• BMB Reports
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• v.47 no.8
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• pp.424-432
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• 2014

The defining feature of Parkinson's disease is a progressive and selective demise of dopaminergic neurons. A recent report on Parkinson's disease animal model demonstrates that poly (ADP-ribose) (PAR) dependent cell death, also named parthanatos, is accountable for selective dopaminergic neuronal loss. Parthanatos is a programmed necrotic cell death, characterized by PARP1 activation, apoptosis inducing factor (AIF) nuclear translocation, and large scale DNA fragmentation. Besides cell death regulation via interaction with AIF, PAR molecule mediates diverse cellular processes including genomic stability, cell division, transcription, epigenetic regulation, and stress granule formation. In this review, we will discuss the roles of PARP1 activation and PAR molecules in the pathological processes of Parkinson's disease. Potential interaction between PAR molecule and Parkinson's disease protein interactome are briefly introduced. Finally, we suggest promising points of therapeutic intervention in the pathological PAR signaling cascade to halt progression in Parkinson's disease.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7451-7457
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• 2013

Background: Understanding and enhancing change capabilities, including Practice Adaptive Reserve (PAR), of Community Health Centers (CHCs) may mitigate cancer-related health disparities. Materials and Methods: Using stratified random sampling, we recruited 232 staff from seven CHCs serving Asian Pacific Islander communities to complete a self-administered survey. We performed multilevel regression analyses to examine PAR composite scores by CHC, position type, and number of years worked at their clinic. Results: The mean PAR score was 0.7 (s.d. 0.14). Higher scores were associated with a greater perceived likelihood that clinic staff would participate in an evidence-based intervention (EBI). Constructs such as communication, clinic flow, sensemaking, change valence, and resource availability were positively associated with EBI implementation or trended toward significance. Conclusions: PAR scores are positively associated with perceived likelihood of clinic staff participation in cancer screening EBI. Future research is needed to determine PAR levels most conducive to implementing change and to developing interventions that enhance Adaptive Reserve.

• Biomedical Science Letters
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• v.26 no.2
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• pp.120-126
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• 2020

Fluoroquinolone (FQ) resistant uropathogenic Escherichia coli (UPEC) have become a major problem in urinary tract infections (UTIs). The purpose of this study was to compare the quinolone resistance-determining region (QRDR) and plasmid mediated quinolone resistance (PMQR) determinants of FQ resistant UPEC between 1989 and 2010-2014. A total of 681 strains of UPEC clinical isolates was collected from Korean healthcare facility in 1989 (123 strains) and in 2010-2014 (558 strains). The minimum inhibitory concentrations (MICs) of FQs were determined by agar dilution method. QRDRs (gyrA, gyrB, parC and parE) and PMQR determinants (qnrA, qnrB, qnrS, aac(6')-Ib-cr and qepA) were analyzed polymerase chain reaction and sequencing method. Among 681 isolates, FQ resistant UPEC were 3 strains (2.4%) in 1989 isolates and 220 strains (39.4%) in 2010-2014 isolates. The rate of the FQ resistant UPEC strains in 2010-2014 isolates was increased than that of in 1989 isolates. UPEC isolates from 1989 and 2010-2014 were shown to carry mutations in gyrA (Ser83 and Asp87), gyrB (Ser464 and Thr469), parC (Ser80 and Glu84) and parE (Glu460, Ser458, Ile464 and Leu445). The most common mutations of QRDRs in 1989 isolates were Ser83Leu and Asp87Gly in gyrA and Ser80Ile in parC (2 strains: 66.7%) while those in 2010-2014 isolates were Ser83Leu and Asp87Asn in gyrA and Ser80Il2 and Glu84Val in parC (88 strains: 40.0%). PMQR determinants were detected only in 2010-2014 UPEC strains (47 strains: 21.4%).

