• Journal of the Society of Cosmetic Scientists of Korea
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• v.34 no.4
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• pp.333-338
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• 2008

The evaluation for the visage volume was performed with human and dummy face using PRIMOS $body^{(R)}$. Three researchers measured the dummy face attached different volume of clay (6.6 mL, 13.2 mL, and 19.8 mL). It is identified that the high correlation between measured values and real volume ($R^2=0.99$). The percent (%) of relative standard deviation (RSD) of the data was shown below 10%. In Gage R&R analysis, the percent of contribution, the percent of study variation and distinct categories values were 0.78%, 8.85%, and 15% respectively. Therefore this method was regarded as the good standard condition in aspect of reproducibility and repetitiveness of data. The face volume variation was measured by PRIMOS $body^{(R)}$ on the face in participated 10 healthy Korean women volunteers. Subjects used the product once a day for two weeks as night sleeping pack. After application of the test products, the 3D image data of face were taken 1 and 2 weeks later. We found the face volume was significantly decreased after using products. In conclusion, this novel non-invasive technique was useful in measuring and visualizing alterations in face volume as a consequence of certain treatments. This system will provide a rapid and precise analysis of 3D topographical information for face.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.3
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• pp.247-254
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• 2017

Optical Coherence Tomography (OCT) is a non-invasive imaging method that utilizes the optical scattering and interference for visualizing the surface as well as cross-sectional structures of tissue. OCT has been used for diagnosing diseases in early stage in various medical fields, but an application in cosmetics is still at early stage. In this study, OCT was adopted to evaluate skin texture and wrinkle. Results showed similar patterns of evaluation with PRIMOS in the assessment using replica. In addition, OCT produced smaller errors at different angles compared to the PRIMOS in the assessment using 3-dimensional models of wrinkles. The resolution of the image was also high enough to differentiate the images of before and after the application of makeup products. Possible use of OCT in the evaluation of fine wrinkle assessment was studied in this research. Further development of methods is necessary to provide more evidences of the effectiveness.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.4
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• pp.281-288
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• 2010

In this study, we investigated anti-oxidative effects of Duchesnea indica extracts by using Oxygen Radical Absorbance Capacity (ORAC). The extracts were prepared with 0 %, 30 %, 50 %, 70 % and 100 % aqueous ethanol respectively. The 30 % EtOH D. indica extract showed higher ORAC activity than the other extracts. Therefore, we performed in vitro studies on cytotoxicity of NIH-3T3 cells and MMP-8 collagenase inhibition using by the 30 % EtOH extract. The 30 % EtOH extract showed no cytotoxicity and significant inhibition on MMP-8 collagenase. And we performed clinical studies for the anti-wrinkle effect of the Di-Wrinkle Free Cream. The cream formula was prepared with 2 % arbutin and 1 % D. indica extract. Twenty one healthy women volunteers, ages of 35 and 50, applied the cream on their faces twice a day for 8 weeks. The skin was evaluated with PRIMOS (phaseshift rapid in vivo measuring of human skin) system and analyzed by the student's paired t-test. The wrinkles on the eye region were reduced by 13 % based on the PRIMOS system after 8 weeks. In the safety study of the Di-Wrinkle Free Cream, no symptoms were observed such as erythema, edema, scaling, itching, stinging, burning, tightness and prickling by visual observation and medical examination of volunteers for 8 weeks. Moreover, there was no noticeable skin disorder during experience period. These results suggested that D. indica extracts could be applied as cosmeceuticals effective for anti-wrinkle.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.3 s.52
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• pp.253-257
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• 2005

Assurance of the objectivity and reproducibility is a major key point in wrinkle measurement used for evaluating the degree of skin aging. The measurement of relief is quickly converted to a non-contact method, of which tools or instruments do not come in contact with skin directly, to minimize the artificial effects which influence the shape or depth of the relief. Here, we showed how wrinkle measurement techniques have been changed briefly and compared PRIMOS and replica method in the point of view of measurement principle and features, the former is non-contact fringe projection tool and the latter is contact type of the method.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.34 no.4
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• pp.303-309
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• 2008

Deficiency of collagen regeneration, denaturalization of elastic fibers, and promotion of reactive oxygen species formation are important factors for deterioration of skin function. They induce wrinckle formation and decrease skin elasticity. Vitamin C and its derivatives have been used as cosmetic ingredients for anti-aging effects but their chemical instability has been a major problem. In an attempt to develop a novel anti-aging agent with a improved stability and bioactivity, the anti-wrinkle effect of 3-O-cetyl-L-ascorbic acid (VCCE), a new vitamin C derivative, was investigated in this study. VCCE increased procollagen type-1 synthesis in a dose-dependent manner (149% at 0.002%) in cultured fiboroblasts. Its potent anti-wrinkle effect was confirmed in vivo by analyzing human skin replica by a visiometer and the PRIMOS system. It did not cause any irritation in human patch test. Taken together, our findings suggest that the VCCE has potential benefits applicable to cosmetics for anti-wrinkle effects.

