• Journal of the Korea Society for Simulation
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• v.21 no.3
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• pp.1-9
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• 2012

This paper proposes automatic precision approach radar (PAR) control system using digital signal to increase the safety of aircraft, and discrete event systems specification (DEVS) methodology is utilized to verify the proposed system. Traditionally, a landing aircraft is controlled by the human voice of a final approach controller. However, the voice information can be missed during transmission, and pilots may also act improperly because of incorrectness of auditory signals. The proposed system enables the stable operation of the aircraft, regardless of the pilot's capability. Communicating DEVS (C-DEVS) is used to analyze and verify the behavior of the proposed system. A composed C-DEVS atomic model has overall composed discrete state sets of models, and the state sequence acquired through full state search is utilized to verify the safeness and the liveness of a system behavior. The C-DEVS model of the proposed system shows the same behavior with the traditional PAR control system.

• Korean Journal of Medicinal Crop Science
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• v.12 no.1
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• pp.47-52
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• 2004

The root of Patrinia villosa Jussieu (Valerianaceae) has long been used for treatment of infectious diseases in Korea. In this study, the anti-inflammatory effect of the Patrinia villosa root water extract (PVWX) was investigated in proteinase-activated receptor-2 (PAR2)-mediated rat paw edema. Paw edema was induced by injection of trypsin or $trans-cinnamoyl-LIGRLO-NH_2\;(tc-NH_2)$ into hindpaw of rats. PVWX. (10, 50, 100 and 200 mg/kg) was orally administered 1 h before the induction of inflammation. At doses of 50, 100 and 200 mg/kg, PVWX. showed significant inhibition on both change in paw volume and vascular permeability. PVWX. (100 mg/kg) significant1y inhibited PAR2 agonists-induced myeloperoxidase (MPO) activity in paw tissue. These results indicate that PVWX has an anti-inflammatory action in PAR2-mediated paw edema.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2003.11a
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• pp.113-118
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• 2003

An investigation has been carried out on collision-induced dissociation (CID) in the development of an analytical protocol for the determination of polycyclic aromatic hydrocarbons (PARs) by ion trap tandem mass spectrometry. Two different considerations were used to choose the optimal CID conditions for complex matrix environmental samples, namely, to determine the highest signal-to-noise (SIN) ratio and the other to eliminate the background interferences originated from complex matrix samples. The PAR content of agricultural soil was measured to estimate overall distribution of PAR in throughout the country, we collected and analyzed 226 soil samples from paddy and upland soil. The average content of total PAR in all samples was 236 ${\mu}g$ $kg^{-1}$, and the range was from 23.3 to 2, 834 ${\mu}g$ $kg^{-1}$. The overall distribution of PAR was found to be closely related to the pollution sources, the size of city and the type of industry.

• Korean Journal of Clinical Laboratory Science
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• v.48 no.2
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• pp.74-81
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• 2016

Ureaplasma species can normally colonize in the bodies of healthy individuals. Their colonization is associated with various diseases including non-gonococcal urethritis, chorioamnionitis, neonatal meningitis, and prematurity. In 2012, the sum of the resistant and intermediate resistant rates of Ureaplasma spp. to ofloxacin and ciprofloxacin was 66.08% and 92.69%, respectively. DNA point mutations in the genes encoding DNA gyrase (topoisomerase II) and topoisomerase IV are commonly responsible for fluoroquinolone resistance. Each enzyme is composed of two subunits encoded by gyrA and gyrB genes for DNA gyrase and parC and parE genes for topoisomerase IV. In the current study, these genes were sequenced in order to determine the role of amino acid substitutions in Ureaplasma spp. clinical isolates. From December 2012 to May 2013, we examined mutation patterns of the quinolone resistance-determining region (QRDR) in Ureaplasma spp. DNA sequences in the QRDR region of Ureaplasma clinical isolates were compared with those of reference strains including U. urealyticum serovar 8 (ATCC 27618) and U. parvum serovar 3 (ATCC 27815). Mutations were detected in all ofloxacin- and ciprofloxacin-resistant isolates, however no mutations were detected in drug-susceptible isolates. Most of the mutations related to fluoroquinolone resistance occurred in the parC gene, causing amino acid substitutions. Newly found amino acid substitutions in this study were Asn481Ser in GyrB; Phe149Leu, Asp150Met, Asp151Ile, and Ser152Val in ParC; and Pro446Ser and Arg448Lys in ParE. Continuous monitoring and accumulation of mutation data in fluoroquinolone-resistant Ureaplasma clinical isolates are essential to determining the tendency and to understanding the mechanisms underlying antimicrobial resistance.

