• Journal of Preventive Medicine and Public Health
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• 제39권4호
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• pp.331-338
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• 2006

Objectives: The goal of this study is to measure women's willingness to pay for cancer screening and to identify those factors associated with this willingness to pay. Methods: A population-based telephone survey was performed on 1,562 women (aged 30 years or over) for 2 weeks (9-23th, July, 2004). Data about sociodemographic characteristics, health behaviors, the intention of the cancer screenings and willingness to pay for cancer screening were collected. 1,400 respondents were included in the analysis. The women's willingness to pay for cancer screening and the factors associated with this willingness to pay were evaluated. Results: The results show that 76% of all respondents have a willingness to pay for cancer screening. Among those who are willing to pay, the average and median amount of money for which the respondents are willing to pay are 126,636 (s.d.: 58,414) and 120,000 won, respectively. As the status of education & the income are higher, the average amount that women are willing to pay becomes much more. The amount of money women are willing to pay is the highest during the 'contemplation' stage. Being willing to payor not is associated with a change of behavior (transtheoretical model), the income, the concern about the cancer risk, the family cancer history, the marital status, the general health exam, age and the place of residence. Income is associated with a greater willingness to pay. Old age was associated with a lower willingness to pay. Conclusions: According to the two-part model, income and TTM are the most important variables associated with the willingness to pay for cancer screening. The cancer screening participation rate is low compared with the willingness to pay for cancer screening. It is thought that we have to consider the participants' behavior that's associated with cancer screening and their willingness to pay in order to organize and manage cancer screening program.

• 대한지역사회영양학회지
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• 제4권1호
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• pp.83-94
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• 1999

This study was carried out to investigate the general characteristics of public health nutritionists, the current status of nutrition services operation, the recognition about nutrition services of public health center related man power, the job satisfaction and self-assessment and the need for a retraining course of public health nutritionists. The subjects were 58 public health nutritionists who responded to the questionnaire distributed at the annual retraining program in 1998. The results of this study are summarized as follows. 1) 46.5% of the nutritionists were 26-30 years old, 62.1% were 4 year university graduates 74.1% were food and nutrition majors and 51.7% were daily workers. 2) Among the public health center-related manpower, the recognition about nutrition services was the highest for the manager of family health section, followed by the head of public health centers, and then the general nurse in public health centers. 3) The ranking of the reasons for job satisfaction of the public health nutritionists was, relationship with colleagues(3.84), inhabitants response after nutrition counselling(3.53), specialized value realization/conviction about duty(3.35), contents of the work(3.10), value achievement(3.08), self achievement/development(3.00), self discretion(2.92), participation in policy decisions(2.90), work load(2.75), chance of retraining and acquisition of new information(2.73), working environment(2.69), supervisio $n^port by superiors(2.67), salary(2.38), supply of necessary education material, technique(2.37), and budget security(2.22). 4) The satisfaction of the inhabitant's responses after nutrition counseling was the highest among the 4 year university graduates(p<0.05), the satisfaction of the specialized value realization/conviction about duty was the highest among the nutritionists 26-30 years old(p<0.05). Food and nutrition majors(p<0.05) and those having worked less than 3-5years at public health centers also showed much satisfaction(p<0.05). Satisfaction with the salary was the lowest among the food and nutrition majors(p<0.01) and daily workers(p<0.001). The satisfaction with the participation in policy decisions was the lowest among the daily workers(p<0.01). 5) The ranking for the level of self-assessment were, nutrition and dietetic practice(2.92), communication(2.80), management(2.77), public health science and practice(2.66)(p<0.01). The general characteristics such as the level of education, major, employment condition, current public health center's tenure, and charge experience of the nutrition guidance work were not significantly related to self-assessment except the management part(p<0.05). The higher the satisfaction of specialized value realization/conviction about the duty, the better the total score on the self-assessment(p<0.05)..

