• Applied Chemistry for Engineering
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• v.1 no.2
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• pp.182-189
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• 1990

Various crosslinked poly(4-vinylpyridines) having different degrees of crosslinking were prepared by radical copolymerizations of 4-vinylpyridine with N, N'-2, 6-pyridinebisacrylamide as a crosslinker. The abilities of these crosslinked polymers to bind methyl orange and butyl orange were investigated at various temperatures in a buffer solution of pH 7. The first binding constants were evaluated from the equilibrium binding amounts. The first binding constants against the temperatures showed bell-shaped curves. Also, the first binding constants against the degree of crosslinking showed bell-shaped curves. When the temperature and the degree of crosslinking of maximum binding in the curves of these binding systems were compared with those of previous systems containing crosslinked poly(4-vinylpyridines) prepared by using N, N'-methylenebisacrylamide, N, N'-tetramethy-lenebisacryamide and divinylbenzene as crosslinkers, respectively, they were varied with the crosslinked poly(4-vinyl pyridines) containing different crosslinkers. These results were discussed in terms of the properties of the crosslinkers.

• Biomaterials and Biomechanics in Bioengineering
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• v.2 no.3
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• pp.127-141
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• 2015

Silver-based systems activated by low intensity direct current continue to be investigated as an alternative antimicrobial for infection prophylaxis and treatment. However there has been limited research on the quantitative characterization of the antimicrobial efficacy of such systems. The objective of this study was to develop a semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model providing the quantitative relationship between the critical system parameters and the degree of antimicrobial efficacy. First, time-kill curves were experimentally established for a strain of Staphylococcus aureus in a nutrientrich fluid environment over 48 hours. Based on these curves, a modified PK/PD model was developed with two components: a growing silver-susceptible bacterial population and a depreciating bactericidal process. The test of goodness-of-fit showed that the model was robust and had good predictability ($R^2>0.7$). The model demonstrated that the current intensity was positively correlated to the initial killing rate and the bactericidal fatigue rate of the system while the anode surface area was negatively correlated to the fatigue rate. The model also allowed the determination of the effective range of these two parameters within which the system has significant antimicrobial efficacy. In conclusion, the modified PK/PD model successfully described bacterial growth and killing kinetics when the bacteria were exposed to the electrically activated silver-titanium implant system. This modeling approach as well as the model itself can also potentially contribute to the development of optimal design strategies for other similar antimicrobial systems.

• Journal of the Korean Mathematical Society
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• v.53 no.6
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• pp.1431-1443
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• 2016

Let k be a global field of characteristic unequal to two. Let $C:y^2=f(x)$ be a nonsingular projective curve over k, where f(x) is a quartic polynomial over k with nonzero discriminant, and K = k(C) be the function field of C. For each prime spot p on k, let ${\hat{k}}_p$ denote the corresponding completion of k and ${\hat{k}}_p(C)$ the function field of $C{\times}_k{\hat{k}}_p$. Consider the map $$h:Br(K){\rightarrow}{\prod\limits_{\mathfrak{p}}}Br({\hat{k}}_p(C))$$, where p ranges over all the prime spots of k. In this paper, we explicitly describe all the constant classes (coming from Br(k)) lying in the kernel of the map h, which is an obstruction to the Hasse principle for the Brauer groups of the curve. The kernel of h can be expressed in terms of quaternion algebras with their prime spots. We also provide specific examples over ${\mathbb{Q}}$, the rationals, for this kernel.

