• Journal of Pharmaceutical Investigation
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• v.22 no.4
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• pp.289-300
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• 1992

The counter-transport phenomena in the hepatic transport of 1-anilino-8-naphthalene sulfonate (ANS) were kinetically investigated by analyzing the plasma disappearance-time profiles and the transport into the isolated hepatocytes. In vivo "counter transport phenomena" were simulated based on the perfusion model which incorporated the carrier-mediated transport and the saturable intracellular binding. The condition that the mobility of carrier-ligand complex is greater than that of free carrier is not essential for the occurrence of counter-transport phenomenon. To examine the inhibitory effects on the initial uptake of a ligand by the liver, it is necessary to judge whether the true counter-transport mechanism (trans-stimulation) is working or not. The initial plasma disappearance curves of ANS were then kinetically analyzed based on a two-compartment model, in which the ligand is eliminated only from the peripheral compartment (liver compartment). No effects on the initial plasma disappearance rates of ANS were observed after preloading of bromophenol blue (BPB) or rose bengal (RB) in the liver. Inhibitory effect of BPB or RB on the initial uptake (or efflux) rates of ANS by the isolated hepatocytes were not observed, suggesting that the true counter transport mechanism is not working. In conclusion, checking the preloading effects of transstimulation on the initial uptake of a ligand by the liver could be a useful criterion for carrier cycling and common use of the same carrier between two ligands. However, one cannot exclude those possibilities even if the preloading effects cannot be observed.

• Geomechanics and Engineering
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• v.28 no.2
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• pp.157-169
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• 2022

Preloading of soft clays is a common ground stabilization method for improvement of compressibility and the undrained shear strength. The waiting period under preload is a primary design criterion controlling the degree of improvement obtained. Upon unloading the overconsolidation attained with respect to actual loads defines the long term performance. This paper presents a laboratory study for investigation of creep behavior of Famagusta Bay alluvial soft soil preloaded under various effective stresses for analysis of long term performance based on the degree of overconsolidation. Traditional one-dimensional consolidation tests as well as modified creep tests are performed on reconstituted soft specimens. Compressibility parameters are precisely backcalculated using one dimensional consolidation theory and the coefficient of creep is determined using the traditional Cassagrande method as well as two modified methods based on log cycles of time and the inflection of the creep curve. The test results indicated that the long term creep can be successfully predicted considering the proposed method. The creep coefficients derived as part of this method can also be related to the recompression index (recompression index, swelling index) considering the results of the testing method adopted in this study.

• Journal of the Korean Geotechnical Society
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• v.15 no.5
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• pp.99-110
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• 1999

Settlement and consolidation time were predicted through systematic soil investigation at the delta of Nakdong river where the preloading method was applied. Field measurements were executed with well-selected instruments. As the results of the comparison, the predicted settlement on the sand layer of about 20m thick underestimated the observed one by 20%. This underestimation was due to the effects of vibration during installation of PBD, creep, the overestimated deformation modulus, and so on. For the clay layer of about 20m in thickness under the sand layer, an ID analysis for underconsolidated soil initially overestimated the observed settlement by 240%. However, when the laboratory compression curve was reconstructed and a conventional ID analysis for NC clay was applied, the re-calculated settlement of the clay layer was relatively similar with the observed one. And the predicted consolidation time was about 45% less than the observed one, because of different influencing factors.

• Geomechanics and Engineering
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• v.8 no.2
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• pp.187-220
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• 2015

Soil disturbance induced by installation of mandrel driven vertical drains decreases the in situ horizontal hydraulic conductivity of the soil in the vicinity of the drains, decelerating the consolidation rate. According to available literature, several different profiles for the hydraulic conductivity variation with the radial distance from the vertical drain, influencing the excess pore water pressure dissipation rate, have been identified. In addition, it is well known that the visco-plastic properties of the soil also influence the excess pore water pressure dissipation rate and consequently the settlement rate. In this study, a numerical solution adopting an elastic visco-plastic model with nonlinear creep function incorporated in the consolidation equations has been developed to investigate the effects of disturbed zone properties on the time dependent behaviour of soft soil deposits improved with vertical drains and preloading. The employed elastic visco-plastic model is based on the framework of the modified Cam-Clay model capturing soil creep during excess pore water pressure dissipation. Besides, nonlinear variations of creep coefficient with stress and time and permeability variations during the consolidation process are considered. The predicted results have been compared with V$\ddot{a}$sby test fill measurements. According to the results, different variations of the hydraulic conductivity profile in the disturbed zone result in varying excess pore water pressure dissipation rate and consequently varying the effective vertical stresses in the soil profile. Thus, the creep coefficient and the creep strain limit are notably influenced resulting in significant changes in the predicted settlement rate.

