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Human Recombinant Endostatin Combined with Cisplatin Based Doublets in Treating Patients with Advanced NSCLC and Evaluation by CT Perfusion Imaging

  • Zhang, Feng-Lin;Gao, Er-Yun;Shu, Rong-Bao;Wang, Hui;Zhang, Yan;Sun, Peng;Li, Min;Tang, Wei;Jiang, Bang-Qin;Chen, Shuang-Qi;Cui, Fang-Bo
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.15
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    • pp.6765-6768
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    • 2015
  • Aims: To study the effectiveness of human recombinant endostatin injection (Endostar(R)) combined with cisplatin doublets in treating advanced non-small cell lung cancer (NSCLC), and to evaluate outcome by CT perfusion imaging. Methods: From April 2011 to September 2014, 76 patients with advanced NSCLC who were treated with platinum-based doublets were divided into group A (36 patients) and group B (40 patients). Endostar(R) 15mg/day was administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A, and combined with chemotherapy from the first day in Group B. Endostar(R) in the two groups was injected intravenously for 14 days. Results: Treatment effectiveness in the two groups differed with statistical significance (p<0.05). Effectiveness evaluated by CT perfusion imaging, BF, BV, MTT and PS also demonstrated significant differences (all p<0.05). Adverse reactions in the two groups did not significantly vary (p> 0.05). Conclusions: The response rate with Endostar(R) administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A was better than Endostar(R) combined with chemotherapy from the first day, and CT perfusion imaging could be a reasonable method for evaluation of patient outcomes.

Antibacterial Activities of Flower Tea Extracts against Oral Bacteria (꽃차용 꽃 추출물의 구강위생균에 대한 항균특성)

  • Han, Young-Sook;Kang, So-Jin;Pack, Se-A;Lee, Sun-Suk;Song, Hee-Ja
    • Korean journal of food and cookery science
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    • v.27 no.3
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    • pp.21-28
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    • 2011
  • In this study, we analyzed flower tea activity against oral bacteria. Lagerstroemia indica, Paeonia suffruticosa and Hemerocallis fulva showed high extract yields. Bellis perennis, Punica granatum and Cercis chinensis showed the high rates of yield by ethanol extraction. Extract yield seemed to be related to the characteristics of the specimens rather than to the solvent. Streptococcus mutans, Streptococcus obrinus, Porphyromonas gingivalis and Prevotella intermedia were used to investigate extracts activity against bacteria; the former two cause dental caries and the latter two cause halitosis. Cornus officinalis, L. indica, P. granatum and P.s uffruticosa showed high antibacterial activities against S. mutans. In specimens extracted with ethanol, P. suffruticosa, Camellia sinensis, Camellia japonica L. and Rosa hybrida showed high antibacterial activities. L. indica, P. granatum and C. officinalis showed high antibacterial activities against S. sobrinus. C. officinalis, P. granatum, L. indica and P. suffruticosa showed high activities for specimens extracted with ethanol. The results show that the warm extracts of C. officinalis, L. indica and P. granatum may be effective to prevent dental caries. In particular, the ethanol-based extracts of C. officinalis, P. suffruticosa and C. sinensis were effective to prevent dental caries and thus may be highly marketable. Chrysanthemum zawadskii, R. hybrida, P. granatum, C. japonica L. and Zinnia elegans showed high antibacterial activity against P.gingivalis. R. hybrida showed the highest ethanol extract activity, followed by P. suffruticosa, P. granatum, C. japonica L. and L. indica. R. hybrida, P. granatum, C. morifolium and C. japonica showed high activity against Pr.intermedia in the order named. C. zawadskii, P. granatum, L. indica, C. japonica and A. princeps showed high ethanol extract activity. Thus, the warm extracts of R. hybrida, P. granatum and C. japonica may be helpful to reduce halitosis. In addition, the ethanol-based extracts of P. granatum, C. japonica and L. indica are expected to be highly marketable as mouthwashes.

Relationship of career-related stress, commitment to a career choice and career decision self-efficacy of college students (대학생의 진로스트레스, 진로선택몰입 및 진로결정 자기효능감과의 관계)

  • Lee, Mi-Ra
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.12
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    • pp.8767-8775
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    • 2015
  • The purpose of this study was to identify the relationship of career-related stress, commitment to a career choice and career decision self-efficacy of college students. The participants were 293 college students in P city. Data were collected by using self-report questionnaires from May 6 to 29, 2015. Data were analyzed with descriptive statistics, t-test, ANOVA, Pearson,s correlation coefficient and Hierarchical regression analysis by SPSS/WIN 23.0 program. The career-related stress was negatively correlated with commitment to a career choice (r=-.731, p<.001) and career decision self-efficacy(r=-.449, p<.001). The influencing factors of career-related stress were grade(${\beta}$=.99, p<.017) and commitment to a career choice(${\beta}$=-.707, p<.001). This study concludes that it is necessary to develop education program to improve commitment to a career choice and career decision self-efficacy.

