• 대한예방한의학회지
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• 제20권1호
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• pp.99-110
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• 2016

In Korea and China, traditional medicine's holistic approaches, based on the views of whole-body and whole-person, have been applied to make the solution of health problem. However, these holistic approaches of traditional korea or chinese medicine have been limited in interpreting their theories in a view of modern scientific aspects of medicine. This limitation seems to be mainly due to the reductionism approaches of modern scientific medicine. Traditionally, science has taken a reductionism approach; dissecting biological systems into their constituent parts and studying them in isolation. However, systems biology based on omics technologies is providing a new thought and method for traditional medicine's research and interpretation. Systems biology uses integrity study as the characteristic and bioinformatic technology as the key method for connecting reductionism and holism. Therefore, it has much in common with the theory of traditional medicine. It was reviewed that how systems biology is applied to traditional medicine in Korea and China. Also it was suggested that more future researches on interpretation between traditional medicine and systems biology must be focused on personalized medicine since systems biology will have a major impact on future personalized therapeutic approaches.

• 대한예방한의학회지
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• 제21권2호
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• pp.1-13
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• 2017

Objectives : This paper serves to explore current trends of systems biology in Traditional Chinese Medicine (TCM) and examine how it may influence the Traditional Korean medicine. Methods : Literature review method was collectively used to classify Introduction to systems biology, diagnosis and syndrome classification of systems biology in TCM perspective, physiotherapy including acupuncture, herbs and formula functions, TCM systems biology, and directions of academic development. Results : The term 'Systems biology' is coined as a combination of systems science and biology. It is a field of study that tries to understand living organism by establishing a theory based on an ideal model that analyzes and predicts the desired output with understanding of interrelationships and dynamics between variables. Systems biology has an integrated and multi-dimensional nature that observes the interaction among the elements constructing the network. The current state of systems biology in TCM is categorized into 4 parts: diagnosis and syndrome, physical therapy, herbs and formulas and academic development of TCM systems biology and its technology. Diagnosis and syndrome field is focusing on developing TCM into personalized medicine by clarifying Kidney yin deficiency patterns and metabolic differences among five patterns of diabetes and analyzing plasma metabolism and biomarkers of coronary heart disease patients. In the field of physical therapy such as acupuncture and moxibustion, researchers discovered the effect of stimulating acupoint ST40 on gene expression and the effects of acupuncture on treating functional dyspepsia and acute ischemic stroke. Herbs and formulas were analyzed with TCM network pharmacology. The therapeutic mechanisms of Si Wu Tang and its series formulas are explained by identifying potential active substances, targets and mechanism of action, including metabolic pathways of amino acid and fatty acid. For the academic development of TCM systems biology and its technology, it is necessary to integrate massive database, integrate pharmacokinetics and pharmacodynamics, as well as systems biology. It is also essential to establish a platform to maximize herbal treatment through accumulation of research data and diseases-specific, or drug-specific network combined with clinical experiences, and identify functions and roles of molecules in herbs and conduct animal-based studies within TCM frame. So far, few literature reviews exist for systems biology in traditional Korean medicine and they merely re-examine known efficacies of simple substances, herbs and formulas. For the future, it is necessary to identify specific mechanisms of working agents and targets to maximize the effects of traditional medicine modalities. Conclusions : Systems biology is widely accepted and studied in TCM and already advanced into a field known as 'TCM systems biology', which calls for the study of incorporating TCM and systems biology. It is time for traditional Korean medicine to acknowledge the importance of systems biology and present scientific basis of traditional medicine and establish the principles of diagnosis, prevention and treatment of diseases. By doing so, traditional Korean medicine would be innovated and further developed into a personalized medicine.

