• 제목/요약/키워드: PTCA

검색결과 56건 처리시간 0.029초

심혈관질환수술에 대한 임상적 고찰 -2094례 보고- (Clinical Analysis of Cardiovascular Surgery -Report of 2094 Cases-)

  • 김병열
    • Journal of Chest Surgery
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    • 제21권6호
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    • pp.1030-1039
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    • 1988
  • From 1985 through Oct. 1988, we have experienced 5 cases of Aorto-Coronary Bypass Surgery [ACBS] and 3 cases of Percutaneous Transluminal Coronary Anogioplasty [PTCA]under the diagnosis of unstable angina. There were 6 males and 2 females who ranged from 48 to 70 years old. Almost all patients had a evidence of hypertension & hyperlipidemia. Two patients showed old myocardial infarction and remaining patients showed myocardial ischemia on resting state. The patterns of involvement of coronary artery disease were single vessel disease [4 cases], double vessel disease [3 cases], Triple vessel disease [1 case]. Among 5 cases of ACBS, double bypass graft was in 3 cases and single bypass graft was in 2 cases. Mode of anastomosis were all individual anastomosis, using Saphenous vein graft. Postoperative complications were perioperative myocardial infarction [2 cases], postoperative bleeding [1 case], leg wound disruption [1 case]. Perioperative myocardial infarction cases didn*t survive. In cases of PTCA, there were no complications. Follow up periods were ranged from 1 month to 25 months. All survived cases were asymptomatic except one case, who showed Functional Class II.

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Preventive Effect of Traditional Korean Formulations on Intimal Thickening of Rat Carotid Artery Injured by Balloon Catheter

  • Kim, Seong Bin;Paudel, Keshav Raj;Kim, Dong Wook
    • 한국자원식물학회지
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    • 제26권6호
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    • pp.678-685
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    • 2013
  • The objective of this study was to examine the effect of 7 traditional Korean formulations (7TKFs) on intimal thickening of rat carotid artery injured by balloon catheter in vivo and on the proliferation of human smooth muscle cells (HASMCs) and secretion of matrix metalloproteinase-2 (MMP-2) in vitro. 7TKFs (400 mg/kg) were administered orally for 4 weeks from the day of balloon injury in the rats. HASMC proliferation was assessed by 3-(4,5-dimethylthiazol-2)-2,5-diphenyltetrazolium bromide (MTT) assay while enzymatic action of MMP-2 was carried out by gelatin zymography. Among 7TKFs, Samhwang-sasim-tang (SST), Banha-sasim-tang (BST) and Kegi-honghwa-tang (KHT) significantly reduced the intimal thickening by suppressing HASMC proliferation and MMP-2 expression in both extracellular and intracellular levels. Thus, the results suggest that SST, BST and KHT can be considered as a therapeutic value in the prevention of atherosclerosis because restenosis after PTCA (percutaneous transluminal coronary angioplasty) is supposed to be 'accelerated atherosclerosis'.

관상동맥우회로술(CABG)환자의 재원일수와 병원 내 사망률 변이에 대한 경피적관상동맥성형술(PTCA)과 소아심장수술(PHS)의 영향분석 (A Study on the Effects of Percutaneous Transluminal Coronary Angioplasty and Pediatric Heart Surgery on the Differences of Risk-Adjusted Length of Stay and In-Hospital Death for Coronary Artery Bypass Graft Patients)

  • 김다양;이광수
    • 보건의료산업학회지
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    • 제8권4호
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    • pp.47-55
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    • 2014
  • The purpose of this study was to analyze the differences in the outcome for CABG according to whether hospitals provided heart related surgeries. The 2011 National Inpatient Sample (NIS) and inpatient quality indicator principles from the Healthcare Research and Quality (AHRQ) were used for analysis. Hospitals were divided into three groups according to the surgeries they provided. The length of stay and in-hospital deaths were adjusted for the differences in risks. ANOVA was performed to examine the differences for the risk-adjusted in-hospital mortality rate and risk-adjusted length of stay among the three groups. The analysis results showed that hospitals providing CABG, PTCA, and PHS had lower risk-adjusted in-hospital mortality rates or similar risk-adjusted lengths of stay compared to those of hospitals providing only CABG. However, the three groups did not have statistically significant differences in outcome indicators. Another study will be needed with a larger sample.

