• 한국발생생물학회지:발생과생식
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• 제16권3호
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• pp.227-233
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• 2012

Circadian timing system plays a major role in a wide range of reproductive function. However it is plausible idea that other environmental and/or internal cue might be simultaneously participated in the optimal regulation of reproductive system. In the present study we extended the reverse feeding (RF) time regimen up to 8 weeks, then measured the general and reproductive indices of the animals. The animals of ad libitum feeding group (Control, CON) have free access to food for 4, 6 and 8 weeks, respectively. The day feeding animals (reverse feeding, RF group) have restricted access to food during daytime (09:00-18:00) for 4, 6 and 8 weeks, respectively. When the feeding schedules were over, key indices were measured. After 4 weeks and 8 weeks of feeding, body weights of animals were not significantly different. However, body weights of 6 weeks RF animals were significantly smaller than those of control animals (CON : RF = $333.46{\pm}12.71$ g : $289.91{\pm}8.31$ g, p<0.01). The blood glucose levels of 4 weeks RF animals were significantly decreased compared to the levels of control animals (CON : RF = $161.4{\pm}2.7$ mg/dL : $176.7{\pm}5$ mg/dL, p<0.01) while the levels of 6 weeks RF and 8 weeks RF animals were not different form those of control animals. Reproductive and non-reproductive tissue weights from 6 weeks RF group were significantly lowered than those from CON group (testis, CON : RF = $1.4714{\pm}0.0174$ g : $1.3724{\pm}0.0168$ g, p<0.001; epididymis, CON : RF = $0.3574{\pm}0.0059$ g : $0.3243{\pm}0.0068$ g, p<0.001; seminal vesicle, CON : RF = $0.1655{\pm}0.0068$ g : $0.1328{\pm}0.0054$ g, p<0.001; prostate, CON : RF = $0.3350{\pm}0.0231$ g : $0.2528{\pm}0.0143$ g, p<0.01). After 4 weeks and 8 weeks of reverse feeding, sperm counts in RF animals were markedly reduced than those in control animals[CON 4W : RF 4W = $121.17{\pm}9.96\;({\times}10^6)$ : $50.86{\pm}9\;({\times}10^6)$, p<0.001; CON 8W : RF 8W= $138.69{\pm}9.8\;({\times}10^6)$ : $108.94{\pm}4.22\;({\times}10^6)$, p<0.001]. Present study indicates that RF may induce an adaptable metabolic stress and cause impairment of androgen-dependent reproductive tissues. On-going longitudinal studies will allow a better understanding of the how does mealtime shift affect the reproductive function and exact nature of adaptation.

• 한국전자통신학회논문지
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• 제7권4호
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• pp.721-726
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• 2012

이 논문에서 SPFA(shortest path faster algorithm)을 사용해서 기존의 벨만-포드(Bellman-Ford)을 개선한 효율적인 알고리듬을 제안한다. 벨만-포드 알고리듬은 딕스트라(Dijkstra) 알고리듬과 다르게 부(-)인 가중치를 갖는 그래프에서 사용할 수 있다. SPFA 알고리듬은 한 대기열을 이용하여 노드를 저장한다. 그래서 중북을 피할 수 있다. 벨만-포드 알고리듬은 시간을 더 사용하여 노드 표를 업데이트를 시킨다. 이 개산 알고리듬에서는 인접 리스트를 이용하여 표의 각 노드를 저장한다. 한 대기열을 통하여 데이트를 저장한다. 개선 방법에서는 새로운 점에 계속 relaxation을 통하여 최적 패스를 얻을 수 있다. 딕스트라 알고리듬과 SPFA 알고리듬과 개선된 알고리듬의 성능을 비교하기 위해서 시뮬레이션을 하였다. 실험 결과에서 랜덤(random) 그래프에서 개선된 알고리듬, SPFA 알고리듬과 딕스트라 알고리듬은 효율이 비슷했었는데, 격자형 지도에서 개선 알고리듬의 효율이 더 높았었다. 처리시간에서 개선된 알고리듬은 SPFA 알고리듬 보다 3분의 2를 감소시켰다.

• 한국방재학회 논문집
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• 제9권3호
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• pp.117-126
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• 2009

유역종합치수계획 수립 시 유역 내 적용이 가능한 구조물적 비구조물적 치수계획은 매우 광범위하고, 특히 그 중에서도 구조물적 홍수방어 시설들의 특성은 매우 다양하다. 이들을 조합하여 유역의 홍수 저감능력을 최대화 하는 최적대안을 선정하는 것은 쉬운 일이 아니며, 현재 구조물적 홍수방어 후보대안에 대한 적절한 평가 기준이나 다양한 홍수방어 후보대안들 중 최적대안의 선정에 관한 지침 또한 미흡한 실정이다. 본 연구에서는 유역종합치수계획의 구조물적 홍수방어 후보대안들에 대한 치수경제성 및 정책성 평가 결과를 바탕으로 최적대안을 선정하는 과정에서, 의사결정기법 중의 하나인 계층화분석기법을 도입하여 적용함으로써 평가항목들 간의 가중치 결정 및 최적대안을 도출하는 과정을 예시하였다. 후보대안들 각각의 하위 세부 평가항목들의 가중치 결정에는 계층화분석기법 전용 프로그램인 Expert Choice 11.5를 활용하였으며, 연구 결과를 바탕으로 유역종합치수계획의 구조물적 홍수방어 최적대안 선정에 있어 보다 표준화된 절차를 제시하였다.

