• Title/Summary/Keyword: PP2A

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The analysis of endocrine distruptors in commercial cosmetics (유통 화장품 중 내분비계 장애물질 탐색 및 규명에 관한 연구)

  • Koo, Heesoo;Na, Youngran;Lee, Seungju;Min, Sangkee;Kang, Jungmi;Jin, Sung Hyun
    • Analytical Science and Technology
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    • v.28 no.3
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    • pp.212-220
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    • 2015
  • This study aims to identify the characteristics of phthalates (DMP, DEP, DBP, DEHA, BBP, DEHP, and DNOP) and heavy metals such as lead (Pb), cadmium (Cd), and mercury (Hg) in cosmetics and their containers. Phthalates and heavy metals may be endocrine distruptors. Sixty-five cosmetics were purchased from online and offline stores in Busan. This study developed a simultaneous method for the analysis of phthalates by GC-FID. The results showed that among the 65 cosmetics, DBP, DEHP, and DEP were detected at 20.0%, 7.7%, 1.5%, respectively. The amounts of DBP and DEHP detected in 18 samples were less than 100 μg/g, which satisfies the Regulations of Cosmetic Safety Standards in Korea. In order to detect phthalates in cosmetic containers, a dissolution test was conducted by extracting solutions, such as water, n-heptane, 20% ethanol, 50% ethanol and 4% acetic acid, which were prepared with different levels of pH, alcohol content, and fat content following the Korea Standards and Specifications for Utensils, Containers, and Packaging. The results showed that DMP, DBP, DEHA, BBP, DEHP, and DNOP were not detected, DEP was detected in plastics such as PE, PP, and others, when a 50% alcohol solvent was used. Phthalates may not be detected in cosmetic containers if they are not packaged with the above 20% alcohol constituent. We also analyzed the concentration of heavy metals, such as Pb, Cd, and Hg, by using ICP-OES and a mercury analyzer. The ranges of concentration were ND~2.71 μg/g for Pb, ND~0.31 μg/g for Cd, and ND~0.01 μg/g for Hg, which are below the regulated level.

Survey on Packaging Status and Effects of Precooling on the Quality of $Agaricus$ $bisporus$ (양송이버섯의 포장실태조사 및 예냉처리가 품질에 미치는 효과)

  • Chang, Min-Sun;Lee, Da-Uhm;Cho, Sun-Duk;Jhune, Chang-Sung;Kim, Gun-Hee
    • Food Science and Preservation
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    • v.19 no.1
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    • pp.67-73
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    • 2012
  • This study was carried out to investigate the packaging status of the $Agaricus$ $bisporus$ mushrooms and the benefits of storing them after precooling to improve their distribution system using small packages. The packaging status of the $Agaricus$ $bisporus$ mushrooms was surveyed at a farm, a department store, a wholesale market, and a supermarket from May to September 2011. The packaging materials that were used were PS, carton, PP, LDPE, PLA, and PVC. The harvested $Agaricus$ $bisporus$ mushrooms were precooled at $4^{\circ}C$ for three hours and were then stored at $20^{\circ}C$ for three days. The weight loss rate of the precooled sample was slightly lower than that of the unprecooled sample; conversely, the L value of the precooled sample was higher than that of the unprecooled sample. The ${\Delta}E$ value was lowest in the precooled sample after packaging. The precooling process effectively prolonged the shelf life and enhanced the quality of the$Agaricus$ $bisporus$ mushrooms.

Improvement of Students' Problem Finding and Hypothesis Generating Abilities: Gifted Science Education Program Utilizing Mendel's Law (문제발견 및 가설설정 능력 신장 과학영재교육프로그램 개발: 멘델의 과학적 사고과정 적용)

