• Journal of the Korean Society of Visualization
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• v.19 no.1
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• pp.74-80
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• 2021

Cells regulate their shapes and motility by sensing the cues from the internal and external microenvironment. Under different circumstances, microglia, the brain resident immune cells, undergo dynamic phenotypic changes, one of which is a remarkable periodic oscillatory migration in vitro. However, very little is known about the kinematic and dynamic perspectives of this oscillatory behavior. In this study, we tracked the changes in cell morphology and nuclear displacement, and visualized the forces using traction force microscopy (TFM). By correlation analyses, we confirmed that the lamellipodia formation preceded the nuclear translocation. Moreover, traction, developed following lamellipodia formation, was found to be localized and fluctuated at two ends of the oscillating cells. Taken together, our results imply that oscillatory microglial cells feature a viscoelastic migration, which will contribute to the field of cell mechanics.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.28 no.2
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• pp.63-72
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• 2016

An expected-discounted cost model based on RRP(Renewal Reward Process), referred to as a stochastic decision model, has been developed to estimate the optimal period of in-depth inspection which is one of critical issues in the life-cycle maintenance management of harbor structures such as rubble-mound breakwaters. A mathematical model, which is a function of the probability distribution of the service-life, has been formulated by simultaneously adopting PIM(Periodic Inspection and Maintenance) and CBIM(Condition-Based Inspection and Maintenance) policies so as to resolve limitations of other models, also all the costs in the model associated with monitoring and repair have been discounted with time. From both an analytical solution derived in this paper under the condition in which a failure rate function is a constant and the sensitivity analyses for the variety of different distribution functions and conditions, it has been confirmed that the present solution is more versatile than the existing solution suggested in a very simplified setting. Additionally, even in that case which the probability distribution of the service-life is estimated through the stochastic process, the present model is of course also well suited to interpret the nonlinearity of deterioration process. In particular, a MCS(Monte-Carlo Simulation)-based sample path method has been used to evaluate the parameters of a damage intensity function in stochastic process. Finally, the present stochastic decision model can satisfactorily be applied to armor units of rubble mound breakwaters. The optimal periods of in-depth inspection of rubble-mound breakwaters can be determined by minimizing the expected total cost rate with respect to the behavioral feature of damage process, the level of serviceability limit, and the consequence of that structure.

• Annals of Clinical Neurophysiology
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• v.2 no.2
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• pp.119-124
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• 2000

Background : We studied EEG changes during pilocarpine-induced status epilepticus(SE), a widely used model whose EEG characteristics have not been fully described previously. Methods : Male Sprague-Dawley rats weighing 250-350 grams were used as subjects. SE was induced 5-7 days after placement of chronic epidural electrodes, using 360-380 mg/Kg pilocarpine IP. Rats were observed with continuous EEG recording following pilocarpine injection until end of the SE episode. Results : SE occurred in 10/12 rats studied. SE began with a series of discrete seizures $11.1{\pm}3.93$ minutes after pilocarpine injection. $5.2{\pm}2.71$ seizures occurred over $10.9{\pm}4.62$ minutes, until the EEG converted to a waxing and waning pattern, during which the amplitude and frequency of epileptiform activity increased. After $1.4{\pm}1.82$ minutes, a pattern of continuous high amplitude rapid spiking was established. Continuous spiking continued for $3.4{\pm}0.48$ hours with a very gradual decline in amplitude and frequency, until periodic epileptiform discharges(PEDs) began to occur. The EEG consisted primarily of PEDs for another $7.4{\pm}3.09$ hours, until electrographic generalized seizures began to occur. These continued for $5.8{\pm}4.82$ hours until death. Duration of SE was $17.0{\pm}5.88$ hours. Flat periods were a prominent feature during all EEG patterns in this model. Conclusion : EEG features distinctive in pilocarpine SE(but not unique to it) include flat periods during all patterns and resumption of continuous spiking episodes after the onset of PEDs. The sequence of discrete seizures to waxing and waning to continuous spiking to PEDs was identical to that which has been described in humans and other animal models.

