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Does blastomere biopsy in preimplantation genetic diagnosis affect early serum ${\beta}$-hCG levels?

  • Cho, Yeon-Jean;Kim, Jin-Yeong;Song, In-Ok;Lee, Hyung-Song;Lim, Chun-Kyu;Koong, Mi-Kyoung;Kang, Inn-Soo
    • Clinical and Experimental Reproductive Medicine
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    • v.38 no.1
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    • pp.31-36
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    • 2011
  • Objective: To determine whether the serum ${\beta}$-human chorionic gonadotropin (hCG) profile following preimplantation genetic diagnosis (PGD) is lower than that of intracytoplasmic sperm injection (ICSI) cycles. Methods: A total of 129 PGD cycles and 1,161 age-matched ICSI cycles, which resulted in pregnancy (serum ${\beta}-hCG{\geq}5$ mIU/mL) on post-ovulation day (POD) 12 were included. We compared the mean serum ${\beta}$-hCG levels on POD 12, 14, 21, and 28, doubling time of serum hCG, and created a cut-off value for predicting a singleton pregnancy in each group. Results: The mean serum ${\beta}$-hCG concentration of the PGD group was significantly lower than that of the control group on POD 12, 14, and 21. The doubling time of serum ${\beta}$-hCG at each time interval showed no significant difference. The cut-off-value of serum ${\beta}$-hCG for predicting a single viable pregnancy was 32.5 mIU/mL on POD 12 and 113.5 mIU/mL on POD 14 for the PGD group, which was lower than that for the control group. Conclusion: Blastomere biopsy may decrease the ${\beta}$-hCG-producing activity of the trophoblasts, especially in early pregnancy. Setting a lower cut-off value of serum ${\beta}$-hCG for predicting pregnancy outcomes in PGD may be needed.

A Study of the Validity of and Cut-Off Scores for the Korean Version of Asperger Syndrome Diagnostic Scale (한국판 아스퍼거 증후군 진단척도의 타당화 및 진단 분할점 산출)

  • Kim, Ha-Na;Shin, Min-Sup
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.22 no.2
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    • pp.81-88
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    • 2011
  • Objectives : This study examined the reliability and validity of the Korean version of Asperger Syndrome Diagnostic Scale (K-ASDS), to calculate the cut-off score in the diagnosis of Asperger syndrome. Further, we examined classification error rate when applying cut-off scores. Methods : One hundred sixty-seven children participated in this study, including 46 with Asperger syndrome, 26 with PDD or PDD NOS, 43 with ADHD, and 52 normal children. Results : An ANCOVA demonstrated no significant differences in the K-ASDS total score between the Asperger and the PDD & PDD NOS groups. However, these groups did show significantly higher scores than the ADHD and normal groups. Among the five subscales on the K-ASDS, the Asperger group obtained significantly higher scores on the language and cognition subscales than the PDD & PDD NOS groups. Two scales were found to be useful in distinguishing the Asperger group from the PDD & PDD NOS group through a discriminant analysis. According to an analysis of ROC curve, the cut-off score on the K-ASDS for the diagnosis of PDD including Asperger syndrome was 121. Conclusion : We discussed that K-ASDS has pretty limit.

Numerical Analysis for Supersonic Off-Design Turbulent Jet Flow (초음속 불완전 팽창 난류 제트 유동에 관한 수치적 연구)

  • Kim Jae-Soo
    • Journal of computational fluids engineering
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    • v.4 no.2
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    • pp.57-66
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    • 1999
  • Numerical Analysis has been done for the supersonic off-design jet flow due to the pressure difference between the jet and the ambient fluid. The difference of pressure generates an oblique shock or an expansion wave at the nozzle exit. The waves reflect repeatedly on the center axis and the sonic surface in the shear layer. The pressure difference is resolved across these reflected waves. In this paper, the axi-symmetric Navier-Stokes equation has been used with the κ-ε turbulence model. The second order TVD scheme with flux limiters, based on the flux vector split with the smooth eigenvalue split, has been used to capture internal shocks and other discontinuities. Numerical calculations have been done to analyze the off-design jet flow due to the pressure difference. The variation of pressure along the flow axis is compared with an experimental result and other numerical result. The characteristics of the interaction between the shock cell and the turbulence mixing layer have been analyzed.