Ara - C유도체의 항암작용에 관한 연구 (1) : 암세포에 대한 Ara-C 유도체의 항암효과에 대한 in vivo 연구

  • 이형환;조동인;지용훈;이철규;강헌;최희백;이혜열;김은태
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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    • pp.199-199
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    • 1994
  • Thioglycerol과 glycerol로부터 rac-1-S-octa-decyl-2-O-palmitoyl-1-S-thioglycerol-3-phosphate (DL -PTBA-P)와 rac-1-O-octadecyl-2-O-palmitoyl-g1ycerol-3-phosphate (DL-PBA-P)등을 합성하였고, 이들에 ara-C 유도체인 ara-CMP morpholidate를 반응시켜 최종 산물인 ara-CDP-DL-PCA, ara-CDP-DL-PBA, ara-CDP-DL-PTCA 및 ara-CDP-DL-PTBA등을 합성하였다. 이들 최종산믈의 항암효과는 L1210 lymphoid leukemia, colon 26 carcioma, M5076 sarcoma, C-1300 neuroblastoma, 3-Lewis lung carcinoma, WEHI-3B leukemia, human colon cancer, hum an pancreatic cancer 등의 암세포주를 사용하여 실험하였다. L1210를 DB/2J의 뇌막 또는 복강, DBA/1J의 복강내에 이식하여 ara-C, Ehss thioether lipid의 ara-C 유도체 (ara-CDP-L-DP, ara-CDP-DL-PCA, ara-CDP-DL-PBA, ara -CDP-DL-PTCA, ara-CDP-D-PTBA, ara-CDP-L-PTBA, ara-CDP-DL-PTBA)를 단일 투여 또는 중복 투여하였고, 3-Lewis는 C57BL/6 의 발바닥 피하, colon26은 BALB/C의 견갑상부 히아조직, M5076은 C57BL/6의 피하, WEHI-3B는 BALB/C의 복강, C-1300는 A/strong Ros에 각각 이식한 후 ara-C 또는 ara-CDP-DL-PTBA를 단일 또는 중복 투여하였다.

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개심술시 Intra-aortic balloon pump (IABP)의 임상적 적용 (Clinical Experience with IABP in Cardiac Surgery)

  • 옥창석;지현근
    • Journal of Chest Surgery
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    • 제30권1호
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    • pp.34-39
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    • 1997
  • 1994년 5월부터 1995년 12월까지 성인에서 심장수술을 시행한 122례중 18례(14.8%)에서 IABP를 순환보조장치로 사용하였다. 그중 술전에 IABP(intra-aortic balloon pump)를 시행한 경우는 9례이고, 술 중에는 7례, 그리고 술후에는 2례에서 시행하였다. 그 이유는 술전에는 저심박출, PTCA(percutaneous transluminal coronary angioplasty)의 실패였고, 술중에는 체외순환기 이탈을 위해서이며, 술후에는 술후 발생한 부정 맥 때문이었다. 환자들의 평균 나이는 61.8$\pm$6.9세(39세에서 75세)였다. 술전 및 술중에 IABP를 시행한 환자의 수술사망율은 각각 33.3, 42.9%였으며 술후 IABP를 시행한 환자는 모두 생존하였다. IABP이탈율은 술전의 경우 66.77%. 술중의 경우 85.7%였으며 술후에 시행한 IABP는 모두 이탈 가능하였다. 결론적으로 IABP는 심근 손상이 가역적인 시기에 적용할 경우, 수술전후 어느시기에나 안전하게 사용가능하며 수술전후의 혈류역학적 불안정, 체외순환기 이탈 및 저심박출증의 치료에 도움을 줄 수 있다고 판단된다.

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