• 대한한의학회지
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• 제36권1호
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• pp.86-92
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• 2015

불면을 동반한 건선(乾癬) 환자(患者)에게 불면과 건선(乾癬)의 경중이 비례하는 양상을 보인 환자(患者)에게 불면을 치료(治療)하면 건선(乾癬)이 회복될 것으로 판단되었다. 이와 관련하여 심혈부족(心血不足)이 불면의 원인(原因)이라고 판단되는 건선(乾癬) 환자(患者)에게 귀비탕(歸脾湯)을 투약해서 불면과 건선(乾癬)이 동시에 회복되는 결과(結果)를 확인했다. 아직 명확한 건선(乾癬) 치료(治療) 지침이 확립되지 않은 상황에서 건선(乾癬) 자체를 보고 접근해야 하는 경우도 있지만 건선(乾癬)과 동반된 기저 질환이 건선(乾癬)의 경중과 비례한다면 동반된 질환을 치료(治療)해서 건선(乾癬)을 치료(治療)할 수 있다는 가능성을 얻었다. 앞으로 건선(乾癬) 환자(患者)가 다른 기저 질환을 동반하고 이러한 질환의 경중이 건선(乾癬)과 비례한다면 이 질환의 치료(治療)를 시도하는 것이 건선(乾癬)의 회복에 도움을 줄 수 있을 것으로 보인다.

• 대한임상검사과학회지
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• 제44권2호
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• pp.59-65
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• 2012

Previous studies have shown that modified Je-Ho-Tang (MJHT) has anti-platelet effects. Je-Ho-Tang (JHT), a Korean court beverage, is a traditional Korean herbal medicine that has been used for the treatment of a disease attended by great thirst, and for prevention of illness in hot summers. We made MJHT from JHT by excluding honey. The present study was performed to determine the acute oral toxicity of crude extract of MJHT in male and female ICR mice. We investigated the in vivo single dose acute toxicity of MJHT hot-water extraction. This test was orally administered once by gavage to 20 mice of each sex received doses of 0 (control group), 1250, 2500 and 5000 mg/kg body weight. Mortalities, clinical findings, autopsy findings and body weight changes were monitored daily for 14 days following the administration. We observed survival rates, general toxicities, changes of body weight, and autopsy. No significant lethality was observed after single oral administration of MJHT at the different dosages. Autopsies on the animals revealed no gross abnormalities. Therefore, the LD50 value of MJHT for ICR mice was estimated more than 5000 mg/kg by the oral route. These results suggest that no toxic dose level of MJHT in mice is considered to be more than 5000 mg/kg. Consequently, it was concluded that MJHT have no effect on acute toxicity and side effect in ICR mice.

• 한방재활의학과학회지
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• 제29권2호
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• pp.101-113
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• 2019

Objectives Bogol-tang has clinically been used to protect joint cartilage and to treat osteoarthritis. Our objective was to study the protective effect of Bogol-tang extract (BGT) in functional impairment, behavioral disorders, cartilage loss and pathological changes in a monoiodoacetate (MIA)-induced murine osteoarthritis (OA) model and interleukin (IL)-$1{\beta}$ -treated primary rat chondrocytes. Methods Mouse knee joints were injected with MIA, a chemical that inhibits glycolysis and causes joint inflammation and matrix loss. MIA-OA induced mice orally administered BGT or acetaminophen (AAP) for 18 days by daily. Primary rat chondrocytes were pretreated with BGT or dexamethasone (DEX) and followed by co-incubation with IL-$1{\beta}$ (10 ng/mL). Results In MIA-OA mice model, BGT led to delayed response on hot plate analysis, and suppressed the cartilage loss and damages in joint tissues. BGT suppressed the elevated levels of inflammatory mediators, nitrite and $PGE_2$, the gene expression of matrix degrading enzymes, and extracellular-signal-regulated kinases 1/2 and c-JunN-terminal kinase phosphorylation in IL-$1{\beta}$-treated primary rat chondrocytes. Conclusions Our results suggest that BGT improve the knee joint function and delay the cartilage damages by anti-nociceptive, anti-inflammatory and ant-catabolic effects, which indicate BGT could be a potential candidate for osteoarthritis treatment.

