• Journal of Gastric Cancer
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• 제18권1호
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• pp.1-19
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• 2018

Gastric cancer (GC) is the second leading cause of cancer mortality and the fourth most commonly diagnosed malignant diseases. While continued efforts have been focused on GC treatment, the introduction of trastuzumab marked the beginning of a new era of target-specific treatments. Considering the diversity of mutations in GC, satisfactory results obtained from various target-specific therapies were expected, yet most of them were unsuccessful in controlled clinical trials. There are several possible reasons underlying the failures, including the absence of patient selection depending on validated predictive biomarkers, the inappropriate combination of drugs, and tumor heterogeneity. In contrast to targeted agents, immuno-oncologic agents are designed to regulate and boost immunity, are not target-specific, and may overcome tumor heterogeneity. With the successful establishment of predictive biomarkers, including Epstein-Barr virus pattern, microsatellite instability status, and programmed death-ligand 1 (PD-L1) expression, as well as ideal combination regimens, a new frontier in the immuno-oncology of GC treatment is on the horizon. Since the field of immuno-oncology has witnessed innovative, practice-changing successes in other cancer types, several trials on GC are ongoing. Among immuno-oncologic therapies, immune checkpoint inhibitors are the mainstay of clinical trials performed on GC. In this article, we review target-specific agents currently used in clinics or are undergoing clinical trials, and highlight the future clinical application of immuno-oncologic agents in inoperable GC.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1998년도 춘계학술대회 논문집
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• pp.293-296
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• 1998

Surface electrical conduction in insulator is most important factor to assess the insulation performances of outdoor insulating materials. In this paper, contamination performance of the widely used materials for outdoor insulator - porcelain, EPDM, Silicone rubber - were discussed by measuring properties of average leakage current and scintillation discharge pulses under artificial contamination conditions. The artificial contaminations used were deionized distilled water fog, 0.5wt% NaCl salt fog of light pollution and 2wt% NaCl salt fog of medium pollution. The average leakage current was appeared linearly with applied voltage at dry and clean surface condition. The magnitude of leakage current was almost same at different kinds of samples. In case of deionized distilled water fog, the characteristics of leakage current and applied voltage was most different to that in case of dry and clean condition. In case of salt fog pollution condition, The leakage current was increased above critical voltage. The scintillation discharges were also activated at the level. the leakage current and scintillation discharges were increased with increasing pollution degree. The resistance to pollution properties of silicone rubber appeared excellent among them.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 추계학술대회 논문집 전기물성,응용부문
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• pp.145-146
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• 2006

본 논문은 부분방전(PD: Partial Discharge)의 패턴인식 확률 극대화를 목적으로 신경망(NN: Neural Network) 파라미터 중에서 은닉층 뉴런의 수, 모멘텀(momentum)의 Step size와 Decay rate 를 최적화하기 위하여 유전 알고리즘(GA: Genetic Algonthm)을 적응하였다. 실험적 연구의 대상으로서, GIS(Gas Insulated Switchgear)사고의 주요 원인으로 보고되어있는 결함들을 인위적으로 모의한 16개 Test cell을 이용하여 부분방전을 발생시켰다. 부분방전 신호는 본 연구팀이 개발한 센서를 이용하여 검출되어 데이터베이스가 구축되어 그로부터 추출된 학습 데이터들의 학습에 다음과 같은 5가지 신경망 모델이 적응되었다: Multilayer Perception (MLP), Jordan-Elman Network (JEN), Recurrent Network (RN), Self-Organizing Feature Map (SOFM), Time-Lag Recurrent Network (TLRN). 유전 알고리즘 적용 효율성을 분석하기 위하여 동일한 데이터를 이용하여 다음과 같은 두 가지 방법을 적용한 결과를 상호 비교하였다. 우선 상기 선택된 모델만 적용하였고 다근 하나는 상기 모델과 Genetic Algorithm이 동시에 적용되었다. 모든 모델에 대하여 학습오차와 패턴 분류 확률을 비교한 결과, 유전 알고리즘 적응 시 부분방전 패턴인식 확률이 향상되었음이 확인되어 향후 신뢰성 있는 GIS 부분방전 진단기술에 활용될 수 있을 것으로 사료된다.

• 한국식품저장유통학회지
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• 제14권6호
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• pp.688-694
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• 2007

To evaluate the human risk of long-term intake of genetically modified (GM) rice, we carried out RT-PCR of housekeeping genes. Housekeeping genes, which show highly uniform expression in living organisms during various stages of development and under different environmental conditions, were normalized by RT-PCR. We assessed the expression of 10 common housekeeping genes (18s rRNA, 25S rRNA, UBC, UBQ5, UBQ10, ACT11, GAPDH, eEF-$1{\alpha}$, ${\beta}$-TUB, GAPDH, ${\beta}$-actin, B2m, G6pd2, Gyk, Gus, Hprt, Cyclophlin A, Tfrc, ${\alpha}$-tubulin and RPL13A) in the liver, stomach, small intestine, large intestine, kidney and spleen of mice fed GM or non-GM rice. We found no significant differences in the expression of housekeeping genes between the two groups of mice.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 제36회 하계학술대회 논문집 C
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• pp.2223-2225
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• 2005

In this work, experimental investigation has been mainly done. For this purpose, UHF sensor has been designed and fabricated to detect the partial discharges produced from the 10 artificial defects introduced into the real scale 70kV GIS mock-up under the high voltage at the well shielded room. And also, in order to verify the applicability of the proposed method at the site, the proposed CAPD (chaos analysis of partial discharge) is combined with spectral analysis method in order to identify the nature of the above 10 defects. The PD pattern recognition of each defect has been fulfilled by applying self developed artificial neural network soft ware. The result shows that the recognition rate is reached to be 80% by newly proposed method while the traditional PRPD analysis method leads us to obtain 41%. In consequence, it can be pointed out that the proposed method seems likely to be applicable to the real GIS at the site.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 하계학술대회 논문집 C
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• pp.1726-1728
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• 2003