• Journal of Biomedical and Translational Research
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• 제19권4호
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• pp.116-124
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• 2018

Korean Native Pig (KNP) has a uniform black coat color, excellent meat quality, white colored fat, solid fat structure and good marbling. However, its growth performance is low, while the western origin Yorkshire pig has high growth performance. To take advantage of the unique performance of the two pig breeds, we raised crossbreeds (KNP ${\times}$ Yorkshire to make use of the heterotic effect. We then analyzed the liver transcriptome as it plays an important role in fat metabolism. We sampled at two stages: 10 weeks and at 26 weeks. The stages were chosen to correspond to the change in feeding system. A total of 16 pigs (8 from each stage) were sampled and RNA sequencing was performed. The reads were mapped to the reference genome and differential expression analysis was performed with edgeR package. A total of 324 genes were found to be significantly differentially expressed (${\left|log2FC\right|}$ > 1 & q < 0.01), out of which 180 genes were up-regulated and 144 genes were down-regulated. Principal Component Analysis (PCA) showed that the samples clustered according to stages. Functional annotation of significant DEGs (differentially expressed genes) showed that GO terms such as DNA replication, cell division, protein phosphorylation, regulation of signal transduction by p53 class mediator, ribosome, focal adhesion, DNA helicase activity, protein kinase activity etc. were enriched. KEGG pathway analysis showed that the DEGs functioned in cell cycle, Ras signaling pathway, p53 signaling pathway, MAPK signaling pathway etc. Twenty-nine transcripts were also part of the DEGs, these were predominantly Cys2His2-like fold group (C2H2) family of zinc fingers. A protein-protein interaction (PPI) network analysis showed that there were three highly interconnected clusters, suggesting an enrichment of genes with similar biological function. This study presents the first report of liver tissue specific gene regulation in a cross-bred Korean pig.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2002년도 학술대회지
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• pp.96-112
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• 2002

In the present study, we have investigated the effects of centrally administered ginsenoside Rc or Rgl on the modulation of NMDA receptor and $GABA_A$ receptor binding in rat brain. The NMDA receptor binding was analyzed by quantitative autoradiography using $[^3H]MK-801$ binding, and $GABA_A$ receptor bindings were analyzed by using $[^3H]muscimol\;and\;[^3H]flunitrazepam$ in rat brain slices. Rats were infused with ginsenoside Rc or Rg1 ($10\;{\mu}g/10{\mu}l/hr$, i.c.v.) for 7 days, through pre-implanted cannula by osmotic minipumps (Alzet, model 2ML), The levels of $[^3H]MK-801$ binding were highly decreased in part of cortex and cingulated by ginsenoside Rc and Rgl. The levels of $[^3H]muscimol$ binding were strongly elevated in almost all regions of frontal cortex by the treatment of ginseoside Rc but decreased by ginsenoside Rg 1. However, the $[^3H]flunitrazepam$ binding was not modulated by ginsenoside Rc or ginsenoside Rgl infusion. These results suggest that prolonged infusion of ginsenoside could differentially modulate $[^3H]MK-801\;and\;[^3H]muscimol$ binding in a region-specific manner. Also, we investigated the influence of centrally administered ginsenoside on the regulation of mRNA levels of the family of NMDA receptor subtypes (NR1, NR2A, NR2B, NR2C) by in situ hybridization histochemistry in the rat brain. The level of NR1 mRNA is significantly increased in temporal cortex, caudate putamen, hippocampus, and granule layer of cerebellum in Rgl-infused rats as compared to control group. The level of NR2A mRNA is elevated in the frontal cortex. In contrast, it was decreased in CAI area of hippocampus in Rgl-infused rats. However, there was no significant change of NR1 and NR2A mRNA levels in Rc-infused rats. The level of NR2B mRNA is elevated in cortex, caudate putamen, and thalamus in both Rc- and Rg-infused rats. In contrast, NR2B level is decreased in CA3 in Rgl-infused rats. The level of NR2C mRNA is increased in the granule layer of cerebellum in only Rg1 but not Rc infused rats. These results show that structure difference of ginsenoside may diversely affect the modulation of expression of NMDA receptor subunit mRNA after infusion into cerebroventricle in rats.