• BMB Reports
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• 제43권10호
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• pp.643-648
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• 2010

Sir William Osler (1849-1919) recognized that "variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the abnormal conditions we know as disease". Accordingly, the traditional methods of medicine are not always best for all patients. Over the last decade, the study of genomes and their derivatives (RNA, protein and metabolite) has rapidly advanced to the point that genomic research now serves as the basis for many medical decisions and public health initiatives. Genomic tools such as sequence variation, transcription and, more recently, personal genome sequencing enable the precise prediction and treatment of disease. At present, DNA-based risk assessment for common complex diseases, application of molecular signatures for cancer diagnosis and prognosis, genome-guided therapy, and dose selection of therapeutic drugs are the important issues in personalized medicine. In order to make personalized medicine effective, these genomic techniques must be standardized and integrated into health systems and clinical workflow. In addition, full application of personalized or genomic medicine requires dramatic changes in regulatory and reimbursement policies as well as legislative protection related to privacy. This review aims to provide a general overview of these topics in the field of personalized medicine.

• 한국한의학연구원논문집
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• 제15권3호
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• pp.35-43
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• 2009

Introduction : Interests in personalized medicine or tailored medicine is growing in recent years, but traditional medicine with properties of tailored medicine have already been developing from many parts of the world. In this review paper, we tried to investigate the current research status and characteristics of traditional constitutional medicine by a comparative study. Methods and Material : We compared Sasang medicine from Korea, Ikkando medicine from Japan, Chinese constitutional medicine, Ayurveda from India. We investigated the current research status by searching academic DBs such as Medline, Riss4u, Kiss, CNKI, CINII. Then we examined characteristics of each medicine from various aspects of physiology-pathology-diagnosis-treatment-prevention. Results : We found out that each constitutional medicine is being studied the most in their native land. In addition, after analysing characteristics of these constitutional medicine, we learned that Sasang medicine and Ayurveda were putting emphasis on psychological factors in physiology-pathology-diagnosis-treatment-prevention, while Chinese constitutional medicine and Ikkando medicine were focusing on pathological factors. Discussion : We studied theories of constitutional medicine in various traditional medicine, and verified that Sasang medicine shares similarities and differences with these medicine. We suggest that deeper understandings of other constitutional medicine and attempts at clinical application can lead to advance of Sasang medicine.

• 대한예방한의학회지
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• 제19권3호
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• pp.171-178
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• 2015

Objective : To assess the utilization patternsand satisfaction factors of Traditional Korean Medicine(TKM) in Korea. Method : The study design of this paper is from a nationally representative random e-mails and interview surveys. In this survey, we asked 2000 Korean adults between the ages of 20 and 69, whether they have used TKM in the past three years and if so, what were their experiences and how satisfied they were with the care they have received. Results : Sixty percent of respondents(n=1239) answered that they had used TKM in the past three years. The odds of using TKM were higher in female(OR 1.48; 95% CI 1.24-1.78) and academic backgrounds of university graduate or beyond (OR 1.27; 95% CI 1.01-1.60), and lower in unmarried person (OR 0.68; 95% CI 0.55-0.84) in the multivariable analysis. The most frequent purpose for seeking TKM and receiving treatment was to 'treat illness'.In addition, the use herbal medicine among types of TKM is statistically significant in sexual groupings.748(60.4%) among TKM users responded that they had a satisfying experience during TKM treatment. In multivariable logistic model, the odds of satisfaction from using TKM were higher in employed groups(OR 1.34; 95% CI 1.02-1.77), the reason for using of personalized medicine into TKM(OR 1.50; 95% CI 1.00-2.26). Conclusion : Korean traditional medicine doctors need to develop and provide the personalized medicine for the group of high utilization rate and satisfaction, and make strategies to disseminate TKM utilization for the group of lower utilization.

• 한국한의학연구원논문집
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• 제16권1호
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• pp.101-109
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• 2010

The medical and healthy paradigm is changing by various reasons such as improving of life quality, the limit of western medicine, demographic changes and so on. And the demand, interest and market size of traditional medicine(TM) and complementary and alternative medicine(CAM) are increasing continuously and there is a good traditional medicine called TKM(Traditional Korean Medicine) in Korea. TKM have differentiated characteristics like nature-friendly, systematic, preventive and personalized medicine from western medicine. TKM with these characteristics have possibility to increase national competitiveness and contribute to growth of economy. At this time, it is necessary to select key area of TKM R&D to increase competitiveness of TKM and to create new growth engine. In this paper, we suggest key area of TKM R&D through SWOT analysis, the analysis of world traditional medicine and expert's counsel. As a result, 3 key area and 10 specific fields of TKM R&D was selected, which they are 'the standardization for TKM technology and technique', 'the development of generic technology based on TKM' and 'the establishment of infrastructure for TKM information and material'. This study may contribute to make plan for TKM research and policy such as TKM middle and long term plan and TKM promotion plan.

