• 약학회지
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• 제44권6호
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• pp.613-619
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• 2000

The author examined whether the methanol extracts of Opuntia ficus-indica fruit and Saururus chinensis have the inhibitory action on xanthine/xanthine oxidase (X/XO)-, $FeCl_2/ascorbic$ acid- and arachidonic acid-induced neurotoxicity in mouse cortical cell cultures. The methanol extracts ($10\;{\mu}g/ml{\sim}1\;mg/ml$) of Opuntia ficus-indica and Saururus chinensis were exhibited 53-89% and $48{\sim}100%$ inhibitory action on X/XO-induced neurotoxicity, respectively. At the range of same concentration, both extracts also attenuated the $FeCl_2/ascorbic$ acid-induced neurotoxicity by $35{\sim}100%$ and $15{\sim}98%$, respectively. In arachidonic acid neurotoxicity, the methanol extract (1 mg/ml) of Opuntia ficus-indica and Saururus chinensis reduced neuronal injury by 22% and 38%, respectively. These results suggest that Opuntia ficus-indica fruit and Saururus chinensis may contribute the neuroprotection in certain free radical-mediated neuronal injury.

• Journal of Korean Biological Nursing Science
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• 제23권1호
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• pp.1-10
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• 2021

Purpose: To verify the anti-microbiotic activity and to develop eco-friendly surface disinfectants using the Opuntia ficus-indica extract. Methods: The stem and fruits of the Opuntia cultivated in Jeju Island were extracted with hot water, 70% EtOH and 100% MeOH, respectively. To examine the antimicrobial activity of the extracts, gram positive bacteria (Bacillus subtilis, Staphylococcus aureus), gram negative bacteria (Escherichia coli, Salmonella typhimurium), yeast (Candida albicans), mold (Aspergillus flavus) and antibiotic resistant bacteria (E. coli, S. aureus) were measured to form a clear zone. Results: The antibacterial activity of the fruit extract was higher than that of the stem extract, and the antibacterial activity of the 100% MeOH (FM) extract and the 70% EtOH (FE) extract of the palm cactus fruit was suitable for the surface disinfectant overall, and clear-zone formed even at relatively low concentrations (250 mg/mL). The FM and FE have antibacterial activity against various bacteria, therefore they can be used as disinfectants. Conclusion: The antimicrobial activity of Opuntia ficus-indica extract from Jeju Island by stem and fruit was determined at relatively low concentrations (250 mg/mL). The Opuntia ficus-indica extract will be useful for surface disinfectants dissolving the patients' bath, oral gargling, and powdered powder in water or ethanol in appropriate concentrations.

• 한국염색가공학회지
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• 제18권2호
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• pp.8-14
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• 2006

The pigment extraction of Opuntia ficus-indica has been conducted to develop useful natural dyes in place of synthetic dyes which are suspected to bring serious environmental pollutions. The dyeing ability on wool fabric by addition of ascorbic acid and several mordants were investigated by means of color measurement. In addition, the fastness of washing, perspiration, rubbing, light, dry cleaning, effect on bacterial reduction and UV-B protection were also investigated. From these investigation, it is suggested that the pigment extracted from Opuntia ficus-indica can be used as a source of natural dyes and the obtained result are as follows. 1. Maximum absorption band (${\lambda}max$) of Opuntia ficus-indica extract is 533nm. 2. The wool fabric dyed with Opuntia ficus-indica extract has stable color by the addition of ascorbic acid and is achieved with addition of 0.1% ascorbic acid, 0.5% several mordant, and three repeated dying at $50^{\circ}C$ for 1.5hr. 3. The wash fastness of the dyed wool fabric when it is washed with neutral detergent is more effective than alkaline detergent. The dry cleaning fastness of the dyed wool fabric is more excellent. In addition, the perspiration fastness of the dyed wool fabric is increased by mordanting method. And than the rubbing fastness of the dyed wool fabric is showed excellent under dryness and wetness. Light fastness of the dyed wool fabric, however is showed inferiority. 4. The wool fabric dyed with Opuntia ficus-indica extract is showed effective bacterial reduction and UV-B protection is increased remarkably.

• 대한수의학회지
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• 제61권1호
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• pp.6.1-6.6
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• 2021

Opuntia ficus-indica has traditionally been used in prevention and treatment of various diseases such as diabetes mellitus. The current study was performed to determine whether Opuntia ficus-indica is associated with diabetes. Diabetic rat models were induced with streptozotocin (STZ). This study divided rats into 1 day (short-term) and 4 consecutive weeks (long-terms) of daily administration. These groups were subdivided into four groups each other for assessment of blood glucose level as follows: Group 1, untreated rats given distilled water; Group 2, untreated rats given Opuntia ficus-indica; Group 3, STZ-induced diabetic rats given distilled water; Group 4, STZ-induced diabetic rats given Opuntia ficus-indica. Blood glucose level was measured for one day and four weeks. In addition, serum markers of alanine aminotransferase (ALT), aspartate transaminase (AST), cholesterol, and creatinine were determined, and total protein triglycerides were measured at four weeks. Blood glucose level was highest in both groups (Group 3 and Group 4) at 30 minutes and two weeks and gradually decreased in a time-dependent manner. The difference in blood glucose among the four groups was significant (p < 0.05). Additionally, the levels of ALT, AST and triglycerides were significantly decreased by Opuntia ficus-indica.