• 한국수산과학회지
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• 제28권1호
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• pp.35-48
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• 1995

To develop the optimal design method for the longline type scallop culturing facilities in the open sea numerical calculations and hydraulic model experiments are carried out for the stability and function optimization. Using the results for the motion and tension of the facilities, stable design concepts and effects of motion control system by vertical anchor and resistance discs art discussed. The results of this study that can be applied to the design are as follows: 1) Total external forces by design wave $(H_{1/3}\;=\;6,7\;m,\;T_{1/3}\;=\;12sec)$ at the coastal waters of Jumunjin for unit facility (one main line) are estimated to 5-20 tons, and required anchor weights are 10-40 tons in the case of 2-point mooring system. Though the present facilities are stable to steady currents, but is unstable to the extreme wave condition of return period of 10 years. 2) The dimensions and depth of array systems must be designed considering the ecological environments as well as the physical characteristics including the mooring and holding forces that are proportional to the length and relative depth of main line to wave length, and the number of buoys and nets. 3) Oscillation of the facility is influenced by water particle motion and the weight of hanging net, and is excited at both edge, especially at the lee side. To reduce the motion of the nets, the vertical anchoring system and the resistence disc method are recommended by the experimental results, 4) The damage of rope near the anchor by abrasion should be prevented using the ring-type connection parts or anchor chains.

• 대한수의학회지
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• 제30권3호
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• pp.297-307
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• 1990

To establish an agar-gel immunodiffusion (AGID) test for detection of antibodies to Aujeszky's disease virus(ADV) in swine, the precipitating antigens were prepared by four procedures using the Aujeszky's disease virus, NYJ-1-87 strain isolated from the affected piglets in Korea. The optimal condition for AGID test and the properties of the antigens were investigated. To determine the optimal concentration of antigens, four antigens were experimentally prepared by concentrating the viral fluids by 1/30 to 1/200. It was proved that the antigen precipitated with ammonium sulfate at concentration of 1/100 was the most efficient to detect ADV antibodies by AGID test. When the relationship between the concentration of the antigens and the size of precipitating in radial immunodiffusion test was investigated, a high correlation coefficiency at r=0.95 (y=0.23x+23.4) was estimated, In study on the effects of various buffered salt solutions and agars on the sensitivity of AGID test by using the experimental ADV antigens, it was found that 0.05M tris buffer without sodium chloride at pH 7.2 induced the most distinctive precipitating lines, and that there was no significant differences in the sensitivity between the agarose and Noble's special agar. When the efficiency of AGID test was compared with serum neutralization(SN) test, the sensitivity of AGID test was 100% in SN titer over 1 : 16, 91.7% in SN titer of 1 : 8 and 57.1% in SN titer of 1 : 4. The specificity of AGID test compared with the sera with SN titer under 1 : 2 was 98.4%. Protein analysis of the antigens by SDS-PAGE indicated that antigen I and antigen III showed a specific band of polypeptides with molecular weight of 116 K in comparison with the control antigen. Antigen IV, treated with tween-80 and ammonium sulfate, revealed specific polypeptides bands at the molecular weights 45K, 98K and 150 K.

• 한국수자원학회논문집
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• 제38권9호
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• pp.737-746
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• 2005

최적화란 목적함수가 최대 또는 최소가 되도록 하는 결정변수를 찾아가는 절차이다. 기존의 많은 연구자들은 최적해의 효율적인 탐색과정에 집중한 반면 최적화의 시작점이라 할 수 있는 목적함수 구성을 위한 연구는 상대적으로 미진한 것이 사실이다. 따라서 본 연구에서는 국내외에서 빈번히 사용되고 있는 가중평균법을 사용하여 tradeoff를 고려한 목적함수와 절대우선순위를 위한 가중값을 적용한 목적함수를 구성하여 표본추계학적 동적계획법을 통해 산정한 최적운영률을 비교하였다. 그 결과 절대우선순위를 위한 가중값을 적용한 경우가 보다 실제 저수지운영과 부합하는 결과를 나타내는 것을 확인할 수 있었다. 따라서 국내 다목적댐 운영계획에 보다 적합한 목적함수를 구성하기 위해서는 절대우선순위를 위한 가중값을 부여하여 목적함수를 구성하는 것이 타당한 것으로 판단된다.