  • Kim, Soon-Ok;Kim, Bong-Sun;Seo, Hae-Ae;Kim, Young-Min;Park, Jong-Seok
    • Journal of Gifted/Talented Education
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    • v.21 no.4
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    • pp.1033-1053
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    • 2011
  • In the process of establishing the principle of genetics, Mendel discovered problems based on various observations. Mendel's scientific thinking ability can be effective if this ability is embedded in gifted science education programs. The study aims to develop a science gifted education program utilizing Mendel's scientific thinking ability shown in the principles of genetics and examine students' changes in scientific thinking ability before and after the program implementation. For the program development, first, the characteristics of Mendel's scientific thinking ability in the process of establishing the principle of genetics were investigated and extracted the major elements of inquiry. Second, the science gifted education programs was developed by applying the inquiry elements from the Mendel's Law. The program was implemented with 19 students of $7^{th}$, $8^{th}$ graders who attend the science gifted education center affiliated with university during July 2011. The Mendel's scientific thinking ability was classified into induction, deduction, and integration. The elements of inquiry extracted from the Mendel's scientific thinking include making observation, puzzling observation, proposing causal questions, generating hypothesis, drawing inference, designing experiment, gathering and analyzing data, drawing conclusions, and making generalization. With applying these elements, the program was developed with four phases: $1^{st}$ - problem finding; $2^{nd}$ - hypothesis generating; $3^{rs}$ - hypothesis testing and $4^{th}$ - problem solving. After implementation, students' changes in scientific thinking ability were measured. The findings from the study are as follows: First, students' abilities of problem finding is significantly (p<.05) increased. Second, students' abilities of hypothesis generating is significantly (pp<.05) increased.

The Age-specific Change of Refraction(D) Power and Relative Risks of Refractive Errors (연령에 따른 굴절력 변화와 굴절이상의 상대 위험도)

  • Lee, Eun-Hee;Lee, Sang-Yoon;Lee, Hee-Jung;Cho, Sung-Il;Paek, Domyung
    • Journal of Korean Ophthalmic Optics Society
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    • v.12 no.3
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    • pp.1-5
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    • 2007
  • This is a succeeding article of J. Korean Optalmic Optics Society vol. 11(2) pp. 121-129(2006) [Research about the distribution of refractive errors in distinction of gender and at age of Kyonggi province's partial area]. The former article showed age-specific distribution of myopia, hyperopia and astigmatism which generally appears in refractive errors. This paper aimed to investigate the change of refractive power and prevalence of refractive errors by age. Total 928 subjects were sampled and their refractive errors were determined using auto refractometer. As the results, change of refractive power of subjects appeared at the age about 40, and suddenly reduced over 46 years resulting in (+)refractive power at their fifties. Relative risks of refractive errors of myopia increased in younger subjects but the risks decreased in older subjects (over 46 years). On the other hand, the risks of hyperopia decreased as the age of subjects increase, but could increase to 0.24 (95% CI: 0.07-0.88) after 36 years. This results showed that presbyopia might progress more early when people were before 40 years.

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A Study on the Model Development and Empirical Application for Predicting the Efficiency and Optimum Size of Investment in Domestic Seaports (국내항만투자의 효율성 및 적정 투자규모 예측을 위한 모형개발 및 실증적 적용에 관한 연구)

  • Park, Ro-Kyung
    • Journal of Korea Port Economic Association
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    • v.26 no.3
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    • pp.18-41
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    • 2010
  • The purpose of this paper is to show the empirical measurement way for predicting the seaport efficiency by using Super SBM(Slack-based Measure) with Wilcoxson signed-rank test under CRS(constant returns to scale) condition for 20 Korean ports during 11 years(1997-2007) for 3 inputs(port investment amount, birthing capacity, and cargo handling capacity) and 5 outputs(Export and Import Quantity, Number of Ship Calls, Port Revenue, Customer Satisfaction Point for Port Service and Container Cargo Throughput). The main empirical results of this paper are as follows. First, Super SBM model has well reflected the real data according to the Wilcoxon signed rank test, because p values have exceeded the significance level. Second,Super-SBM has shown about 87% of predicting ratio for the ports efficiency and the optimal size of investment in domestic seaport. The policy implication to the Korean seaports and planner is that Korean seaports should introduce the new methods like Super-SBM method with Wilcoxon signed rank test for predicting the efficiency of port performance and the optimal size of investment as indicated by Panayides et al.(2009, pp.203-204).