A REMARK ON MULTIPLICATION MODULES

  • Choi, Chang-Woo;Kim, Eun-Sup
    • Bulletin of the Korean Mathematical Society
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    • v.31 no.2
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    • pp.163-165
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    • 1994
  • Modules which satisfy the converse of Schur's lemma have been studied by many authors. In [6], R. Ware proved that a projective module P over a semiprime ring R is irreducible if and only if En $d_{R}$(P) is a division ring. Also, Y. Hirano and J.K. Park proved that a torsionless module M over a semiprime ring R is irreducible if and only if En $d_{R}$(M) is a division ring. In case R is a commutative ring, we obtain the following: An R-module M is irreducible if and only if En $d_{R}$(M) is a division ring and M is a multiplication R-module. Throughout this paper, R is commutative ring with identity and all modules are unital left R-modules. Let R be a commutative ring with identity and let M be an R-module. Then M is called a multiplication module if for each submodule N of M, there exists and ideal I of R such that N=IM. Cyclic R-modules are multiplication modules. In particular, irreducible R-modules are multiplication modules.dules.

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Relationship Between Carotid Intima-Media Thickness Using Ultrasonography and Diagnostic Indices of Metabolic Syndrome (초음파를 이용한 경동맥 내-중막 두께와 대사증후군 진단지표의 연관성)

  • Ko, Kyung-Sun;Heo, Kyung-Hwa;Won, Yong-Lim;Lee, Sung-Kook;Kim, Ki-Woong
    • Journal of radiological science and technology
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    • v.32 no.3
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    • pp.285-291
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    • 2009
  • The aim of the present study was undertaken to investigate the association between diagnostic indices of metabolic syndrome(MetS) with carotid intima-media thickness using ultrasonography. The participants in the study were 315 male employees without carotid atherosclerosis and other cardiovascular disease. This study was approved by the Institutional Review Board of Occupational Safety and Health Research Institute. Written informed consent for the participants in this study was obtained from all individuals. Anthropometric parameters and biochemical characteristics were done using each specific equipments and the NCEP-ATP III criteria were used to define MetS. They were examined by B-mode ultrasound to measure the carotid intima-media thickness(carotid IMT) at the near and far walls of common carotid and bifurcation(bulb). The mean carotid IMT was $0.739{\pm}0.137\;mm$ and it's thickness significantly increased with the increase in age. Also, amounts of systolic and diastolic blood pressure, triglyceride and fasting glucose were significantly increased with the increase in age. Carotid IMT were significantly correlated with BMI(r=0.170, p=0.004), systolic(r=0.148, p=0.011) and diastolic blood pressure(r=0.123, p=0.036) and HDL-cholesterol(r=-0.164, p=0.005). On multiple logistic regression analysis for the diagnostic indices of MetS, carotid IMT were significantly associated with blood pressure(OR=4.220, p<0.01) and MetS(OR=1.301, p<0.05). The results indicate that blood pressure and MetS are important risk factors for carotid atherosclerosis.

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Influence of Non-compliance of Treatment and Family Support on Depression in Diabetic Patients with Hypoglycemia (저혈당을 경험한 당뇨병 환자의 치료지시 불이행, 가족지지가 우울에 미치는 영향)

  • Son, Hye Gyeong;Jeong, Kyeong-Sook
    • The Journal of the Korea Contents Association
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    • v.18 no.6
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    • pp.518-528
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    • 2018
  • This study was to identify the effective factors on the Depression in Diabetic patients with hypoglycemia. This study used 119 questionnaires from Diabetic patients with hypoglycemia in B city to collect data from October 1, 2015 to March 15, 2016. Data were analyzed by SPSS 20.0 program using descriptive statistics, t-test, ANOVA, Scheffe's test. Pearson's correlation coefficient and Stepwise Multiple Regression. The Depression in Diabetic patients with hypoglycemia showed a positive correlation with Non-Compliance of Treatment(r=42, p<.001), a negative correlation with Family support(r=-.38, p<.001). According to the result of multiple regression analysis, the significant factors influencing depression were Family support(${\beta}=-.29$, p<.001), Drug therapy(${\beta}=.21$, p=.020), Dietetic therapy(${\beta}=.23$, p=.014), Monthly average income over 3,000,000won (${\beta}=-.20$, p=.014), Monthly average income 2,000-3,000 thousand(${\beta}=-.17$, p=.033), it was explained by 30.0%. Based on these findings, it is suggested to develop and apply a family support program to reduce the depression of diabetic patients with hypoglycemia.

