• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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• pp.238-238
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• 2002

We studied whether kinase pathways are involved in TCDD-induced gene expression by treating specific kinase inhibitors ncluding MEK1 inhibitor PD98059, p38 inhibitor SB202190, PI-3 kinase inhibitor Wortmannin or LY294002 or protein tyrosine kinase inhibitor Genestein and then tested the effects of individual inhibitors on TCDD-induced gene expression of cytochromelAl gene (CYPlAl). Our results show that PD98059, MEK-1 inhibitor reduces dioxin-inducible transcription of CYPlAl. p44/p42MAPK, that is phosphorylated by Mek-1, are phosphorlylated by treatment of TCDD, peaking at lnM, 30min treatments. Overexpressions of p44/p42 MAPK dominant negative mutants suppress dioxin dependent transcription of DRE-driven reporter gene in a dose-dependent manner. Our results demonstrate that p44/p42 MAPK is essential for transcriptional activity of AHR/ARNT heterodimer. We found that PD98059 dose-dependently blocks TCDD-induced DRE binding of the AHR/ARNT heterodimer, thereby it reduces TCDD-induced gene expression. Therefore, our results indicate that Mek-1/p44/p42 MAPK pathway is involved in TCDD-induced gene expression, [This study was supported by a grant from Korean Research Foundation Grant (X01529)to H. Park]

• 조명전기설비학회논문지
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• 제15권1호
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• pp.104-111
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• 2001

본 연구에서는 대기중 두가지 형태의 전극부에서 부분방전(partial discharge : PD)시 방사되는 VHF(30∼230 [MHz])대역의 방사전자파를 측정하고, 그 스펙트럼의 특이한 패턴을 나타냈다. 또한 PD에 의해 방사되는 방사전자파에 대한 거리 및 편파특성에 관하여 연구하였다. 에폭시절연체를 삽입한 경우, 방사전자파의 잡음레벨은 90 [MHz] 대역 이하에서 대기중에 비하여 0.6∼6.2 [db] 높게 나타났다. 방사전자파의 스펙트럼 분포는 안테나 엘리먼트 배치에 따라 전주파수 영역에서 차이를 나타내고 있다.

• Parasites, Hosts and Diseases
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• 제53권4호
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• pp.371-377
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• 2015

Trichomonas vaginalis induces proinflammation in cervicovaginal mucosal epithelium. To investigate the signaling pathways in $TNF-{\alpha}$ production in cervical mucosal epithelium after T. vaginalis infection, the phosphorylation of PI3K/AKT and MAPK pathways were evaluated in T. vaginalis-infected SiHa cells in the presence and absence of specific inhibitors. T. vaginalis increased $TNF-{\alpha}$ production in SiHa cells, in a parasite burden-dependent and incubation time-dependent manner. In T. vaginalis-infected SiHa cells, AKT, ERK1/2, p38 MAPK, and JNK were phosphorylated from 1 hr after infection; however, the phosphorylation patterns were different from each other. After pretreatment with inhibitors of the PI3K/AKT and MAPK pathways, $TNF-{\alpha}$ production was significantly decreased compared to the control; however, $TNF-{\alpha}$ reduction patterns were different depending on the type of PI3K/MAPK inhibitors. $TNF-{\alpha}$ production was reduced in a dose-dependent manner by treatment with wortmannin and PD98059, whereas it was increased by SP600125. These data suggested that PI3K/AKT and MAPK signaling pathways are important in regulation of $TNF-{\alpha}$ production in cervical mucosal epithelial SiHa cells. However, activation patterns of each pathway were different from the types of PI3K/MAPK pathways.