• BMB Reports
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• v.47 no.8
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• pp.424-432
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• 2014

The defining feature of Parkinson's disease is a progressive and selective demise of dopaminergic neurons. A recent report on Parkinson's disease animal model demonstrates that poly (ADP-ribose) (PAR) dependent cell death, also named parthanatos, is accountable for selective dopaminergic neuronal loss. Parthanatos is a programmed necrotic cell death, characterized by PARP1 activation, apoptosis inducing factor (AIF) nuclear translocation, and large scale DNA fragmentation. Besides cell death regulation via interaction with AIF, PAR molecule mediates diverse cellular processes including genomic stability, cell division, transcription, epigenetic regulation, and stress granule formation. In this review, we will discuss the roles of PARP1 activation and PAR molecules in the pathological processes of Parkinson's disease. Potential interaction between PAR molecule and Parkinson's disease protein interactome are briefly introduced. Finally, we suggest promising points of therapeutic intervention in the pathological PAR signaling cascade to halt progression in Parkinson's disease.

• Journal of applied mathematics & informatics
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• v.27 no.3_4
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• pp.955-961
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• 2009

In this paper, we establish some characterizations which is satisfied by the independence of the upper record values from the Pareto distribution. We prove that $X\;{\in}\;PAR(1,\;{\beta})$, $\beta$ > 0, if and only if $\frac{X_{U(n)}}{X_{U(m)}}$ and $X_{U(m)}$, $1\;{\le}\;m\;<\;n$ are independent. We show that $X\;{\in}\;PAR(1,\;{\beta})$, $\beta$ > 0 if and only if $\frac{X_{U(n)}+X_{U{(n+1)}}}{X_{U(n)}}$ and $X_{U(n)}$, $n\;{\ge}\;1$ are independent. And we characterize that $X\;{\in}\;PAR(1,\;{\beta})$, $\beta$ > 0, if and only if $\frac{X_{U(n)}}{X_{U(n)}+X_{U{(n+1)}}}$ and $X_{U(n)}$, $n\;{\ge}\;1$ are independent.

• Journal of architectural history
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• v.5 no.1 s.9
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• pp.113-122
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• 1996

Cette etude vise a reveler une verite du Nouveau Brutalisme des Smithson (Alison et Peter). Nous examinerons donc d'abord l'universalitf de leur oeuvre representatif, Ecole Secondaire de Hunstanton(projet, 1949; concours, 1950; construction, 1951-1954) et projet de Maison Soho a Londres(1952) comme un mouvement architectural. Et apres nous trouverons la faussete de leur but, realisation de l'ethique architecturale, sur ce mouvement en comparant les oeuvres des Smithson avec les deux constructions considerees souvent comme la categorie du Nouveau Brutalisme, la Calorie d'Art de l'Universite Yale(1951-1953) realisee par Louis I. Kahn(1901-1974) et le Centre Cuturelle de Georges-Pompodou(1971-1977) par Renzo Piano et Richard Rogers. En resultat, l'etique de Nouveau Brutalisme soutenue par les Smithson et defendue par Reyner Banham etait seulement pour cacher low limite architecturale et sa faiblesse. Ce mouvement etait aussi un mouvement personel plutot que general. On ne pourrait pas donc considerer les Smithson comme nouveaux brutalistes.