• Journal of Astronomy and Space Sciences
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• v.30 no.2
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• pp.79-82
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• 2013

We present the Hilbert-Huang transform (HHT) analysis on the quasi-periodic modulation of SMC X-1. SMC X-1, consisting of a neutron star and a massive companion, exhibits superorbital modulation with a period varying between ~40 d and ~65 d. We applied the HHT on the light curve observed by the All-Sky Monitor onboard Rossi X-ray Timing Explorer (RXTE) to obtain the instantaneous frequency of the superorbital modulation of SMC X-1. The resultant Hilbert spectrum is consistent with the dynamic power spectrum while it shows more detailed information in both the time and frequency domains. According to the instantaneous frequency, we found a correlation between the superorbital period and the modulation amplitude. Combining the spectral observation made by the Proportional Counter Array onboard RXTE and the superorbital phase derived in the HHT, we performed a superorbital phase-resolved spectral analysis of SMC X-1. An analysis of the spectral parameters versus the orbital phase for different superorbital states revealed that the diversity of $n_H$ has an orbital dependence. Furthermore, we obtained the variation in the eclipse profiles by folding the All Sky Monitor light curve with orbital period for different superorbital states. A dip feature, similar to the pre-eclipse dip of Her X-1, can be observed only in the superorbital ascending and descending states, while the width is anti-correlated with the X-ray flux.

• Proceedings of the KSPS conference
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• 2007.05a
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• pp.143-145
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• 2007

Muscle groups that are located in and around the vocal tract can produce audible changes in frequency and/or intensity of the voice. Vocal vibrato is a characteristic feature in the singing of performers trained in the western classical tradition and vibrato is generally considered to result from modulation in frequency amplitude and timbre. Vocal tremor is also characterized by periodic fluctuations in the voice frequency or intensity and vocal tremor is symptom of a neurological disease as Spasmodic dysphonia , Parkinson's disease. Vocal vibrato and Vocal tremor may have many of the same origins and mechanisms in the voice production systems. The purpose of this study is to find acostic character of Korean traditional song Pansori singer's vibrato and Spasmodic dysphonia patient's vocal tremor. twelve Pansori singers and seven Spasmodic dysponia patients participated to this study. Power spectrum and Real time Spectrogram are used to analyze the acoustic characteristics of Pansori singing and Spasmodic dysphonia patient's voice The results are as follows; First, vowel formant differences between Pansori singing and Spasmodic dysphonia patient's voice are higher F1, F3. Second, The vibrato rate show differences between Pansori singing and Spasmodic dysphonia patients;$4^{\sim}6/sec$ and $5{\sim}6/sec$ Vibrato rate of pitch is 5.7 Hz ${\sim}$ 42.4 Hz for Pansori singing , 3.8 Hz ${\sim}$ 27.9 Hz for Spasmodic dysphonia patients ;Vibrato rate of intensity range is 0.07 dB ${\sim}$ 8.26 dB for Pansori singing and 0.07 dB ${\sim}$ 4.81 dB for Spasmodic dysphonia patients

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2002.11a
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• pp.407-411
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• 2002

Ternary sequences are digital codes consisting of discrete values -1, 0, and 1 only. They are advantageous in that the correlation can be carried out using additions only. Also, they feature an ideal circular autocorrelation function, but in channel characterization tasks, the usual requirement is that the linear autocorrelation function be ideal, i.e., a Kronecker delta function. In this article, we consider two approaches to improving their linear autocorrelation or crosscorrelation properties: one is an inverse filtering method with thresholding, and the other is a singular value decomposition (SVD) method. Both methods are simulated under noisy circumstances. The inverse filtering method resulted in an improvement in peak sidelobe level of about 11 dB at an SNR of 30 dB, and the SVD method showed similar performances, albeit more sensitive to noise depending on the singular value selection strategy.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.61 no.11
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• pp.1758-1764
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• 2012

A large number of wire rope has been used in various inderstiries as Cranes and Elevators from expanding the scale of the industrial market. But now, the management of wire rope is used as manually operated by rope replacement from over time or after the accident.It is caused to major accidents as well as economic losses and personal injury. Therefore its time to need periodic fault diagnosis of wire rope or supply of real-time monitoring system. Currently, there are several methods has been reported for fault diagnosis method of the wire rope, to find out the feature point from extracting method is becoming more common compared to time wave and model-based system. This method has implemented a deterministic modeling like the observer and neural network through considering the state of the system as a deterministic signal. However, the out-put of real system has probability characteristics, and if it is used as a current method on this system, the performance will be decreased at the real time. And if the random noise is occurred from unstable measure/experiment environment in wire rope system, diagnostic criterion becomes unclear and accuracy of diagnosis becomes blurred. Thus, more sophisticated techniques are required rather than deterministic fault diagnosis algorithm. In this paper, we developed the fault diagnosis of the wire rope using probability density estimation techniques algorithm. At first, The steady-state wire rope fault signal detection is defined as the probability model through probability distribution estimate. Wire rope defects signal is detected by a hall sensor in real-time, it is estimated by proposed probability estimation algorithm. we judge whether wire rope has defection or not using the error value from comparing two probability distribution.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.10
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• pp.1417-1426
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• 2001