The aging diagnosis method using partial discharge measurement detects discharge signals that critical cause of failure in insulation material operated a long time and can diagnose aging state of insulation materials with an aging analysis algorithm. The HFPD measurement method is a technique to analyze aging state of high voltage insulation materials and detect higher frequency signals than conventional PD measurement method therefore it takes less noise effect and could execute active line measurement. It is possible to analyze main discharge phenomena and obtain access to aging progress occurred in insulation materials through accumulation of HFPD signals during determined interval and expression of fractal dimension using statistical process of accumulated signals. The HFPD signals that occurred in each applied voltages are measured during 180 cycles and accumulated to the same phase of one cycle. These patterns that made by previous method are normalized with logarithm function and than inputted to neural networks. The aging diagnosis of insulation material was possible and the recognition ratio of neural network appeared very high.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 추계학술대회 논문집 전기물성,응용부문
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• pp.101-103
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• 2004

본 연구는 전력 계통에 상용화된 $SF_6$ GIS(Gas Insulated Switchgear) 내부에서 발생되는 부분방전 검출 방법을 개발하기 위하여, GIS의 내부에 유입되거나 생산과정에서 형성 될 수 있는 세 가지 결함들을 연구용 GIS 내부에 모의하였으며 또한 특성이 다른 센서(UHF, CT, AE)를 제작 또는 이용하여 그 부분방전 패턴 결과와 주파수 분석 결과를 상호 비교하였다. 실험결과에 의하면, 동일한 결함에 의하여 센서의 검출 결과는 다르게 나타나거나 전혀 검출이 되지 않음이 밝혀졌다. 따라서, 부분방전 패턴분석을 하나의 분석방법에 의존하는 것은 바람직하지 못한 것으로 사료되며 신뢰성 있는 GIS 진단을 위하여 적합한 센서개발 및 두 가지 이상의 분석 방법이 병행되는 것이 절대적으로 필요한 것으로 사료된다.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2012년도 전력전자학술대회 논문집
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• pp.59-60
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• 2012

Cascaded H-bridge 멀티레벨인버터의 스위칭 패턴을 기본파 생성을 위한 저주파 동작과 파형 개선 목적의 고주파 PWM 스위칭 패턴으로 구분하여 스위칭 손실을 감소시킬 수 있지만 입력단의 DC 독립전압원은 각 H-bridge 모듈이 담당하는 출력전압의 레벨에 따라 용량의 차이가 발생한다. 이는 각 H-Bridge 모듈 스위치의 전류 스트레스 차이를 의미하며, 이로 인해 H-bridge 모듈별 수명 차이를 발생시킨다. 본 논문에서는 용량 창이에 따른 모듈 특성 개선과 인버터 수명 문제를 해결하기 위하여 기존의 다중 반송파 정현 펄스폭 변조방식에 스와핑 스위칭 방법을 적용하여 Cascaded H-bridge 멀티레벨인버터에 적용함으로써 스위칭 손실 개선과 함께 각 H-bridge 별 담당 부하 전력을 동일하게 하여 동일 전류 정격 스위치의 사용을 가능하게 한다. 제안된 스와핑 스위칭 패턴을 PD, POD, APOD방식으로 구현하고 이론적 분석과 시뮬레이션을 통해 타당성을 검증한다.

• 한국균학회지
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• 제23권1호통권72호
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• pp.86-91
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• 1995

Rhizopus oryzae의 카드뮴 적응 및 해독기작과 이에 관련된 세포내 생리 생화학적 변화를 조사하였다. R. oryzae는 카드뮴을 첨가 배양하였을 때 카드뮴 영향하에서는 carbohydrate metabolic pathway에 관련된 효소 활성(MDH, GPI)이 촉진되고 과산화물 제거에 관여하는 효소가 새롭게 유도(CAT2)된 반면, lactate를 이용하는 효소(LDH, ADH)의 활성이 감소된 사실은 중금속 영향하에서 세포의 성장과 에너지 공급을 위해 에너지 수율이 낮은 lactate를 이용하는 경로보다는 에너지 수율이 높은 TCA cycle 경로에 작용하는 효소들과 독성과산화물 제거에 관여하는 효소의 더 많은 derepression이 필요하다는 것을 알 수 있었다.

• 대한건축학회논문집:계획계
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• 제34권4호
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• pp.77-85
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• 2018

Rapid urbanization has fostered development of modern cities. Although Conventional zoning played its role to control urban development, it also segregated land uses and created homogeneous development pattern. Mega cities with satellite bed towns has not shown their unique identity and characters. In order to develop comprehensive approach which may bring social and physical enhancement can be difficult to achieve by considering city as a two dimensions. On contrary, extensive analysis and proposals require an approach which can perceive city with three dimensions. Form-Based Codes (FBCs) are appeared as an alternative to conventional zoning with different design process and principles. FBCs approach urban place with three dimension and giving priority to form rather than land use. The purpose of this study was to analyze the necessity of FBCs and its concept, components and how this would change urban characteristics in the aspects of architectural design through analysis on 4 case studies for zoning codes of US cities. Through comparison of components in Form-Based Codes of 4 different cases, this study can show the reasons for differences in application of Form-Based Codes and how detailed components would play a role to establish better urban environments.