• 한국학교ㆍ지역보건교육학회지
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• 제4권
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• pp.97-115
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• 2003

Middle and high school girl students' menstruation characteristics, appearance of menstruation dysmenorrhea, and coping with the menstruation dysmenorrhea were examined in order to give information in instructing girl students about menstruation dysmenorrhea, in delivering health education in the school, and establishing health policy. 970 girl students in middle and high schools in Cheju-do were selected and surveyed using the questionnaire the author developed based on the previous studies. The findings are as follows. First, the age of first menstruation was average $12.9{\pm}1.22$ years. The younger they were, the earlier their first menstruation came. The most common menstrual cycle was such one that continuously irregular from the beginning or that regular and irregular cycle run together. The first irregular menstrual cycle changed regular one within 1 or 2 years. Most of the respondents had normal menstrual cycle of $21{\sim}35$ days and menstruation period of $3{\sim}8$ days. Second, symptom of menstruation dysmenorrhea was orderly; hurt in the underbelly, tired, hurt in the waist, and headache. It was higher with high school students than middle school students. For the most part, time of heavy menstruation dysmenorrhea was the 2nd day after menstruation starts and period of menstruation dysmenorrhea was 2 days. More than the half of the respondents felt that the present menstruation dysmenorrhea was similar with the first one and they felt not comport in daily life due to menstruation dysmenorrhea, and 'hard to live a normal life' was higher with the high school girl students than with the middle school students. Third, how to cope with menstruation dysmenorrhea was enough sleep, relax and rest, taking a hot water shower, listening to music or watching a movie, taking medicine, and doing excercise. Few of the respondents have ever visited a doctor due to menstruation dysmenorrhea, and the reason was mostly irregular menstruation and heavy dysmenorrhea. Forth, when they took medicine due to menstruation dysmenorrhea, they gathered information on the medicine from family members and friends, while extremely low from a pharmacist or a doctor. The most of them have ever took medicine during menstruation once and took standard dose. While excess dosage was higher with high school students than with middle school students. From these findings, a good many girls are experiencing menstruation dysmenorrhea since their first menstruation. To discover early the severely abnormal findings and to treat, more interest from home and school, counseling and sexual education on time, and expert's diagnosis are necessary. Rather than unconditionally taking pain-relievers which can plainly solve the pain, continuous health education at home and in the school should be carried on for the girls to practice proper measures one think effective or an expert recommends.

• 한국토양비료학회지
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• 제22권4호
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• pp.280-284
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• 1989

서남해안(西南海岸)에 분포(分布)되어 있는 간척가능지(干拓可能地) 442,000ha에 대(對)한 토성별(土性別) 분포현황(分布現況)과 물리화학적(物理化學的) 특성(特性)을 조사(調査) 분석(分析)하고 토양(土壤) 성숙(成熟)에 따라 일어나는 상상(像想) 침하량(沈下量)에 대(對)하여 연구(硏究)한 결과(結果)를 요약(要約)하면 다음과 같다. 1. 기존간척지(旣存干拓地) 257,000ha의 토성별(土性別) 분포면적(分布面積)은 미사식양질(微砂埴壤質) 53.0%, 미사사양질(微砂砂壤質) 36.0%, 사질(砂質) 6.0%, 사양질(砂壤質) 5.0% 이다. 2. 간척가능지(干拓可能地) 442,000ha의 토성별(土性別) 분포면적(分布面積)은 미사식양질(微砂埴壤質) 51.0%, 사질(砂質) 20.0%, 사양질(砂壤質) 15.0%, 징사식양질(徵砂埴壤質) 14.0%이며 지역별(地域別) 분포(分布)는 경기(京機)와 전남(全南)은 미사질계토양(微砂質系土壤), 전북(全北)은 조립질토양(粗粒質土壤), 충남지역(忠南地域)은 각종토성(各種土性)이 고르게 분포(分布)되어 있다. 3. 간척가능지토양(干拓可能地土壤)은 염도(鹽度)(EC) 46~51mmhos/cm, E.S.P 25~60%, pH 7.5~8.0으로 U.S.Salinity Lab의 염류토양(鹽類土壤) 분류(分類)로 함염(含鹽)Alkali토와(土) 유사(類似)하다. 4. 간척가능지(干拓可能地)를 농경지(農耕地)로 개발(開發)할때 예상(豫想)되는 침하량(沈下量)은 미사질양토(微砂質壤土) 18.0%, 치사질식양토(徵砂質埴壤土) 21.0%이다.