• 생약학회지
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• 제30권1호
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• pp.84-86
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• 1999

From the ethyl acetate fraction of the methanol extract of the fruits of Opuntia ficus-indica var. saboten, two dihydroflavonois were isolated and identified as (+)-trans-dihydrokaempferol (1) and (+)-trans-dihydroquercetin (2) by spectroscopic methods.

• 한국식품조리과학회지
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• 제31권4호
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• pp.431-440
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• 2015

세계 10대 슈퍼 푸드인 렌틸과 안정한 붉은 색소로 갖는 것으로 알려진 백년초를 첨가하여 제조한 소시지의이화학적, 물리적 및 관능적 특성의 변화를 관찰하고 건강에 유익한 소시지 제조에 적합한 배합비를 찾고자 하였다. 아질산나트륨 0.15% 첨가군을 대조군(F0)로 하여렌틸 5%와 백년초 추출물(0%, 1%, 3%)을 첨가한 시료군(F1, F2, F3)과 렌틸 10%와 백년초 추출물(0%, 1%, 3%)을 첨가한 시료군(F4, F5, F6)으로 구분하였다. 동물성 단백질을 대체하는 렌틸의 첨가에 의해 조단백의 유의적 증가, 조지방의 유의적 감소를 보였다. 또한, 렌틸에 함유된 다량의 식이섬유와 전분으로 인하여 소시지에서도 렌틸 첨가량 증가에 따라 식이섬유와 전분 함량에 유의적 증가를 나타내었다. 렌틸은 소시지에서 부족한 식이섬유를 보충하고 소시지 제조에 일반적으로 사용되고 있는 증점제인 전분에 대한 대체효과 까지 가능한 것으로 나타났다. 백년초는 렌틸과 마찬가지로 다량의 식이섬유와 미네랄을 함유하고 있어 소시지의 식이섬유를 보충하고 미네랄을 증가시켰다. 렌틸과 백년초 혼합첨가로 소시지의 표면색도는 밝기(L)가 낮아지고 황색도가 높아졌으나 적색도는 각각에 대한 영향이 다르게 나타나서 렌틸 첨가에 의해서는 감소되고, 백년초 첨가에 의해서는 증가하였다. 처리군 중에서 대조군과 가장 유사한 색도를 나타내는 것은 F5(렌틸 10% + 백년초 1%) 이었다. 렌틸과 백년초 첨가로 인한 조직의 변화는 주로 렌틸에 의해 나타났으며 렌틸 첨가량 증가에 의해 경도, 탄력성, 검성, 씹힘성이 증가하여 소시지의 texture를 향상시켰다. 소비자에 대한 기호도 평가에서 색은 F3(렌틸 5% + 백년초 3%)가 대조군과 유의차가 없이 가장 높게 평가되었으며 맛은 대조군보다 F4, F5가 더 높게 평가되었고 전체 기호도는 F3, F4, F5가 유의차 없이 대조군보다 높았다. 렌틸과 백년초를 소시지 제조에 첨가하여 식이섬유가 보충되고 증점제로 주로 첨가되는 전분에 대한 대체효과를 나타내었으며 소시지의 texture를 향상시키고 맛에 대한 기호도를 높여주었다. 또한, 대조군과 적색도가 유사한 것은 F3(렌틸 5% + 백년초 3%) 와 F5(렌틸 10% + 백년초 1%) 이었으나 황색도와 표면밝기를 모두 고려시 대조군과 가장 색도가 유사한 것은 F5 이었다. 따라서, 렌틸과 백년초의 첨가량이 많을수록 식이섬유가 보충되고 물성이 우수한 소시지가 제조되었으나 소시지에 발현되는 색상을 고려할 때 렌틸 10%와 백년초 에탄올 추출물 1%의 첨가가 가장 제조에 적합하였다.