• Journal of the Korean Geotechnical Society
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• v.23 no.6
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• pp.5-21
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• 2007

Despite a number of advantages of reinforced earth walls over conventional concrete retaining walls, there exit concerns over long-term residual deformation when they are subjected to repeated and/or cyclic loads, especially when used as part of permanent structures. In view of these concerns, in this paper time-dependant deformation characteristics of geosynthetic reinforced modular block walls under sustained anuor repeated loads were investigated using reduced-scale model tests. The results indicated that a sustained or repeated load can yield appreciable magnitude of residual deformation, and that the residual deformations are influenced not only by the loading characteristics but by the mechanical properties of geogrid. It is also found that the preloading technique can be effectively used in controlling residual deformations of reinforced soils subjected to sustained and/or repeated loads.

• Proceedings of the Korean Information Science Society Conference
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• 2003.10a
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• pp.253-255
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• 2003

오늘날 많은 가전제품들은 다양화. 쌍방성, 효율성, 개방성등 정보화 시대의 주요 특징들과 접목되어 생산되고 있으며, 이중 모바일 제품군(Low End)은 각광받는 주류 제품이라 할 수 있다. 그러나 대부분의 모바일 제품들은 그 특성상 파일 시스템을 지원하지 못하고 있기에, 본 논문에서 모바일 제품의 운영체제로서 파일 시스템이 지원되지 않는 실시간 운영체제(RTOS- Real Time Operation System)를 선택하여 가상머쉰(VM-Virtual Machine)을 설계 및 구현하였다. 위의 지원을 위해 자바 클래스 파일을 C 언어 형태로 변환하여 VM 과 직접적으로 링크하는 방법인 프리링킹(Prelinking), 프리로딩(Preloading) 혹은 로마이징(ROMizing)이라고 알려져 있는 기법을 도입하였다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.6C
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• pp.287-294
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• 2009

Suction Drain Method is a relatively new technique to improve soft ground using vacuum pressure which can be directly applied to the soft ground through drains that the pore water pressure around them are decreased without changing total stress. This can accelerate volume changes and increase strength of the ground. This paper shows the results of field test of the suction drain method applied at dredged and reclaimed clay. To evaluate the improvement effects of soft ground by the suction drain method, this paper analyzed real-time field measurements to the results of the laboratory tests and numerical analysis. The comparisons of the settlement and shear strength between suction drain method and surcharge preloading method show possibilities for replacement of the preloading methods. The settlements by suction drain method were 2.3 times larger and undrained shear strength were 300%~400% higher than surcharge method. Moreover, the water content is decreased about 30% and the preconsolidation pressure is increased about $0.52kgf/cm^2$.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.18 no.3
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• pp.410-424
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• 1993

In this paper, we present new techniques for designing systolic arrya and asynchronous arrays for digital-signal processings. More specifically, we propose a systolic array with simple local interconnections which achieves optimal performance without having undesirable features such as preloading input data or global broadcasting. As asynchronous array for digital-signal processings, which can speed up the total computation time significantly is also which can speed up the total computation time significantly is also presented. The key component of the asynchronous array is a presented. The key component of the asynchronous array is a comunicaiton protocol which controls input data flow properly and efficiently. Finally, performance of the arrays is analyzed and a simulation using Occam programmed in a Transputer network is reported.

• Journal of the Korean Geotechnical Society
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• v.15 no.6
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• pp.285-296
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• 1999

Preloading method is used to prevent the settling of a foundation and to increase the strength of ground by consolidation settlement in advance. But, the embankment used in preloading method brings large deformation and sliding failure in the soft ground. Recently, reinforcement method is often used in embankment in order to prevent sliding failure. But, until now, the research on the stability analysis considering both the rate of strength increase of clay by embankment load and increase of resistance force by the geosynthetics in the embankment body is not found. In this study, the stability analysis program(REAP) for embankment including these two points is developed. By this program(REAP), the stability analysis can be done about during the gradual increase of embankment and the stability counterplan can be established when the safety factor is lower than allowable safety factor of design. After calculating the position of sliding failure surface, the force of geosynthetics which is selected by either the effective tensile strength or tensile force caused by the displacement of soil mass in this position is applied to stability analysis. And the increase of resisting moment can be calculated by this force. Also, the construction period can be estimated and the time for the appropriate counterplan can be decided in order to maintain the stability of embankment. And then, safe and economical embankment design can be performed.

• Journal of the Korean Geosynthetics Society
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• v.21 no.1
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• pp.11-21
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• 2022

In this study, the individual vacuum seepage consolidation method, a new soft ground improvement method, was developed to supplement the conventional suction drain method (individual vacuum preloading method) and the geotechnical behavior was predicted through numerical analysis. If the individual vacuum seepage consolidation method applied, the effect of accelerating settlement and increasing the amount of settlement was high when the aquifer was located in the middle or at the bottom of the layer to the target improvement layer. It was found that the pumping amount in the aquifer does not affect the settlement behavior when it exceeds a certain level. Even vacuum pumping wells were installed in various locations, such as inside or outside of the embankment, the difference in settlement and horizontal displacement was insignificant. In addition, it was predicted that the settlement rate was the fastest and the horizontal displacement (inward) was large when both methods were carried out at the same time. Since this method can reach the target settlement amount very quickly, it was confirmed that it is possible to increase the spacing of vertical drain, thereby securing economic feasibility.