This study was a descriptived research study to determine the impact of empathy, communication competence, and personality on college adaptation among nursing students attending a university in City Y. The research method was a self-administered survey targeting 200 nursing students at a university in Y City, and data were collected from April 29, 2024 to May 27, 2024. The research statistical method used was the SPSS/WIN 25.0 statistical program, and was analyzed using t-test, one-way analysis of variance, Pearson correlation, and multiple regression analysis. In the correlation between each variable, college adaptation is related to empathy(r=.522, p<.001), communication competence(r=.557, p<.001), and personality(r=.561, p<.001). And as a result of regression analysis, as a factor affecting the subjects' college adaptation, second-year students(β=-.148, p=.013) had a higher level of college adaptation than first-year students(β=-.297, p<.001). Additionally, the level of college adaptation was high in the order of empathy(β=.295, p<.001), personality(β=.230, p<.001), and communication competence(β=.157, p=.050), and the explanatory power was 47.6%(Adj R2=.476, p<.001). Therefore, in order for nursing students to adapt to college, various psychological and emotional supports must be provided at the school and department level, and various customized programs that can improve empathy, communication competence, and personality should be developed and applied by considering the characteristics of nursing students by grade.