• 한국유기농업학회지
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• 제28권4호
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• pp.659-677
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• 2020

본 실험에서는 익모초 지상부 에탄올 추출물의 항산화 및 항염증 효과를 확인하여 건강 기능성 소재로서의 가능성을 평가하고자 하였다. DPPH 및 ABTS radical 소거 활성, 환원력, 총 폴리페놀 및 플라보노이드 함량을 통해 익모초의 항산화능을 측정한 결과, 400 ㎍/mL, 1500 ㎍/mL의 농도에서 57.8%, 62.3%의 DPPH 및 ABTS radical 소거활성을 보였고 환원력 또한 농도 의존적으로 증가하는 경향을 보였다. 총 폴리페놀 함량 및 플라보노이드 함량은 1 mg/mL의 농도에서 각각 51.40 ± 0.47 mg of gallic acid equivalents/g, 73.28 ± 0.10 mg of rutin equivalents/g로 나타났으며, 익모초 추출물은 세포 내 ROS의 생성 억제에 있어서 유의적인 효과를 보였다. 익모초의 항염증 효과를 측정한 결과, LPS로 자극해 활성화된 RAW 264.7 cell에서 익모초 추출물(0~400 ㎍/mL)의 세포 독성은 없었으며 LPS 처리로 유도된 세포의 형태학적 변화도 농도의존적으로 완화되는 경향을 보였다. NO 발생량은 LPS 처리군과 비교해 익모초 추출물 처리 시 농도 의존적으로 감소하였고, 400 ㎍/mL에서는 90.3%로 NO의 생성이 억제되었다. 염증성 cytokine (TNF-α, IL1-β)의 생성도 유의적으로 감소하였고 NO를 생성하는 염증성 단백질 iNOS의 발현 또한 억제되었으며 이와 같은 염증성 단백질의 전사를 조절하는 NF-κB (NF-κB, IκB-α) 및 MAPK (ERK, p38)의 인산화 및 활성화 또한 익모초 추출물 처리로 인해 억제됨을 확인하였다. 따라서 익모초 추출물은 NF-κB signaling pathway 및 ERK/p38 MAPK cascade pathway의 조절을 통해 염증성 단백질 및 염증인자의 발현을 감소시킨다고 볼 수 있다. 이러한 결과를 토대로 익모초 지상부 에탄올 추출물은 천연 기능성 소재로서 활용될 가능성이 있으며, 본 연구 결과는 익모초의 고부가가치 향상을 위한 기초자료로 도움이 될 것으로 생각된다.

• 한국사회정책
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• 제25권3호
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• pp.279-303
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• 2018

인구고령화의 진전과 막대한 통일비용은 독일 연금재정에 심각한 위기를 야기하였다. 이에 더하여 경제의 세계화는 사회보험료를 부담하는 기업의 능력을 감소시켰다. 이를 타개하기 위해 독일은 공적연금의 급여를 삭감하고, 대신 인증제 개인연금인 리스터연금을 도입하여 노후소득보장의 수준을 유지하려 하였다. 리스터연금이 도입된 지 17년이 지난 지금 리스터연금제도의 성과에 대해 논쟁이 본격적으로 진행되고 있다. 이런 점에서 이 연구는 독일 리스터연금의 성과를 평가하고 한국에 주는 시사점을 도출하려 한다. 연구결과에 따르면 리스터연금의 가장 큰 성과는 노후소득보장에서 사적연금의 역할을 강화한 것이다. 리스터연금은 다른 사적연금과 달리 저소득층에게도 혜택을 확대하였다. 리스터연금의 가족정책적인 기능도 사적연금 활용의 새로운 전망을 보여주었다. 하지만 이러한 성과에도 불구하고 리스터연금은 애초의 목표를 달성하지 못하고 있다. 리스터연금은 목표한 가입율을 달성하지 못했고 목표한 저소득층보다는 고소득층이 리스터연금에 더 많이 가입한 것으로 나타났다. 또한 높은 수수료와 낮은 수익율 때문에 급여수준은 애초 기대보다 훨씬 낮을 것으로 예상된다. 이 결과로 리스터연금은 공적연금으로 삭감된 노후소득보장의 부족분을 완전히 보충하지는 못할 것으로 전망된다. 이에 따라 한국에서 리스터연금의 도입은 공적연금활성화, 사적연금시장의 투명성 강화, 공적연금과 사적연금의 협력적 관계 형성과 같은 전제조건이 갖추어진 이후에 고려될 수 있을 것으로 사료된다.