• Journal of Microbiology
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• v.43 no.5
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• pp.391-397
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• 2005

Escherichia coli is a common inhabitant of the intestinal tracts of animals and humans. The intestines of animals also represent an ideal environment for the selection and transfer of antimicrobial resistance genes. The aim of this study was to investigate the resistance of E. coli isolated from chicken fecal samples to fluoroquinolones and to analyze the characterization of mutations in its gyrA and parC gene related resistance. One hundred and twenty-eight E. coil isolates showed a high resistance to ciprofloxacin (CIP; $60.2\%$), enrofloxacin (ENO; $73.4\%$) and norfloxacin (NOR; $60.2\%$). Missense mutation in gyrA was only found in the amino acid codons of Ser-83 or Asp-87. A high percentage of isolates ($60.2\%$) showed mutations at both amino acid codons. Missense mutation in parC was found in the amino acid codon of Ser-80 or Glu-84, and seven isolates showed mutations at both amino acid codons. Isolates with a single mutation in gyrA showed minimal inhibitory concentrations (MIC) for CIP (${\le}0.5\;to\;0.75{\mu}g/ml$), ENO (1 to $4{\mu}g/ml$) and NOR (0.75 to $4{\mu}g/ml$). These MIC were level compared to isolates with two mutations, one in gyrA and one in parC, and three mutations, one in gyrA and two in parC (CIP, ${\le}0.5\;to\;3{\mu}g/ml;\;ENO,\;2\;to\;32<{\mu}g/ml;\;NOR,\;1.5\;to\;6\;{\mu}g/ml$). However, the isolates with two mutation in gyrA regardless of whether there was a mutation in parC showed high MIC for the three fluoroquinolones (CIP, 0.75 to $32{\le}{\mu}g/ml;\;ENO,\;3\;to\;32{\le}{\mu}g/ml;\;NOR,\;3\;to\;32{\le}{\mu}g/ml$). Interestingly, although the E. coil used in this study was isolated from normal flora of chicken, not clinical specimens, a high percentage of isolates showed resistance to fluoroquinolones and possessed mutations at gyrA and parC associated with fluoroquinolone resistance.

• Proceedings of the KSPS conference
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• 1996.10a
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• pp.252-257
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• 1996

La structure syllabique est un facteur important dan la prononciation d'une langue. Dans cette these, on a essaye de montrer que les caracteristiques de la syllabe varie d'une langue a une autre, et que les regles qui regissent la syllabe dan la langue maternelle a le dessue et done fait appliquer ses regles a la langue etrangere. Premierement, l'accentuation du coreen depend de la structure syllabique (qu'elle soit consonne-voyelle(CV) ou consonne-voyelle-consonne(CVC) et de la longueur de la voyelle. Ce qui fait que bien que le francais soit oxyton, et que la longueur et la qualite de la voyelle dependent de la structure syllabique, le francais, le francais parle par les coreens suit les regles du coreen. Autre caracteristique est que le coreen n'admet pas de suite de consonnes avant et apres la voyelle centrale comme dans "premier"[$pr{\partial}mje$] "autre"[o:tR]. D'ou l'insertion de voyelle superflue comme [${\varpi},{\;}{\wedge},{\;}{\partial}$]. Troisiemement, il existe une difference dans la coupe de la chaine parlee: en coreen la coupe ecrite(le blanc) egale a peu pres a la coupe orale(la pause) alors qu'en francais, c'est en groupe de mots que se fait la coupe. A l'interieur du groupe, les mots sont lies entre eux, soity par liaison, soit par enchainement. On peut remarquer donc une nette influence du coreen, ou la regle est de prononcer correctement par unites ecrites (equivalent des mots en francais) : la chaine parlee devient saccadee, avec un accent sur tous les mots, et des coups de glotte entre les mots, et l'une des voyelles [${\varpi},{\;}{\wedge},{\;}{\partial}$] inseree entre un mot se terminant par une consonne suivi d'un mot qui commence par une consonne.

• Journal of Advanced Marine Engineering and Technology
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• v.41 no.4
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• pp.302-309
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• 2017

If a hydrogen explosion occurs in a containment building, its multiplex defense wall may be destroyed and a large amount of radioactive material may be released. The hydrogen occurred interacting with melting fuel rods must be effectively controlled and removed. however, the countermeasures for reducing explosion risk are difficult to carry out, due owing to the various variety of accident scenarios causes and the irregularity of hydrogen distribution and behavior. In this study, We examine the guide structures while considering the ambient flows, in order to improve the efficiency of PAR the widely used Passive Autocatalytic Recombiner(PAR). We simulate the fluid behavior and the hydrogen reduction rate were simulated when a guide is attached to the two-step catalyst PAR. For an upward flow, the consisting of a height of 150mm, a gap of 0mm, and a performs $60^{\circ}$ showed the best. In contrast, for a sideways flow, a consisting of the height of 150mm, a gap of 100mm, and a performs $60^{\circ}$ showed the best in the case of side ward flow. for a downward flow, a consisting of the height of 50mm and a directly attached guide produce the best in the case of down ward flow results.