• Korean Journal of Acupuncture
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• 제20권4호
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• pp.77-84
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• 2003

저자는 황련해독탕약침(黃連解毒湯藥鍼)을 응용한 만성결막염(慢性結膜炎) 또는 안구건조증(眼球乾燥症)이라 추정되는 환자(患者) 1례(例)에 대한 임상적 고찰을 통한 결과 다음과 같이 요약(要約)할 수 있다. 1. 만성결막염(慢性結膜炎과 안구건조증(眼球乾燥症)은 한의학적(韓醫學的)으로 '백삽'과 매우 유사하며, 충혈, 소양감, 이물감, 통증, 눈꼽등의 증상을 주소로 하여 악화와 호전을 반복하며 대개 만성의 경과를 보이는 질환이다. 2. 안과 질환은 대부분 화열(火熱)로 인한 것 장부(臟腑)로는 심(心)과 간(肝)이 밀접한 관련이 있다. 3. 본 증례에서도 열(熱)로 인한 것으로 판단하여 황련해독탕(黃連解毒湯) 약침 요법을 심유(心?) 간유혈(肝?穴)에 시술하고 안구(眼球)에 약침액을 점안하여 충혈, 이물감, 껄껄한 느낌, 통증에 있어 현저한 증상의 호전이 있었다. 4. 본 증례(症例)에서 약물치료나 다른 요법을 사용 하지 않고, 황련해독탕(黃連解毒湯) 약침 요법과 약침액의 점안만으로 치료한 결과 유의한 효과를 거둘 수 있었다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2001년도 추계학술대회 및 정기총회
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• pp.85-85
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• 2001

Sam-Hwang-Sa-Shim-Tang(SHSST), a traditional Chinese medicine, composed of Rhei rhizoma, Scutellaria radix, and Coptidis rhizoma were used in the several disease including hypertension, constipation, and hemorrhage. In the present study, we investigated the neuroprotective effects of SHSST and its ingredients on the ischemia/ reperfusion-induced brain injury was evaluated in the rat brain. Ischemia was induced by intraluminal occlusion of the right middle cerebral artery for 120 min and reperfusion was continued for 22 h. SHSST (450 mg/kg), Rhei rhii oma (100 mg/kg), Coptidis rhizoma (100 mg/kg), and Scutellaria radik (100 mg/kg) were orally administered twice, promptly prior to reperfusion and 2 h after the repefusion. Total infarction volume in the ipsilateral hemisphere of ischemia/ reperfusion rats was significantly lowed by the treatments of SHSST (39.2%) and Scutellaria radix (66.5%). However, Coptidis rhizoma did not show any significant effects on the total infarct volume. The inhibiting effect of Scutellaria radix on the total infarct volume was more potent than that of SHSST. In addition, Scutellaria radix significantly inhibited myeloperoxidase (MPO) activity, an index of neutrophil infiltration in ischemic brain tissue. However, there was marked mismatch between total infarct volume and MPO activity in the Scutellaria radix-treated rats. Our findings suggest that Scutellaria radix as an ingredient of SHSST plays a protective role in ischemia-induced brain injury by inhibiting neutrophil infiltration. The effects of Rhei rhizoma on transient brain ischemia-induced neuronal injury are under study.

• 한방안이비인후피부과학회지
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• 제21권3호
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• pp.215-225
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• 2008

Object : In this study, the effect of herb medication, aromarherapy and acupuncture treatment against atopic dermatitis was investigated. Method : We treated him with herb medication, aromatherapy and acupuncture treatment during 28days. Atopic dermatitis grade ane the effect of medication was determined using Kunz type and SCORAD index. Atopic dermatitis lesion was checked by taking pictures. Result : The SCORAD index was lowered 39 at discharge than before of which the SCORAD index was 74.2. at admission. The patient's symptoms are getting reduced. Conclusion : On the basis of this study, herb medication, aromatherapy and acupuncture treatment were shown to treat atopic dermatitis effectively by decreasing oozing, itching, crust.

• 대한한방소아과학회지
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• 제19권1호
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• pp.143-151
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• 2005

Objectives : The purpose of this study is to report periodic limb movements child in sleep. Methods : We report of 5-year-old male patient with periodic limb movements in sleep. The patient suffered from limb movements in sleep, fatigue in the daytime, nasal discharge, nasal obstruction and intermittent cough. We treated him with Kamibojungikki-tang(加味補中益氣湯) and acupuncture Results : After this treatments, the symptoms(limb movements in sleep, fatigue in the daytime, nasal discharge, nasal obstruction, intermittent cough,) are improved. Conclusion : We had good effects in oriental medical treatment on periodic limb movements in sleep. And the more study about this diseases is needed.