Determination of 4 Parabens in Human Urine by Online SPE and LC-MS/MS Techniques (온라인 고체상추출과 LC-MS/MS 기술을 이용한 소변 중 파라벤류 분석)

  • Kim, Jung Hoan;Kho, Young Lim;Kim, Pan Gyi;Jeong, Jee Yeon;Lee, Eun Hee;Lee, Seung-Youl;Nam, Hye-Seon;Rhee, Gyu-Seek
    • Journal of Environmental Health Sciences
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    • v.38 no.6
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    • pp.561-567
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    • 2012
  • Objectives: Parabens are widely used as antimicrobial agents in pharmaceuticals and cosmetics as well as by the food industry. Parabens have been reported to show weak estrogenic activity and be related to health effects such as allergic reactions and skin and breast cancer. We evaluated an online solid phase extraction (SPE) method coupled with LC-MS/MS technique using free and conjugated parent parabens in human urine for assessing human exposure to parabens. Methods: We employed LC/MS/MS through online solid phase extraction and column-switching techniques and analyzed free and conjugated parabens as biomarkers of human exposure. Four major parabens, methyl-paraben (MP), ethyl-paraben (EP), propyl-paraben (PP) and butyl-paraben (BP), were analyzed. Method validation was performed by sensitivity, accuracy, precision and comparison of the results of online SPE with offline SPE. Results: The limits of detection (LOD) were in the range of 0.2-2 ng/mL, and actual limits of quantification (LOQ) were in the range of 0.7-6 ng/mL urine, depending upon the compound. Accuracy was in the range of 98.3-106.4%, and precision was in the range of 1.3-8.7% (CV) depending upon the compound. We found a good correlation between the results of analysis by online SPE method and that by off-line SPE method. Conclusions: The online SPE method showed proper LOD and validated accuracy, precision and good correlation with the offline method for analyzing parabens in urine.

A cephalometric investigation on the craniofacial configurations of Class ll division 1 and 2 in Korean (한국인 II급 1류 및 2류 부정교합자 두개안면형태의 차에 대한 측모두부방사선계측학적 연구)

  • Kang, Jong-Won;Lee, Young-Jun;Park, Young-Guk
    • The korean journal of orthodontics
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    • v.32 no.3 s.92
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    • pp.195-207
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    • 2002
  • Numerous studies have revealed the similarities and discrepancies in two divisions of class II malocclusion, since these malocclusion groups have been postulated to be disparate criterion, much as classified under one diagnostic umbrella. This study was undertaken to describe the craniofacial configurations of class II division 1 and 2, and consequently to discriminate the morphologic differences between the two malocclusion groups in Korean sample. Lateral headfilms of 34 class H division 1 and 29 division 2 were employed, while those of 142 adults of normal occlusion served as a control. The landmarks were digitized and 26 variables were statistically analyzed for one way ANOVA. 1. There manifested no statistically significant difference in maxillary position anteroposteriorly. Normal occlusion group exhibited most anteriorly positioned mandible, whereas class II division 1 showed the most retroposition. Class II division 1 disclosed clockwise rotation tendency of mandible, which resulted in position of the chin Posteriorly. 2. Class II division 1 showed greater in SN to MP, SN to PP significantly than other groups. 3. Class II division 2 showed smaller genial angle and larger mandibular body length than other groups. 4. Class II division 1 revealed greater anterior lower face height than other groups, whereas division 2 dictated significantly greater posterior face height. 5. Class II division 2 expressed the most retroclined lower incisor, while division 1 manifested the most proclination. The largest interincisal angle resided in Class II division 2 group. There were no significant differences in upper molar position anteroposteriorly.

A Path Analysis on the Effect of Anxiety and Depression on Health-related Quality of Life of Middle aged Women (중년 여성의 불안과 우울이 삶의 질에 미치는 영향에 대한 경로분석)