Water Quality Variations by Irrigation Water Supply Step (Agricultural Reservoir-Irrigation Channel-Paddy Field) (농업용수 공급단계별(저수지-관개수로-논) 수질변화)

  • Nam, Gui Sook
    • Proceedings of the Korea Water Resources Association Conference
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    • 2022.05a
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    • pp.476-476
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    • 2022
  • 농업용수는 전통적 기능으로 농업용수 그 자체로서의 기능과 시대적 요구에 따른 지역용수로서의 기능을 가진다. 농업용수 그 자체의 기능으로 가장 중요한 것은 관개용수이며, 논, 밭관개, 하우스 시설농업에의 용수공급이다. 농업용수의 실 수요량 측면에서는 논용수가 전체용수 수요량의 60.1%로 가장 많은 양을 차지하고 있으며, 다음으로는 밭용수가 18.6%, 그 외 생활용수, 공업용수, 환경용수, 축산용수 등으로 이용되고 있다. 농업용수 수요 측면에서 논용수의 비중이 가장 높게 나타나기 때문에 본 연구에서는 농업용수 공급에 따라 농업용저수지-관개수로-논에 이르는 공급단계별 수질변화를 분석하였다. 본 연구는 경기, 충남 권역의 오염도가 높은 3개 농업용저수지를 대상으로 하였으며, 농업용수를 본격적으로 공급하는 5월부터 관개가 종료되는 10월까지 농업용저수지와 관개수로, 논을 대상으로 수온, TOC, Chl-a 등 10개 항목을 분석하여 나타내었다. 연구기간동안 수온의 변화는 18.6~34.6 ℃로서 관개수로에 가장 낮고, 논에서 가장 높은 값을 보여 주었으며, 공급단계별 평균 수온은 저수지(R) 27.6 ℃, 관개수로(C) 26.4 ℃, 논(P) 28.4 ℃로 논에서 수온증가가 나타났다. pH는 7.4~9.7의 범위로 저수지에서 최고값, 논에서 최저값을 보였으며, 공급단계별 평균값은 R 9.1, C 8.3, P 8.0으로 저수지, 수로, 논으로 이동하면서 감소하였다. 전기전도도(EC)는 저수지 수질오염도에 따라 다양하게 나타났으며, 공급단계별 평균값은 R 706.3 uS/cm, C 585.5 uS/cm, P 771.2 uS/cm로 논에서 가장 높은 값으로 보였으며, 이는 논에서 추가적인 영양분 공급에 의한 것으로 보였다. 평균 용존산소량(DO)은 R 6.3, C 4.0, P 4.5로 저수지에서 가장 높고, 수로에서 가장 낮게 나타났다. 유기물 지표인 COD와 TOC의 변화를 보면 평균 COD R 21.7 mg/L, C 14.5 mg/L, P 22.7 mg/L, 평균 TOC R 11.2 mg/L, C 8.5 mg/L, P 12.3 mg/L로 두 항목 모두 논에서 가장 높은 값을, 수로에서 가장 낮은 값을 나타내었다. 반면 엽록소 a 평균 농도는 R 128.4 mg/m3, C 54.3 mg/m3, P 31.7 mg/m3로 저수지의 내부생산으로 다량 발생한 조류가 수로와 논으로 이동하면서 급격하게 감소하여 나타났다. 이는 저수지와 논의 유기물 성상이 다름을 보여준다. 영양염류인 총인(TP)의 평균값 변화를 보면 R 0.302 mg/L, C 0.374 mg/L, P 0.384 mg/L로, 저수지에서 수로, 논으로 이동하면서 점차 증가하여 나타났다. 이는 농업용저수지에서 수로, 논으로 관개용수가 이동하면서 오염수 유입 또는 비료 등의 투입이 이루어진 결과로 판단된다. 이와 같이, 농업용저수지의 수질이 논에 그대로 유지되어 유입되지 않고 공급단계에 따라 변화하고 있으므로 항목별 수질 변화 특성을 이해한 후 농업용수 수질관리가 이루어 져야 할 것이다.