• Bulletin of the Korean Chemical Society
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• v.35 no.5
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• pp.1422-1432
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• 2014

Convergent all-electron multi-reference configuration-interaction (MRCI) calculations are performed for a lithium dimer with Kaufmann's Rydberg basis functions. A comparison of the results of these calculations with those of the effective core potential/core polarization potential (ECP/CPP) method and experimental data reveals the deficiency of the all-electron ab initio method. The deficiency is related to the mere 51.9% attainment of electron correlation for the ground state. The percent attainment of electron correlation for the first excited state is slightly better than that for the ground state, preventing us from obtaining better agreements with experimental data by means of increasing the size of basis sets. The Kaufmann basis functions are then used with the ECP/CPP method to obtain the accurate convergent potential energy curves for the $^1\prod_u$ states correlated to Li(2p) + Li(2p) and Li(2s) + Li(n = 2, 3, 4). Quantum defect curves (QDCs) calculated for both the $X^2\sum_g$ and 1 $^2\prod_u$ states of the $Li{_2}^+$ ion and the Lu-Fano plot reveal a strong series-series interaction between the two $2snp{\pi}$ and $2pnp{\pi}$ Rydberg series. The QDCs are then used to resolve assignment problems in the literature. The reassignments, performed by Jedrzejewski-Szemek et al., of the dissociation product of the D $^1\prod$ state from (2s+3d) to (2s+3p) and that of the 6 $^1\prod_u$ from (2s+4d) to (2s+4p) are found to be incorrect. It may be more natural to assign their $2snp{\pi}$ Rydberg series as a $2snd{\pi}$ series. The state, assigned as 5p $^1\prod_u$ by Ross et al. and 4d $^1\prod$ by Jedrzejewski-Szemek et al., is assigned as the 7 $^1\prod_u$ state, correlated to the Li(2s) + Li(4f) limit.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5483-5488
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• 2012

Background: Although nicotine dependence plays a role as a main barrier for smoking cessation, there is still a lack of solid evidence on the validity of biomarkers to determine nicotine dependence in clinical settings. This study aimed to investigate whether urinary cotinine levels could reflect the severity of nicotine dependence in active smokers. Materials and Methods: Data regarding general characteristics and smoking status was collected using a self-administered smoking questionnaire. The Fagerstr$\ddot{o}$m test for nicotine dependence (FTND) was used to determine nicotine dependence of the participants, and a total of 381 participants were classified into 3 groups of nicotine dependence: low (n=205, 53.8%), moderate (n=127, 33.3%), and high dependence groups (n=49, 12.9%). Stepwise multiple linear regression model and receiver operating characteristic (ROC) curves analyses were used to determine the validity of urinary cotinine for high nicotine dependence. Results: In correlation analysis, urinary cotinine levels increased with FTND score (r=0.567, P<0.001). ROC curves analysis showed that urinary cotinine levels predicted the high-dependence group with reasonable accuracy (optimal cut-off value=1,000 ng/mL; AUC=0.82; P<0.001; sensitivity=71.4%; specificity=74.4%). In stepwise multiple regression analysis, the total smoking period (${\beta}$=0.042, P=0.001) and urinary cotinine levels (${\beta}$=0.234, P<0.001) were positively associated with nicotine dependence, whereas an inverse association was observed between highest education levels (>16 years) and nicotine dependence (${\beta}$=-0.573, P=0.034). Conclusions: The results of this study support the validity of using urinary cotinine levels for assessment of nicotine dependence in active smokers.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.9
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• pp.965-969
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• 2005

Current density is an important operating parameter in the ion-exchange membrane process. We observed the effects of fouling of a Neosepta AMX anion-exchange membrane(Tokuyama Soda, Japan) in 0.02 M NaCl solution containing 100 mg/L sodium humate. Membrane fouling was analyzed by measuring the change in the electrical resistance in the under- and over-limiting current density regions. The experimental results found that membrane fouling was negligible at under-limiting current densities, but was increased significantly when an over-limiting current was supplied. After the fouling experiments, the current-voltage curves for the fouled membranes were measured. From the curves, we observed increased electric resistance and reduced limiting current density(LCD), caused by the accumulation of humic acid on the membrane surface. Furthermore, membrane fouling increased as the acidity of the electrolyte solution containing humic acid increased. This occurred because the fouling of an anion-exchange membrane is affected more by the physicochemical properties of the humic substance than by the surface charge of the humate.