  • Oh, Yeong-Kyong;Hwang, Seon-Young
    • Journal of Digital Convergence
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    • v.15 no.10
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    • pp.579-588
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    • 2017
  • The purpose of this study was to examine the effect of anxiety and depression on health-related QOL(Quality of Life) of middle aged women and to test hypothetical model of QOL. This study is a pathway analysis study using 1692 middle aged women whose age range is between 40 and 64. This study was performed as secondary analysis using the data from the 2015 Korean Social Psychological Anxiety Examination Survey. Data were analyzed using descriptive statistics, correlation analysis and pathway analysis. As a result, Stress, social support, aged preparation, self-esteem, anxiety, depression and QOL showed significant correlation. Anxiety was directly affected by stress(.21, p=.009) and social support(-.05, p=.046). Depression was directly affected by stress(.28, p=.016), social support(-.10, p=.008) and self-esteem(-.38, p=.039). Both anxiety(-.16, pp=.009) and depression(-.17, p=.011) had effect on QOL but depression was mediated by anxiety in affecting to QOL. Anxiety and depression of middle aged women affect to QOL and QOL is affected by depression via anxiety. It suggests that it needs to provide nursing intervention for mental health such as anxiety and depression for QOL of middle aged women.

Separation and Elution Behavior of Some Iron(Ⅲ)porphyrin Complexes by Reversed-Phase Liquid Chromatography (역상 액체 크로마토그래피에 의한 Iron(Ⅲ)porphyrin 착화합물들의 분리 및 용리거동에 관한 연구)

  • Chang Hee Kang;In Whan Kim;Won Lee
    • Journal of the Korean Chemical Society
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    • v.37 no.12
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    • pp.1035-1046
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    • 1993
  • Some iron(III)porphyrin complexes were prepared, and identified by the spectroscopic methods. Elution behavior of iron(III)porphyrin complexes was investigated by reversed-phase HPLC. The optimum conditions for the separation of iron(III)porphyrin complexes were examined with respect to flow rate and mobile phase strength. These complexes were successfully separated on NOVA-PAK $C_{18}$ column using methanol / water(95/5) for $[T_pCF_3PP)Fe(R)]$ and methanol / water (98/2) for $[(P)Fe(C_6F_5)]$ as a mobile phase. It was found that these complexes were largely eluted in an acceptable range of capacity factor value ($0{\leq}logk'{\leq}1$). The dependence of the capacity factor (k') on the volume fraction of water in the binary mobile phase as well as the dependence of k' on the liquid-liquid extraction distribution ratio$(D_c)$ in methanol-water / n-pentadecane extraction system showed a good linearity. It means that the retention of iron(III)porphyrin complexes on NOVA-PAK $C_{18}$ column is largely due to the solvophobic effect. Also, there was a good linear dependence of the capacity factor(k') on the column temperature and enthalpy calculated by van't Hoff plot. From these results, it was confirmed that the retention mechanism of iron(III)porphyrin complexes in reversed-phase liquid chromatography was invariant under the condition of various temperature, and the solvophobic binding process exhibited isoequilibrium behavior.

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Application of AFLPs to Phylogenetic Analysis of Aegilops (AFLPs에 의한 Aegilops의 계통발생학적 재평가)

  • Park, Yong-Jin;Shim, Jae-Wook
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.42 no.6
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    • pp.790-799
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    • 1997
  • Aegilops genus is known to include the donor species of the Band D genome of the bread wheat(ABD). An effort to establish a better strategy for phylogenetic relationships about Aegilops polyploids by AFLPs(Amplified Fragment Length Polymorphisms) was conducted using the 19 Aegilops sPP. and T. aestivum. The 207 polymorphic bands from the amplified products on the 6% acrylamide denaturing sequencing gels were obtained with the 7 AFLP primer combinations, and used to account for the genetic similarities and cluster analysis using NTSYS program. According to the genome analysis, the $M^h$-genome of Ae. heldreichii was estimated as an intermediate genome between the M-genome of Ae. comosa and N-genome of Ae. uniaristata and supposed to be incorporated in the establishing process of UM-genome as a possible diploid donor. And Ae. ventricosa(DN) was more close to Ae. umbellulata(U) than Ae. squarrosa(D). The close relationship between Ae. squarrosa and T. aestivum was perceived as a diploid donor of D-genome. As for the polyploid species, hexaploid Ae. triaristata was more closely related to Ae. columnaris rather than tetraploid Ae. triaristata. The clustered groups were, basically same to the previous Gihara's sections based on phenotypes and pairing analysis of interspecific hybrids. AFLP was evaluated as an efficient and powerful method in the genome evaluation of closely related species.

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