• Journal of Acupuncture Research
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• 제32권1호
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• pp.37-51
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• 2015

Objectives : This study aimed to evaluate influential factors affecting patients' surveyed medical service perception of Traditional Korean Medicine(TKM). Methods : This study was a randomized single blind parallel design and 335 patients were participated. After treatment, we carried out a survey about medical service perception index from April 1st 2013 to January 31th 2014. We evaluated and analyzed the difference between Korean internal medicine and acupuncture & moxibustion, and also between the age groups of younger than 30s and older than 40s. Results : As the results of the analysis, acupuncture & moxibustion group had higher points on medical service perception sub factors than Korean internal medicine group. There was no meaningful difference between the age groups. Conclusions : The study showed higher satisfaction with acupuncture & moxibustion than Korean internal medicine, and as variable, department was more influential than age for medical service perception.

• 대한한방내과학회지
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• 제45권1호
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• pp.1-10
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• 2024

Objectives: This study investigated the pattern identification (PI) and clinical index of Parkinson's disease (PD) for personalized diagnosis and treatment. Methods: This prospective observational multi-center study recruited 100 patients diagnosed with PD from two Korean medicine hospitals. To cluster new subtypes of PD, items on a PI questionnaire (heat and cold, deficiency and excess, visceral PI) were evaluated along with pulse and tongue analysis. Gait analysis was performed and blood and feces molecular signature changes were assessed to explore biomarkers for new subtypes. In addition, unified PD rating scale II and III scores and the European quality of life 5-dimension questionnaire were assessed. Results: The clinical index obtained in this study analyzed the frequency statistics and hierarchical clustering analysis to classify new subtypes based on PI. Moreover, the biomarkers and current status of herbal medicine treatment were analyzed using the new subtypes. The results provide comprehensive data to investigate new subtypes and subtype-based biomarkers for the personalized diagnosis and treatment of PD patients. Ethical approval was obtained from the medical ethics committees of the two Korean medicine hospitals. All amendments to the research protocol were submitted and approved. Conclusions: An objective and standardized diagnostic tool is needed for the personalized treatment of PD by traditional Korean medicine. Therefore, we developed a clinical index as the basis for the PI clinical evaluation of PD. Trial Registration: This trial is registered with the Clinical Research Information Service (CRIS) (KCT0008677)

• 대한한의학원전학회지
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• 제21권1호
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• pp.285-294
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• 2008

This study investigated the effectiveness of article writing as a mean to teaching the traditional medical classics. We used questionnaire to evaluate the usefulness of the curriculum, reason for difficulty and measures for improvement. The creative and reasonable thinking was the major reason for difficulty, and this article writing program could be a proper methods to tackle this. We also found that the educational system was not satisfactory since other educative programs were not focusing on this issue. This study showed that this article writing program can be a useful teaching tool for achieving the purpose of traditional medical classics curriculum after several improvements such as more personalized guidance and understanding of anatomy of an article, lesser time burden and easier database access.

• 대한암한의학회지
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• 제20권2호
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• pp.37-49
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• 2015

Objectives : Retroperitoneal liposarcoma (RPS) is a rare solid tumor and has a high recurrence rate after surgery. New complementary and alternative medicine is required to manage symptoms of RPS and side effects of surgery, chemotherapy and radiation therapy. The purpose of this case report is to report two cases of reduction of side effects of surgery and radiation therapy in RPS treated with Wheel Balanced Therapy (WBT) which is a traditional Korean medicine treatment program for patients with cancer. Methods : Two patients with RPS were treated with WBT. Each of patients received personalized WBT schedule including acupuncture. The changes in clinical and laboratory findings were evaluated. Results : The symptoms of patients were improved after about 2 weeks hospitalization. Conclusions : This case report suggests that WBT has a potential to treat side effects of surgery and radiation therapy in patients with RPS. Further rigorous studies are necessary to investigate the therapeutic effects of WBT on RPS.