• Journal of architectural history
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• v.5 no.1 s.9
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• pp.113-122
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• 1996

Cette etude vise a reveler une verite du Nouveau Brutalisme des Smithson (Alison et Peter). Nous examinerons donc d'abord l'universalitf de leur oeuvre representatif, Ecole Secondaire de Hunstanton(projet, 1949; concours, 1950; construction, 1951-1954) et projet de Maison Soho a Londres(1952) comme un mouvement architectural. Et apres nous trouverons la faussete de leur but, realisation de l'ethique architecturale, sur ce mouvement en comparant les oeuvres des Smithson avec les deux constructions considerees souvent comme la categorie du Nouveau Brutalisme, la Calorie d'Art de l'Universite Yale(1951-1953) realisee par Louis I. Kahn(1901-1974) et le Centre Cuturelle de Georges-Pompodou(1971-1977) par Renzo Piano et Richard Rogers. En resultat, l'etique de Nouveau Brutalisme soutenue par les Smithson et defendue par Reyner Banham etait seulement pour cacher low limite architecturale et sa faiblesse. Ce mouvement etait aussi un mouvement personel plutot que general. On ne pourrait pas donc considerer les Smithson comme nouveaux brutalistes.

• Proceedings of the KIEE Conference
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• 2006.11a
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• pp.9-11
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• 2006

This paper suggests a revision method for historical fault data using Proportional Aging Reduction(PAR) to consider maintenance effect in time-varying failure rate. In order to product time-varying failure rate, the historical fault data are necessary. However, the maintenance record could be left out in historical data by spot operator's mistake. In this case, the failure rate is produced less than the average failure rate for increasing equipments' life-time by maintenance effect. Hence, it is necessary for new time-varying failure rate to extract maintenance effect from the existing fault data. In this paper, the revision method to reduce equipments' life-time, adversely using PAR among three techniques to consider maintenance effect.

• The korean journal of orthodontics
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• v.52 no.6
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• pp.439-450
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• 2022

This case report describes the treatment of an adult female patient with a history of periodontal disease, Class I malocclusion with extrusion, dental spaces, and pathologic tooth migration. The patient was treated with clear aligners, which effectively controlled the strength and direction of orthodontic forces after 3 months of systematic periodontal treatment. The Peer Assessment Rating (PAR) index was calculated from study models before and after treatment. The pretreatment PAR score was 24, and the posttreatment PAR score was 4. The PAR score for this patient changed by 83%. Satisfactory appearance and good function were achieved for this patient.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.2
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• pp.270-274
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• 2011

The prevalence of atopic dermatitis has markedly increased in recent years but the mechanism has not been clearly revealed. Recent study exhibited that atopic dermatitis was exacerbated by the increase of proteinase-activated receptor (PAR)-2 expression, which activated $I{\kappa}B$ kinase --> nuclear factor kappa B. Therefore, we determined whether the allergens of dust mites induced the expression of PAR-2, intercellular adhesion molecule-1 (ICAM-1, adehision molecule), interleukins (IL)-6 in HaCaT keratocytes and which herbal 1,3-butylene glycol extracts (Mori Cortex Radicis, Sanguisorba officinalis L., Arctium lappa Linne, Torilis japonica DC, Melia azedarach Linne var. japoinca Makino) suppressed their expression. Dust mite allergen increased PAR-2, ICAM-1 and IL-6 expression in HaCaT cells in a dose-dependent manner up to $3{\mu}g/mL$ but their expression reached the plateau over the dosages. The allergen ($3{\mu}g/mL$) also secreted more cytokines such as tumor necrosis factor (TNF)-${\alpha}$ and IL-6 into the media. Among five different herbal extracts ($50{\mu}g/mL$), Mori Cortex Radicis and Sanguisorba officinalis L. suppressed the PAR-2, ICAM-1 and IL-6 expression in HaCaT cells, which was activated by dust mite allergen ($3{\mu}g/mL$) and they also reduced the secretion of TNF-${\alpha}$ and IL-6 into the media. In conclusion, Mori Cortex Radicis and Sanguisorba officinalis L. can effectively reduce the prevalence and progression of atopic dermatitis by dute mite allergen.