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Development of a Hydraulic Level Control System for High-speed Rice Transplanting Machines (고속 이앙기의 유압 수평 제어 장치 개발에 관한 연구)

  • 정연근;정병학;김경욱
    • Journal of Biosystems Engineering
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    • v.27 no.2
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    • pp.79-88
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    • 2002
  • This study was conducted to develop system for high speed rice transplanting machines. The control system includes a sensor detecting the tilt angle of the seedling bed, a micro-controller and a hydraulic system consisting of a double acting cylinder, a four-way three-position solenoid valve, a relief valve and a hydraulic pump. The levelling system shared the pump with the existing steering control, resulting in a tandem center circuit for the steering and levelling control systems. Using the input signal from the sensor, the micro-controller determined and generated the output signal to control the cylinder through the solenoid valve to keep the seedling bed always parallel to the water surface regardless of soil unevenness during the transplanting operations. Both an ON/OFF and a PWM control schemes were tested. When the flow rate was more than 1 ι/min in the ON/OFF control, the system showed unstable rolling. However, in the PWM control, the system worked stably although the flow rate was more than 1 ι/min. The PWM control showed a better performance when a large difference between the angle and the dead band of the control system occurred. The characteristics of tile system response to given tilt angles were predicted by a computer simulation. Both the ON/OFF and the PWM control systems worked well providing that the operating and waiting times were properly adjusted.

Hybrid Passivation for Organic-Thin Film Transistor on Plastic

  • Han, Seung-Hoon;Kim, Yong-Hee;Kim, Sung-Hoon;Kim, Chang-Hyun;Jeon, Tae-Woo;Lee, Sun-Hee;Choi, Min-Hee;Choo, Dong-Jun;Jang, Jin
    • 한국정보디스플레이학회:학술대회논문집
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    • 2008.10a
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    • pp.979-982
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    • 2008
  • We studied hybrid passivation using parylene-C, metal, photoacyl and indium zinc oxide for pentacene OTFT to assure stability in subthreshold region. After the passivation, the changes in S and $V_{on}$ of OTFT were negligible and $I_{off}$ maintained its initial value of ${\sim}10^{-12}$ A. Therefore, the hybrid passivation is suitable for practical applications based on OTFT.

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On-Pump versus Off-pump Myocardial Revascularization in Patients with Renal Insufficiency: Early and Mid-term Results

  • Kim, Hwan-Wook;Lee, Jae-Won;Je, Hyung-Gon;Choi, Soo-Hwan;Jo, Keon-Hyon;Song, Hyun
    • Journal of Chest Surgery
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    • v.44 no.5
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    • pp.323-331
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    • 2011
  • Background: Myocardial revascularization in patients with renal insufficiency is challenging to the cardiac surgeon, irrespective of utilizing extracorporeal circulation. This study aimed to compare the number of bypass grafts and the mid-term results and to evaluate independent survival predictors in patients with renal insufficiency undergoing on-pump or off-pump myocardial revascularization. Materials and Methods: We retrospectively analyzed the data of 103 patients with renal insufficiency, who had isolated myocardial revascularization between January 1999 and January 2009. The patients were divided into two groups, the on-pump group and the off-pump group. Results: The off-pump group received a significantly greater number of distal arterial grafts than the on-pump group. However, the mean number of total grafts, the degree of complete revascularization, and survival rate of the patients were not significantly different between the two groups. Multivariate analysis showed the independent predictors for reduced mid-term survival were the number of total grafts and postoperative periodic renal replacement therapy. Off-pump myocardial revascularization does not decrease the number of bypass grafts or influence on the mid-term results for patients with renal insufficiency, compared to on-pump myocardial revascularization. Conclusion: Myocardial revascularization with a large number of total grafts has a beneficial effect on survival in patients with renal insufficiency, irrespective of utilizing extracorporeal bypass.

Analysis of Long-term Stability of Direct Methanol Fuel Cell and Investigation of the Methods to Improve its Performance (직접메탄올 연료전지의 장기운전 특성 분석 및 성능향상 연구)

  • Lee, Hyun-Sook;Bae, Byung-Chan;Lee, Jae-Young;Im, Tae-Hun;Ha, Heung-Yong;Hong, Seong-Ahn
    • Journal of Hydrogen and New Energy
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    • v.16 no.1
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    • pp.31-39
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    • 2005
  • Direct methanol fuel cell (DMFC) is considered as a candidate for portable power sources, that could overcome the disadvantages of lithium battery. But in order to attain commercial viability the long term stability of the DMFC should be achieved. Understanding the long-term behavior of membrane-electrode assembly (MEA) is a prerequisite to this purpose and the optimization of the MEA is also needed. In this study we have investigated the changes in performance and electrochemical properties of the MEA during extended operation and the effects of heat treatment of MEA on the long-term performance. The MEAs have been treated in an autoclave with saturated water vapor at 120$^{\circ}C$, vacuum oven at 140$^{\circ}C$ and boiling in organic solvents. The autoclaved MEA was found to be have the best long term performance. The on-off operation mode also increased the performance probably due to effective removal of products from the electrodes. Physical and electrochemical analyses using a scanning electron microscope, impedance analyser and half-cell technique have been done to characterize the MEAs.