• 동의신경정신과학회지
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• 제28권4호
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• pp.319-332
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• 2017

Objectives: The present study aimed to provide clinical evidence on the effect of herbal medicine, Hyeolbuchukeo-tang or Xuefu Zhuyu decoction for the treatment of primary insomnia using a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: This study included RCTs that verified the effects of Hyeolbuchukeo-tang or Xuefu Zhuyu decoction for the treatment of primary insomnia. Literature searches of English, Chinese and Korean databases were performed, and the selected literature was assessed for investigating the risk of bias. Results: The analysis included 10 RCTs. The Chinese Classification of Mental Disorders-3 was most frequently used to define the diagnostic criteria for Hyeolbuchukeo-tang or Xuefu Zhuyu decoction intervention in patients with primary insomnia. The effective rate was the most commonly used outcome measure. A meta-analysis revealed that the effective rate, the Pittsburgh Sleep Quality Index, and the Athens Insomnia Scale in the Modified Xuefu Zhuyu decoction (MXZD) group were higher compared to Western Medicine (WM) group (RR: 1.17, 95% Cl: 1.08 to 1.26, p<0.0001, $I^2$=0/MD: -1.29, 95% Cl: -2.09 to -0.49, p=0.002, $I^2$=0%/MD: -0.99, 95% Cl: -1.81 to -0.18, p=0.02, $I^2$=15%). The effective rate of the MXZD+WM group was significantly different compared to the WM group (RR: 1.28, 95% Cl: 1.11 to 1.47, p=0.0006, $I^2$=2%). The included RCTs were of relatively poor quality and had small sample sizes. Conclusions: Treatment with Hyeolbuchukeo-tang or Xuefu Zhuyu decoction was found to be effective in treating primary insomnia. However, the included RCTs were of relatively poor quality and had small sample sizes. It is hypothesized that this study could serve as a foundation for further clinical studies on the development of diagnosis and treatment methods for primary insomnia based on Korean medicine.

• 셀메드
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• 제9권2호
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• pp.5.1-5.2
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• 2019

Which will have a greater impact on life, love or art? We will focus on Hyang-ryun An, a genius singer. There was a genius singer who was recognized by many people in the world of Korean music. It is said that genius is short-lived, and so is the case of Hyang-ryun An. However, it is a pity that her short life was not caused by artistic anguish and conflict, but by her miserable love. For the poor artist, the patron was a force to sustain her artistic career, but for her, love with the person who fit her will was more important. Although poor and troubled, she wanted a fiery love that shared her temperament. Therefore, in the case of Hyang-ryun An, art was long, but love had a terribly short and deadly power. In the end, a love that goes astray drops a genius artist, dangerous love became the triumph of permanent immutable art.

• 사상체질의학회지
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• 제33권3호
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• pp.161-170
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• 2021

Introduction Hand eczema is dermatitis that occurs on the hand and fingers. In this case, the patient had chronic hand eczema that had relapsed for 3 years, worsened for 6 months, and did not improve even with standard dermatological treatment. We report significant improvement of the patient with chronic hand eczema, diagnosed with Soeunmin Greater Yin Symptomatology based on Sasang Constitutional Medicine. Methods We prescribed herbal medicine, Sibimigwanjung-tang(十二味寬中湯), and the western medications were continued throughout the treatment period. To evaluate the treatment progression, we observed objective and subjective symptoms and took pictures of the patient's hands. Results At the first time of the outpatient visit, the patient complained of pain, oozing, scaling and severe itching even though she had taken dermatological medication for over 6 months. After 8 weeks of Korean medicine treatment, most symptoms showed improvement, and after about 47 weeks of treatment, the symptoms maintained 90% improvement even after stopping western medications and herbal medications. Conclusion The patient in this case showed a significant improvement of chronic hand eczema and the improvements have been maintained even stopping western medications and herbal medications during follow-up for 15 weeks. In addition, the patient showed improvement and maintenance of general conditions as well as skin-related symptoms. In this case, we can concern the effect of the Sasang Constitutional Medicine focused on treating the patient's general pathology as well as the patient's chief complaint at chronic hand eczema not responding to standard dermatological treatment.