through this, we come to the conclusion that evaluation result as to the same answer result is changed according to the degree of prior knowledge about the scope which students are studying.

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The Effects of Prior Knowledge, Negative Information and Market Position on the Consumer Attitude about Alliance Apparel Product (의류시장에서 제휴제품에 대한 사전지식, 파트너브랜드의 부정적 정보와 시장 지위가 제휴의류제품에 대한 소비자 태도에 미치는 영향)

  • Hwang, Sun-Jin;Yun, Ji-Young;Chun, Ho-Kyung
    • Journal of the Korean Society of Clothing and Textiles
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    • v.33 no.4
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    • pp.519-530
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    • 2009
  • The purpose of this study is to investigate the effects of the prior knowledge, the market position and negative information of the alliance apparel product on consumer attitude including preference, purchase intent and utility. Smart wear with MP3 was selected for the alliance apparel product. Negative information was manipulated into two types-product related and brand related negative information. 251 subjects participated for the study. For the data analysis, reliability test and three way analysis of variance were conducted. The results showed that when the partner brand has the higher market position, subjects with high prior knowledge revealed preference for the alliance apparel product more. When the partner brand has the higher market position, the subjects who were given the negative information on the alliance apparel product reported preference and utility more than the ones who were given the negative information on the company. The findings of the study imply that apparel industries should make an effort to establish the positive corporate image as well as to produce high quality apparel product. Also marketers should provide consumers with the knowledge about brand new alliance apparel product.

Improvement in Safety Evaluation of Structures using the Bayesian Updating Approach (베이스 경신법을 활용한 구조물 안전성평가 개선)

  • Park, Kidong;Lee, Sangbok;Kim, Junki;Rha, Changsoon
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.29 no.2
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    • pp.115-122
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    • 2016
  • The classical statistical approach using test data samples to estimate true value of Random Variables by calculating mean and variation (standard deviation or coefficient of variation) of samples is very useful to understand the existing condition of the structure. But with this classical approach, our prior knowledge through educational background and professional experience cannot provide any benefit to make decisions by the structural engineers. This paper shows the role of Bayesian methodology by providing chance of using valuable prior knowledge to come up with more accurate estimation of structural condition. This paper also shows how important it is to have a proper prior estimate of Random Variables and corresponding confidence level through gathering and studying more relevant information.

A Study on the Flight Vibration Environmental Specification of Unmanned Flying Vehicle using Random Vibration Test and Analysis Methods (랜덤 진동 시험 및 해석 기법을 이용한 무인 비행체의 비행 진동 환경 규격 연구)

  • Jangseob, Choi;Dongho, Oh
    • Journal of the Korea Institute of Military Science and Technology
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    • v.25 no.6
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    • pp.596-605
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    • 2022
  • In this study, analysis of dynamic characteristics and flight vibration was performed to unmanned aerial vehicles. The analysis model was supplemented by performing a dynamic characteristic test and a random vibration test using manufactured dummy aerial vehicle. For the dynamic characteristic test, a bungee cable was used to implement the free end boundary condition. Prior to the flight vibration test using a multiple electric shaker, a random vibration test was performed to predict the excitation force during the actual flight vibration test. It was judged that the actual test could be predicted more accurately by supplementing the analysis model from the test results. In addition, it was possible to determine the feasibility of the test by predicting the excitation force of the flight vibration test.