Evaluations for Representativeness of Light-Duty Diesel Vehicles' Fuel-based Emission Factors on Vehicle Operating Conditions (연료 소비량에 기반한 소형 경유차 대기오염물질 배출계수의 운전조건별 대표성 평가)

  • Lee, Taewoo;Kwon, Sangil;Son, Jihwan;Kim, Jiyoung;Jeon, Sangzin;Kim, Jeongsoo;Choi, Kwangho
    • Journal of Korean Society for Atmospheric Environment
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    • v.29 no.6
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    • pp.745-756
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    • 2013
  • The purpose of this study is to evaluate representativeness of fuel-based emission factors. Twelve light-duty diesel vehicles which meet Euro-3 to 5 legislative emission limits were selected for emission tests. Second-by-second modal emission rates of vehicles were measured on a standard laboratory chassis dynamometer system. An off-cycle driving cycle was developed as a representative Korean real-world on-road driving cycle. Fuel-based emission factors were developed for short trip segments that involved in the selected driving cycle. Each segment was defined to have unit travel distance, which is 1 km, and characterized by its average speed and Relative Positive Acceleration (RPA). Fuel-based $NO_x$ emission factors demonstrate relatively good representativeness in terms of vehicle operation conditions. $NO_x$ emission factors are estimated to be within ${\pm}20%$ of area-wide emission factor under more than 40% of total driving situations. This result implies that the fuel-based $NO_x$ emission factor could be practically implemented into the on-road emission management strategies, such as a remote sensing device (RSD). High emitting vehicles as well as high emitting operating conditions heavily affect on the mean values and distributions of CO and THC emission factors. Few high emitting conditions are pulling up the mean value and biasing the distributions, which weaken representativeness of fuel-based CO and THC emission factors.

Dielectric Properties of $Ta_2O_5-SiO_2$ Thin Films Deposited at Room Temperature by Continuous Composition Spread (상온에서 연속 조성 확산법에 의해 증착된 $Ta_2O_5-SiO_2$ 유전특성)

  • Kim, Yun-Hoe;Jung, Keun;Yoon, Seok-Jin;Song, Jong-Han;Park, Kyung-Bong;Choi, Ji-Won
    • Journal of the Microelectronics and Packaging Society
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    • v.17 no.2
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    • pp.35-40
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    • 2010
  • The variations of dielectric properties of $Ta_2O_5-SiO_2$ continuous composition spread thin films prepared by off-axis radio-frequency magnetron sputtering were investigated. The dielectric maps of dielectric constant and loss were plotted via 1500 micron-step measuring. The specific points showing superior dielectric properties of high dielectric constant (k~19.5) and loss (tan${\delta}$<0.05) at 1 MHz were found in area of the distance of 16 mm and 22 mm apart from $SiO_2$ side in $75{\times}25mm^2$ sized Pt/Ti/$SiO_2$/Si(100) substrates.

A Survey for Mental Health of Children Whose Parents Have Psychiatric Disorders: A Preliminary Study for Mental Health Screening of High Risk Children (정신질환을 가진 부모의 자녀들의 정신건강 상태 조사 연구: 고위험군 선별을 위한 예비 연구)

  • Seo, Hwo Yeon;Park, Su Mi;Kim, Yeni;Yang, Young Hui;Lee, Ji Yeuon;Lee, Hae Woo;Jung, Hee Yeon
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.28 no.4
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    • pp.235-243
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    • 2017
  • Objectives: This study aimed to evaluate the mental health status of the children of psychiatric patients in order to plan for the resources that may be necessary to help these children achieve their full potential. Methods: Forty-eight children (age 9-18) whose parents were registered in 5 community mental health centers located in Seoul were recruited. Tests assessing 3 psychological domains were conducted: 1) cognition: Korean version of Learning Disability Evaluation Scale, Comprehensive Attention Test, 2) parent reported emotion and behavior: Korean Child Behavior Checklist, Korean attention-deficit hyperactivity disorder Rating Scale, and 3) self-reported emotion and behavior: Korean Beck's Depression Inventory-II/Children's Depression Inventory-II, Korean Youth Self Report). We defined the children as having a high risk of developing mental health problems if their test scores were over the cut-off levels in 2 or more of the 3 domains assessed. Results: Twelve (25%) children were classified as having a high risk of developing mental health issues. 20 (41.6%) children scored above the cut-off in only one of the domains. Conclusion: Our results suggest that the children of psychiatric patients might be vulnerable to mental illness and need early prevention or interven-tions for the sake of their mental health.