• 생명과학회지
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• 제17권7호통권87호
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• pp.915-922
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• 2007

본 연구자들은 동${\cdot}$서양에서 오랫동안 민간요법으로 사용되어져 왔고, 문헌에도 약리적인 작용이 기록되어 있는 Opuntia ficus-indica var. Saboten Makino (손바닥 선인장, 백년초) 줄기 분말을 사용하여 항균생리활성 물질을 규명하고자 하였다. 줄기 분말을 황산으로 가수분해 처리한 후 메탄올, 메틸클로라이드, 에탄올 등의 용매로 추출하였다. 용매추출물 가운데 methylene chloride 추출물의 경우 가장 탁월한 항균활성을 나타내었다. 항균활성을 나타내는 생리활성 물질을 분리 분석하기 위하여 조제용 TLC를 이용하여 산 가수분해 추출물로부터 7개의 분획물을 분리하였다. 7개 분획물 가운데 가장 광범위한 항균활성을 나타내는 유효 분획물로 분리된 것을 MBT-01108이라 명명하였다. 산가수분해로 추출된 분획물 MBT-01108을 구조 분석한 결과 항균 활성을 나타내는 화합물이 levulinic acid임을 밝혀냈다. Opuntia ficus-indica var. Saboten Makino로부터 분리된 levulinic acid는 식품 또는 화장품의 천연 보존제로써 사용가능하리라 판단되며, 또한, 세균성 질병예방, 여드름, 노화 예방, 미백 화장품 성분, 그리고 항생제로도 사용 가능한 물질임을 밝혀냈다.

• 한국식품위생안전성학회지
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• 제27권4호
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• pp.401-405
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• 2012

천연 갈변 및 미생물 억제제 소재를 발굴하기 위해 신선절단 사과에 백년초추출물을 처리하여 색도변화, peroxidase 활성, 황색포도상구균 생육을 조사하였다. 신선절단 사과의 L값은 백련초 추출물 처리구가 대조구에 비해 유의적으로 감소폭이 적어 갈변억제가 나타난 것을 확인할 수 있었으며, a값은 저장기간이 경과함에 따라 증가하였으며 백련초 추출물 처리구는 2일째부터 갈변억제효과를 보였다. Peroxidase 활성도 백년초 추출물 처리구에서 저장기간이 경과함에 따라 갈변억제효과를 확인하였다. 신선절단 사과에서 백년초 추출물 25 mg/mL 이상 처리구에서 유의적으로 황색포도상구균 생육억제 효과가 나타났으며, 온도별로는 $21^{\circ}C$ 저장시 억제효과가 더 큰 것으로 판단되었다. 특히 100 mg/mL 처리구에서 4일째부터 황색포도상구균이 검출한계 이하로 관찰되어 생육억제에 매우 효과적임을 확인 할 수 있었다. 따라서 본 연구결과, 백년초 추출물 처리는 신선절단 사과의 저장 중에 갈변억제 및 황색포도상구균의 생육억제에 효과적인 천연물이며, 향후 신선절단식품의 품질유지에 효과적인 식품첨가제로서 개발 가능하리라 판단된다.

• Natural Product Sciences
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• 제22권2호
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• pp.117-121
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• 2016

On the phytochemical investigation of a 70% ethanol extract of the fruits of Opuntia ficus-indica, (Cacataceae), we could result in the isolation of thirteen phenolic compounds including seven flavonoids (1 - 9) and four simple phenolic glycosides (10 - 13) by column chromatographic methods. Among the isolated compounds, picein (11), androsin (12), and $1-O-feruloyl-{\beta}-{\small{D}}-glucopyranoside$ (13) were isolated for the first time from O. ficus-indica; additionally, this is the first report $benzyl-O-{\beta}-{\small{D}}-glucopyranoside$ (10) from the genus Opuntia. The structures of the compounds were determined by spectral data analysis which included 1D, 2D NMR spectrum and ESIMS.

• Preventive Nutrition and Food Science
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• 제10권1호
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• pp.103-110
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• 2005

Opuntia ficus-indica, commonly known as prickly pear cactus, is commercially grown as a food and medicinal plant in Jeju Island, Korea. The crushed pads and fruits of Opuntia ficus-indica were dried in a freeze-dryer and ground into flour to be used for food materials. The major components of proximate compositions were part of a nitrogen free extract. The major minerals were Ca (4391.2-2086.9㎎%), K (1932.1-2608.7㎎%), and Mg (800.6-1984.8㎎%). The major amino acid was glutamic acid, comprising 16.3% of total amino acids in fruit and 25.2% in pad. Dihydroflavonols were identified as (+)-trans-dihydrokaempferol and (+)-trans-dihydroquercetin. Citric acid methyl esters extracted from fruits showed inhibitory activities against monoamine oxidase-B. The presence of trimethyl citrate has been reported in other plants, but 1,3-dimethyl citrate and 1-monomethyl citrate have not been previously reported. The results of pharmacological efficacy tests, including serum biochemical and hematological parameters, autonomic nervous system, anti-inflammatory, analgestic activity, anti-diabetic activity, antithrombotic, anticoagulant, dopamine beta-hydroxylase, monoamine oxidase activity, hyperlipidemia, the respiratory system, antigastic, and anti-ulcerative actions indicate that the fruit and pad of the Opuntia ficus-indica are rich sources of food and medicinal materials.