Turbulent flow characteristics in the near wake of a square cylinder have been studied experimentally by using a Digital PIV method. Experiments are performed at the Reynolds numbers of 1600 and 3900 based on the free-stream velocity and the square height. The ensemble averaged turbulence statistics are acquired from 2030 realizations of instantaneous fluctuating velocity field after the conventional Reynolds decomposition. The differences in turbulent intensity and Reynolds shear stress profiles fur both oases indicate that the effect of Reynolds number seems to be descernible mainly due to the occurrence of transition in the separated shear layer. Because of the periodic nature of vortex shedding process, transverse velocity fluctuations contribute dominantly , to turbulent kinetic energy distribution. A comparison with previous LDV data obtained at much higher Reynolds number shows a fairly good agreement each other. It turns out that the effect of Reynolds number diminishes as increasing Reynolds number, which is a well-known feature of a sharp-edged bluff body wake. The streamwise variation of turbulence intensities are compared with those from a circular cylinder along the centerline at the same Reynolds number. The overall magnitudes and the decay rates of turbulence intensities are quite similar, but some differences are noticeble especially in the transverse intensity variation.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 2002.11a
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• pp.407-411
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• 2002

Ternary sequences are digital codes consisting of discrete values -1, 0, and 1 only. They are advantageous in that the correlation can be carried out using additions only Also, they feature an ideal circular autocorrelation function, but in channel characterization tasks, the usual requirement is that the linear autocorrelation function be ideal, i.e., a Kronecker delta function. In this article, we consider two approaches to improving their linear autocorrelation or crosscorrelation properties: one is an inverse filtering method with theresholding and the other is a singular value decomposition (SVD) method. Both methods are simulated under noisy circumstances. The inverse filtering method resulted in an improvement in peak sidelobe level of about 1㏈ at an SNR of 30㏈, and the SVD method showed similar performances, albeit more sensitive to noise depending on the singular value selection strategy.

• Pediatric Infection and Vaccine
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• v.10 no.2
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• pp.200-207
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• 2003

Purpose : Malaria is known to have been eradicated for a few decades through persistent national health program in South Korea. However, malaria caused by Plasmodium vivax has started to reappear incidiously among military personnel near to DMZ since 1993. After then, the number of malarial cases have been increased abruptly year by year. We analyzed the children of indigenous malaria who were diagnosed by peripheral blood smear and malarial antibody test with regards to epidemiologic and clinical manifestations. Methods : The study 13 cases below 15 years of age, who were confirmed as vivax malaria during from January 2000 to August 2003. We retrospectively analyzed epidemiologic data, clinical manifestations, laboratory findings and therapeutic responses. Results : All of 13 cases were indigenous and tested positive for Plasmodium vivax. Of 13 patients, 9 were male and 4 were female. Mean age of onset was $9.5{\pm}3.6$ years old. Ilsan(n=9) was the most prevalent area, the most patients(n=11) were presented in summer (from June to August). A characteristic feature of periodic 3 day fever in patients with P.vivax infection was reported in only 2 among 13 cases. Thrombocytopenia was most prominent findings, which was accompanied by 12 of 13 patients and pancytopenia was appeared in 3 patients on this study. The therapeutic responses of hydroxycholoquine were very good in all cases, and abnormal laboratory findings were recovered and no relapse during follow-up period. Conclusion : Vivax malaria is indigenous in Korea near to DMZ, but recently endemic area seemed to be extended southward. Plasmodium vivax is the cause of indigenous malaria of children. As for children with high fever accompanying thrombocytopenia in endemic area of Korea, malaria must be included in differential diagnosis whether the type of fewer is periodic 3 day fever or not. Malaria antibody test is helpful as a screening test for malaria.