• 한국광학회지
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• 제16권6호
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• pp.516-520
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• 2005

본 논문에서는 광섬유형 전자 스페클 패턴 간섭계에 적용할 효과적인 위상이동 방법을 제안한다. 광섬유 마이켈슨 간섭계에 4$\pi$ 위상변조를 주기적으로 가하면서 각각 $\pi$의 위상차이를 갖는 4개의 영점위치를 검출하여 CCD 카메라의 이미지 취득신호를 생성한다. 이 신호에 따라 얻어지는 스페클 패턴은 위상추출 과정에 필요한 $\pi$/2 위상차이를 갖게 되며 후처리를 통하여 측정 대상체의 3차원적인 표면 위상정보를 얻게 된다. 환경적인 외란에 비하여 충분히 빠른 위상변조를 가할 경우 귀환제어 없이 빠르고 정확하게 $\pi$/2 위상 이동에 따른 CCD 동작신호를 생성할 수 있었으며, 위상변조기의 비선형적인 동작특성에 영향 받지 않는 실험결과를 얻을 수 있었다. 실험을 통하여 100 Hz의 영상 취득 속도를 얻었고, 25 Hz의 위상변조를 가할 때 출력 위상계단 신호의 오차는 0.6 mrad이었다.

• 한국생산제조학회지
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• 제8권6호
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• pp.35-42
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• 1999

This paper concentrates on the position control of a pneumatic cylinder under parameter variation. A closed-loop control is proposed to design the different controllers(P, PI, PID, PD controller) in order to choose the best con-troller based on the fast and accurate control of the system. It is shown that the control algorithm, is robust and effective in attaining the fast and accurate position control of system under time-dependent parameter variation. Experimental results showed that PD controller law is effective to obtain the fast response and to increase that sta-blity of the system The method is a useful control algorithm which always automatically adjusts the position con-trol in accordance with the error using carrier wave of triangle type regardless of changes on the operating condi-tion and physical differences between components.

• 전기학회논문지
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• 제67권12호
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• pp.1626-1632
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• 2018

In this paper, we describe the fabrication and characterization of a hydrogen peroxide ($H_2O_2$) sensor based on palladium and copper (PdCu) electroplated laser induced graphene (LIG) electrodes. $CO_2$ laser was used to form LIG electrodes on a PI film. This fabrication method allows simple control of the LIG electrode size and shape. The PdCu was electrochemically deposited on the LIG electrodes to improve the electrocatalytic reaction with $H_2O_2$. The electrochemical performance of this sensor was evaluated in terms of selectivity, sensitivity, and linearity. The physical characterization of this sensor was conducted using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS), which confirmed that PdCu was formed on the laser induced graphene electrode. In order to increase the sensor sensitivity, the Pd:Cu ratio of the electroplated PdCu was varied to five different values and the condition of highest amperometric current at an identical of $H_2O_2$ concentration was chosen among them. The resulting amperometric current was highest when the ratio of Pd:Cu was 7:3 and this Pd;Cu ratio was employed in the sensor fabrication. The fabricated PdCu/LIG electrode based $H_2O_2$ sensor exhibited a sensitivity of $139.4{\mu}A/mM{\cdot}cm^2$, a broad linear range between 0 mM and 16 mM of $H_2O_2$ concentrations at applied potential of -0.15 V, and high reproducibility (RSD = 2.6%). The selectivity of the fabricated sensors was also evaluated by applying ascorbic acid, glucose, and lactose separately onto the sensor in order to see if the sensor ourput is affected by one of them and the sensor output was not affected. In conclusion, the proposed PdCu/LIG electrode based $H_2O_2$ sensor seems to be suitable $H_2O_2$ sensor in various applications.

• Journal of Periodontal and Implant Science
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• 제51권3호
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• pp.147-162
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• 2021

