• Archives of Pharmacal Research
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• v.22 no.6
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• pp.575-578
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• 1999

Derivatives of elema-1,3-diene were synthesized in several steps as polar analogs of $\beta$-elemene, antitumor agent under clinical phase. The lactone ring of compound 1 was opened by LiAlH4 to give diol 2 which was selectively protected by TBDPSCI. After acetylation of the secondary alcohol, the acetylated product was ozonolyzed and reduced to give elemene derivative 4 which was converted to diolefin 8 via selenides subsequent deprotection by tetrabutylammonium fluoride gave two compounds 9, 10.

• YAKHAK HOEJI
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• v.47 no.6
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• pp.345-351
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• 2003

Heptaplatin, cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II), is a novel platinum-based antitumor agent with clinical potential against human stomach cancer and the 3rd generation of the cisplatin. This study was performed to study how cisplain, heptaplatin and sunpla which is a mixture of heptaplatin and mannitol (w: w=l : 2) affect cell viability of SK-MEL-28 human melanoma cell line. Heptaplatin ($IC_{50}$/; 95.35 $\mu$M) and sunpla ($IC_{50}$/; 10.95 11M) were less effect than cisplatin (IC $_{50}$; 10.92 $\mu$M) on the SK-MEL-28 cells. By cell cycle analysis using flow cytometry, it was identified that the cells were arrested at G2/M phase by cisplatin, heptaplatin and sunpla, and percentage of cell death group was increased according to increasing of time and concentration. These results suggest that cisplatin, heptaplatin and sunpla are a novel anticancer agent against human melanoma cell.l.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2013.05a
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• pp.144-145
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• 2013

With the increasing public concerns on sustainability in construction industry around the world, a variety of standards for sustainable construction have been developed and implemented. However, most of the them focuses operation and maintenance phases and do not have been approached integrally in terms of all construction phases. Especially, considering the quantities of environmental loads occurred intensively at the construction phases, it should not be overlooked. Therefore, the purpose of this study is to deduct primary management works for reduction of the potential environmental loads at the construction phases. In order to assess them quantitatively, we conduct a survey from professionals who are in the relevant fields and analyze these data using Fuzzy-AHP.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2011.05a
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• pp.5-6
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• 2011

CO₂ reduction is the most urgent issue the world is facing. So, there should be a measure to reduce the CO₂ emission in construction industry which has more released CO₂ gas than other industries. CO₂ emission of building depend on using energy. Then efficient energy use process working efficiently at CO₂ reduction. Therefore In this study, author find the technical possibility of saving the building energy using the PCM which is able to control heat, storage heat and potential heat. So, it considered that apply to floor heating type which is major heating system of living space in Korea. And evaluate the Using possibility.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2013.05a
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• pp.210-212
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• 2013

The construction cost estimates during the design phase becomes the standard to judge profitability and validity, and is very important in various decision-makings by project owner. However, since approximate costs are quoted when many parts are undecided in the early stage of project, differences are bound to occur between the construction cost calculated through approximate quotation and that put into construction actually. Also, since in existing quotation works, quantity calculations have been dependent on the staff's manual work, involving error potential, and thus differences are likely in quantity calculation depending on the quotation staff's method of calculation. In this study, the process of creating space model to deduce 3D geometry information for approximate quotation in association with knowledge information and the expression for calculation of finishing area were proposed.

• Microbiology and Biotechnology Letters
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• v.25 no.3
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• pp.286-292
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• 1997

This study was undertaken to evaluate an antioxidative activity of silymarin and silybin obtained from Silybum marianum against oxidation of human low density lipoprotein (LDL). The electrophoretic mobility observed apparently was higher phase for LDL oxidized by macrophages compared to native LDL. Silymarin and silybin inhibited the copper-catalysed oxidation of human LDL in a dose-dependent manner. Silymarin and silybin at the concentration of 50 $\mu$M/ml also inhibited the copper catalysed oxidation of LDL induced by the cell J774 and macrophages. LDL reisolated from the cell incubation in the presence of silymarin or silybin was degraded at rates similar with native LDL. Silymarin or silybin found to be potential inhibitors against oxidation of $^{125}$I-LDL by macrophages and endothelial cells.

• Proceedings of the KIEE Conference
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• summer
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• pp.1064-1066
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• 2004

This paper deals with analysis of a 3-phase high speed machine with diametrically magnetized rotor. The field equations due to magnet and stator windings are established in terms of vector potential and 2-d polar coordinate systems and then, characteristic equation of torque and back emf are derived by using field equations. Finally, this paper predicts open-circuit field, armature reaction field distributions, field distributions on load, torque and back emf distributions from those of equations. Results are compared with predictions from corresponding finite element analyses.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.53 no.5
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• pp.253-257
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• 2004

In order to analyze the frequency dependance of ground impedance in grounding grids for lightning and surge protection, a novel method for measuring the ground impedance as a function of frequency were experimentally investigated. The experiments were carried out in rectangular grounding grids with $6{\times}8$ conductors of 22 $mm^2$ buried at a depth of 0.5 m. The test current was injected by the variable frequency inverter whose frequency is linearly controlled for the established period in the range of 5∼500 KHz. The amplitude and phase of ground impedance were calculated from the waveforms of the test current and ground potential rise measured by the band-pass filter tuned in a specific frequency. The frequency dependence of ground impedance was mainly caused by the inductive current flowing through grounding conductors over the frequency of 100 KHz. The proposed measurement method of ground impedance would be applicable to evaluate the transient response characteristics in lightning protection grounding systems.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09a
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• pp.411-412
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• 2006

A high nitrogen PM tool steel has shown to have an excellent galling resistance due to the introduction of a high amount of a low friction phase predominantly consisting of VN. Tool making and heat treatment are according to standard procedures. An increase of tool life of more than two times compared to ordinary tool steels is found. Furthermore, the new low friction tool steel shows a potential for sintered parts with higher densities through the applica bility of increased compaction pressure or minimized lubricant amount.

• 한국방재학회:학술대회논문집
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• 2008.02a
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• pp.629-632
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• 2008

Risk-based security impact evaluation may be affected by various factors according to numerous combinations of explosive devices, cutting devices, impact vehicles, and specific attack location to consider. Presently, in planning and design phases, designers are still often uncertain of their responsibility, lack of information and training of security. Therefore, designers are still failing to exploit the potential to reduce threats on site. In this study, the concept of security impact assessment is introduced in order to derive the performing design for safety in design phase. For this purpose, a framework for security impact assessment model using risk-based approach for bridge structures is suggested. The suggested model includes of information survey, classification of terror threats, and quantitative estimation of severity and occurrence.