• Investigative Magnetic Resonance Imaging
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• 제24권3호
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• pp.123-131
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• 2020

Purpose: Joint label fusion (JLF) is a popular multi-atlas-based segmentation algorithm, which compensates for dependent errors that may exist between atlases. However, in order to get good segmentation results, it is very important to set the several free parameters of the algorithm to optimal values. In this study, we first investigate the feasibility of a JLF algorithm for prostate segmentation in MR images, and then suggest the optimal set of parameters for the automatic prostate segmentation by validating the results of each parameter combination. Materials and Methods: We acquired T2-weighted prostate MR images from 20 normal heathy volunteers and did a series of cross validations for every set of parameters of JLF. In each case, the atlases were rigidly registered for the target image. Then, we calculated their voting weights for label fusion from each combination of JLF's parameters (r_pxy, r_pz, r_sxy, r_sz, β). We evaluated the segmentation performances by five validation metrics of the Prostate MR Image Segmentation challenge. Results: As the number of voxels participating in the voting weight calculation and the number of referenced atlases is increased, the overall segmentation performance is gradually improved. The JLF algorithm showed the best results for dice similarity coefficient, 0.8495 ± 0.0392; relative volume difference, 15.2353 ± 17.2350; absolute relative volume difference, 18.8710 ± 13.1546; 95% Hausdorff distance, 7.2366 ± 1.8502; and average boundary distance, 2.2107 ± 0.4972; in parameters of r_pxy = 10, r_pz = 1, r_sxy = 3, r_sz = 1, and β = 3. Conclusion: The evaluated results showed the feasibility of the JLF algorithm for automatic segmentation of prostate MRI. This empirical analysis of segmentation results by label fusion allows for the appropriate setting of parameters.

• Preventive Nutrition and Food Science
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• 제21권2호
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• pp.97-103
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• 2016

In our previous study, an early-maturing variety of rice (Oryza sativa L.), Jinbu can have feature with unique green color, various phytochemicals as well as nutritive components by the optimal early harvesting, called Green Rice$^{(R)}$ (GR). The aims of the present field experiments were to evaluate the changes in the weight of 1,000 kernels, yield, and contents of proximate and bioactive compounds in Chuchung, a mid-late maturing variety, during the pre-harvest maturation of rough rice and to research the appropriate harvest time and potent bioactivity of Chuchung GR. The weights of 1,000 kernels of Chuchung GR dramatically increased until 27 days after heading (DAH). The yields of Chuchung GR declined after 27 DAH and significantly declined to 0.0% after 45 DAH. The caloric value and total mineral contents were higher in the GR than in the full ripe stage, the brown rice (BR). In the GR, the contents of bioactive compounds, such as ${\gamma}$-aminobutyric acid, ${\gamma}$-oryzanol, and ${\alpha}$-tocopherol, were much higher (P<0.05) than those in the BR, specifically during 24~27 DAH. Therefore, bioactive Chuchung GR can be produced with a reasonable yield at 24~27 DAH and it could be useful for applications in various nutritive and functional food products.

• 한국작물학회지
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• 제46권5호
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• pp.407-410
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• 2001

This study was conducted to determine the optimal planting distance in cultivation of yacon (Polymnia sonchifolia Poeppig ＆ Endlicher). Plug seedlings were planted with 6 different plant densities of 80 $\times$ 60, 80 $\times$ 50, 70 $\times$ 50, 70 $\times$ 45, 70 $\times$ 40 and 60 $\times$ 45 cm. The plant height and the petiole length were increased with increasing the planting distance. The tallest plant height of yacon was 165.4cm with the plant density of 80 $\times$ 60 cm. However, branch number per plant, leaf number on main stem and stem diameter were not significantly difference among planting densities. Tuberous root was harvested 31.42 tons/ha in 70 $\times$ 50 cm spacing. The ratio of heavier tuberous roots than 200 g to total tuberous roots decreased significantly according to increase of planting density. Fresh weights of shoot and root, contain the crown bud, were decreased, as planting distance was shorter. Tuberous root number was fewer but its weight was heavier in wide planting than in dense planting. We think that optimal planting density is about 30,000 plants/ha, if it were to be 70 cm row spacing, intrarow spacing should calculate about 47cm.

• 생물환경조절학회지
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• 제11권4호
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• pp.199-204
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• 2002

한국의 인삼재배시 연작장해로 인한 생산량 감소가 문제가 되고 있다 이를 극복하기 위하여 본 연구에서는 한국인삼 재배를 위하여 양액재배 시스템을 적용하였다. 최적의 양액재배용 배지를 선발하기 위하여 모래, TSK-2 (S＋T), 피트모스 (P), 재활용 암면 (RR)과 입상 암면 (GR)등의 다양한 배지를 단독 및 혼합처리구로 사용하였다. RR배지의 경우 전반적인 물리화학적 특성은 기존에 보고된 인삼배지의 토양특성과 유사하였다. S＋T배지는 가밀도가 인삼용 토양보다 높았다 인삼의 지상부 생체중은 RR배지와 S＋T배지에서 높았다. 인삼 뿌리의 생체중 및 건물중은 RR배지에서 가장 높았다. 인삼의 뿌리의 품질적 측면에서 vitamin C함량은 양액재배로 생육시킨 인삼이 토양에서 생육한 인삼보다 높았으나, crude saponin과 ginsenosides 함량에서는 차이를 나타내지 않았다.