Purpose: This systematic review and meta-analysis was conducted to assess the effects of glycine powder air-polishing (GPAP) in patients during supportive periodontal therapy (SPT) compared to hand instrumentation and ultrasonic scaling. Methods: The authors searched for randomized clinical trials in 8 electronic databases for relevant studies through November 15, 2019. The eligibility criteria were as follows: population, patients with chronic periodontitis undergoing SPT; intervention and comparison, patients treated by GPAP with a standard/nozzle type jet or mechanical instrumentation; and outcomes, bleeding on probing (BOP), patient discomfort/pain (assessed by a visual analogue scale [VAS]), probing depth (PD), gingival recession (Rec), plaque index (PI), clinical attachment level (CAL), gingival epithelium score, and subgingival bacteria count. After extracting the data and assessing the risk of bias, the authors performed the meta-analysis. Results: In total, 17 studies were included in this study. The difference of means for BOP in patients who received GPAP was lower (difference of means: -8.02%; 95% confidence interval [CI], -12.10% to -3.95%; P<0.00001; I²=10%) than that in patients treated with hand instrumentation. The results of patient discomfort/pain measured by a VAS (difference of means: -1.48, 95% CI, -1.90 to -1.06; P<0.001; I²=83%) indicated that treatment with GPAP might be less painful than ultrasonic scaling. The results of PD, Rec, PI, and CAL showed that GPAP had no advantage over hand instrumentation or ultrasonic scaling. Conclusions: The findings of this study suggest that GPAP may alleviate gingival inflammation more effectively and be less painful than traditional methods, which makes it a promising alternative for dental clinical use. With regards to PD, Rec, PI, and CAL, there was insufficient evidence to support a difference among GPAP, hand instrumentation, and ultrasonic scaling. Higher-quality studies are still needed to assess the effects of GPAP.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2011년도 제42회 하계학술대회
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• pp.1948-1949
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• 2011

본 논문은 볼빔시스템 제어에 대해 입자군집최적화(Particle Swarm Optimization; PSO)을 이용한 최적 퍼지제어기 설계방법을 연구한다. 볼빔 시스템은 모터와 빔, 움직이는 볼로 구성되며 볼의 위치제어를 기본 동작으로 한다. 본 논문에서는 제어성능이 우수한 퍼지제어기를 사용하여 제어시스템을 설계하는데, 퍼지제어구조는 1차 제어기와 2차 제어기로 구성되고, 최적 퍼지제어기 설계를 위해 PSO를 사용하며 PSO는 초기값에 영향이 적고 일반적인 탐색알고리즘과 달리 초기 수렴의 문제를 극복한다. 본 논문에서는 퍼지제어기와 기존의 PD 제어기의 성능비교를 시도 하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2000년도 추계학술대회 논문집 학회본부 D
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• pp.682-685
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• 2000

In this paper, Using CDM(Coefficient Diagram Method), we set target polynomial constraints and design 4-PID controller which have different structures such as Textbook PID-controller, Derivative of output PID-controller, set point of I only controller(I-PD controller) and PI controller followed by lag network(PI lag network controller) were tested by simulations. The plant we used are that used in IFAC 93 benchmark test. A controller designer, using CDM could use these results to select the controller's structure which is the best one fer him.

• 대한의생명과학회지
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• 제20권4호
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• pp.244-249
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• 2014

Arazyme is a metalloprotease secreted by Aranicola proteolyticus that was previously shown to suppress cytokine expression of keratinocytes and endothelial cells and inhibit histopathological features in an atopic dermatitis-like animal model. However, the regulatory effects of arazyme in other allergic diseases have yet to be elucidated. In this study, we investigated whether arazyme is effective against neutrophil apoptosis in allergic diseases such as allergic rhinitis and asthma. Arazyme inhibited neutrophil apoptosis of normal subjects in a dose-dependent manner. However, the antiapoptotic effect of arazyme was reversed by LY294002, an inhibitor of PI3K, AKTi, an inhibitor of Akt, PD98059, an inhibitor of MEK, and BAY-11-7085, an inhibitor of NF-${\kappa}B$. Arazyme induced activation of NF-${\kappa}B$ via PI3K/Akt/ERK pathway. The anti-apoptotic effect of arazyme is associated with inhibition of cleavage of caspase 3 and caspase 9. Arazyme inhibited constitutive apoptosis of neutrophil in a dose-dependent manner in allergic subjects, and its mechanism was shown to be associated with PI3K/Akt/ERK/NF-${\kappa}B$. The results presented here improve our understanding of neutrophil apoptosis regulation and will facilitate development of drugs for treatment of allergic diseases.