• Proceedings of the KIEE Conference
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• 1988.07a
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• pp.574-578
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• 1988

This paper proposes testable design method of Domino CMOS NOR-NOR Array Logic design method. Previous Domino CMOS PLA method is composed of 2 level NAND-NAND Logic. Because NOR-NOR Logic is realized by a parallel circuit, this method can prevent delay time each level and DNOR-PLA include testable circuit system that DNOR-PLA circuit. DNOR-PLA testable algorithm is realized on Prime (Primos) in Pascal language and DNOR-PLA circuit is simulated by PSPICE.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.34 no.4
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• pp.1-11
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• 2021

Objectives : The aim of this study was to investigated the anti-aging and anti-wrinkles effects of the pinus koreaiensis seed(PKS) oil. Methods : The anti-oxidant effect was performed by beta-carotene bleaching assay and the intracellular proteome was analyzed expression of each 15 proteins by 2-D electrophoresis. And fatty acid was analysed by gas chromatography. Anti-wrinkle effect was analyzing human skin by the PRIMOS system. Results : Fatty acid analysis of PKS oil has shown oleic acid was 49.7% and linoleic acid was 34.1%. And the antioxidant effect was about 125% compared with alpha-tocoperol(0.1%) by beta carotene bleaching assay. In 2D PAGE analysis, fifteen protein changes in five mechanisms which was collagen synthesis pathway, MMPs, ECM-cell interaction, cytokine, antioxidant enzymes were analyzed. In case of anti-wrinkle effect was proved in vivo by analyzing human skin by the PRIMOS system. The analysis results of eye wrinkles for 4 weeks showed an improvement effect of over 6%. Conclusions : In this study, the amount of protein change in the five mechanism through the cell experiment and the skin anti wrinkle efficacy by the human in vivo test were investigated. As a result pinus koreaiensis seed oil by supercritical extraction could be used as a anti-aging and anti-wrinkle substance for the skin.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.15 no.1
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• pp.85-91
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• 2009

Objectives: We investigated the influence of the neck acupressure massage and the neck cream including korean herbal extract on the neck wrinkles and blood circulation. Methods: Korean female($37.47{\pm}3.66$ years, n=18) aged 30-39 years were participated in this study. We measured the neck wrinkles with PRIMOS(GFMesstechnik GmbH, Germany) and blood circulation of neck and facial skin with Laser Doppler Imaging-Periscan PIM II(Perimed AB, Sweden). Results: The neck wrinkles were significantly decreased after applying neck cream. But when with the neck acupressure massage, the neck wrinkles were decreased 2-fold than applying only the neck cream. The skin blood circulation was significantly increased on the neck and facial skin immediately after the neck acupressure massage. But this effect was not significantly different after 8 weeks Conclusions: This result suggests that the neck acupressure massage can improve the anti-wrinkles effect of the neck cream including Korean herbal extract.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.29 no.2 s.43
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• pp.79-104
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• 2003

Introducing to the market place, safe and effective product is an important responsibility of clinical investigators as well as regulatory agencies in all developed countries. Products claiming to improve skin wrinkles are no exceptions. To date, Renova(R) (all-trans retinoic acid), Avage(R) (tazarotene), and Botox(R) (botulinum toxin) are the only agents FDA approved to ameliorate wrinkles associated with photoaged skin in the USA. For all three, clinical evaluation of wrinkle severity was the primary endpoint required for the approval process. No sophisticated instrument measurements of wrinkles were required, nor used in the pivotal studies. The Division of Dermatologic & Dental Products of the US FDA (Director, Jonathan Wilkin, MD) is not against the use of mechanical instruments in assessing wrinkle severity. Its position on this issue however, remains that any such device must be grounded in patients' or product users' perspective, which means that the evaluation instrument must be clinically relevant and clinically perceptible. Sophisticated devices that can detect minimal improvement, but imperceptible to the users are considered useless in the eyes of the US FDA. Two instruments that have been tried in some antiwrinkle studies in the USA are silicone replicas and Primos. Despite their sophistications, they have clear limitations; thus have never replaced clinical evaluations in these studies. At most, they have served as secondary measures to provide corroborative data on the clinical efficacy of antiwrinkle products. For the foreseeable future, at least in the USA, careful clinical assessment of wrinkles will continue to serve as the critical benchmark to determine whether an antiwrinkle product has enough efficacy to benefit its users. We must not lose sight of the fact that sophisticated devices are only to serve in generating supportive evidence, and not the primary evidence, in any clinical studies.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.45 no.1
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• pp.9-17
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• 2019

In this study, $L-{\alpha}-amino$ acid, which is a constituent of natural moisturizing factor, was applied to skin in periodic cycle to improve skin tone and texture roughness. Based on the polarity of the alkyl group (R) of the $L-{\alpha}-amino$ acid, the acid was categorized into two groups and their efficacy was studied. As a result, it was found that the improvement rate of $L-{\alpha}-amino$ acid complex with polar alkyl group ($L-{\alpha}-AAC-1$) is 21% higher than that of $L-{\alpha}-amino$ acid complex with non-polar alkyl group ($L-{\alpha}-AAC-2$). For clinical trials, emulsions containing $L-{\alpha}-amino$ acid complex ($L-{\alpha}-AAC-1$) were applied to the randomly selected 20 to 40 year old female participants, as an experimental group, on the right facial cheek once per day for 8 weeks, and emulsions without $L-{\alpha}-amino$ acid complex, as a control group, were applied to the left facial cheek in the same way. Improvements in skin tone were measured using $JANUS^{(R)}$ equipment and analyzed using image analysis software. Skin texture improvement was measured and analyzed mechanically using the phaseshift rapid in-vivo measurement of the skin (PRIMOS) equipment. As a result, improvements of skin tone and skin texture were 11.7% and 6.7%, respectively. In addition, a questionnaire survey was conducted to the participants on the aesthetic improvement and the degree of the feeling of skin improvement. The results suggest that $L-{\alpha}-amino$ acid can be used as a cosmetic substance that can provide aesthetic satisfaction through physiological skin tone and texture roughness.