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Total Energy Expenditure and Its Relationship with Physical Characteristics in Korean Children (한국 아동의 운동에너지 소비량과 신체적 특성과의 연관성)

  • Cho, Kang-Ok;Choi, Hye-Jung
    • 한국체육학회지인문사회과학편
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    • v.51 no.6
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    • pp.515-522
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    • 2012
  • The purpose of this study was to investigate the total energy expenditure (TEE) and then it's relationship between degree of energy expenditure and physical characteristics of Korean 1,370 children. The values of total energy expenditure were classified into under 1,000kcal/week, 1.000~2,000kcal/week, and over 2,000kcal/week. The average TEE of boys and girls were 2,088.4kcal/week and 1,695.6kcal/week. When compared with children of under 1,000kcal/week, the boys of the 1,000~2,000kcal/week showed significant difference in height (p<.001), weight (p<.05), waist circumference (p<.05), blood pressure (p<.001) and girls showed in height (p<.05), blood pressure (p<.01), heart rate (p<.01). However, the boys of over 2,000kcal/week showed significant difference in height, weight, waist circumference, BMJ, and blood pressure (p<.001) and girls in height (p<.001), waist circumference (p<.001), BMI (p<.05), blood pressure (p<.001). For correlation between the TEE and physical characteristics, TEE had significantly correlations with height (r=.298, p<.001), body weight (r=-.331, p<.001), waist circumference (r=-.236, p<.001), BMI (r=-.252, p<.001), blood pressure (r=-.239, p<.001), and heart rate (r=-.226, p<.001) for boys and height (r=.236, p<.001), systolic blood pressure (r=-.310, p<.001), and diastolic blood pressure (r=-.180, p=.016) for girls. These results show that physical characteristics were affected by physical activity for boys while only height and blood pressure were affected in girls.

Nucleotide Sequence and Inducibility Analysis of Chloramphenicol Acetyltransferase Gene from Staphylococcus aureus R-plasmid pSBK203 (Staphylococcus aureus에서 분리된 R-plasmid pSBK203상의 chloramphenicol acetyltransferase 인자의 염기서열 및 유발성 분석)

  • 권동현;변우현
    • Korean Journal of Microbiology
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    • v.27 no.3
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    • pp.194-200
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    • 1989
  • The nucleotide sequence of inducible chloramphenicol acetyl-transferase(CAT) gene isolated from a small plasmid pSBK203 of Staphylococcus aureus was determined. The base sequence shows that structural gene of pSBK203-CAT encodes a protein of 213 amino acids and has a leader region which encodes a short polypeptide of 9 amino-acids in its upstream. vertical bar /sup 35/S vertical bar-Methionine labelled CAT gene product in minicell showed almost same mobility with pC194-CAT of which molecular weight is 24Kdal on polyacrylamide gel electrophoresis. Predicted amino acid sequence of pSBK203-CAT has revealed a high degree of homology with the CATs of pC194 and pC221 than those of cat-86, Tn9 and proteus mirabilis PM13.

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Interrelationships Between Follicular Size, Estradiol-17β, Progesterone and Testosterone Concentrations in Individual Buffalo Overian Follicles

  • Palta, P.;Bansal, N.;Manik, R.S.;Prakash, B.S.;Madan, M.L.
    • Asian-Australasian Journal of Animal Sciences
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    • v.11 no.3
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    • pp.293-299
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    • 1998
  • This study was undertaken to measure the concentrations of estradiol-$17{\beta}$, progesterone and testosterone, and to study their relationship with each other and with follicular size in individual buffalo ovarian follicles categorized as small (4 to 5 mm diameter), medium (6 to 9 mm diameter) and large (${\geq}10mm$ diameter). Steroid hormone concentrations varied markedly within follicles of each size category. Estradiol-$17{\beta}$ concentrations (pmol/ml) were positively related to follicular diameter (R = 0.34, n = 308, p < 0.001) and were significantly higher (p < 0.001) in large (1$118.46{\pm}30.25$), compared to those in medium follicles ($50.32{\pm}8.29$) which, in turn were significantly higher (p < 0.001) than those in small follicles ($19.70{\pm}$5.57). Progesterone and testosterone concentrations (pmol/ml) were not related to follicular diameter and were not different among small ($330.99{\pm}27.32$ and $17.68{\pm}2.44$ respectively), medium ($384.84{\pm}26.20$ and $36.47{\pm}4.55$, respectively) and large follicles ($253.25{\pm}32.23$ and $22.57{\pm}4.48$, respectively). Estradiol-$17{\beta}$ and progesterone concentrations were positively related (R = 0.39, n = 47, p < 0.01) in small, unrelated in medium and negatively related in large follicles (R = -0.59, n = 23, p < 0.01). There was no relationship between estradiol-$17{\beta}$ and testosterone concentrations in follicles of all the three size categories. Progesterone and testosterone concentrations were positively related in large follicles (R = 0.57, n = 18, p < 0.02). There was no relationship between the two hormones in small and medium sized follicles. When the follicles with estradiol-$17{\beta}$/progesterone molar ratios of > 1.00 were considered non-atretic, and the rest at different stages of atresia, 197/208(95%) follicles were found to be atretic.