• Journal of Bio-Environment Control
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• v.30 no.4
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• pp.401-409
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• 2021

This study aimed to estimate the photosynthetic capacity of tomato plants grown in a semi-closed greenhouse using temperature response models of plant photosynthesis by calculating the ribulose 1,5-bisphosphate carboxylase/oxygenase maximum carboxylation rate (V_cmax), maximum electron transport rate (J_max), thermal breakdown (high-temperature inhibition), and leaf respiration to predict the optimal conditions of the CO₂-controlled greenhouse, for maximizing the photosynthetic rate. Gas exchange measurements for the A-C_i curve response to CO₂ level with different light intensities {PAR (Photosynthetically Active Radiation) 200µmol·m^-2·s^-1 to 1500µmol·m^-2·s^-1} and leaf temperatures (20℃ to 35℃) were conducted with a portable infrared gas analyzer system. Arrhenius function, net CO₂ assimilation (A_n), thermal breakdown, and daylight leaf respiration (R_d) were also calculated using the modeling equation. Estimated J_max, A_n, Arrhenius function value, and thermal breakdown decreased in response to increased leaf temperature (> 30℃), and the optimum leaf temperature for the estimated J_max was 30℃. The CO₂ saturation point of the fifth leaf from the apical region was reached at 600ppm for 200 and 400µmol·m^-2·s^-1 of PAR, at 800ppm for 600 and 800µmol·m^-2·s^-1 of PAR, at 1000ppm for 1000µmol of PAR, and at 1500ppm for 1200 and 1500µmol·m^-2·s^-1 of PAR levels. The results suggest that the optimal conditions of CO₂ concentration can be determined, using the photosynthetic model equation, to improve the photosynthetic rates of fruit vegetables grown in greenhouses.

• Journal of Microbiology
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• v.40 no.1
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• pp.63-69
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• 2002

A total of twenty-five norfloxacin resistant Escherichia coli were isolated from Joongrang-chun stream, a branch of the Han River in Seoul, Korea from May to July in 2000 and their norfloxacin resistance mechanism was characterized for target site mutation, permeability, and efflux pump. Fourteen iso- lates contained the same three mutations, Ser83→Leu and Asp87→Asn in GyrA and Ser90→ lle in ParC. Six isolates had Ser83→Leu and Asp87→Tyr in GyrA and Ser87→lle in ParC while one isolate had Ser83→Leu and Va1103→Ala in GyrA and Ser80→lle in ParC. Two isolates had mutation(s) in GyrA without any mutation in ParC. Two isolates had Ser80→Arg in ParC instead of the commonly found Ser80→lle. Every norfloxacin resistant isolate had an efflux system but the correlation between the efflux activity and MIC was not observed. The amount of OmpF for norfloxacin permeability decreased in resistant isolates compared to the susceptible strains. When amplified polymorphic DNA (RAPD) and pulse field gel electrophoresis (PFGE) were performed, these isolates showed no similarity to each other or clinical isolates.

• ALGAE
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• v.29 no.1
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• pp.27-34
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• 2014

Availability of nutrients is known to influence marine primary production; and it is of general interest to see how nutrient limitation mediates phytoplankton responses to solar ultraviolet radiation (UVR, 280-400 nm). The red tide diatom Skeletonema costatum was cultured under nitrate (N)-limited and N-replete conditions and exposed to different solar irradiation treatments with or without UV-A (315-400 nm) and UV-B (280-315 nm) radiation. Its photochemical quantum yield decreased by 13.6% in N-limited cells as compared to that in N-replete ones under photosynthetically active radiation (PAR)-alone treatment, and the presence of UV-A or UV-B decreased the yield further by 2.8 and 3.1%, respectively. The non-photochemical quenching (NPQ), when the cells were exposed to stressful light condition, was higher in N-limited than in N-replete grown cells by 180% under PAR alone, by 204% under PAR + UV-A and by 76% under PAR + UV-A + UV-B treatments. Our results indicate that the N limitation exacerbates the UVR effects on the S. costatum photosynthetic performance and stimulate its NPQ.