• 한국아동복지학
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• 제59호
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• pp.115-150
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• 2017

2007년 시범사업으로 시작한 드림스타트 도입 10년을 맞아 그간의 변화와 성장을 사회투자전략의 관점에서 평가하고, 향후 발전과제를 제시하고자 하였다. 헤드스타트와 슈어스타트 프로그램과 관련된 연구 성과와 정책근거에 기반 해 도입된 드림스타트는 아동복지프로그램에서 주요한 공적 전달체계로 자리 잡고있다. 12세 이하 취약계층 아동에게 맞춤형 통합서비스를 제공해, 아동의 복지를 증진시키며, 불평등 격차를 줄여 취약계층 아동에게 최선의 출발선을 제공하는 것이 드림스타트의 주된 목적이다. 이를 위해 상담, 보건, 부모교육, 학습지원, 방과 후 활동 등 다양한 서비스를 통합적으로 제공하는 사례관리접근이 핵심적으로 활용되고 있다. 도입 이후 실시된 여러 효과성연구는 긍정적인 영향과 개선을 보고하고 있지만, 강력하고 기대했던 성과를 충분히 보여주지는 못하고 있다. 드림스타트가 애초 달성하려 했던 정책목표를 위해서는 향후 재정지원 확대와 안정적인 정책지원이 필요하다. 드림스타트 표적 집단인 취약계층 아동 모두가 드림스타트를 이용하고, 그들이 경험하는 불평등과 격차를 극복하기 위해서는 풀어야 할 과제가 여전히 남아있다. 드림스타트가 고려하고 추진해야 할 향후 과제들을 실천적 측면과 정책적 측면에서 제시하였다.

• 한국콘텐츠학회논문지
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• 제19권8호
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• pp.332-344
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• 2019

지리적 위치로 인해 한국과 중국은 오랜 문화교류의 역사를 가지고 있으며, 오랜 기간의 교류를 통해 중국의 전통문화는 다양한 방식으로 한반도 선조들의 일상생활에 스며들고 있다. 중국의 전통문화 중 하나인 도교는 한반도의 삼국시대에 전파되기 시작했다. 도교가 한반도에 녹아들고 발전하면서 한반도만의 특징을 지닌 도교 문화를 형성하게 되었고, 한반도 선조들의 전통적인 이념 및 문화적 생활의 일부가 되었다. 한반도의 가구발달 과정에서 도교의 음양오행설, 풍수지리설 등 도참설(圖讖說)은 한반도 전통가구의 용도, 조형, 재질, 문양 등에 중요한 영향을 미쳤다. 조선왕조 후기는 한반도 수공업 발전의 전성기였다. 이 시기에는 가구류가 증가하여 도교적 특성이 뚜렷하고, 모양이 아름답고, 디자인이 우수하고, 용도가 다른 가구들이 많이 출현하였다. 본 연구는 조선후기 가구의 조형, 재질, 문양, 도장, 디자인 등에 대한 연구를 통하여 도교사상이 한국의 전통가구의 형태와 문양의 발전에 영향을 준 주요 요소 중의 하나임을 확인하였으며, 여러 가지 자연물이나 동식물을 가구 디자인의 문양으로 활용한 것은 가족들이 화(禍)를 피하고 하늘로부터 복(福)을 받기를 기원하는 도교의 기복(祈福)사상으로부터 영향을 받은 것임을 알 수 있었다.