• BMB Reports
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• v.35 no.2
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• pp.143-154
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• 2002

The structural and functional aspects of ervatamin B were studied in solution. Ervatamin B belongs to the $\alpha+\beta$ class of proteins. The intrinsic fluorescence emission maximum of the enzyme was at 350 nm under neutral conditions, and at 355 nm under denaturing conditions. Between pH 1.0-2.5 the enzyme exists in a partially unfolded state with minimum or no tertiary structure, and no proteolytic activity. At still lower pH, the enzyme regains substantial secondary structure, which is predominantly $\beta$-sheet conformation and shows a strong binding to 8-anilino-1-napthalene-sulfonic acid (ANS). In the presence of salt, the enzyme attains a similar state directly from the native state. Under neutral conditions, the enzyme was stable in urea, while the guanidine hydrochloride (GuHCl) induced equilibrium unfolding was cooperative. The GuHCl induced unfolding transition curves at pH 3.0 and 4.0 were non-coincidental, indicating the presence of intermediates in the unfolding pathway. This was substantiated by strong ANS binding that was observed at low concentrations of GuHCl at both pH 3.0 and 4.0. The urea induced transition curves at pH 3.0 were, however, coincidental, but non-cooperative. This indicates that the different structural units of the enzyme unfold in steps through intermediates. This observation is further supported by two emission maxima in ANS binding assay during urea denaturation. Hence, denaturant induced equilibrium unfolding pathway of ervatamin B, which differs from the acid induced unfolding pathway, is not a simple two-state transition but involves intermediates which probably accumulate at different stages of protein folding and hence adds a new dimension to the unfolding pathway of plant proteases of the papain superfamily.

• Earthquakes and Structures
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• v.23 no.4
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• pp.353-361
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• 2022

The dynamic behavior of a single pile was investigated by using analytical and numerical studies. The focus of this study was to develop the dynamic p-y curve of a pile for pseudo-static analysis considering the shear wave velocity of the soil by using three-dimensional numerical analyses. Numerical analyses were conducted for a single pile in dry sand under changing conditions such as the shear wave velocity of the soil and the acceleration amplitudes. The proposed dynamic p-y curve is a shape of hyperbolic function that was developed to take into account the influence of the shear wave velocity of soil. The applicability of pseudo-static analysis using the proposed dynamic p-y curve shows good agreement with the general trends observed by dynamic analysis. Therefore, the proposed dynamic p-y curve represents practical improvements for the seismic design of piles.

• Communications of the Korean Mathematical Society
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• v.10 no.4
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• pp.925-929
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• 1995

Consider the problem $-div($\mid$\bigtriangledown_u$\mid$^{p-2}\bigtriangledown_u) = $\mid$u$\mid$^{p^*-2}u + \lambda$\mid$u$\mid$^{q-2}u$ in B, u = 0 on $\partial B$; where $B \subset R^n$ is a ball, $\lambda < 0, 1 < p < n$ and $p^* = \frac{np}{n-p}$ is the critical Sobolev exponent. For given $\lambda > 0$, we show that there exists $k = k(\lambda) \in N$ such that any radial solutions to this problem have at most k noda curves when $p \leq q \leq p^* - 1$.

• Elastomers and Composites
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• v.7 no.1
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• pp.53-58
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• 1972

Sublimatographic study on the method of test for sulfur in the petroleum and rubber products was as following results: (1) The relation between the heating temperature$(t_h)$ and the vacuum condensing point(V.C.P.) of sulfur at different degree of vacuum appeared as Fig.4. The results were in good agreement with those expected from the $t_h-V.C.P$ curves of sublimatographic separation of sulfur. (2) The relation between the degree of vacuum and the V.C.P. at different heating temperature of sulfur appeared as follows; $$tv.c.p.=\alpha+{\beta}logP_{va}$$ (3) The V.C.P of sulfur could be physical property comparing with melting point and boiling point. (4) The relation between the V.C.P. and the quantity of sublimation of sulfur becomes quantitative as Fig.7.